HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HECT-domain (ubiquitin-transferase), putative

Species:

Leishmania braziliensis

UniProt:

A4HBB9_LEIBR

TriTrypDb:

LbrM.20.3590 , LBRM2903_200050100 , LBRM2903_200050200

Length:

1368

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBB9

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

Biological processes
Term	Name	Level	Count
GO:0006508	proteolysis	4	11
GO:0006511	ubiquitin-dependent protein catabolic process	7	11
GO:0006807	nitrogen compound metabolic process	2	11
GO:0008152	metabolic process	1	11
GO:0009056	catabolic process	2	11
GO:0009057	macromolecule catabolic process	4	11
GO:0009987	cellular process	1	11
GO:0019538	protein metabolic process	3	11
GO:0019941	modification-dependent protein catabolic process	6	11
GO:0043170	macromolecule metabolic process	3	11
GO:0043632	modification-dependent macromolecule catabolic process	5	11
GO:0044237	cellular metabolic process	2	11
GO:0044238	primary metabolic process	2	11
GO:0044248	cellular catabolic process	3	11
GO:0044260	obsolete cellular macromolecule metabolic process	3	11
GO:0044265	obsolete cellular macromolecule catabolic process	4	11
GO:0051603	proteolysis involved in protein catabolic process	5	11
GO:0071704	organic substance metabolic process	2	11
GO:1901564	organonitrogen compound metabolic process	3	11
GO:1901575	organic substance catabolic process	3	11
GO:0000209	protein polyubiquitination	8	1
GO:0010498	proteasomal protein catabolic process	5	1
GO:0016567	protein ubiquitination	7	1
GO:0030163	protein catabolic process	4	1
GO:0032446	protein modification by small protein conjugation	6	1
GO:0036211	protein modification process	4	1
GO:0043161	proteasome-mediated ubiquitin-dependent protein catabolic process	6	1
GO:0043412	macromolecule modification	4	1
GO:0070647	protein modification by small protein conjugation or removal	5	1
GO:1901565	organonitrogen compound catabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004842	ubiquitin-protein transferase activity	4	11
GO:0016740	transferase activity	2	11
GO:0019787	ubiquitin-like protein transferase activity	3	11
GO:0061630	ubiquitin protein ligase activity	5	11
GO:0061659	ubiquitin-like protein ligase activity	4	11
GO:0140096	catalytic activity, acting on a protein	2	11
GO:0005488	binding	1	4
GO:0008270	zinc ion binding	6	2
GO:0043167	ion binding	2	4
GO:0043169	cation binding	3	4
GO:0046872	metal ion binding	4	4
GO:0046914	transition metal ion binding	5	2
GO:0016874	ligase activity	2	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	104	108	PF00656	0.378
CLV_C14_Caspase3-7	1179	1183	PF00656	0.186
CLV_C14_Caspase3-7	1243	1247	PF00656	0.186
CLV_C14_Caspase3-7	593	597	PF00656	0.420
CLV_NRD_NRD_1	1166	1168	PF00675	0.286
CLV_NRD_NRD_1	1362	1364	PF00675	0.314
CLV_NRD_NRD_1	245	247	PF00675	0.566
CLV_NRD_NRD_1	432	434	PF00675	0.424
CLV_NRD_NRD_1	516	518	PF00675	0.417
CLV_NRD_NRD_1	622	624	PF00675	0.574
CLV_NRD_NRD_1	973	975	PF00675	0.363
CLV_PCSK_KEX2_1	116	118	PF00082	0.428
CLV_PCSK_KEX2_1	1166	1168	PF00082	0.286
CLV_PCSK_KEX2_1	1362	1364	PF00082	0.352
CLV_PCSK_KEX2_1	247	249	PF00082	0.550
CLV_PCSK_KEX2_1	432	434	PF00082	0.431
CLV_PCSK_KEX2_1	457	459	PF00082	0.396
CLV_PCSK_KEX2_1	516	518	PF00082	0.367
CLV_PCSK_KEX2_1	622	624	PF00082	0.539
CLV_PCSK_KEX2_1	723	725	PF00082	0.535
CLV_PCSK_KEX2_1	94	96	PF00082	0.277
CLV_PCSK_KEX2_1	973	975	PF00082	0.340
CLV_PCSK_PC1ET2_1	116	118	PF00082	0.428
CLV_PCSK_PC1ET2_1	247	249	PF00082	0.558
CLV_PCSK_PC1ET2_1	457	459	PF00082	0.399
CLV_PCSK_PC1ET2_1	723	725	PF00082	0.432
CLV_PCSK_PC1ET2_1	94	96	PF00082	0.314
CLV_PCSK_PC7_1	90	96	PF00082	0.334
CLV_PCSK_SKI1_1	1084	1088	PF00082	0.347
CLV_PCSK_SKI1_1	1089	1093	PF00082	0.297
CLV_PCSK_SKI1_1	1148	1152	PF00082	0.244
CLV_PCSK_SKI1_1	1235	1239	PF00082	0.446
CLV_PCSK_SKI1_1	1248	1252	PF00082	0.344
CLV_PCSK_SKI1_1	1312	1316	PF00082	0.274
CLV_PCSK_SKI1_1	1353	1357	PF00082	0.278
CLV_PCSK_SKI1_1	190	194	PF00082	0.437
CLV_PCSK_SKI1_1	214	218	PF00082	0.466
CLV_PCSK_SKI1_1	333	337	PF00082	0.526
CLV_PCSK_SKI1_1	444	448	PF00082	0.261
CLV_PCSK_SKI1_1	468	472	PF00082	0.403
CLV_PCSK_SKI1_1	479	483	PF00082	0.440
CLV_PCSK_SKI1_1	557	561	PF00082	0.518
CLV_PCSK_SKI1_1	649	653	PF00082	0.602
CLV_PCSK_SKI1_1	67	71	PF00082	0.392
CLV_PCSK_SKI1_1	739	743	PF00082	0.367
CLV_PCSK_SKI1_1	843	847	PF00082	0.462
CLV_PCSK_SKI1_1	90	94	PF00082	0.362
CLV_PCSK_SKI1_1	920	924	PF00082	0.432
CLV_PCSK_SKI1_1	946	950	PF00082	0.373
CLV_PCSK_SKI1_1	974	978	PF00082	0.416
DEG_APCC_DBOX_1	1147	1155	PF00400	0.287
DEG_APCC_DBOX_1	89	97	PF00400	0.337
DEG_SCF_FBW7_2	572	577	PF00400	0.243
DEG_SPOP_SBC_1	361	365	PF00917	0.578
DOC_ANK_TNKS_1	351	358	PF00023	0.359
DOC_CDC14_PxL_1	1021	1029	PF14671	0.248
DOC_CDC14_PxL_1	1119	1127	PF14671	0.410
DOC_CKS1_1	415	420	PF01111	0.420
DOC_CKS1_1	629	634	PF01111	0.510
DOC_CKS1_1	873	878	PF01111	0.216
DOC_CYCLIN_RxL_1	1081	1090	PF00134	0.355
DOC_CYCLIN_RxL_1	1145	1155	PF00134	0.197
DOC_CYCLIN_RxL_1	1347	1360	PF00134	0.406
DOC_CYCLIN_RxL_1	463	475	PF00134	0.216
DOC_CYCLIN_RxL_1	64	71	PF00134	0.356
DOC_CYCLIN_RxL_1	917	927	PF00134	0.422
DOC_CYCLIN_yClb5_NLxxxL_5	1148	1154	PF00134	0.186
DOC_CYCLIN_yCln2_LP_2	38	44	PF00134	0.498
DOC_CYCLIN_yCln2_LP_2	470	476	PF00134	0.207
DOC_CYCLIN_yCln2_LP_2	853	859	PF00134	0.260
DOC_MAPK_DCC_7	1020	1029	PF00069	0.208
DOC_MAPK_gen_1	1007	1016	PF00069	0.439
DOC_MAPK_gen_1	1351	1358	PF00069	0.350
DOC_MAPK_gen_1	337	345	PF00069	0.531
DOC_MAPK_gen_1	432	442	PF00069	0.432
DOC_MAPK_gen_1	456	464	PF00069	0.450
DOC_MAPK_gen_1	723	730	PF00069	0.536
DOC_MAPK_HePTP_8	1017	1029	PF00069	0.214
DOC_MAPK_HePTP_8	720	732	PF00069	0.440
DOC_MAPK_JIP1_4	1010	1016	PF00069	0.424
DOC_MAPK_MEF2A_6	1020	1029	PF00069	0.311
DOC_MAPK_MEF2A_6	1351	1358	PF00069	0.341
DOC_MAPK_MEF2A_6	153	162	PF00069	0.385
DOC_MAPK_MEF2A_6	723	732	PF00069	0.445
DOC_MAPK_NFAT4_5	1351	1359	PF00069	0.397
DOC_MAPK_RevD_3	958	974	PF00069	0.394
DOC_PP1_RVXF_1	1028	1034	PF00149	0.314
DOC_PP1_RVXF_1	466	473	PF00149	0.312
DOC_PP1_RVXF_1	477	483	PF00149	0.305
DOC_PP1_RVXF_1	841	848	PF00149	0.460
DOC_PP2B_LxvP_1	1120	1123	PF13499	0.410
DOC_PP2B_LxvP_1	1125	1128	PF13499	0.410
DOC_PP2B_LxvP_1	1339	1342	PF13499	0.455
DOC_PP2B_LxvP_1	142	145	PF13499	0.412
DOC_PP2B_LxvP_1	633	636	PF13499	0.370
DOC_PP4_FxxP_1	761	764	PF00568	0.517
DOC_USP7_MATH_1	131	135	PF00917	0.441
DOC_USP7_MATH_1	199	203	PF00917	0.455
DOC_USP7_MATH_1	2	6	PF00917	0.629
DOC_USP7_MATH_1	253	257	PF00917	0.551
DOC_USP7_MATH_1	30	34	PF00917	0.443
DOC_USP7_MATH_1	317	321	PF00917	0.365
DOC_USP7_MATH_1	348	352	PF00917	0.430
DOC_USP7_MATH_1	356	360	PF00917	0.491
DOC_USP7_MATH_1	362	366	PF00917	0.602
DOC_USP7_MATH_1	491	495	PF00917	0.298
DOC_USP7_MATH_1	563	567	PF00917	0.266
DOC_USP7_MATH_1	812	816	PF00917	0.276
DOC_USP7_MATH_1	859	863	PF00917	0.253
DOC_USP7_MATH_1	884	888	PF00917	0.445
DOC_USP7_UBL2_3	80	84	PF12436	0.407
DOC_WW_Pin1_4	1181	1186	PF00397	0.433
DOC_WW_Pin1_4	1296	1301	PF00397	0.292
DOC_WW_Pin1_4	235	240	PF00397	0.580
DOC_WW_Pin1_4	288	293	PF00397	0.434
DOC_WW_Pin1_4	414	419	PF00397	0.409
DOC_WW_Pin1_4	570	575	PF00397	0.388
DOC_WW_Pin1_4	608	613	PF00397	0.549
DOC_WW_Pin1_4	628	633	PF00397	0.453
DOC_WW_Pin1_4	872	877	PF00397	0.462
LIG_14-3-3_CanoR_1	1166	1173	PF00244	0.323
LIG_14-3-3_CanoR_1	1248	1256	PF00244	0.415
LIG_14-3-3_CanoR_1	1257	1263	PF00244	0.400
LIG_14-3-3_CanoR_1	1312	1317	PF00244	0.274
LIG_14-3-3_CanoR_1	1362	1368	PF00244	0.274
LIG_14-3-3_CanoR_1	175	183	PF00244	0.455
LIG_14-3-3_CanoR_1	214	223	PF00244	0.379
LIG_14-3-3_CanoR_1	229	236	PF00244	0.581
LIG_14-3-3_CanoR_1	299	303	PF00244	0.400
LIG_14-3-3_CanoR_1	337	345	PF00244	0.494
LIG_14-3-3_CanoR_1	946	956	PF00244	0.449
LIG_Actin_WH2_2	160	177	PF00022	0.335
LIG_Actin_WH2_2	725	741	PF00022	0.310
LIG_Actin_WH2_2	78	96	PF00022	0.235
LIG_APCC_ABBAyCdc20_2	843	849	PF00400	0.451
LIG_BIR_II_1	1	5	PF00653	0.526
LIG_BIR_III_1	1	5	PF00653	0.465
LIG_BIR_III_3	1	5	PF00653	0.465
LIG_BRCT_BRCA1_1	1053	1057	PF00533	0.446
LIG_BRCT_BRCA1_1	299	303	PF00533	0.505
LIG_BRCT_BRCA1_1	757	761	PF00533	0.438
LIG_Clathr_ClatBox_1	1028	1032	PF01394	0.373
LIG_CtBP_PxDLS_1	645	649	PF00389	0.408
LIG_deltaCOP1_diTrp_1	469	474	PF00928	0.413
LIG_EH_1	346	350	PF12763	0.467
LIG_EH1_1	517	525	PF00400	0.243
LIG_eIF4E_1	1213	1219	PF01652	0.186
LIG_eIF4E_1	540	546	PF01652	0.415
LIG_FAT_LD_1	660	668	PF03623	0.465
LIG_FAT_LD_1	713	721	PF03623	0.423
LIG_FHA_1	1024	1030	PF00498	0.297
LIG_FHA_1	1081	1087	PF00498	0.355
LIG_FHA_1	1332	1338	PF00498	0.274
LIG_FHA_1	1344	1350	PF00498	0.274
LIG_FHA_1	16	22	PF00498	0.413
LIG_FHA_1	184	190	PF00498	0.276
LIG_FHA_1	23	29	PF00498	0.367
LIG_FHA_1	231	237	PF00498	0.475
LIG_FHA_1	289	295	PF00498	0.433
LIG_FHA_1	334	340	PF00498	0.504
LIG_FHA_1	361	367	PF00498	0.478
LIG_FHA_1	571	577	PF00498	0.443
LIG_FHA_1	598	604	PF00498	0.570
LIG_FHA_1	629	635	PF00498	0.566
LIG_FHA_1	716	722	PF00498	0.432
LIG_FHA_1	840	846	PF00498	0.586
LIG_FHA_1	947	953	PF00498	0.471
LIG_FHA_1	963	969	PF00498	0.469
LIG_FHA_2	1065	1071	PF00498	0.475
LIG_FHA_2	1186	1192	PF00498	0.476
LIG_FHA_2	1200	1206	PF00498	0.462
LIG_FHA_2	1250	1256	PF00498	0.406
LIG_FHA_2	1269	1275	PF00498	0.248
LIG_FHA_2	367	373	PF00498	0.454
LIG_FHA_2	464	470	PF00498	0.346
LIG_FHA_2	591	597	PF00498	0.488
LIG_FHA_2	749	755	PF00498	0.448
LIG_FHA_2	817	823	PF00498	0.474
LIG_GBD_Chelix_1	327	335	PF00786	0.462
LIG_LIR_Apic_2	758	764	PF02991	0.507
LIG_LIR_Gen_1	1048	1057	PF02991	0.333
LIG_LIR_Gen_1	1161	1168	PF02991	0.387
LIG_LIR_Gen_1	1291	1300	PF02991	0.465
LIG_LIR_Gen_1	1334	1344	PF02991	0.274
LIG_LIR_Gen_1	14	23	PF02991	0.417
LIG_LIR_Gen_1	195	205	PF02991	0.331
LIG_LIR_Gen_1	208	216	PF02991	0.362
LIG_LIR_Gen_1	965	975	PF02991	0.351
LIG_LIR_LC3C_4	718	722	PF02991	0.349
LIG_LIR_Nem_3	1048	1053	PF02991	0.348
LIG_LIR_Nem_3	107	113	PF02991	0.371
LIG_LIR_Nem_3	1090	1094	PF02991	0.331
LIG_LIR_Nem_3	1161	1165	PF02991	0.439
LIG_LIR_Nem_3	1291	1295	PF02991	0.465
LIG_LIR_Nem_3	1334	1339	PF02991	0.274
LIG_LIR_Nem_3	14	20	PF02991	0.431
LIG_LIR_Nem_3	195	200	PF02991	0.332
LIG_LIR_Nem_3	208	212	PF02991	0.370
LIG_LIR_Nem_3	397	403	PF02991	0.344
LIG_LIR_Nem_3	419	425	PF02991	0.458
LIG_LIR_Nem_3	965	970	PF02991	0.386
LIG_MLH1_MIPbox_1	1053	1057	PF16413	0.446
LIG_MYND_1	632	636	PF01753	0.536
LIG_NRBOX	1146	1152	PF00104	0.357
LIG_NRBOX	44	50	PF00104	0.518
LIG_NRBOX	545	551	PF00104	0.452
LIG_NRBOX	712	718	PF00104	0.427
LIG_PCNA_TLS_4	67	74	PF02747	0.348
LIG_PCNA_yPIPBox_3	1212	1222	PF02747	0.406
LIG_Pex14_2	1087	1091	PF04695	0.410
LIG_Pex14_2	193	197	PF04695	0.245
LIG_PTB_Apo_2	1207	1214	PF02174	0.186
LIG_PTB_Phospho_1	1207	1213	PF10480	0.186
LIG_RPA_C_Fungi	512	524	PF08784	0.230
LIG_SH2_CRK	1198	1202	PF00017	0.186
LIG_SH2_CRK	17	21	PF00017	0.403
LIG_SH2_NCK_1	1198	1202	PF00017	0.186
LIG_SH2_NCK_1	489	493	PF00017	0.476
LIG_SH2_NCK_1	926	930	PF00017	0.414
LIG_SH2_PTP2	967	970	PF00017	0.410
LIG_SH2_STAP1	17	21	PF00017	0.438
LIG_SH2_STAP1	430	434	PF00017	0.423
LIG_SH2_STAP1	489	493	PF00017	0.216
LIG_SH2_STAP1	798	802	PF00017	0.365
LIG_SH2_STAP1	981	985	PF00017	0.335
LIG_SH2_STAT5	1050	1053	PF00017	0.388
LIG_SH2_STAT5	1056	1059	PF00017	0.338
LIG_SH2_STAT5	1198	1201	PF00017	0.196
LIG_SH2_STAT5	1213	1216	PF00017	0.235
LIG_SH2_STAT5	1338	1341	PF00017	0.274
LIG_SH2_STAT5	17	20	PF00017	0.470
LIG_SH2_STAT5	874	877	PF00017	0.362
LIG_SH2_STAT5	967	970	PF00017	0.349
LIG_SH3_3	1150	1156	PF00018	0.406
LIG_SH3_3	1297	1303	PF00018	0.274
LIG_SH3_3	233	239	PF00018	0.475
LIG_SH3_3	352	358	PF00018	0.359
LIG_SH3_3	395	401	PF00018	0.406
LIG_SH3_3	412	418	PF00018	0.481
LIG_SH3_3	493	499	PF00018	0.385
LIG_SH3_3	548	554	PF00018	0.459
LIG_SH3_3	626	632	PF00018	0.517
LIG_SH3_3	951	957	PF00018	0.393
LIG_Sin3_3	306	313	PF02671	0.250
LIG_SUMO_SIM_anti_2	276	283	PF11976	0.448
LIG_SUMO_SIM_anti_2	688	694	PF11976	0.343
LIG_SUMO_SIM_par_1	1118	1124	PF11976	0.355
LIG_SUMO_SIM_par_1	1149	1155	PF11976	0.353
LIG_SUMO_SIM_par_1	1217	1223	PF11976	0.359
LIG_SUMO_SIM_par_1	1354	1360	PF11976	0.341
LIG_SUMO_SIM_par_1	18	26	PF11976	0.413
LIG_SUMO_SIM_par_1	341	346	PF11976	0.420
LIG_SUMO_SIM_par_1	746	751	PF11976	0.298
LIG_TRAF2_1	1045	1048	PF00917	0.367
LIG_TRAF2_1	12	15	PF00917	0.517
LIG_TRAF2_1	1231	1234	PF00917	0.393
LIG_TRAF2_1	1252	1255	PF00917	0.433
LIG_TRAF2_1	144	147	PF00917	0.399
LIG_TRAF2_1	240	243	PF00917	0.516
LIG_TYR_ITSM	963	970	PF00017	0.362
LIG_UBA3_1	405	413	PF00899	0.448
LIG_UBA3_1	716	723	PF00899	0.421
LIG_WRC_WIRS_1	564	569	PF05994	0.466
MOD_CDK_SPK_2	1296	1301	PF00069	0.292
MOD_CDK_SPxK_1	1181	1187	PF00069	0.210
MOD_CDK_SPxK_1	608	614	PF00069	0.593
MOD_CK1_1	103	109	PF00069	0.468
MOD_CK1_1	1043	1049	PF00069	0.503
MOD_CK1_1	1140	1146	PF00069	0.393
MOD_CK1_1	1264	1270	PF00069	0.328
MOD_CK1_1	1331	1337	PF00069	0.279
MOD_CK1_1	251	257	PF00069	0.620
MOD_CK1_1	311	317	PF00069	0.408
MOD_CK1_1	320	326	PF00069	0.422
MOD_CK1_1	338	344	PF00069	0.298
MOD_CK1_1	558	564	PF00069	0.396
MOD_CK1_1	627	633	PF00069	0.515
MOD_CK1_1	75	81	PF00069	0.393
MOD_CK1_1	755	761	PF00069	0.525
MOD_CK1_1	834	840	PF00069	0.502
MOD_CK2_1	1166	1172	PF00069	0.294
MOD_CK2_1	1199	1205	PF00069	0.487
MOD_CK2_1	1217	1223	PF00069	0.186
MOD_CK2_1	1228	1234	PF00069	0.242
MOD_CK2_1	1249	1255	PF00069	0.371
MOD_CK2_1	1268	1274	PF00069	0.248
MOD_CK2_1	1320	1326	PF00069	0.342
MOD_CK2_1	1342	1348	PF00069	0.282
MOD_CK2_1	16	22	PF00069	0.507
MOD_CK2_1	366	372	PF00069	0.609
MOD_CK2_1	463	469	PF00069	0.437
MOD_CK2_1	655	661	PF00069	0.419
MOD_CK2_1	789	795	PF00069	0.491
MOD_CK2_1	994	1000	PF00069	0.313
MOD_Cter_Amidation	1360	1363	PF01082	0.292
MOD_GlcNHglycan	1042	1045	PF01048	0.517
MOD_GlcNHglycan	1139	1142	PF01048	0.288
MOD_GlcNHglycan	1263	1266	PF01048	0.382
MOD_GlcNHglycan	1267	1270	PF01048	0.390
MOD_GlcNHglycan	128	131	PF01048	0.432
MOD_GlcNHglycan	255	258	PF01048	0.517
MOD_GlcNHglycan	319	322	PF01048	0.497
MOD_GlcNHglycan	358	361	PF01048	0.615
MOD_GlcNHglycan	557	560	PF01048	0.290
MOD_GlcNHglycan	606	609	PF01048	0.493
MOD_GlcNHglycan	754	757	PF01048	0.313
MOD_GlcNHglycan	90	93	PF01048	0.448
MOD_GlcNHglycan	927	930	PF01048	0.393
MOD_GlcNHglycan	982	986	PF01048	0.371
MOD_GlcNHglycan	990	993	PF01048	0.434
MOD_GSK3_1	1135	1142	PF00069	0.391
MOD_GSK3_1	1181	1188	PF00069	0.342
MOD_GSK3_1	1257	1264	PF00069	0.476
MOD_GSK3_1	1321	1328	PF00069	0.221
MOD_GSK3_1	173	180	PF00069	0.505
MOD_GSK3_1	2	9	PF00069	0.499
MOD_GSK3_1	249	256	PF00069	0.470
MOD_GSK3_1	297	304	PF00069	0.407
MOD_GSK3_1	311	318	PF00069	0.281
MOD_GSK3_1	335	342	PF00069	0.349
MOD_GSK3_1	356	363	PF00069	0.552
MOD_GSK3_1	536	543	PF00069	0.277
MOD_GSK3_1	604	611	PF00069	0.550
MOD_GSK3_1	624	631	PF00069	0.465
MOD_GSK3_1	663	670	PF00069	0.320
MOD_GSK3_1	72	79	PF00069	0.346
MOD_GSK3_1	748	755	PF00069	0.441
MOD_GSK3_1	800	807	PF00069	0.429
MOD_GSK3_1	812	819	PF00069	0.406
MOD_GSK3_1	831	838	PF00069	0.393
MOD_LATS_1	555	561	PF00433	0.398
MOD_N-GLC_1	1363	1368	PF02516	0.274
MOD_N-GLC_1	685	690	PF02516	0.310
MOD_N-GLC_1	812	817	PF02516	0.290
MOD_N-GLC_2	1333	1335	PF02516	0.274
MOD_N-GLC_2	150	152	PF02516	0.463
MOD_NEK2_1	100	105	PF00069	0.398
MOD_NEK2_1	112	117	PF00069	0.368
MOD_NEK2_1	1139	1144	PF00069	0.242
MOD_NEK2_1	1158	1163	PF00069	0.256
MOD_NEK2_1	1196	1201	PF00069	0.363
MOD_NEK2_1	1275	1280	PF00069	0.317
MOD_NEK2_1	1284	1289	PF00069	0.317
MOD_NEK2_1	151	156	PF00069	0.395
MOD_NEK2_1	173	178	PF00069	0.374
MOD_NEK2_1	192	197	PF00069	0.196
MOD_NEK2_1	298	303	PF00069	0.417
MOD_NEK2_1	335	340	PF00069	0.341
MOD_NEK2_1	343	348	PF00069	0.325
MOD_NEK2_1	421	426	PF00069	0.551
MOD_NEK2_1	440	445	PF00069	0.211
MOD_NEK2_1	527	532	PF00069	0.343
MOD_NEK2_1	568	573	PF00069	0.230
MOD_NEK2_1	604	609	PF00069	0.574
MOD_NEK2_1	663	668	PF00069	0.313
MOD_NEK2_1	669	674	PF00069	0.273
MOD_NEK2_1	73	78	PF00069	0.237
MOD_NEK2_1	732	737	PF00069	0.379
MOD_NEK2_1	752	757	PF00069	0.236
MOD_NEK2_1	800	805	PF00069	0.503
MOD_NEK2_1	816	821	PF00069	0.396
MOD_NEK2_1	986	991	PF00069	0.470
MOD_NEK2_2	219	224	PF00069	0.369
MOD_NEK2_2	680	685	PF00069	0.493
MOD_NEK2_2	903	908	PF00069	0.211
MOD_PIKK_1	1043	1049	PF00454	0.371
MOD_PIKK_1	1284	1290	PF00454	0.421
MOD_PIKK_1	174	180	PF00454	0.252
MOD_PKA_1	1166	1172	PF00069	0.294
MOD_PKA_1	248	254	PF00069	0.619
MOD_PKA_1	432	438	PF00069	0.497
MOD_PKA_1	457	463	PF00069	0.453
MOD_PKA_1	94	100	PF00069	0.422
MOD_PKA_2	1166	1172	PF00069	0.327
MOD_PKA_2	174	180	PF00069	0.447
MOD_PKA_2	228	234	PF00069	0.374
MOD_PKA_2	249	255	PF00069	0.507
MOD_PKA_2	298	304	PF00069	0.502
MOD_PKA_2	339	345	PF00069	0.530
MOD_PKA_2	432	438	PF00069	0.441
MOD_PKA_2	440	446	PF00069	0.348
MOD_PKA_2	457	463	PF00069	0.319
MOD_PKA_2	680	686	PF00069	0.346
MOD_PKA_2	694	700	PF00069	0.393
MOD_PKA_2	94	100	PF00069	0.495
MOD_PKB_1	246	254	PF00069	0.670
MOD_Plk_1	1031	1037	PF00069	0.393
MOD_Plk_1	1051	1057	PF00069	0.194
MOD_Plk_1	1233	1239	PF00069	0.274
MOD_Plk_1	13	19	PF00069	0.320
MOD_Plk_1	1325	1331	PF00069	0.274
MOD_Plk_1	156	162	PF00069	0.428
MOD_Plk_1	311	317	PF00069	0.382
MOD_Plk_1	56	62	PF00069	0.428
MOD_Plk_1	688	694	PF00069	0.516
MOD_Plk_1	748	754	PF00069	0.295
MOD_Plk_1	835	841	PF00069	0.389
MOD_Plk_1	896	902	PF00069	0.383
MOD_Plk_1	981	987	PF00069	0.316
MOD_Plk_4	1023	1029	PF00069	0.302
MOD_Plk_4	1051	1057	PF00069	0.381
MOD_Plk_4	1196	1202	PF00069	0.435
MOD_Plk_4	1217	1223	PF00069	0.288
MOD_Plk_4	1275	1281	PF00069	0.359
MOD_Plk_4	16	22	PF00069	0.385
MOD_Plk_4	298	304	PF00069	0.396
MOD_Plk_4	362	368	PF00069	0.433
MOD_Plk_4	540	546	PF00069	0.503
MOD_Plk_4	56	62	PF00069	0.445
MOD_Plk_4	563	569	PF00069	0.535
MOD_Plk_4	590	596	PF00069	0.474
MOD_Plk_4	680	686	PF00069	0.377
MOD_Plk_4	688	694	PF00069	0.397
MOD_Plk_4	896	902	PF00069	0.453
MOD_ProDKin_1	1181	1187	PF00069	0.433
MOD_ProDKin_1	1296	1302	PF00069	0.292
MOD_ProDKin_1	235	241	PF00069	0.585
MOD_ProDKin_1	288	294	PF00069	0.436
MOD_ProDKin_1	414	420	PF00069	0.415
MOD_ProDKin_1	570	576	PF00069	0.391
MOD_ProDKin_1	608	614	PF00069	0.549
MOD_ProDKin_1	628	634	PF00069	0.456
MOD_ProDKin_1	872	878	PF00069	0.462
MOD_SUMO_rev_2	1054	1063	PF00179	0.436
MOD_SUMO_rev_2	231	236	PF00179	0.399
MOD_SUMO_rev_2	238	245	PF00179	0.474
MOD_SUMO_rev_2	996	1003	PF00179	0.494
TRG_DiLeu_BaEn_1	1234	1239	PF01217	0.450
TRG_DiLeu_BaEn_1	277	282	PF01217	0.463
TRG_DiLeu_BaEn_1	399	404	PF01217	0.437
TRG_DiLeu_BaEn_1	849	854	PF01217	0.416
TRG_DiLeu_BaLyEn_6	1009	1014	PF01217	0.277
TRG_DiLeu_BaLyEn_6	1115	1120	PF01217	0.410
TRG_DiLeu_BaLyEn_6	1309	1314	PF01217	0.378
TRG_DiLeu_BaLyEn_6	1350	1355	PF01217	0.274
TRG_DiLeu_BaLyEn_6	208	213	PF01217	0.502
TRG_DiLeu_BaLyEn_6	398	403	PF01217	0.441
TRG_DiLeu_BaLyEn_6	571	576	PF01217	0.392
TRG_DiLeu_BaLyEn_6	629	634	PF01217	0.499
TRG_ENDOCYTIC_2	1050	1053	PF00928	0.344
TRG_ENDOCYTIC_2	1198	1201	PF00928	0.186
TRG_ENDOCYTIC_2	1338	1341	PF00928	0.274
TRG_ENDOCYTIC_2	17	20	PF00928	0.363
TRG_ENDOCYTIC_2	967	970	PF00928	0.354
TRG_ER_diArg_1	1165	1167	PF00400	0.294
TRG_ER_diArg_1	193	196	PF00400	0.370
TRG_ER_diArg_1	432	434	PF00400	0.433
TRG_ER_diArg_1	515	517	PF00400	0.214
TRG_ER_diArg_1	621	623	PF00400	0.587
TRG_ER_diArg_1	973	975	PF00400	0.363
TRG_NLS_Bipartite_1	234	252	PF00514	0.443
TRG_NLS_MonoCore_2	245	250	PF00514	0.734
TRG_NLS_MonoExtC_3	245	250	PF00514	0.630
TRG_NLS_MonoExtN_4	244	251	PF00514	0.634
TRG_Pf-PMV_PEXEL_1	1015	1019	PF00026	0.455
TRG_Pf-PMV_PEXEL_1	1148	1152	PF00026	0.273
TRG_Pf-PMV_PEXEL_1	1166	1170	PF00026	0.306
TRG_Pf-PMV_PEXEL_1	1248	1253	PF00026	0.186
TRG_Pf-PMV_PEXEL_1	214	218	PF00026	0.453
TRG_Pf-PMV_PEXEL_1	479	483	PF00026	0.360
TRG_Pf-PMV_PEXEL_1	67	71	PF00026	0.371
TRG_Pf-PMV_PEXEL_1	739	743	PF00026	0.505

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILS0	Leptomonas seymouri	57%	99%
A0A1X0PAF7	Trypanosomatidae	30%	100%
A0A3Q8INT8	Leishmania donovani	78%	100%
A0A3R7KJ27	Trypanosoma rangeli	31%	100%
A4IAG7	Leishmania infantum	78%	100%
C9ZLS5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5J1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q2E5	Leishmania major	78%	100%
V5BLT4	Trypanosoma cruzi	30%	100%