FCP1 homology domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

NLI interacting factor-like phosphatase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBB3_LEIBR

TriTrypDb:

LbrM.20.3530 , LBRM2903_200049200

Length:

419

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005730	nucleolus	5	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBB3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBB3

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	1
GO:0004721	phosphoprotein phosphatase activity	3	1
GO:0016787	hydrolase activity	2	1
GO:0016788	hydrolase activity, acting on ester bonds	3	1
GO:0016791	phosphatase activity	5	1
GO:0042578	phosphoric ester hydrolase activity	4	1
GO:0140096	catalytic activity, acting on a protein	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	111	115	PF00656	0.704
CLV_C14_Caspase3-7	230	234	PF00656	0.710
CLV_C14_Caspase3-7	86	90	PF00656	0.741
CLV_NRD_NRD_1	15	17	PF00675	0.551
CLV_NRD_NRD_1	156	158	PF00675	0.659
CLV_NRD_NRD_1	206	208	PF00675	0.638
CLV_NRD_NRD_1	209	211	PF00675	0.611
CLV_NRD_NRD_1	239	241	PF00675	0.681
CLV_NRD_NRD_1	307	309	PF00675	0.342
CLV_NRD_NRD_1	39	41	PF00675	0.714
CLV_PCSK_FUR_1	207	211	PF00082	0.542
CLV_PCSK_FUR_1	317	321	PF00082	0.429
CLV_PCSK_KEX2_1	15	17	PF00082	0.551
CLV_PCSK_KEX2_1	155	157	PF00082	0.668
CLV_PCSK_KEX2_1	206	208	PF00082	0.648
CLV_PCSK_KEX2_1	209	211	PF00082	0.605
CLV_PCSK_KEX2_1	239	241	PF00082	0.681
CLV_PCSK_KEX2_1	307	309	PF00082	0.375
CLV_PCSK_KEX2_1	319	321	PF00082	0.375
CLV_PCSK_KEX2_1	39	41	PF00082	0.714
CLV_PCSK_PC1ET2_1	319	321	PF00082	0.419
CLV_PCSK_PC7_1	202	208	PF00082	0.482
CLV_PCSK_SKI1_1	157	161	PF00082	0.688
CLV_PCSK_SKI1_1	373	377	PF00082	0.443
CLV_PCSK_SKI1_1	379	383	PF00082	0.413
CLV_PCSK_SKI1_1	39	43	PF00082	0.664
CLV_Separin_Metazoa	271	275	PF03568	0.499
DOC_CKS1_1	65	70	PF01111	0.446
DOC_CYCLIN_yCln2_LP_2	220	226	PF00134	0.552
DOC_MAPK_gen_1	319	329	PF00069	0.280
DOC_MAPK_MEF2A_6	274	283	PF00069	0.429
DOC_PP4_FxxP_1	3	6	PF00568	0.691
DOC_USP7_MATH_1	159	163	PF00917	0.727
DOC_USP7_MATH_1	176	180	PF00917	0.727
DOC_USP7_MATH_1	354	358	PF00917	0.426
DOC_USP7_MATH_1	371	375	PF00917	0.259
DOC_USP7_MATH_1	390	394	PF00917	0.558
DOC_USP7_MATH_1	85	89	PF00917	0.457
DOC_WW_Pin1_4	172	177	PF00397	0.664
DOC_WW_Pin1_4	64	69	PF00397	0.596
LIG_14-3-3_CanoR_1	15	19	PF00244	0.639
LIG_14-3-3_CanoR_1	34	38	PF00244	0.788
LIG_14-3-3_CanoR_1	367	376	PF00244	0.345
LIG_14-3-3_CanoR_1	394	399	PF00244	0.571
LIG_14-3-3_CanoR_1	43	51	PF00244	0.664
LIG_BIR_II_1	1	5	PF00653	0.690
LIG_Clathr_ClatBox_1	342	346	PF01394	0.499
LIG_eIF4E_1	92	98	PF01652	0.621
LIG_FHA_1	178	184	PF00498	0.729
LIG_FHA_1	18	24	PF00498	0.593
LIG_FHA_1	393	399	PF00498	0.506
LIG_FHA_1	46	52	PF00498	0.592
LIG_FHA_2	134	140	PF00498	0.479
LIG_FHA_2	149	155	PF00498	0.476
LIG_GBD_Chelix_1	247	255	PF00786	0.375
LIG_LIR_Apic_2	2	6	PF02991	0.689
LIG_LIR_Apic_2	216	222	PF02991	0.562
LIG_LIR_Apic_2	290	296	PF02991	0.499
LIG_LIR_Apic_2	363	368	PF02991	0.429
LIG_LIR_Gen_1	380	390	PF02991	0.258
LIG_LIR_Gen_1	76	85	PF02991	0.522
LIG_LIR_Gen_1	93	102	PF02991	0.549
LIG_LIR_Nem_3	380	385	PF02991	0.258
LIG_LIR_Nem_3	76	82	PF02991	0.551
LIG_LIR_Nem_3	89	95	PF02991	0.641
LIG_NRBOX	357	363	PF00104	0.499
LIG_Pex14_2	129	133	PF04695	0.717
LIG_Pex14_2	245	249	PF04695	0.429
LIG_SH2_CRK	95	99	PF00017	0.668
LIG_SH2_GRB2like	293	296	PF00017	0.429
LIG_SH2_NCK_1	95	99	PF00017	0.668
LIG_SH2_PTP2	293	296	PF00017	0.499
LIG_SH2_SRC	293	296	PF00017	0.429
LIG_SH2_STAT5	268	271	PF00017	0.266
LIG_SH2_STAT5	293	296	PF00017	0.429
LIG_SH2_STAT5	365	368	PF00017	0.429
LIG_SH3_3	62	68	PF00018	0.702
LIG_SUMO_SIM_anti_2	374	380	PF11976	0.471
LIG_SUMO_SIM_par_1	340	346	PF11976	0.377
LIG_SUMO_SIM_par_1	374	380	PF11976	0.372
LIG_UBA3_1	182	191	PF00899	0.499
LIG_UBA3_1	375	379	PF00899	0.499
MOD_CK1_1	109	115	PF00069	0.627
MOD_CK1_1	164	170	PF00069	0.730
MOD_CK1_1	17	23	PF00069	0.538
MOD_CK1_1	177	183	PF00069	0.754
MOD_CK1_1	393	399	PF00069	0.536
MOD_CK1_1	70	76	PF00069	0.630
MOD_CK1_1	90	96	PF00069	0.555
MOD_CK2_1	133	139	PF00069	0.481
MOD_CK2_1	85	91	PF00069	0.671
MOD_Cter_Amidation	305	308	PF01082	0.429
MOD_GlcNHglycan	130	133	PF01048	0.541
MOD_GlcNHglycan	224	227	PF01048	0.651
MOD_GlcNHglycan	289	292	PF01048	0.278
MOD_GlcNHglycan	350	353	PF01048	0.499
MOD_GlcNHglycan	85	88	PF01048	0.721
MOD_GSK3_1	106	113	PF00069	0.744
MOD_GSK3_1	14	21	PF00069	0.646
MOD_GSK3_1	172	179	PF00069	0.716
MOD_GSK3_1	181	188	PF00069	0.803
MOD_GSK3_1	197	204	PF00069	0.475
MOD_GSK3_1	367	374	PF00069	0.215
MOD_GSK3_1	390	397	PF00069	0.580
MOD_GSK3_1	412	419	PF00069	0.711
MOD_GSK3_1	63	70	PF00069	0.636
MOD_GSK3_1	83	90	PF00069	0.456
MOD_N-GLC_2	326	328	PF02516	0.390
MOD_NEK2_1	1	6	PF00069	0.693
MOD_NEK2_1	14	19	PF00069	0.680
MOD_NEK2_1	196	201	PF00069	0.507
MOD_NEK2_1	251	256	PF00069	0.375
MOD_NEK2_1	272	277	PF00069	0.499
MOD_NEK2_1	398	403	PF00069	0.575
MOD_NEK2_1	42	47	PF00069	0.728
MOD_NEK2_2	19	24	PF00069	0.622
MOD_PIKK_1	197	203	PF00454	0.491
MOD_PIKK_1	45	51	PF00454	0.590
MOD_PKA_2	14	20	PF00069	0.705
MOD_PKA_2	147	153	PF00069	0.672
MOD_PKA_2	201	207	PF00069	0.753
MOD_PKA_2	322	328	PF00069	0.324
MOD_PKA_2	33	39	PF00069	0.506
MOD_PKA_2	390	396	PF00069	0.547
MOD_PKA_2	42	48	PF00069	0.555
MOD_Plk_1	251	257	PF00069	0.375
MOD_Plk_1	371	377	PF00069	0.375
MOD_Plk_2-3	110	116	PF00069	0.754
MOD_Plk_4	178	184	PF00069	0.729
MOD_Plk_4	251	257	PF00069	0.375
MOD_Plk_4	371	377	PF00069	0.492
MOD_Plk_4	75	81	PF00069	0.576
MOD_ProDKin_1	172	178	PF00069	0.660
MOD_ProDKin_1	64	70	PF00069	0.592
MOD_SUMO_rev_2	57	62	PF00179	0.640
TRG_DiLeu_BaEn_1	216	221	PF01217	0.634
TRG_ENDOCYTIC_2	95	98	PF00928	0.677
TRG_ER_diArg_1	14	16	PF00400	0.553
TRG_ER_diArg_1	155	157	PF00400	0.665
TRG_ER_diArg_1	206	209	PF00400	0.635
TRG_ER_diArg_1	38	40	PF00400	0.680
TRG_NES_CRM1_1	241	253	PF08389	0.499
TRG_NES_CRM1_1	271	282	PF08389	0.429
TRG_NES_CRM1_1	334	346	PF08389	0.499

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCT0	Leptomonas seymouri	56%	82%
A0A3R7NMC5	Trypanosoma rangeli	32%	100%
A0A3S7X8G2	Leishmania donovani	73%	79%
A4IAG1	Leishmania infantum	73%	79%
E9B5I5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	72%
Q4Q2F0	Leishmania major	77%	100%