Non-specific serine/threonine protein kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

target of rapamycin kinase 3, putative

Species:

Leishmania braziliensis

UniProt:

A4HBB5_LEIBR

TriTrypDb:

LbrM.20.3550 , LBRM2903_200049400

Length:

2624

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005737	cytoplasm	2	1
GO:0031931	TORC1 complex	4	1
GO:0031932	TORC2 complex	4	1
GO:0032991	protein-containing complex	1	12
GO:0038201	TOR complex	3	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

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Expansion

Sequence features

A4HBB5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

No structure information available for this entry

Related structures:

Function

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Biological processes
Term	Name	Level	Count
GO:0006468	protein phosphorylation	5	1
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0006807	nitrogen compound metabolic process	2	1
GO:0006950	response to stress	2	1
GO:0007154	cell communication	2	1
GO:0007165	signal transduction	2	1
GO:0008152	metabolic process	1	12
GO:0009267	cellular response to starvation	4	1
GO:0009605	response to external stimulus	2	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0004672	protein kinase activity	3	12
GO:0004674	protein serine/threonine kinase activity	4	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	1470	1474	PF00656	0.441
CLV_C14_Caspase3-7	1654	1658	PF00656	0.406
CLV_C14_Caspase3-7	1729	1733	PF00656	0.189
CLV_C14_Caspase3-7	209	213	PF00656	0.484
CLV_C14_Caspase3-7	2167	2171	PF00656	0.398
CLV_C14_Caspase3-7	2386	2390	PF00656	0.266
CLV_C14_Caspase3-7	2470	2474	PF00656	0.366
CLV_C14_Caspase3-7	2545	2549	PF00656	0.514
CLV_C14_Caspase3-7	2607	2611	PF00656	0.266
CLV_C14_Caspase3-7	944	948	PF00656	0.469

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6X1	Leptomonas seymouri	77%	100%
A0A0S4JDP2	Bodo saltans	40%	100%
A0A1X0PAZ7	Trypanosomatidae	50%	100%
A0A3R7KS37	Trypanosoma rangeli	51%	100%
A0A3S7X8F9	Leishmania donovani	89%	100%
A4IAG3	Leishmania infantum	89%	100%
C9ZLS9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9B5I7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	88%	100%
Q4Q2E8	Leishmania major	89%	100%
V5B692	Trypanosoma cruzi	51%	100%

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