Ubiquitin carboxyl-terminal hydrolase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

ubiquitin hydrolase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBC9_LEIBR

TriTrypDb:

LbrM.20.3690 , LBRM2903_200051200

Length:

903

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBC9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBC9

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	9
GO:0006511	ubiquitin-dependent protein catabolic process	7	9
GO:0006807	nitrogen compound metabolic process	2	9
GO:0008152	metabolic process	1	9
GO:0009056	catabolic process	2	9
GO:0009057	macromolecule catabolic process	4	9
GO:0009987	cellular process	1	9
GO:0016579	protein deubiquitination	6	9
GO:0019538	protein metabolic process	3	9
GO:0019941	modification-dependent protein catabolic process	6	9
GO:0036211	protein modification process	4	9
GO:0043170	macromolecule metabolic process	3	9
GO:0043412	macromolecule modification	4	9
GO:0043632	modification-dependent macromolecule catabolic process	5	9
GO:0044237	cellular metabolic process	2	9
GO:0044238	primary metabolic process	2	9
GO:0044248	cellular catabolic process	3	9
GO:0044260	obsolete cellular macromolecule metabolic process	3	9
GO:0044265	obsolete cellular macromolecule catabolic process	4	9
GO:0051603	proteolysis involved in protein catabolic process	5	9
GO:0070646	protein modification by small protein removal	5	9
GO:0070647	protein modification by small protein conjugation or removal	5	9
GO:0071704	organic substance metabolic process	2	9
GO:1901564	organonitrogen compound metabolic process	3	9
GO:1901575	organic substance catabolic process	3	9

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	9
GO:0004843	cysteine-type deubiquitinase activity	5	9
GO:0008233	peptidase activity	3	9
GO:0008234	cysteine-type peptidase activity	4	9
GO:0016787	hydrolase activity	2	9
GO:0019783	ubiquitin-like protein peptidase activity	4	9
GO:0101005	deubiquitinase activity	5	9
GO:0140096	catalytic activity, acting on a protein	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	31	33	PF00675	0.290
CLV_NRD_NRD_1	359	361	PF00675	0.617
CLV_NRD_NRD_1	364	366	PF00675	0.576
CLV_NRD_NRD_1	481	483	PF00675	0.595
CLV_NRD_NRD_1	741	743	PF00675	0.664
CLV_NRD_NRD_1	786	788	PF00675	0.589
CLV_NRD_NRD_1	814	816	PF00675	0.510
CLV_NRD_NRD_1	841	843	PF00675	0.585
CLV_PCSK_FUR_1	739	743	PF00082	0.634
CLV_PCSK_KEX2_1	31	33	PF00082	0.290
CLV_PCSK_KEX2_1	741	743	PF00082	0.646
CLV_PCSK_KEX2_1	785	787	PF00082	0.548
CLV_PCSK_KEX2_1	814	816	PF00082	0.510
CLV_PCSK_SKI1_1	110	114	PF00082	0.407
CLV_PCSK_SKI1_1	192	196	PF00082	0.458
CLV_PCSK_SKI1_1	200	204	PF00082	0.471
CLV_PCSK_SKI1_1	261	265	PF00082	0.517
CLV_PCSK_SKI1_1	303	307	PF00082	0.489
CLV_PCSK_SKI1_1	50	54	PF00082	0.407
CLV_PCSK_SKI1_1	597	601	PF00082	0.615
CLV_PCSK_SKI1_1	815	819	PF00082	0.563
CLV_PCSK_SKI1_1	831	835	PF00082	0.547
CLV_PCSK_SKI1_1	850	854	PF00082	0.366
DEG_APCC_DBOX_1	741	749	PF00400	0.636
DEG_Nend_UBRbox_1	1	4	PF02207	0.685
DEG_SCF_FBW7_1	338	345	PF00400	0.670
DOC_CDC14_PxL_1	630	638	PF14671	0.378
DOC_CKS1_1	417	422	PF01111	0.401
DOC_CKS1_1	606	611	PF01111	0.408
DOC_CYCLIN_yClb1_LxF_4	612	618	PF00134	0.605
DOC_MAPK_gen_1	389	398	PF00069	0.622
DOC_MAPK_gen_1	731	740	PF00069	0.476
DOC_MAPK_gen_1	741	748	PF00069	0.590
DOC_MAPK_gen_1	830	836	PF00069	0.541
DOC_MAPK_JIP1_4	871	877	PF00069	0.648
DOC_MAPK_MEF2A_6	162	170	PF00069	0.407
DOC_MAPK_MEF2A_6	322	329	PF00069	0.470
DOC_MAPK_MEF2A_6	389	398	PF00069	0.622
DOC_MAPK_MEF2A_6	671	680	PF00069	0.600
DOC_PP1_RVXF_1	198	204	PF00149	0.441
DOC_PP2B_LxvP_1	665	668	PF13499	0.462
DOC_PP4_FxxP_1	628	631	PF00568	0.599
DOC_PP4_FxxP_1	793	796	PF00568	0.475
DOC_USP7_MATH_1	508	512	PF00917	0.417
DOC_USP7_MATH_2	693	699	PF00917	0.627
DOC_USP7_UBL2_3	893	897	PF12436	0.824
DOC_WW_Pin1_4	100	105	PF00397	0.377
DOC_WW_Pin1_4	168	173	PF00397	0.472
DOC_WW_Pin1_4	174	179	PF00397	0.504
DOC_WW_Pin1_4	338	343	PF00397	0.615
DOC_WW_Pin1_4	396	401	PF00397	0.694
DOC_WW_Pin1_4	416	421	PF00397	0.319
DOC_WW_Pin1_4	431	436	PF00397	0.668
DOC_WW_Pin1_4	583	588	PF00397	0.603
DOC_WW_Pin1_4	605	610	PF00397	0.440
DOC_WW_Pin1_4	767	772	PF00397	0.483
LIG_14-3-3_CanoR_1	214	220	PF00244	0.462
LIG_14-3-3_CanoR_1	322	326	PF00244	0.471
LIG_14-3-3_CanoR_1	392	397	PF00244	0.644
LIG_14-3-3_CanoR_1	544	548	PF00244	0.421
LIG_14-3-3_CanoR_1	59	68	PF00244	0.465
LIG_14-3-3_CanoR_1	715	724	PF00244	0.515
LIG_14-3-3_CanoR_1	842	852	PF00244	0.574
LIG_Actin_WH2_2	198	216	PF00022	0.489
LIG_Actin_WH2_2	701	719	PF00022	0.611
LIG_Actin_WH2_2	798	816	PF00022	0.554
LIG_Actin_WH2_2	85	103	PF00022	0.489
LIG_APCC_ABBA_1	564	569	PF00400	0.548
LIG_APCC_ABBAyCdc20_2	563	569	PF00400	0.553
LIG_BIR_III_2	175	179	PF00653	0.542
LIG_BRCT_BRCA1_1	183	187	PF00533	0.417
LIG_BRCT_BRCA1_1	217	221	PF00533	0.517
LIG_BRCT_BRCA1_1	697	701	PF00533	0.594
LIG_Clathr_ClatBox_1	755	759	PF01394	0.371
LIG_deltaCOP1_diTrp_1	282	288	PF00928	0.445
LIG_EH1_1	82	90	PF00400	0.441
LIG_EVH1_1	606	610	PF00568	0.667
LIG_FAT_LD_1	705	713	PF03623	0.341
LIG_FHA_1	12	18	PF00498	0.407
LIG_FHA_1	205	211	PF00498	0.407
LIG_FHA_1	527	533	PF00498	0.667
LIG_FHA_1	63	69	PF00498	0.449
LIG_FHA_1	673	679	PF00498	0.552
LIG_FHA_1	885	891	PF00498	0.550
LIG_FHA_2	295	301	PF00498	0.489
LIG_FHA_2	357	363	PF00498	0.616
LIG_FHA_2	62	68	PF00498	0.489
LIG_FHA_2	644	650	PF00498	0.563
LIG_FHA_2	698	704	PF00498	0.535
LIG_FHA_2	752	758	PF00498	0.615
LIG_FHA_2	97	103	PF00498	0.458
LIG_LIR_Apic_2	446	452	PF02991	0.728
LIG_LIR_Apic_2	790	796	PF02991	0.508
LIG_LIR_Gen_1	206	216	PF02991	0.489
LIG_LIR_Gen_1	282	293	PF02991	0.416
LIG_LIR_Gen_1	434	440	PF02991	0.640
LIG_LIR_Gen_1	475	484	PF02991	0.635
LIG_LIR_Gen_1	51	58	PF02991	0.458
LIG_LIR_Gen_1	585	596	PF02991	0.489
LIG_LIR_Gen_1	698	709	PF02991	0.333
LIG_LIR_LC3C_4	139	144	PF02991	0.489
LIG_LIR_Nem_3	111	116	PF02991	0.407
LIG_LIR_Nem_3	135	140	PF02991	0.417
LIG_LIR_Nem_3	206	211	PF02991	0.489
LIG_LIR_Nem_3	243	248	PF02991	0.528
LIG_LIR_Nem_3	282	288	PF02991	0.424
LIG_LIR_Nem_3	3	8	PF02991	0.571
LIG_LIR_Nem_3	313	318	PF02991	0.686
LIG_LIR_Nem_3	378	383	PF02991	0.516
LIG_LIR_Nem_3	434	439	PF02991	0.622
LIG_LIR_Nem_3	442	448	PF02991	0.614
LIG_LIR_Nem_3	475	480	PF02991	0.545
LIG_LIR_Nem_3	51	56	PF02991	0.458
LIG_LIR_Nem_3	585	591	PF02991	0.505
LIG_LIR_Nem_3	611	617	PF02991	0.554
LIG_LIR_Nem_3	637	643	PF02991	0.638
LIG_LIR_Nem_3	649	654	PF02991	0.479
LIG_LIR_Nem_3	698	704	PF02991	0.519
LIG_LIR_Nem_3	790	795	PF02991	0.588
LIG_LYPXL_yS_3	450	453	PF13949	0.675
LIG_NRBOX	733	739	PF00104	0.590
LIG_PCNA_PIPBox_1	547	556	PF02747	0.374
LIG_PCNA_yPIPBox_3	18	32	PF02747	0.441
LIG_PCNA_yPIPBox_3	222	236	PF02747	0.445
LIG_PCNA_yPIPBox_3	592	604	PF02747	0.656
LIG_Pex14_1	217	221	PF04695	0.542
LIG_Pex14_2	281	285	PF04695	0.441
LIG_PTB_Apo_2	777	784	PF02174	0.581
LIG_Rb_pABgroove_1	87	95	PF01858	0.489
LIG_REV1ctd_RIR_1	615	623	PF16727	0.581
LIG_SH2_CRK	25	29	PF00017	0.489
LIG_SH2_CRK	35	39	PF00017	0.441
LIG_SH2_CRK	588	592	PF00017	0.605
LIG_SH2_CRK	684	688	PF00017	0.621
LIG_SH2_GRB2like	16	19	PF00017	0.407
LIG_SH2_GRB2like	278	281	PF00017	0.489
LIG_SH2_GRB2like	328	331	PF00017	0.450
LIG_SH2_NCK_1	208	212	PF00017	0.489
LIG_SH2_NCK_1	35	39	PF00017	0.542
LIG_SH2_PTP2	276	279	PF00017	0.445
LIG_SH2_PTP2	5	8	PF00017	0.441
LIG_SH2_SRC	16	19	PF00017	0.407
LIG_SH2_SRC	276	279	PF00017	0.445
LIG_SH2_STAP1	138	142	PF00017	0.407
LIG_SH2_STAP1	445	449	PF00017	0.763
LIG_SH2_STAP1	626	630	PF00017	0.570
LIG_SH2_STAT3	540	543	PF00017	0.623
LIG_SH2_STAT3	724	727	PF00017	0.561
LIG_SH2_STAT5	129	132	PF00017	0.441
LIG_SH2_STAT5	16	19	PF00017	0.377
LIG_SH2_STAT5	228	231	PF00017	0.407
LIG_SH2_STAT5	276	279	PF00017	0.441
LIG_SH2_STAT5	328	331	PF00017	0.442
LIG_SH2_STAT5	370	373	PF00017	0.484
LIG_SH2_STAT5	5	8	PF00017	0.428
LIG_SH2_STAT5	522	525	PF00017	0.654
LIG_SH2_STAT5	540	543	PF00017	0.381
LIG_SH2_STAT5	553	556	PF00017	0.462
LIG_SH2_STAT5	565	568	PF00017	0.459
LIG_SH2_STAT5	570	573	PF00017	0.457
LIG_SH2_STAT5	614	617	PF00017	0.372
LIG_SH2_STAT5	691	694	PF00017	0.538
LIG_SH2_STAT5	792	795	PF00017	0.570
LIG_SH3_1	604	610	PF00018	0.637
LIG_SH3_1	768	774	PF00018	0.598
LIG_SH3_3	454	460	PF00018	0.603
LIG_SH3_3	604	610	PF00018	0.558
LIG_SH3_3	628	634	PF00018	0.453
LIG_SH3_3	687	693	PF00018	0.537
LIG_SH3_3	768	774	PF00018	0.568
LIG_SH3_3	866	872	PF00018	0.552
LIG_SUMO_SIM_anti_2	139	144	PF11976	0.441
LIG_SUMO_SIM_anti_2	673	679	PF11976	0.558
LIG_SUMO_SIM_anti_2	703	710	PF11976	0.587
LIG_SUMO_SIM_anti_2	744	750	PF11976	0.622
LIG_SUMO_SIM_par_1	375	381	PF11976	0.550
LIG_SUMO_SIM_par_1	673	679	PF11976	0.577
LIG_SUMO_SIM_par_1	744	750	PF11976	0.622
LIG_SUMO_SIM_par_1	753	760	PF11976	0.583
LIG_SUMO_SIM_par_1	865	870	PF11976	0.332
LIG_TRAF2_1	296	299	PF00917	0.489
LIG_TRAF2_1	39	42	PF00917	0.391
LIG_TRAF2_1	75	78	PF00917	0.489
LIG_TRAF2_1	804	807	PF00917	0.480
LIG_TRAF2_1	823	826	PF00917	0.652
LIG_UBA3_1	812	819	PF00899	0.609
LIG_UBA3_1	92	101	PF00899	0.407
LIG_WRC_WIRS_1	216	221	PF05994	0.465
MOD_CDK_SPxK_1	100	106	PF00069	0.466
MOD_CK1_1	249	255	PF00069	0.532
MOD_CK1_1	259	265	PF00069	0.453
MOD_CK1_1	310	316	PF00069	0.669
MOD_CK1_1	434	440	PF00069	0.636
MOD_CK1_1	444	450	PF00069	0.706
MOD_CK1_1	524	530	PF00069	0.455
MOD_CK1_1	546	552	PF00069	0.471
MOD_CK1_1	602	608	PF00069	0.672
MOD_CK1_1	841	847	PF00069	0.575
MOD_CK1_1	95	101	PF00069	0.542
MOD_CK2_1	150	156	PF00069	0.460
MOD_CK2_1	292	298	PF00069	0.524
MOD_CK2_1	356	362	PF00069	0.630
MOD_CK2_1	434	440	PF00069	0.531
MOD_CK2_1	496	502	PF00069	0.541
MOD_CK2_1	61	67	PF00069	0.441
MOD_CK2_1	697	703	PF00069	0.503
MOD_CK2_1	72	78	PF00069	0.441
MOD_CK2_1	800	806	PF00069	0.520
MOD_CK2_1	845	851	PF00069	0.667
MOD_CK2_1	96	102	PF00069	0.458
MOD_GlcNHglycan	158	161	PF01048	0.542
MOD_GlcNHglycan	2	5	PF01048	0.604
MOD_GlcNHglycan	294	297	PF01048	0.472
MOD_GlcNHglycan	303	306	PF01048	0.396
MOD_GlcNHglycan	344	347	PF01048	0.652
MOD_GlcNHglycan	436	439	PF01048	0.481
MOD_GlcNHglycan	523	526	PF01048	0.425
MOD_GlcNHglycan	718	721	PF01048	0.479
MOD_GlcNHglycan	74	77	PF01048	0.489
MOD_GlcNHglycan	787	790	PF01048	0.660
MOD_GlcNHglycan	899	903	PF01048	0.723
MOD_GSK3_1	177	184	PF00069	0.507
MOD_GSK3_1	338	345	PF00069	0.670
MOD_GSK3_1	392	399	PF00069	0.590
MOD_GSK3_1	434	441	PF00069	0.643
MOD_GSK3_1	492	499	PF00069	0.549
MOD_GSK3_1	538	545	PF00069	0.639
MOD_GSK3_1	568	575	PF00069	0.577
MOD_GSK3_1	582	589	PF00069	0.440
MOD_GSK3_1	62	69	PF00069	0.421
MOD_GSK3_1	639	646	PF00069	0.579
MOD_GSK3_1	672	679	PF00069	0.530
MOD_GSK3_1	841	848	PF00069	0.620
MOD_GSK3_1	891	898	PF00069	0.751
MOD_GSK3_1	92	99	PF00069	0.542
MOD_N-GLC_1	221	226	PF02516	0.445
MOD_N-GLC_1	61	66	PF02516	0.451
MOD_N-GLC_1	643	648	PF02516	0.586
MOD_N-GLC_1	801	806	PF02516	0.584
MOD_N-GLC_2	798	800	PF02516	0.583
MOD_NEK2_1	221	226	PF00069	0.449
MOD_NEK2_1	254	259	PF00069	0.377
MOD_NEK2_1	538	543	PF00069	0.582
MOD_NEK2_1	559	564	PF00069	0.551
MOD_NEK2_1	599	604	PF00069	0.689
MOD_NEK2_1	716	721	PF00069	0.464
MOD_NEK2_1	72	77	PF00069	0.477
MOD_NEK2_1	96	101	PF00069	0.542
MOD_NEK2_2	231	236	PF00069	0.290
MOD_NEK2_2	256	261	PF00069	0.466
MOD_NEK2_2	643	648	PF00069	0.627
MOD_NEK2_2	697	702	PF00069	0.595
MOD_PIKK_1	181	187	PF00454	0.441
MOD_PIKK_1	238	244	PF00454	0.542
MOD_PIKK_1	483	489	PF00454	0.389
MOD_PK_1	392	398	PF00069	0.625
MOD_PK_1	886	892	PF00069	0.808
MOD_PKA_1	785	791	PF00069	0.701
MOD_PKA_2	321	327	PF00069	0.354
MOD_PKA_2	543	549	PF00069	0.670
MOD_PKA_2	60	66	PF00069	0.542
MOD_PKA_2	716	722	PF00069	0.441
MOD_PKA_2	785	791	PF00069	0.647
MOD_PKA_2	841	847	PF00069	0.566
MOD_PKB_1	59	67	PF00069	0.489
MOD_Plk_1	150	156	PF00069	0.462
MOD_Plk_1	221	227	PF00069	0.494
MOD_Plk_1	231	237	PF00069	0.501
MOD_Plk_1	268	274	PF00069	0.467
MOD_Plk_1	372	378	PF00069	0.530
MOD_Plk_1	41	47	PF00069	0.485
MOD_Plk_1	643	649	PF00069	0.549
MOD_Plk_1	672	678	PF00069	0.547
MOD_Plk_1	801	807	PF00069	0.580
MOD_Plk_1	96	102	PF00069	0.553
MOD_Plk_2-3	204	210	PF00069	0.489
MOD_Plk_2-3	294	300	PF00069	0.489
MOD_Plk_4	16	22	PF00069	0.429
MOD_Plk_4	321	327	PF00069	0.442
MOD_Plk_4	372	378	PF00069	0.477
MOD_Plk_4	444	450	PF00069	0.755
MOD_Plk_4	492	498	PF00069	0.650
MOD_Plk_4	508	514	PF00069	0.476
MOD_Plk_4	660	666	PF00069	0.523
MOD_Plk_4	672	678	PF00069	0.454
MOD_Plk_4	751	757	PF00069	0.503
MOD_Plk_4	886	892	PF00069	0.675
MOD_ProDKin_1	100	106	PF00069	0.377
MOD_ProDKin_1	168	174	PF00069	0.472
MOD_ProDKin_1	338	344	PF00069	0.613
MOD_ProDKin_1	396	402	PF00069	0.694
MOD_ProDKin_1	416	422	PF00069	0.317
MOD_ProDKin_1	431	437	PF00069	0.669
MOD_ProDKin_1	583	589	PF00069	0.606
MOD_ProDKin_1	605	611	PF00069	0.433
MOD_ProDKin_1	767	773	PF00069	0.484
MOD_SUMO_for_1	333	336	PF00179	0.593
MOD_SUMO_rev_2	653	661	PF00179	0.664
TRG_AP2beta_CARGO_1	111	120	PF09066	0.489
TRG_DiLeu_BaEn_1	206	211	PF01217	0.489
TRG_DiLeu_BaEn_1	321	326	PF01217	0.444
TRG_DiLeu_BaEn_1	502	507	PF01217	0.447
TRG_DiLeu_BaEn_1	703	708	PF01217	0.586
TRG_DiLeu_BaLyEn_6	730	735	PF01217	0.507
TRG_ENDOCYTIC_2	208	211	PF00928	0.489
TRG_ENDOCYTIC_2	276	279	PF00928	0.413
TRG_ENDOCYTIC_2	315	318	PF00928	0.677
TRG_ENDOCYTIC_2	450	453	PF00928	0.633
TRG_ENDOCYTIC_2	5	8	PF00928	0.407
TRG_ENDOCYTIC_2	588	591	PF00928	0.473
TRG_ENDOCYTIC_2	596	599	PF00928	0.501
TRG_ENDOCYTIC_2	614	617	PF00928	0.320
TRG_ENDOCYTIC_2	684	687	PF00928	0.575
TRG_ENDOCYTIC_2	792	795	PF00928	0.437
TRG_ER_diArg_1	119	122	PF00400	0.542
TRG_ER_diArg_1	30	32	PF00400	0.290
TRG_ER_diArg_1	58	61	PF00400	0.489
TRG_ER_diArg_1	738	741	PF00400	0.597
TRG_ER_diArg_1	785	787	PF00400	0.627
TRG_ER_diArg_1	813	815	PF00400	0.512
TRG_NES_CRM1_1	132	145	PF08389	0.489
TRG_NLS_Bipartite_1	830	846	PF00514	0.585
TRG_NLS_MonoExtN_4	815	822	PF00514	0.366
TRG_NLS_MonoExtN_4	840	846	PF00514	0.667
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.624

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYY5	Leptomonas seymouri	62%	99%
A0A1X0PA66	Trypanosomatidae	32%	100%
A0A3Q8IIK1	Leishmania donovani	87%	100%
A4IAH7	Leishmania infantum	87%	100%
E9B5K1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q2D5	Leishmania major	87%	100%
V5DMT5	Trypanosoma cruzi	34%	100%