Arrestin_N domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBC2_LEIBR

TriTrypDb:

LbrM.20.3620 , LBRM2903_200050500

Length:

478

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0000139	Golgi membrane	5	1
GO:0005829	cytosol	2	1
GO:0016020	membrane	2	1
GO:0031090	organelle membrane	3	1
GO:0032045	guanyl-nucleotide exchange factor complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0034066	Ric1-Rgp1 guanyl-nucleotide exchange factor complex	4	1
GO:0098588	bounding membrane of organelle	4	1
GO:0110165	cellular anatomical entity	1	1
GO:0140535	intracellular protein-containing complex	2	1

Expansion

Sequence features

A4HBC2

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBC2

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0009987	cellular process	1	1
GO:0016192	vesicle-mediated transport	4	1
GO:0016197	endosomal transport	4	1
GO:0016482	cytosolic transport	4	1
GO:0042147	retrograde transport, endosome to Golgi	5	1
GO:0046907	intracellular transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0051641	cellular localization	2	1
GO:0051649	establishment of localization in cell	3	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	383	385	PF00675	0.576
CLV_NRD_NRD_1	433	435	PF00675	0.562
CLV_PCSK_KEX2_1	134	136	PF00082	0.581
CLV_PCSK_KEX2_1	383	385	PF00082	0.552
CLV_PCSK_PC1ET2_1	134	136	PF00082	0.614
CLV_PCSK_SKI1_1	124	128	PF00082	0.423
DEG_APCC_DBOX_1	24	32	PF00400	0.553
DEG_APCC_DBOX_1	277	285	PF00400	0.706
DEG_APCC_DBOX_1	73	81	PF00400	0.290
DEG_Nend_UBRbox_2	1	3	PF02207	0.606
DEG_SPOP_SBC_1	175	179	PF00917	0.533
DOC_CKS1_1	236	241	PF01111	0.742
DOC_CKS1_1	336	341	PF01111	0.388
DOC_CKS1_1	353	358	PF01111	0.279
DOC_CKS1_1	394	399	PF01111	0.596
DOC_MAPK_FxFP_2	401	404	PF00069	0.354
DOC_MAPK_gen_1	190	197	PF00069	0.498
DOC_MAPK_MEF2A_6	190	197	PF00069	0.495
DOC_MAPK_MEF2A_6	278	285	PF00069	0.679
DOC_MAPK_MEF2A_6	69	77	PF00069	0.555
DOC_PP1_RVXF_1	87	94	PF00149	0.605
DOC_PP2B_LxvP_1	283	286	PF13499	0.699
DOC_PP2B_LxvP_1	462	465	PF13499	0.440
DOC_PP4_FxxP_1	145	148	PF00568	0.448
DOC_PP4_FxxP_1	213	216	PF00568	0.601
DOC_PP4_FxxP_1	401	404	PF00568	0.507
DOC_USP7_MATH_1	103	107	PF00917	0.731
DOC_USP7_MATH_1	208	212	PF00917	0.517
DOC_USP7_MATH_1	411	415	PF00917	0.552
DOC_USP7_MATH_1	443	447	PF00917	0.615
DOC_USP7_MATH_1	60	64	PF00917	0.496
DOC_USP7_MATH_1	95	99	PF00917	0.702
DOC_WW_Pin1_4	148	153	PF00397	0.476
DOC_WW_Pin1_4	235	240	PF00397	0.633
DOC_WW_Pin1_4	335	340	PF00397	0.656
DOC_WW_Pin1_4	352	357	PF00397	0.543
DOC_WW_Pin1_4	393	398	PF00397	0.593
DOC_WW_Pin1_4	439	444	PF00397	0.536
DOC_WW_Pin1_4	450	455	PF00397	0.467
LIG_14-3-3_CanoR_1	176	186	PF00244	0.655
LIG_14-3-3_CanoR_1	25	34	PF00244	0.601
LIG_14-3-3_CanoR_1	257	263	PF00244	0.702
LIG_14-3-3_CanoR_1	269	275	PF00244	0.692
LIG_14-3-3_CanoR_1	278	284	PF00244	0.701
LIG_14-3-3_CanoR_1	434	438	PF00244	0.491
LIG_Actin_WH2_2	242	259	PF00022	0.718
LIG_Actin_WH2_2	411	428	PF00022	0.532
LIG_Clathr_ClatBox_1	80	84	PF01394	0.514
LIG_EVH1_1	213	217	PF00568	0.606
LIG_FHA_1	394	400	PF00498	0.555
LIG_FHA_1	417	423	PF00498	0.423
LIG_FHA_1	440	446	PF00498	0.421
LIG_LIR_Apic_2	142	148	PF02991	0.479
LIG_LIR_Apic_2	211	216	PF02991	0.607
LIG_LIR_Apic_2	352	356	PF02991	0.547
LIG_LIR_Apic_2	402	406	PF02991	0.523
LIG_LIR_Gen_1	196	205	PF02991	0.364
LIG_LIR_Nem_3	171	175	PF02991	0.550
LIG_LIR_Nem_3	196	201	PF02991	0.344
LIG_LIR_Nem_3	311	315	PF02991	0.584
LIG_LIR_Nem_3	381	385	PF02991	0.453
LIG_LIR_Nem_3	395	401	PF02991	0.497
LIG_MYND_1	450	454	PF01753	0.577
LIG_PAM2_1	450	462	PF00658	0.330
LIG_PCNA_PIPBox_1	206	215	PF02747	0.610
LIG_SH2_CRK	382	386	PF00017	0.330
LIG_SH2_NCK_1	136	140	PF00017	0.604
LIG_SH2_PTP2	353	356	PF00017	0.331
LIG_SH2_STAP1	136	140	PF00017	0.594
LIG_SH2_STAP1	264	268	PF00017	0.456
LIG_SH2_STAT5	117	120	PF00017	0.524
LIG_SH2_STAT5	16	19	PF00017	0.542
LIG_SH2_STAT5	173	176	PF00017	0.404
LIG_SH2_STAT5	307	310	PF00017	0.604
LIG_SH2_STAT5	353	356	PF00017	0.331
LIG_SH2_STAT5	398	401	PF00017	0.539
LIG_SH3_2	466	471	PF14604	0.654
LIG_SH3_3	211	217	PF00018	0.547
LIG_SH3_3	233	239	PF00018	0.622
LIG_SH3_3	245	251	PF00018	0.685
LIG_SH3_3	333	339	PF00018	0.440
LIG_SH3_3	391	397	PF00018	0.583
LIG_SH3_3	460	466	PF00018	0.462
LIG_SH3_3	84	90	PF00018	0.492
LIG_SUMO_SIM_anti_2	347	352	PF11976	0.515
LIG_SUMO_SIM_par_1	340	345	PF11976	0.582
LIG_SUMO_SIM_par_1	427	433	PF11976	0.288
LIG_SUMO_SIM_par_1	79	86	PF11976	0.456
LIG_TRFH_1	213	217	PF08558	0.606
LIG_WRC_WIRS_1	418	423	PF05994	0.480
MOD_CDK_SPxK_1	235	241	PF00069	0.481
MOD_CK1_1	110	116	PF00069	0.545
MOD_CK1_1	151	157	PF00069	0.352
MOD_CK1_1	177	183	PF00069	0.694
MOD_CK1_1	200	206	PF00069	0.607
MOD_CK1_1	273	279	PF00069	0.583
MOD_CK1_1	300	306	PF00069	0.482
MOD_CK1_1	322	328	PF00069	0.629
MOD_CK1_1	413	419	PF00069	0.466
MOD_CK1_1	433	439	PF00069	0.270
MOD_CK1_1	467	473	PF00069	0.460
MOD_CK1_1	55	61	PF00069	0.759
MOD_CK1_1	63	69	PF00069	0.617
MOD_CK2_1	56	62	PF00069	0.671
MOD_CK2_1	95	101	PF00069	0.729
MOD_GlcNHglycan	218	221	PF01048	0.614
MOD_GlcNHglycan	264	267	PF01048	0.529
MOD_GlcNHglycan	344	347	PF01048	0.491
MOD_GlcNHglycan	357	360	PF01048	0.411
MOD_GlcNHglycan	57	61	PF01048	0.741
MOD_GlcNHglycan	7	10	PF01048	0.520
MOD_GSK3_1	1	8	PF00069	0.586
MOD_GSK3_1	103	110	PF00069	0.697
MOD_GSK3_1	115	122	PF00069	0.527
MOD_GSK3_1	164	171	PF00069	0.533
MOD_GSK3_1	177	184	PF00069	0.424
MOD_GSK3_1	193	200	PF00069	0.368
MOD_GSK3_1	258	265	PF00069	0.651
MOD_GSK3_1	269	276	PF00069	0.684
MOD_GSK3_1	296	303	PF00069	0.528
MOD_GSK3_1	310	317	PF00069	0.646
MOD_GSK3_1	340	347	PF00069	0.594
MOD_GSK3_1	363	370	PF00069	0.632
MOD_GSK3_1	413	420	PF00069	0.572
MOD_GSK3_1	433	440	PF00069	0.309
MOD_GSK3_1	52	59	PF00069	0.771
MOD_N-GLC_1	322	327	PF02516	0.638
MOD_N-GLC_1	363	368	PF02516	0.438
MOD_NEK2_1	1	6	PF00069	0.524
MOD_NEK2_1	108	113	PF00069	0.700
MOD_NEK2_1	115	120	PF00069	0.565
MOD_NEK2_1	256	261	PF00069	0.692
MOD_NEK2_1	26	31	PF00069	0.582
MOD_NEK2_1	270	275	PF00069	0.594
MOD_NEK2_1	297	302	PF00069	0.502
MOD_NEK2_1	308	313	PF00069	0.461
MOD_NEK2_1	315	320	PF00069	0.537
MOD_NEK2_1	378	383	PF00069	0.539
MOD_NEK2_1	430	435	PF00069	0.451
MOD_NEK2_1	437	442	PF00069	0.544
MOD_NEK2_1	83	88	PF00069	0.527
MOD_NEK2_2	208	213	PF00069	0.611
MOD_PIKK_1	273	279	PF00454	0.574
MOD_PIKK_1	315	321	PF00454	0.605
MOD_PIKK_1	35	41	PF00454	0.731
MOD_PIKK_1	443	449	PF00454	0.542
MOD_PKA_2	175	181	PF00069	0.553
MOD_PKA_2	24	30	PF00069	0.534
MOD_PKA_2	256	262	PF00069	0.669
MOD_PKA_2	433	439	PF00069	0.501
MOD_Plk_1	1	7	PF00069	0.587
MOD_Plk_1	164	170	PF00069	0.425
MOD_Plk_1	362	368	PF00069	0.599
MOD_Plk_1	416	422	PF00069	0.556
MOD_Plk_1	83	89	PF00069	0.536
MOD_Plk_2-3	363	369	PF00069	0.437
MOD_Plk_4	115	121	PF00069	0.530
MOD_Plk_4	168	174	PF00069	0.524
MOD_Plk_4	193	199	PF00069	0.434
MOD_Plk_4	208	214	PF00069	0.574
MOD_Plk_4	279	285	PF00069	0.658
MOD_Plk_4	417	423	PF00069	0.482
MOD_Plk_4	83	89	PF00069	0.529
MOD_ProDKin_1	148	154	PF00069	0.477
MOD_ProDKin_1	235	241	PF00069	0.639
MOD_ProDKin_1	335	341	PF00069	0.645
MOD_ProDKin_1	352	358	PF00069	0.545
MOD_ProDKin_1	393	399	PF00069	0.586
MOD_ProDKin_1	439	445	PF00069	0.535
MOD_ProDKin_1	450	456	PF00069	0.463
TRG_DiLeu_BaEn_1	76	81	PF01217	0.508
TRG_DiLeu_BaLyEn_6	447	452	PF01217	0.555
TRG_DiLeu_BaLyEn_6	457	462	PF01217	0.426
TRG_ENDOCYTIC_2	382	385	PF00928	0.333
TRG_ENDOCYTIC_2	398	401	PF00928	0.341
TRG_ER_diArg_1	382	384	PF00400	0.572
TRG_NES_CRM1_1	206	218	PF08389	0.392

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I798	Leptomonas seymouri	56%	100%
A0A1X0PA91	Trypanosomatidae	22%	100%
A0A3Q8ILJ7	Leishmania donovani	76%	100%
A0A422NVD8	Trypanosoma rangeli	24%	100%
A4IAH0	Leishmania infantum	76%	100%
C9ZLS1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	22%	100%
E9B5J4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q4Q2E2	Leishmania major	74%	100%
V5BRG2	Trypanosoma cruzi	25%	100%