Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBC7_LEIBR

TriTrypDb:

LbrM.20.3670 , LBRM2903_200051000

Length:

339

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 10
NetGPI	no	yes: 0, no: 11

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBC7

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBC7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	135	139	PF00656	0.460
CLV_C14_Caspase3-7	4	8	PF00656	0.635
CLV_NRD_NRD_1	209	211	PF00675	0.436
CLV_NRD_NRD_1	21	23	PF00675	0.581
CLV_NRD_NRD_1	275	277	PF00675	0.565
CLV_NRD_NRD_1	66	68	PF00675	0.756
CLV_PCSK_KEX2_1	160	162	PF00082	0.419
CLV_PCSK_KEX2_1	21	23	PF00082	0.606
CLV_PCSK_KEX2_1	275	277	PF00082	0.553
CLV_PCSK_KEX2_1	66	68	PF00082	0.756
CLV_PCSK_PC1ET2_1	160	162	PF00082	0.419
CLV_PCSK_SKI1_1	110	114	PF00082	0.527
CLV_PCSK_SKI1_1	289	293	PF00082	0.399
CLV_PCSK_SKI1_1	312	316	PF00082	0.415
DEG_APCC_DBOX_1	165	173	PF00400	0.507
DEG_APCC_DBOX_1	183	191	PF00400	0.357
DEG_APCC_DBOX_1	25	33	PF00400	0.516
DEG_APCC_DBOX_1	288	296	PF00400	0.397
DEG_MDM2_SWIB_1	24	32	PF02201	0.294
DEG_Nend_UBRbox_2	1	3	PF02207	0.670
DOC_CKS1_1	16	21	PF01111	0.351
DOC_MAPK_DCC_7	286	296	PF00069	0.508
DOC_MAPK_gen_1	286	296	PF00069	0.472
DOC_MAPK_gen_1	319	329	PF00069	0.493
DOC_MAPK_MEF2A_6	289	296	PF00069	0.459
DOC_MAPK_NFAT4_5	289	297	PF00069	0.501
DOC_PP4_FxxP_1	46	49	PF00568	0.491
DOC_PP4_FxxP_1	82	85	PF00568	0.542
DOC_USP7_MATH_1	206	210	PF00917	0.542
DOC_USP7_MATH_1	254	258	PF00917	0.443
DOC_USP7_MATH_1	59	63	PF00917	0.724
DOC_WW_Pin1_4	15	20	PF00397	0.536
DOC_WW_Pin1_4	330	335	PF00397	0.425
DOC_WW_Pin1_4	55	60	PF00397	0.724
DOC_WW_Pin1_4	76	81	PF00397	0.466
LIG_14-3-3_CanoR_1	141	151	PF00244	0.516
LIG_14-3-3_CanoR_1	178	184	PF00244	0.318
LIG_14-3-3_CanoR_1	195	205	PF00244	0.327
LIG_14-3-3_CanoR_1	275	281	PF00244	0.620
LIG_14-3-3_CanoR_1	324	328	PF00244	0.494
LIG_BRCT_BRCA1_1	325	329	PF00533	0.416
LIG_BRCT_BRCA1_1	78	82	PF00533	0.419
LIG_deltaCOP1_diTrp_1	72	82	PF00928	0.511
LIG_EVH1_1	164	168	PF00568	0.534
LIG_FHA_1	11	17	PF00498	0.532
LIG_FHA_1	178	184	PF00498	0.405
LIG_FHA_1	200	206	PF00498	0.540
LIG_FHA_1	297	303	PF00498	0.455
LIG_FHA_1	84	90	PF00498	0.554
LIG_FHA_2	102	108	PF00498	0.576
LIG_FHA_2	133	139	PF00498	0.426
LIG_FHA_2	142	148	PF00498	0.554
LIG_LIR_Apic_2	43	49	PF02991	0.479
LIG_LIR_Apic_2	79	85	PF02991	0.453
LIG_LIR_Gen_1	326	336	PF02991	0.430
LIG_LIR_Nem_3	326	332	PF02991	0.434
LIG_LIR_Nem_3	79	84	PF02991	0.477
LIG_MLH1_MIPbox_1	78	82	PF16413	0.419
LIG_NRBOX	108	114	PF00104	0.505
LIG_Pex14_2	24	28	PF04695	0.564
LIG_SH2_PTP2	267	270	PF00017	0.424
LIG_SH2_STAT5	267	270	PF00017	0.353
LIG_SH2_STAT5	38	41	PF00017	0.495
LIG_SH2_STAT5	81	84	PF00017	0.447
LIG_SH3_3	162	168	PF00018	0.468
LIG_SUMO_SIM_anti_2	123	128	PF11976	0.464
LIG_SUMO_SIM_anti_2	144	154	PF11976	0.522
LIG_SUMO_SIM_par_1	179	185	PF11976	0.521
LIG_SUMO_SIM_par_1	292	297	PF11976	0.495
LIG_TRAF2_1	40	43	PF00917	0.635
LIG_WRC_WIRS_1	6	11	PF05994	0.601
MOD_CDK_SPK_2	55	60	PF00069	0.746
MOD_CDK_SPxK_1	15	21	PF00069	0.358
MOD_CDK_SPxxK_3	15	22	PF00069	0.353
MOD_CK1_1	15	21	PF00069	0.497
MOD_CK1_1	330	336	PF00069	0.420
MOD_CK1_1	58	64	PF00069	0.717
MOD_CK1_1	76	82	PF00069	0.290
MOD_CK1_1	83	89	PF00069	0.424
MOD_CK2_1	141	147	PF00069	0.534
MOD_CK2_1	179	185	PF00069	0.539
MOD_CK2_1	37	43	PF00069	0.467
MOD_GlcNHglycan	256	259	PF01048	0.391
MOD_GlcNHglycan	75	78	PF01048	0.536
MOD_GlcNHglycan	96	99	PF01048	0.353
MOD_GSK3_1	1	8	PF00069	0.558
MOD_GSK3_1	10	17	PF00069	0.487
MOD_GSK3_1	213	220	PF00069	0.438
MOD_GSK3_1	276	283	PF00069	0.588
MOD_GSK3_1	323	330	PF00069	0.413
MOD_GSK3_1	55	62	PF00069	0.631
MOD_GSK3_1	76	83	PF00069	0.475
MOD_NEK2_1	1	6	PF00069	0.628
MOD_NEK2_1	151	156	PF00069	0.454
MOD_NEK2_1	196	201	PF00069	0.350
MOD_NEK2_1	280	285	PF00069	0.481
MOD_NEK2_1	327	332	PF00069	0.530
MOD_NEK2_1	9	14	PF00069	0.582
MOD_NEK2_1	94	99	PF00069	0.323
MOD_NEK2_2	179	184	PF00069	0.293
MOD_PKA_2	177	183	PF00069	0.364
MOD_PKA_2	323	329	PF00069	0.510
MOD_PKA_2	59	65	PF00069	0.731
MOD_PKA_2	94	100	PF00069	0.299
MOD_Plk_1	1	7	PF00069	0.633
MOD_Plk_1	217	223	PF00069	0.491
MOD_Plk_1	71	77	PF00069	0.459
MOD_Plk_4	1	7	PF00069	0.652
MOD_Plk_4	323	329	PF00069	0.420
MOD_ProDKin_1	15	21	PF00069	0.533
MOD_ProDKin_1	330	336	PF00069	0.420
MOD_ProDKin_1	55	61	PF00069	0.726
MOD_ProDKin_1	76	82	PF00069	0.460
MOD_SUMO_for_1	117	120	PF00179	0.511
TRG_DiLeu_BaEn_1	147	152	PF01217	0.499
TRG_DiLeu_BaEn_1	229	234	PF01217	0.407
TRG_DiLeu_BaEn_1	287	292	PF01217	0.382
TRG_DiLeu_BaLyEn_6	290	295	PF01217	0.456
TRG_ENDOCYTIC_2	267	270	PF00928	0.368
TRG_ENDOCYTIC_2	81	84	PF00928	0.555
TRG_NES_CRM1_1	107	123	PF08389	0.502

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P703	Leptomonas seymouri	58%	80%
A0A0S4KKR7	Bodo saltans	33%	66%
A0A1X0PA52	Trypanosomatidae	48%	84%
A0A3S7X8N4	Leishmania donovani	82%	100%
A0A422NVD0	Trypanosoma rangeli	45%	90%
A4IAH5	Leishmania infantum	82%	100%
C9ZLR5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	89%
E9B5J9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2D7	Leishmania major	82%	100%
V5BW32	Trypanosoma cruzi	43%	89%