Putative expression site-associated protein 5 (ESAG5)

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

expression site-associated protein 5 (ESAG5), putative

Species:

Leishmania braziliensis

UniProt:

A4HBB4_LEIBR

TriTrypDb:

LbrM.20.3540 , LBRM2903_200049300

Length:

540

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	3
GO:0110165	cellular anatomical entity	1	3

Expansion

Sequence features

A4HBB4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBB4

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0005488	binding	1	8
GO:0008289	lipid binding	2	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	15	17	PF00675	0.492
CLV_NRD_NRD_1	425	427	PF00675	0.592
CLV_PCSK_KEX2_1	15	17	PF00082	0.466
CLV_PCSK_KEX2_1	6	8	PF00082	0.637
CLV_PCSK_PC1ET2_1	6	8	PF00082	0.637
CLV_PCSK_SKI1_1	115	119	PF00082	0.453
CLV_PCSK_SKI1_1	144	148	PF00082	0.447
CLV_PCSK_SKI1_1	254	258	PF00082	0.466
CLV_PCSK_SKI1_1	267	271	PF00082	0.310
CLV_PCSK_SKI1_1	510	514	PF00082	0.326
DEG_APCC_DBOX_1	298	306	PF00400	0.289
DEG_APCC_DBOX_1	425	433	PF00400	0.332
DEG_SPOP_SBC_1	67	71	PF00917	0.509
DOC_MAPK_DCC_7	267	277	PF00069	0.295
DOC_MAPK_DCC_7	424	434	PF00069	0.335
DOC_MAPK_gen_1	15	26	PF00069	0.532
DOC_MAPK_gen_1	424	434	PF00069	0.452
DOC_MAPK_MEF2A_6	374	382	PF00069	0.525
DOC_MAPK_MEF2A_6	426	434	PF00069	0.452
DOC_MAPK_MEF2A_6	510	517	PF00069	0.297
DOC_PP1_RVXF_1	17	24	PF00149	0.422
DOC_PP2B_LxvP_1	361	364	PF13499	0.309
DOC_PP2B_LxvP_1	502	505	PF13499	0.487
DOC_PP2B_LxvP_1	92	95	PF13499	0.398
DOC_PP4_FxxP_1	491	494	PF00568	0.463
DOC_PP4_MxPP_1	256	259	PF00568	0.275
DOC_USP7_MATH_1	240	244	PF00917	0.390
DOC_USP7_MATH_1	283	287	PF00917	0.561
DOC_USP7_MATH_1	409	413	PF00917	0.535
DOC_USP7_MATH_1	67	71	PF00917	0.424
DOC_USP7_MATH_2	459	465	PF00917	0.302
DOC_USP7_UBL2_3	482	486	PF12436	0.451
DOC_WW_Pin1_4	254	259	PF00397	0.416
DOC_WW_Pin1_4	497	502	PF00397	0.526
LIG_14-3-3_CanoR_1	172	176	PF00244	0.481
LIG_14-3-3_CanoR_1	180	186	PF00244	0.385
LIG_14-3-3_CanoR_1	19	24	PF00244	0.517
LIG_14-3-3_CanoR_1	299	309	PF00244	0.441
LIG_14-3-3_CanoR_1	435	442	PF00244	0.320
LIG_14-3-3_CanoR_1	451	456	PF00244	0.291
LIG_14-3-3_CanoR_1	47	57	PF00244	0.578
LIG_BRCT_BRCA1_1	132	136	PF00533	0.281
LIG_BRCT_BRCA1_1	181	185	PF00533	0.277
LIG_BRCT_BRCA1_1	411	415	PF00533	0.441
LIG_Clathr_ClatBox_1	457	461	PF01394	0.297
LIG_deltaCOP1_diTrp_1	178	185	PF00928	0.441
LIG_deltaCOP1_diTrp_1	327	333	PF00928	0.321
LIG_DLG_GKlike_1	451	458	PF00625	0.307
LIG_FHA_1	155	161	PF00498	0.323
LIG_FHA_1	255	261	PF00498	0.418
LIG_FHA_1	263	269	PF00498	0.446
LIG_FHA_1	40	46	PF00498	0.714
LIG_FHA_1	475	481	PF00498	0.553
LIG_FHA_1	67	73	PF00498	0.332
LIG_FHA_1	89	95	PF00498	0.528
LIG_FHA_2	159	165	PF00498	0.378
LIG_FHA_2	390	396	PF00498	0.337
LIG_FHA_2	476	482	PF00498	0.338
LIG_FXI_DFP_1	217	221	PF00024	0.298
LIG_GBD_Chelix_1	224	232	PF00786	0.286
LIG_GBD_Chelix_1	372	380	PF00786	0.285
LIG_LIR_Apic_2	490	494	PF02991	0.548
LIG_LIR_Gen_1	157	167	PF02991	0.423
LIG_LIR_Gen_1	219	228	PF02991	0.281
LIG_LIR_Gen_1	22	29	PF02991	0.357
LIG_LIR_Gen_1	246	256	PF02991	0.440
LIG_LIR_Gen_1	330	341	PF02991	0.351
LIG_LIR_Gen_1	452	463	PF02991	0.460
LIG_LIR_LC3C_4	368	372	PF02991	0.342
LIG_LIR_Nem_3	157	162	PF02991	0.445
LIG_LIR_Nem_3	182	188	PF02991	0.473
LIG_LIR_Nem_3	189	195	PF02991	0.415
LIG_LIR_Nem_3	219	223	PF02991	0.290
LIG_LIR_Nem_3	22	26	PF02991	0.459
LIG_LIR_Nem_3	246	251	PF02991	0.455
LIG_LIR_Nem_3	330	336	PF02991	0.406
LIG_LIR_Nem_3	452	458	PF02991	0.457
LIG_PDZ_Class_1	535	540	PF00595	0.553
LIG_Pex14_1	181	185	PF04695	0.434
LIG_Pex14_2	216	220	PF04695	0.313
LIG_PTB_Apo_2	304	311	PF02174	0.424
LIG_PTB_Phospho_1	304	310	PF10480	0.426
LIG_REV1ctd_RIR_1	505	514	PF16727	0.342
LIG_SH2_CRK	149	153	PF00017	0.482
LIG_SH2_NCK_1	310	314	PF00017	0.457
LIG_SH2_NCK_1	350	354	PF00017	0.448
LIG_SH2_PTP2	381	384	PF00017	0.405
LIG_SH2_SRC	381	384	PF00017	0.265
LIG_SH2_STAT5	348	351	PF00017	0.367
LIG_SH2_STAT5	381	384	PF00017	0.444
LIG_SH3_3	54	60	PF00018	0.411
LIG_SUMO_SIM_anti_2	368	373	PF11976	0.284
LIG_SUMO_SIM_par_1	90	96	PF11976	0.351
LIG_TRAF2_1	95	98	PF00917	0.488
LIG_TRAF2_2	95	100	PF00917	0.364
LIG_TRFH_1	455	459	PF08558	0.458
LIG_TYR_ITIM	196	201	PF00017	0.289
LIG_TYR_ITIM	453	458	PF00017	0.441
LIG_UBA3_1	376	385	PF00899	0.308
MOD_CDC14_SPxK_1	500	503	PF00782	0.492
MOD_CDK_SPxK_1	497	503	PF00069	0.494
MOD_CK1_1	422	428	PF00069	0.452
MOD_CK1_1	446	452	PF00069	0.471
MOD_CK2_1	158	164	PF00069	0.401
MOD_CK2_1	328	334	PF00069	0.343
MOD_CK2_1	475	481	PF00069	0.366
MOD_Cter_Amidation	4	7	PF01082	0.643
MOD_DYRK1A_RPxSP_1	254	258	PF00069	0.433
MOD_GlcNHglycan	181	184	PF01048	0.278
MOD_GlcNHglycan	285	288	PF01048	0.375
MOD_GlcNHglycan	401	404	PF01048	0.678
MOD_GlcNHglycan	407	410	PF01048	0.623
MOD_GlcNHglycan	436	439	PF01048	0.421
MOD_GlcNHglycan	445	448	PF01048	0.500
MOD_GlcNHglycan	8	11	PF01048	0.577
MOD_GSK3_1	154	161	PF00069	0.373
MOD_GSK3_1	297	304	PF00069	0.444
MOD_GSK3_1	39	46	PF00069	0.527
MOD_GSK3_1	395	402	PF00069	0.478
MOD_GSK3_1	405	412	PF00069	0.515
MOD_GSK3_1	418	425	PF00069	0.582
MOD_GSK3_1	62	69	PF00069	0.390
MOD_LATS_1	111	117	PF00433	0.441
MOD_N-GLC_1	162	167	PF02516	0.273
MOD_N-GLC_1	328	333	PF02516	0.419
MOD_N-GLC_1	443	448	PF02516	0.422
MOD_N-GLC_1	461	466	PF02516	0.310
MOD_N-GLC_1	475	480	PF02516	0.316
MOD_N-GLC_1	62	67	PF02516	0.427
MOD_N-GLC_1	88	93	PF02516	0.482
MOD_NEK2_1	158	163	PF00069	0.425
MOD_NEK2_1	171	176	PF00069	0.327
MOD_NEK2_1	223	228	PF00069	0.451
MOD_NEK2_1	39	44	PF00069	0.602
MOD_NEK2_2	328	333	PF00069	0.310
MOD_PIKK_1	223	229	PF00454	0.276
MOD_PKA_1	418	424	PF00069	0.595
MOD_PKA_1	6	12	PF00069	0.518
MOD_PKA_2	171	177	PF00069	0.332
MOD_PKA_2	179	185	PF00069	0.398
MOD_PKA_2	298	304	PF00069	0.448
MOD_PKA_2	434	440	PF00069	0.361
MOD_PKA_2	48	54	PF00069	0.579
MOD_PKA_2	6	12	PF00069	0.579
MOD_Plk_1	125	131	PF00069	0.385
MOD_Plk_1	140	146	PF00069	0.389
MOD_Plk_1	328	334	PF00069	0.425
MOD_Plk_1	461	467	PF00069	0.336
MOD_Plk_1	62	68	PF00069	0.428
MOD_Plk_1	88	94	PF00069	0.327
MOD_Plk_4	125	131	PF00069	0.432
MOD_Plk_4	154	160	PF00069	0.452
MOD_Plk_4	171	177	PF00069	0.284
MOD_Plk_4	19	25	PF00069	0.506
MOD_Plk_4	328	334	PF00069	0.397
MOD_Plk_4	383	389	PF00069	0.573
MOD_Plk_4	68	74	PF00069	0.434
MOD_Plk_4	88	94	PF00069	0.296
MOD_ProDKin_1	254	260	PF00069	0.419
MOD_ProDKin_1	497	503	PF00069	0.531
MOD_SUMO_rev_2	395	402	PF00179	0.375
MOD_SUMO_rev_2	412	420	PF00179	0.435
TRG_DiLeu_BaEn_2	140	146	PF01217	0.278
TRG_ENDOCYTIC_2	149	152	PF00928	0.495
TRG_ENDOCYTIC_2	198	201	PF00928	0.336
TRG_ENDOCYTIC_2	350	353	PF00928	0.340
TRG_ENDOCYTIC_2	455	458	PF00928	0.435
TRG_ER_diArg_1	15	17	PF00400	0.412
TRG_ER_diArg_1	317	320	PF00400	0.367
TRG_ER_diArg_1	423	426	PF00400	0.559
TRG_NES_CRM1_1	456	468	PF08389	0.306
TRG_Pf-PMV_PEXEL_1	230	234	PF00026	0.464
TRG_PTS1	537	540	PF00515	0.409

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I082	Leptomonas seymouri	40%	97%
A0A1X0PA44	Trypanosomatidae	21%	100%
A0A3S5H7X9	Leishmania donovani	59%	99%
A4IAG2	Leishmania infantum	59%	99%
E9B5I6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	57%	99%
Q4Q2E9	Leishmania major	57%	100%