Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

conserved protein, unknown function

Species:

Leishmania braziliensis

UniProt:

A4HBC8_LEIBR

TriTrypDb:

LbrM.20.3680 , LBRM2903_200051100

Length:

674

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBC8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBC8

Function

Biological processes
Term	Name	Level	Count
GO:0044145	modulation of formation of structure involved in a symbiotic process	3	1
GO:0050789	regulation of biological process	2	1
GO:0065007	biological regulation	1	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	319	323	PF00656	0.490
CLV_NRD_NRD_1	130	132	PF00675	0.631
CLV_NRD_NRD_1	29	31	PF00675	0.593
CLV_NRD_NRD_1	36	38	PF00675	0.606
CLV_NRD_NRD_1	367	369	PF00675	0.560
CLV_NRD_NRD_1	431	433	PF00675	0.603
CLV_NRD_NRD_1	637	639	PF00675	0.804
CLV_PCSK_FUR_1	27	31	PF00082	0.611
CLV_PCSK_KEX2_1	29	31	PF00082	0.588
CLV_PCSK_KEX2_1	36	38	PF00082	0.594
CLV_PCSK_KEX2_1	367	369	PF00082	0.474
CLV_PCSK_KEX2_1	430	432	PF00082	0.632
CLV_PCSK_KEX2_1	607	609	PF00082	0.570
CLV_PCSK_KEX2_1	637	639	PF00082	0.786
CLV_PCSK_PC1ET2_1	29	31	PF00082	0.588
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.594
CLV_PCSK_PC1ET2_1	607	609	PF00082	0.594
CLV_PCSK_PC7_1	633	639	PF00082	0.586
CLV_PCSK_SKI1_1	368	372	PF00082	0.653
CLV_PCSK_SKI1_1	433	437	PF00082	0.453
CLV_PCSK_SKI1_1	483	487	PF00082	0.501
CLV_PCSK_SKI1_1	670	674	PF00082	0.703
CLV_PCSK_SKI1_1	88	92	PF00082	0.390
CLV_Separin_Metazoa	197	201	PF03568	0.385
DEG_APCC_DBOX_1	104	112	PF00400	0.378
DEG_APCC_DBOX_1	199	207	PF00400	0.436
DEG_APCC_DBOX_1	430	438	PF00400	0.689
DEG_APCC_DBOX_1	482	490	PF00400	0.503
DEG_Nend_UBRbox_2	1	3	PF02207	0.685
DEG_SPOP_SBC_1	272	276	PF00917	0.692
DOC_CYCLIN_RxL_1	481	491	PF00134	0.350
DOC_CYCLIN_yCln2_LP_2	627	630	PF00134	0.530
DOC_MAPK_gen_1	102	110	PF00069	0.628
DOC_MAPK_gen_1	27	34	PF00069	0.508
DOC_MAPK_gen_1	36	44	PF00069	0.546
DOC_MAPK_gen_1	430	436	PF00069	0.597
DOC_MAPK_gen_1	607	613	PF00069	0.609
DOC_MAPK_MEF2A_6	36	44	PF00069	0.494
DOC_PP1_RVXF_1	326	332	PF00149	0.410
DOC_PP2B_LxvP_1	167	170	PF13499	0.625
DOC_PP2B_LxvP_1	288	291	PF13499	0.521
DOC_PP2B_LxvP_1	533	536	PF13499	0.662
DOC_PP2B_LxvP_1	627	630	PF13499	0.530
DOC_PP2B_PxIxI_1	535	541	PF00149	0.462
DOC_PP4_FxxP_1	591	594	PF00568	0.745
DOC_PP4_FxxP_1	668	671	PF00568	0.702
DOC_USP7_MATH_1	138	142	PF00917	0.638
DOC_USP7_MATH_1	159	163	PF00917	0.614
DOC_USP7_MATH_1	168	172	PF00917	0.507
DOC_USP7_MATH_1	225	229	PF00917	0.573
DOC_USP7_MATH_1	268	272	PF00917	0.692
DOC_USP7_MATH_1	443	447	PF00917	0.638
DOC_USP7_MATH_1	49	53	PF00917	0.708
DOC_USP7_MATH_1	526	530	PF00917	0.607
DOC_USP7_MATH_1	599	603	PF00917	0.650
DOC_USP7_UBL2_3	658	662	PF12436	0.775
DOC_WW_Pin1_4	291	296	PF00397	0.560
DOC_WW_Pin1_4	404	409	PF00397	0.626
DOC_WW_Pin1_4	499	504	PF00397	0.379
DOC_WW_Pin1_4	582	587	PF00397	0.660
LIG_14-3-3_CanoR_1	131	136	PF00244	0.537
LIG_14-3-3_CanoR_1	328	338	PF00244	0.440
LIG_14-3-3_CanoR_1	598	604	PF00244	0.659
LIG_14-3-3_CanoR_1	88	93	PF00244	0.519
LIG_Actin_WH2_2	89	107	PF00022	0.368
LIG_BRCT_BRCA1_1	106	110	PF00533	0.383
LIG_BRCT_BRCA1_1	181	185	PF00533	0.288
LIG_BRCT_BRCA1_1	445	449	PF00533	0.676
LIG_BRCT_BRCA1_1	587	591	PF00533	0.752
LIG_EH1_1	479	487	PF00400	0.572
LIG_EVH1_1	628	632	PF00568	0.535
LIG_FHA_1	143	149	PF00498	0.673
LIG_FHA_1	162	168	PF00498	0.535
LIG_FHA_1	2	8	PF00498	0.529
LIG_FHA_1	276	282	PF00498	0.568
LIG_FHA_1	284	290	PF00498	0.445
LIG_FHA_1	379	385	PF00498	0.641
LIG_FHA_1	405	411	PF00498	0.561
LIG_FHA_1	63	69	PF00498	0.457
LIG_FHA_2	317	323	PF00498	0.696
LIG_FHA_2	330	336	PF00498	0.518
LIG_FHA_2	385	391	PF00498	0.494
LIG_FHA_2	546	552	PF00498	0.766
LIG_GBD_Chelix_1	342	350	PF00786	0.517
LIG_Integrin_RGD_1	633	635	PF01839	0.592
LIG_LIR_Apic_2	588	594	PF02991	0.719
LIG_LIR_Gen_1	116	123	PF02991	0.535
LIG_LIR_Gen_1	228	236	PF02991	0.609
LIG_LIR_Nem_3	116	122	PF02991	0.545
LIG_LIR_Nem_3	664	669	PF02991	0.506
LIG_LYPXL_yS_3	666	669	PF13949	0.503
LIG_MYND_1	626	630	PF01753	0.525
LIG_NRBOX	189	195	PF00104	0.473
LIG_NRBOX	345	351	PF00104	0.314
LIG_NRBOX	485	491	PF00104	0.364
LIG_NRBOX	71	77	PF00104	0.594
LIG_Pex14_2	668	672	PF04695	0.701
LIG_Rb_LxCxE_1	238	259	PF01857	0.603
LIG_SH2_CRK	302	306	PF00017	0.492
LIG_SH2_SRC	204	207	PF00017	0.452
LIG_SH2_STAP1	204	208	PF00017	0.553
LIG_SH2_STAT3	218	221	PF00017	0.511
LIG_SH2_STAT3	25	28	PF00017	0.595
LIG_SH2_STAT5	115	118	PF00017	0.603
LIG_SH2_STAT5	202	205	PF00017	0.400
LIG_SH2_STAT5	230	233	PF00017	0.600
LIG_SH2_STAT5	25	28	PF00017	0.621
LIG_SH2_STAT5	527	530	PF00017	0.618
LIG_SH2_STAT5	600	603	PF00017	0.683
LIG_SH3_1	497	503	PF00018	0.378
LIG_SH3_3	497	503	PF00018	0.378
LIG_SH3_3	623	629	PF00018	0.752
LIG_SH3_3	657	663	PF00018	0.610
LIG_SH3_4	658	665	PF00018	0.636
LIG_SUMO_SIM_anti_2	188	194	PF11976	0.422
LIG_SUMO_SIM_anti_2	57	63	PF11976	0.485
LIG_SUMO_SIM_par_1	2	8	PF11976	0.529
LIG_SUMO_SIM_par_1	376	381	PF11976	0.677
LIG_SUMO_SIM_par_1	52	59	PF11976	0.588
LIG_WRC_WIRS_1	355	360	PF05994	0.331
MOD_CK1_1	11	17	PF00069	0.522
MOD_CK1_1	141	147	PF00069	0.729
MOD_CK1_1	155	161	PF00069	0.648
MOD_CK1_1	163	169	PF00069	0.657
MOD_CK1_1	271	277	PF00069	0.598
MOD_CK1_1	3	9	PF00069	0.742
MOD_CK1_1	404	410	PF00069	0.662
MOD_CK1_1	518	524	PF00069	0.477
MOD_CK1_1	557	563	PF00069	0.648
MOD_CK1_1	62	68	PF00069	0.525
MOD_CK1_1	83	89	PF00069	0.610
MOD_CK2_1	106	112	PF00069	0.537
MOD_CK2_1	114	120	PF00069	0.574
MOD_CK2_1	276	282	PF00069	0.662
MOD_CK2_1	442	448	PF00069	0.562
MOD_CK2_1	545	551	PF00069	0.632
MOD_Cter_Amidation	428	431	PF01082	0.681
MOD_GlcNHglycan	116	119	PF01048	0.502
MOD_GlcNHglycan	157	160	PF01048	0.675
MOD_GlcNHglycan	179	182	PF01048	0.365
MOD_GlcNHglycan	278	281	PF01048	0.427
MOD_GlcNHglycan	322	325	PF01048	0.662
MOD_GlcNHglycan	368	371	PF01048	0.618
MOD_GlcNHglycan	543	546	PF01048	0.711
MOD_GlcNHglycan	594	597	PF01048	0.708
MOD_GlcNHglycan	7	10	PF01048	0.520
MOD_GlcNHglycan	83	86	PF01048	0.599
MOD_GSK3_1	1	8	PF00069	0.667
MOD_GSK3_1	138	145	PF00069	0.680
MOD_GSK3_1	155	162	PF00069	0.679
MOD_GSK3_1	175	182	PF00069	0.278
MOD_GSK3_1	268	275	PF00069	0.669
MOD_GSK3_1	316	323	PF00069	0.717
MOD_GSK3_1	541	548	PF00069	0.579
MOD_GSK3_1	552	559	PF00069	0.620
MOD_GSK3_1	80	87	PF00069	0.631
MOD_N-GLC_1	320	325	PF02516	0.630
MOD_N-GLC_1	464	469	PF02516	0.635
MOD_NEK2_1	1	6	PF00069	0.689
MOD_NEK2_1	104	109	PF00069	0.384
MOD_NEK2_1	179	184	PF00069	0.420
MOD_NEK2_1	186	191	PF00069	0.349
MOD_NEK2_1	226	231	PF00069	0.594
MOD_NEK2_1	316	321	PF00069	0.574
MOD_NEK2_1	337	342	PF00069	0.488
MOD_NEK2_1	366	371	PF00069	0.515
MOD_NEK2_1	378	383	PF00069	0.666
MOD_NEK2_1	401	406	PF00069	0.640
MOD_NEK2_1	457	462	PF00069	0.568
MOD_NEK2_1	75	80	PF00069	0.618
MOD_NEK2_2	536	541	PF00069	0.471
MOD_PKA_1	131	137	PF00069	0.464
MOD_PKA_2	104	110	PF00069	0.390
MOD_PKA_2	366	372	PF00069	0.591
MOD_Plk_1	1	7	PF00069	0.644
MOD_Plk_1	324	330	PF00069	0.625
MOD_Plk_1	464	470	PF00069	0.594
MOD_Plk_2-3	106	112	PF00069	0.635
MOD_Plk_4	106	112	PF00069	0.602
MOD_Plk_4	13	19	PF00069	0.472
MOD_Plk_4	144	150	PF00069	0.493
MOD_Plk_4	226	232	PF00069	0.609
MOD_Plk_4	345	351	PF00069	0.546
MOD_Plk_4	88	94	PF00069	0.547
MOD_ProDKin_1	291	297	PF00069	0.574
MOD_ProDKin_1	404	410	PF00069	0.625
MOD_ProDKin_1	499	505	PF00069	0.376
MOD_ProDKin_1	582	588	PF00069	0.661
MOD_SUMO_for_1	661	664	PF00179	0.538
MOD_SUMO_rev_2	125	134	PF00179	0.610
MOD_SUMO_rev_2	616	626	PF00179	0.445
TRG_DiLeu_BaEn_1	71	76	PF01217	0.565
TRG_DiLeu_BaEn_2	105	111	PF01217	0.633
TRG_DiLeu_BaEn_2	608	614	PF01217	0.633
TRG_DiLeu_BaEn_2	663	669	PF01217	0.508
TRG_DiLeu_BaLyEn_6	480	485	PF01217	0.588
TRG_DiLeu_LyEn_5	623	628	PF01217	0.495
TRG_ENDOCYTIC_2	230	233	PF00928	0.645
TRG_ENDOCYTIC_2	302	305	PF00928	0.495
TRG_ENDOCYTIC_2	472	475	PF00928	0.524
TRG_ENDOCYTIC_2	666	669	PF00928	0.503
TRG_ER_diArg_1	366	368	PF00400	0.542
TRG_ER_diArg_1	430	432	PF00400	0.661
TRG_ER_diArg_1	481	484	PF00400	0.497
TRG_ER_diArg_1	574	577	PF00400	0.533
TRG_NLS_MonoExtC_3	35	41	PF00514	0.619
TRG_NLS_MonoExtN_4	27	33	PF00514	0.552
TRG_Pf-PMV_PEXEL_1	102	106	PF00026	0.551
TRG_Pf-PMV_PEXEL_1	121	125	PF00026	0.642
TRG_Pf-PMV_PEXEL_1	473	477	PF00026	0.436
TRG_Pf-PMV_PEXEL_1	487	491	PF00026	0.546
TRG_Pf-PMV_PEXEL_1	612	616	PF00026	0.625

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P7E6	Leptomonas seymouri	45%	100%
A0A0S4KLZ0	Bodo saltans	27%	84%
A0A1X0PAG6	Trypanosomatidae	34%	100%
A0A3Q8IIY0	Leishmania donovani	74%	100%
A0A422NVB5	Trypanosoma rangeli	30%	100%
A4IAH6	Leishmania infantum	73%	100%
C9ZLR4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B5K0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	72%	100%
Q4Q2D6	Leishmania major	72%	98%
V5BRF7	Trypanosoma cruzi	32%	100%