Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Peptidase family C78, putative

Species:

Leishmania braziliensis

UniProt:

A4HBC3_LEIBR

TriTrypDb:

LbrM.20.3630 , LBRM2903_200050600

Length:

505

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBC3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBC3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	105	109	PF00656	0.579
CLV_NRD_NRD_1	229	231	PF00675	0.442
CLV_NRD_NRD_1	399	401	PF00675	0.307
CLV_PCSK_KEX2_1	228	230	PF00082	0.437
CLV_PCSK_KEX2_1	399	401	PF00082	0.307
CLV_PCSK_KEX2_1	83	85	PF00082	0.419
CLV_PCSK_PC1ET2_1	228	230	PF00082	0.324
CLV_PCSK_PC1ET2_1	83	85	PF00082	0.419
CLV_PCSK_PC7_1	224	230	PF00082	0.472
CLV_PCSK_SKI1_1	175	179	PF00082	0.330
CLV_PCSK_SKI1_1	190	194	PF00082	0.359
CLV_PCSK_SKI1_1	368	372	PF00082	0.301
CLV_PCSK_SKI1_1	80	84	PF00082	0.454
DEG_Nend_UBRbox_2	1	3	PF02207	0.636
DOC_CKS1_1	126	131	PF01111	0.522
DOC_CYCLIN_RxL_1	171	181	PF00134	0.429
DOC_CYCLIN_yCln2_LP_2	425	431	PF00134	0.319
DOC_MAPK_gen_1	80	89	PF00069	0.437
DOC_MAPK_MEF2A_6	134	142	PF00069	0.372
DOC_MAPK_MEF2A_6	422	431	PF00069	0.186
DOC_PP1_RVXF_1	92	99	PF00149	0.286
DOC_PP2B_LxvP_1	236	239	PF13499	0.392
DOC_PP2B_LxvP_1	425	428	PF13499	0.319
DOC_PP2B_LxvP_1	494	497	PF13499	0.276
DOC_PP4_FxxP_1	421	424	PF00568	0.440
DOC_USP7_MATH_1	160	164	PF00917	0.561
DOC_USP7_MATH_1	167	171	PF00917	0.510
DOC_USP7_MATH_1	327	331	PF00917	0.284
DOC_USP7_UBL2_3	365	369	PF12436	0.228
DOC_USP7_UBL2_3	469	473	PF12436	0.276
DOC_USP7_UBL2_3	480	484	PF12436	0.258
DOC_WW_Pin1_4	125	130	PF00397	0.495
DOC_WW_Pin1_4	178	183	PF00397	0.396
DOC_WW_Pin1_4	281	286	PF00397	0.428
DOC_WW_Pin1_4	287	292	PF00397	0.438
LIG_14-3-3_CanoR_1	121	129	PF00244	0.339
LIG_14-3-3_CanoR_1	195	204	PF00244	0.355
LIG_14-3-3_CanoR_1	279	285	PF00244	0.442
LIG_14-3-3_CanoR_1	329	335	PF00244	0.327
LIG_14-3-3_CanoR_1	47	56	PF00244	0.409
LIG_14-3-3_CanoR_1	73	79	PF00244	0.359
LIG_BIR_III_2	108	112	PF00653	0.379
LIG_BRCT_BRCA1_1	482	486	PF00533	0.355
LIG_Clathr_ClatBox_1	415	419	PF01394	0.283
LIG_deltaCOP1_diTrp_1	208	217	PF00928	0.398
LIG_deltaCOP1_diTrp_1	376	381	PF00928	0.267
LIG_FHA_1	133	139	PF00498	0.473
LIG_FHA_1	171	177	PF00498	0.428
LIG_FHA_1	43	49	PF00498	0.459
LIG_FHA_1	67	73	PF00498	0.297
LIG_FHA_2	115	121	PF00498	0.298
LIG_FHA_2	152	158	PF00498	0.566
LIG_FHA_2	197	203	PF00498	0.479
LIG_FHA_2	221	227	PF00498	0.434
LIG_FHA_2	253	259	PF00498	0.358
LIG_FHA_2	50	56	PF00498	0.378
LIG_LIR_Apic_2	123	129	PF02991	0.540
LIG_LIR_Apic_2	419	424	PF02991	0.446
LIG_LIR_Gen_1	113	120	PF02991	0.454
LIG_LIR_Gen_1	380	387	PF02991	0.267
LIG_LIR_Gen_1	451	461	PF02991	0.327
LIG_LIR_Nem_3	113	119	PF02991	0.453
LIG_LIR_Nem_3	254	259	PF02991	0.422
LIG_LIR_Nem_3	306	312	PF02991	0.280
LIG_LIR_Nem_3	451	457	PF02991	0.327
LIG_LIR_Nem_3	458	464	PF02991	0.343
LIG_LIR_Nem_3	490	494	PF02991	0.294
LIG_MLH1_MIPbox_1	482	486	PF16413	0.327
LIG_MYND_3	391	395	PF01753	0.271
LIG_PCNA_PIPBox_1	384	393	PF02747	0.343
LIG_PCNA_PIPBox_1	414	423	PF02747	0.267
LIG_Pex14_1	324	328	PF04695	0.267
LIG_Pex14_1	377	381	PF04695	0.267
LIG_Rb_pABgroove_1	187	195	PF01858	0.273
LIG_SH2_CRK	240	244	PF00017	0.404
LIG_SH2_CRK	328	332	PF00017	0.267
LIG_SH2_SRC	390	393	PF00017	0.271
LIG_SH2_STAP1	436	440	PF00017	0.267
LIG_SH2_STAT3	464	467	PF00017	0.343
LIG_SH2_STAT5	359	362	PF00017	0.186
LIG_SH2_STAT5	390	393	PF00017	0.343
LIG_SH2_STAT5	454	457	PF00017	0.267
LIG_SH2_STAT5	476	479	PF00017	0.327
LIG_SH3_3	143	149	PF00018	0.508
LIG_SH3_3	206	212	PF00018	0.365
LIG_SH3_3	292	298	PF00018	0.489
LIG_SH3_3	32	38	PF00018	0.271
LIG_SH3_3	357	363	PF00018	0.186
LIG_SH3_3	421	427	PF00018	0.241
LIG_SUMO_SIM_anti_2	382	387	PF11976	0.267
LIG_TYR_ITIM	238	243	PF00017	0.416
LIG_WRC_WIRS_1	378	383	PF05994	0.267
MOD_CDK_SPxxK_3	127	134	PF00069	0.375
MOD_CK1_1	170	176	PF00069	0.462
MOD_CK1_1	293	299	PF00069	0.473
MOD_CK1_1	330	336	PF00069	0.284
MOD_CK1_1	40	46	PF00069	0.480
MOD_CK1_1	49	55	PF00069	0.532
MOD_CK2_1	114	120	PF00069	0.406
MOD_CK2_1	141	147	PF00069	0.466
MOD_CK2_1	178	184	PF00069	0.412
MOD_CK2_1	196	202	PF00069	0.298
MOD_CK2_1	251	257	PF00069	0.344
MOD_CK2_1	347	353	PF00069	0.186
MOD_CK2_1	49	55	PF00069	0.485
MOD_CMANNOS	253	256	PF00535	0.417
MOD_GlcNHglycan	162	165	PF01048	0.580
MOD_GlcNHglycan	204	207	PF01048	0.362
MOD_GlcNHglycan	292	295	PF01048	0.458
MOD_GlcNHglycan	305	308	PF01048	0.220
MOD_GlcNHglycan	39	42	PF01048	0.373
MOD_GlcNHglycan	402	405	PF01048	0.181
MOD_GlcNHglycan	461	464	PF01048	0.327
MOD_GlcNHglycan	49	52	PF01048	0.574
MOD_GlcNHglycan	98	101	PF01048	0.508
MOD_GSK3_1	148	155	PF00069	0.518
MOD_GSK3_1	167	174	PF00069	0.555
MOD_GSK3_1	196	203	PF00069	0.437
MOD_GSK3_1	280	287	PF00069	0.368
MOD_GSK3_1	299	306	PF00069	0.301
MOD_GSK3_1	33	40	PF00069	0.332
MOD_GSK3_1	42	49	PF00069	0.390
MOD_GSK3_1	432	439	PF00069	0.298
MOD_GSK3_1	459	466	PF00069	0.267
MOD_GSK3_1	74	81	PF00069	0.394
MOD_N-GLC_2	493	495	PF02516	0.267
MOD_NEK2_1	394	399	PF00069	0.349
MOD_NEK2_1	58	63	PF00069	0.621
MOD_NEK2_1	78	83	PF00069	0.432
MOD_PIKK_1	463	469	PF00454	0.327
MOD_PKA_2	103	109	PF00069	0.374
MOD_PKA_2	120	126	PF00069	0.375
MOD_PKA_2	20	26	PF00069	0.381
MOD_PKA_2	46	52	PF00069	0.428
MOD_PKA_2	74	80	PF00069	0.374
MOD_Plk_1	394	400	PF00069	0.248
MOD_Plk_1	409	415	PF00069	0.356
MOD_Plk_4	111	117	PF00069	0.472
MOD_Plk_4	299	305	PF00069	0.333
MOD_Plk_4	330	336	PF00069	0.272
MOD_Plk_4	436	442	PF00069	0.297
MOD_Plk_4	467	473	PF00069	0.208
MOD_Plk_4	487	493	PF00069	0.216
MOD_Plk_4	58	64	PF00069	0.442
MOD_ProDKin_1	125	131	PF00069	0.509
MOD_ProDKin_1	178	184	PF00069	0.396
MOD_ProDKin_1	281	287	PF00069	0.437
TRG_DiLeu_BaEn_1	232	237	PF01217	0.280
TRG_DiLeu_BaEn_1	451	456	PF01217	0.267
TRG_DiLeu_BaLyEn_6	192	197	PF01217	0.273
TRG_ENDOCYTIC_2	240	243	PF00928	0.417
TRG_ENDOCYTIC_2	328	331	PF00928	0.267
TRG_ENDOCYTIC_2	454	457	PF00928	0.327
TRG_ER_diArg_1	398	400	PF00400	0.301
TRG_ER_diArg_1	72	75	PF00400	0.225
TRG_NES_CRM1_1	376	388	PF08389	0.267
TRG_NES_CRM1_1	53	65	PF08389	0.332
TRG_Pf-PMV_PEXEL_1	175	180	PF00026	0.412
TRG_Pf-PMV_PEXEL_1	190	194	PF00026	0.281
TRG_Pf-PMV_PEXEL_1	195	200	PF00026	0.253
TRG_Pf-PMV_PEXEL_1	352	356	PF00026	0.327

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I0K1	Leptomonas seymouri	59%	98%
A0A1X0PB53	Trypanosomatidae	44%	100%
A0A3Q8IHV3	Leishmania donovani	78%	100%
A4IAH1	Leishmania infantum	79%	100%
E9B5J5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q0INW1	Oryza sativa subsp. japonica	33%	79%
Q4Q2E1	Leishmania major	78%	100%