Casc1_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBD0_LEIBR

TriTrypDb:

LbrM.20.3700 , LBRM2903_200051300

Length:

689

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 3
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005930	axoneme	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBD0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBD0

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	1
GO:0005515	protein binding	2	1
GO:0008017	microtubule binding	5	1
GO:0008092	cytoskeletal protein binding	3	1
GO:0015631	tubulin binding	4	1
GO:0048487	beta-tubulin binding	5	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	241	245	PF00656	0.525
CLV_NRD_NRD_1	325	327	PF00675	0.526
CLV_NRD_NRD_1	436	438	PF00675	0.407
CLV_NRD_NRD_1	523	525	PF00675	0.474
CLV_NRD_NRD_1	673	675	PF00675	0.360
CLV_NRD_NRD_1	71	73	PF00675	0.214
CLV_PCSK_KEX2_1	166	168	PF00082	0.304
CLV_PCSK_KEX2_1	325	327	PF00082	0.525
CLV_PCSK_KEX2_1	436	438	PF00082	0.425
CLV_PCSK_KEX2_1	591	593	PF00082	0.623
CLV_PCSK_KEX2_1	673	675	PF00082	0.364
CLV_PCSK_KEX2_1	71	73	PF00082	0.372
CLV_PCSK_PC1ET2_1	166	168	PF00082	0.358
CLV_PCSK_PC1ET2_1	591	593	PF00082	0.623
CLV_PCSK_SKI1_1	126	130	PF00082	0.228
CLV_PCSK_SKI1_1	15	19	PF00082	0.651
CLV_PCSK_SKI1_1	152	156	PF00082	0.362
CLV_PCSK_SKI1_1	167	171	PF00082	0.324
CLV_PCSK_SKI1_1	268	272	PF00082	0.587
CLV_PCSK_SKI1_1	436	440	PF00082	0.423
CLV_PCSK_SKI1_1	472	476	PF00082	0.508
CLV_PCSK_SKI1_1	491	495	PF00082	0.440
CLV_PCSK_SKI1_1	524	528	PF00082	0.440
CLV_PCSK_SKI1_1	674	678	PF00082	0.389
CLV_PCSK_SKI1_1	684	688	PF00082	0.363
DEG_APCC_DBOX_1	673	681	PF00400	0.503
DOC_CKS1_1	651	656	PF01111	0.518
DOC_CYCLIN_RxL_1	295	305	PF00134	0.462
DOC_CYCLIN_RxL_1	546	555	PF00134	0.303
DOC_MAPK_gen_1	50	58	PF00069	0.562
DOC_MAPK_gen_1	588	596	PF00069	0.342
DOC_MAPK_gen_1	673	679	PF00069	0.500
DOC_MAPK_MEF2A_6	378	386	PF00069	0.546
DOC_PP1_RVXF_1	150	156	PF00149	0.539
DOC_PP1_RVXF_1	383	389	PF00149	0.400
DOC_PP1_RVXF_1	470	476	PF00149	0.324
DOC_PP1_RVXF_1	682	689	PF00149	0.368
DOC_PP2B_PxIxI_1	279	285	PF00149	0.443
DOC_PP4_FxxP_1	388	391	PF00568	0.386
DOC_PP4_FxxP_1	603	606	PF00568	0.532
DOC_USP7_MATH_1	102	106	PF00917	0.415
DOC_USP7_MATH_1	459	463	PF00917	0.455
DOC_USP7_MATH_1	467	471	PF00917	0.386
DOC_USP7_MATH_1	511	515	PF00917	0.444
DOC_USP7_MATH_2	459	465	PF00917	0.271
DOC_USP7_UBL2_3	11	15	PF12436	0.668
DOC_USP7_UBL2_3	29	33	PF12436	0.309
DOC_WW_Pin1_4	356	361	PF00397	0.620
DOC_WW_Pin1_4	500	505	PF00397	0.483
DOC_WW_Pin1_4	515	520	PF00397	0.462
DOC_WW_Pin1_4	544	549	PF00397	0.416
DOC_WW_Pin1_4	650	655	PF00397	0.510
LIG_14-3-3_CanoR_1	126	131	PF00244	0.457
LIG_14-3-3_CanoR_1	250	259	PF00244	0.562
LIG_14-3-3_CanoR_1	272	278	PF00244	0.430
LIG_14-3-3_CanoR_1	325	332	PF00244	0.518
LIG_14-3-3_CanoR_1	385	389	PF00244	0.407
LIG_14-3-3_CanoR_1	397	402	PF00244	0.342
LIG_14-3-3_CanoR_1	436	441	PF00244	0.448
LIG_14-3-3_CanoR_1	472	478	PF00244	0.527
LIG_14-3-3_CanoR_1	513	517	PF00244	0.479
LIG_14-3-3_CanoR_1	616	624	PF00244	0.410
LIG_14-3-3_CanoR_1	684	689	PF00244	0.351
LIG_BRCT_BRCA1_1	275	279	PF00533	0.428
LIG_BRCT_BRCA1_1	398	402	PF00533	0.314
LIG_BRCT_BRCA1_1	564	568	PF00533	0.521
LIG_Clathr_ClatBox_1	340	344	PF01394	0.431
LIG_Clathr_ClatBox_1	474	478	PF01394	0.396
LIG_CSL_BTD_1	516	519	PF09270	0.405
LIG_deltaCOP1_diTrp_1	461	468	PF00928	0.408
LIG_eIF4E_1	646	652	PF01652	0.495
LIG_FHA_1	135	141	PF00498	0.520
LIG_FHA_1	146	152	PF00498	0.530
LIG_FHA_1	209	215	PF00498	0.478
LIG_FHA_1	228	234	PF00498	0.539
LIG_FHA_1	265	271	PF00498	0.576
LIG_FHA_1	333	339	PF00498	0.499
LIG_FHA_1	391	397	PF00498	0.375
LIG_FHA_1	426	432	PF00498	0.637
LIG_FHA_1	437	443	PF00498	0.366
LIG_FHA_1	600	606	PF00498	0.570
LIG_FHA_1	666	672	PF00498	0.493
LIG_FHA_2	340	346	PF00498	0.520
LIG_FHA_2	41	47	PF00498	0.574
LIG_FHA_2	452	458	PF00498	0.489
LIG_FHA_2	484	490	PF00498	0.587
LIG_FHA_2	605	611	PF00498	0.576
LIG_FHA_2	626	632	PF00498	0.510
LIG_FHA_2	651	657	PF00498	0.519
LIG_Integrin_RGD_1	482	484	PF01839	0.653
LIG_IRF3_LxIS_1	382	387	PF10401	0.484
LIG_LIR_Apic_2	387	391	PF02991	0.405
LIG_LIR_Apic_2	453	459	PF02991	0.286
LIG_LIR_Apic_2	514	519	PF02991	0.289
LIG_LIR_Apic_2	600	606	PF02991	0.539
LIG_LIR_Gen_1	224	233	PF02991	0.483
LIG_LIR_Gen_1	271	282	PF02991	0.435
LIG_LIR_Gen_1	529	535	PF02991	0.437
LIG_LIR_Gen_1	54	63	PF02991	0.563
LIG_LIR_Gen_1	555	564	PF02991	0.406
LIG_LIR_Gen_1	590	600	PF02991	0.376
LIG_LIR_Gen_1	610	617	PF02991	0.399
LIG_LIR_Gen_1	678	686	PF02991	0.498
LIG_LIR_Gen_1	96	104	PF02991	0.539
LIG_LIR_Nem_3	129	133	PF02991	0.447
LIG_LIR_Nem_3	215	221	PF02991	0.499
LIG_LIR_Nem_3	224	228	PF02991	0.459
LIG_LIR_Nem_3	271	277	PF02991	0.456
LIG_LIR_Nem_3	317	322	PF02991	0.427
LIG_LIR_Nem_3	327	332	PF02991	0.319
LIG_LIR_Nem_3	487	493	PF02991	0.452
LIG_LIR_Nem_3	529	534	PF02991	0.438
LIG_LIR_Nem_3	54	58	PF02991	0.563
LIG_LIR_Nem_3	565	570	PF02991	0.438
LIG_LIR_Nem_3	590	596	PF02991	0.364
LIG_LIR_Nem_3	610	615	PF02991	0.382
LIG_LIR_Nem_3	643	649	PF02991	0.467
LIG_LIR_Nem_3	678	682	PF02991	0.506
LIG_LIR_Nem_3	96	101	PF02991	0.532
LIG_MLH1_MIPbox_1	564	568	PF16413	0.424
LIG_NRBOX	647	653	PF00104	0.393
LIG_PDZ_Wminus1_1	687	689	PF00595	0.356
LIG_Pex14_2	119	123	PF04695	0.476
LIG_Pex14_2	402	406	PF04695	0.500
LIG_Pex14_2	564	568	PF04695	0.385
LIG_PTB_Apo_2	664	671	PF02174	0.516
LIG_PTB_Phospho_1	664	670	PF10480	0.519
LIG_Rb_LxCxE_1	529	550	PF01857	0.285
LIG_RPA_C_Fungi	61	73	PF08784	0.223
LIG_SH2_CRK	218	222	PF00017	0.329
LIG_SH2_CRK	236	240	PF00017	0.301
LIG_SH2_CRK	456	460	PF00017	0.263
LIG_SH2_CRK	649	653	PF00017	0.389
LIG_SH2_NCK_1	182	186	PF00017	0.413
LIG_SH2_NCK_1	456	460	PF00017	0.263
LIG_SH2_STAP1	236	240	PF00017	0.359
LIG_SH2_STAP1	319	323	PF00017	0.522
LIG_SH2_STAP1	558	562	PF00017	0.376
LIG_SH2_STAT5	55	58	PF00017	0.453
LIG_SH2_STAT5	670	673	PF00017	0.473
LIG_SH3_3	291	297	PF00018	0.525
LIG_SH3_3	376	382	PF00018	0.587
LIG_SH3_4	11	18	PF00018	0.673
LIG_SUMO_SIM_par_1	136	142	PF11976	0.475
LIG_UBA3_1	522	527	PF00899	0.473
LIG_WRC_WIRS_1	340	345	PF05994	0.458
LIG_WW_3	370	374	PF00397	0.606
MOD_CDK_SPK_2	544	549	PF00069	0.324
MOD_CK1_1	197	203	PF00069	0.455
MOD_CK1_1	204	210	PF00069	0.288
MOD_CK1_1	273	279	PF00069	0.412
MOD_CK1_1	324	330	PF00069	0.546
MOD_CK1_1	417	423	PF00069	0.454
MOD_CK1_1	515	521	PF00069	0.520
MOD_CK1_1	650	656	PF00069	0.552
MOD_CK2_1	339	345	PF00069	0.452
MOD_CK2_1	483	489	PF00069	0.477
MOD_CK2_1	650	656	PF00069	0.552
MOD_GlcNHglycan	241	244	PF01048	0.473
MOD_GlcNHglycan	349	352	PF01048	0.501
MOD_GlcNHglycan	416	419	PF01048	0.532
MOD_GlcNHglycan	528	531	PF01048	0.500
MOD_GSK3_1	193	200	PF00069	0.448
MOD_GSK3_1	204	211	PF00069	0.397
MOD_GSK3_1	244	251	PF00069	0.393
MOD_GSK3_1	264	271	PF00069	0.420
MOD_GSK3_1	317	324	PF00069	0.514
MOD_GSK3_1	417	424	PF00069	0.465
MOD_GSK3_1	511	518	PF00069	0.542
MOD_GSK3_1	562	569	PF00069	0.499
MOD_GSK3_1	627	634	PF00069	0.557
MOD_N-GLC_1	544	549	PF02516	0.324
MOD_NEK2_1	119	124	PF00069	0.475
MOD_NEK2_1	201	206	PF00069	0.386
MOD_NEK2_1	227	232	PF00069	0.489
MOD_NEK2_1	332	337	PF00069	0.455
MOD_NEK2_1	421	426	PF00069	0.610
MOD_NEK2_1	451	456	PF00069	0.472
MOD_NEK2_1	468	473	PF00069	0.405
MOD_NEK2_1	512	517	PF00069	0.511
MOD_NEK2_1	526	531	PF00069	0.345
MOD_NEK2_1	58	63	PF00069	0.415
MOD_NEK2_1	587	592	PF00069	0.417
MOD_NEK2_1	611	616	PF00069	0.529
MOD_NEK2_1	665	670	PF00069	0.486
MOD_PIKK_1	227	233	PF00454	0.471
MOD_PIKK_1	324	330	PF00454	0.560
MOD_PIKK_1	562	568	PF00454	0.506
MOD_PKA_1	436	442	PF00069	0.476
MOD_PKA_2	324	330	PF00069	0.511
MOD_PKA_2	347	353	PF00069	0.474
MOD_PKA_2	384	390	PF00069	0.409
MOD_PKA_2	396	402	PF00069	0.374
MOD_PKA_2	436	442	PF00069	0.511
MOD_PKA_2	512	518	PF00069	0.537
MOD_PKA_2	587	593	PF00069	0.413
MOD_PKB_1	480	488	PF00069	0.367
MOD_Plk_1	102	108	PF00069	0.344
MOD_Plk_1	332	338	PF00069	0.424
MOD_Plk_1	468	474	PF00069	0.288
MOD_Plk_1	58	64	PF00069	0.391
MOD_Plk_1	599	605	PF00069	0.553
MOD_Plk_2-3	339	345	PF00069	0.435
MOD_Plk_2-3	599	605	PF00069	0.610
MOD_Plk_4	134	140	PF00069	0.439
MOD_Plk_4	244	250	PF00069	0.428
MOD_Plk_4	390	396	PF00069	0.381
MOD_Plk_4	397	403	PF00069	0.375
MOD_Plk_4	451	457	PF00069	0.481
MOD_Plk_4	512	518	PF00069	0.299
MOD_Plk_4	647	653	PF00069	0.370
MOD_ProDKin_1	356	362	PF00069	0.618
MOD_ProDKin_1	500	506	PF00069	0.482
MOD_ProDKin_1	515	521	PF00069	0.458
MOD_ProDKin_1	544	550	PF00069	0.411
MOD_ProDKin_1	650	656	PF00069	0.514
MOD_SUMO_for_1	171	174	PF00179	0.223
MOD_SUMO_for_1	67	70	PF00179	0.449
MOD_SUMO_for_1	81	84	PF00179	0.358
MOD_SUMO_rev_2	550	557	PF00179	0.332
TRG_DiLeu_BaEn_1	489	494	PF01217	0.381
TRG_DiLeu_BaEn_1	678	683	PF01217	0.505
TRG_DiLeu_BaEn_2	537	543	PF01217	0.427
TRG_DiLeu_BaEn_4	538	544	PF01217	0.521
TRG_DiLeu_BaLyEn_6	497	502	PF01217	0.532
TRG_ENDOCYTIC_2	218	221	PF00928	0.378
TRG_ENDOCYTIC_2	236	239	PF00928	0.203
TRG_ENDOCYTIC_2	55	58	PF00928	0.475
TRG_ENDOCYTIC_2	558	561	PF00928	0.363
TRG_ENDOCYTIC_2	649	652	PF00928	0.396
TRG_ER_diArg_1	346	349	PF00400	0.539
TRG_ER_diArg_1	435	437	PF00400	0.571
TRG_ER_diArg_1	64	67	PF00400	0.232
TRG_ER_diArg_1	672	674	PF00400	0.371
TRG_ER_diArg_1	71	73	PF00400	0.223
TRG_Pf-PMV_PEXEL_1	491	495	PF00026	0.393
TRG_Pf-PMV_PEXEL_1	500	505	PF00026	0.413
TRG_Pf-PMV_PEXEL_1	524	528	PF00026	0.360

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P710	Leptomonas seymouri	70%	98%
A0A0S4KLU8	Bodo saltans	38%	100%
A0A1X0PA51	Trypanosomatidae	48%	100%
A0A3Q8IFW2	Leishmania donovani	83%	100%
A0A3R7MX42	Trypanosoma rangeli	44%	98%
A4IAH8	Leishmania infantum	83%	100%
C9ZLR1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B5K2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q2D4	Leishmania major	83%	100%
V5BLS6	Trypanosoma cruzi	46%	98%