Protein-serine/threonine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase, putative

Species:

Leishmania braziliensis

UniProt:

A4HBB1_LEIBR

TriTrypDb:

LbrM.20.3510 , LBRM2903_200049000

Length:

492

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005759	mitochondrial matrix	5	9
GO:0031974	membrane-enclosed lumen	2	9
GO:0043233	organelle lumen	3	9
GO:0070013	intracellular organelle lumen	4	9
GO:0110165	cellular anatomical entity	1	9
GO:0005737	cytoplasm	2	1
GO:0005739	mitochondrion	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HBB1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBB1

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	9
GO:0006796	phosphate-containing compound metabolic process	4	9
GO:0008152	metabolic process	1	9
GO:0009987	cellular process	1	9
GO:0016310	phosphorylation	5	9
GO:0044237	cellular metabolic process	2	9
GO:0006109	regulation of carbohydrate metabolic process	5	1
GO:0006468	protein phosphorylation	5	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0010675	obsolete regulation of cellular carbohydrate metabolic process	5	1
GO:0010906	regulation of glucose metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0019538	protein metabolic process	3	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0036211	protein modification process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0043412	macromolecule modification	4	1
GO:0044238	primary metabolic process	2	1
GO:0050789	regulation of biological process	2	1
GO:0050794	regulation of cellular process	3	1
GO:0062012	regulation of small molecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0071704	organic substance metabolic process	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:1901564	organonitrogen compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	9
GO:0004672	protein kinase activity	3	9
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	9
GO:0016740	transferase activity	2	9
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	9
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	9
GO:0017076	purine nucleotide binding	4	9
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:0140096	catalytic activity, acting on a protein	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9
GO:0004740	pyruvate dehydrogenase (acetyl-transferring) kinase activity	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	148	152	PF00656	0.650
CLV_NRD_NRD_1	207	209	PF00675	0.476
CLV_NRD_NRD_1	252	254	PF00675	0.339
CLV_NRD_NRD_1	287	289	PF00675	0.472
CLV_NRD_NRD_1	5	7	PF00675	0.600
CLV_NRD_NRD_1	70	72	PF00675	0.529
CLV_PCSK_KEX2_1	207	209	PF00082	0.418
CLV_PCSK_KEX2_1	251	253	PF00082	0.345
CLV_PCSK_KEX2_1	287	289	PF00082	0.472
CLV_PCSK_KEX2_1	317	319	PF00082	0.502
CLV_PCSK_KEX2_1	5	7	PF00082	0.595
CLV_PCSK_PC1ET2_1	317	319	PF00082	0.502
CLV_PCSK_PC7_1	248	254	PF00082	0.391
CLV_PCSK_SKI1_1	159	163	PF00082	0.533
CLV_PCSK_SKI1_1	208	212	PF00082	0.623
CLV_PCSK_SKI1_1	317	321	PF00082	0.509
CLV_PCSK_SKI1_1	367	371	PF00082	0.382
CLV_PCSK_SKI1_1	79	83	PF00082	0.433
CLV_Separin_Metazoa	284	288	PF03568	0.259
DEG_APCC_DBOX_1	223	231	PF00400	0.403
DEG_SCF_FBW7_1	347	352	PF00400	0.457
DEG_SPOP_SBC_1	329	333	PF00917	0.464
DOC_CKS1_1	21	26	PF01111	0.384
DOC_CYCLIN_yCln2_LP_2	336	342	PF00134	0.576
DOC_MAPK_gen_1	207	216	PF00069	0.492
DOC_MAPK_gen_1	222	230	PF00069	0.325
DOC_MAPK_gen_1	379	388	PF00069	0.293
DOC_MAPK_gen_1	467	477	PF00069	0.434
DOC_MAPK_HePTP_8	204	216	PF00069	0.356
DOC_MAPK_MEF2A_6	207	216	PF00069	0.492
DOC_MAPK_MEF2A_6	224	232	PF00069	0.308
DOC_MAPK_MEF2A_6	379	388	PF00069	0.293
DOC_MAPK_MEF2A_6	470	477	PF00069	0.415
DOC_MAPK_NFAT4_5	209	217	PF00069	0.466
DOC_PP1_RVXF_1	250	257	PF00149	0.319
DOC_PP1_RVXF_1	463	469	PF00149	0.288
DOC_PP1_RVXF_1	75	81	PF00149	0.485
DOC_PP2B_LxvP_1	18	21	PF13499	0.475
DOC_PP2B_LxvP_1	25	28	PF13499	0.229
DOC_PP2B_PxIxI_1	324	330	PF00149	0.299
DOC_PP2B_PxIxI_1	381	387	PF00149	0.382
DOC_PP4_FxxP_1	61	64	PF00568	0.489
DOC_USP7_MATH_1	223	227	PF00917	0.484
DOC_USP7_MATH_1	236	240	PF00917	0.486
DOC_USP7_MATH_1	349	353	PF00917	0.487
DOC_USP7_MATH_2	143	149	PF00917	0.492
DOC_USP7_UBL2_3	414	418	PF12436	0.382
DOC_USP7_UBL2_3	68	72	PF12436	0.511
DOC_WW_Pin1_4	20	25	PF00397	0.377
DOC_WW_Pin1_4	320	325	PF00397	0.306
DOC_WW_Pin1_4	331	336	PF00397	0.628
DOC_WW_Pin1_4	345	350	PF00397	0.535
LIG_14-3-3_CanoR_1	110	116	PF00244	0.408
LIG_14-3-3_CanoR_1	130	140	PF00244	0.619
LIG_14-3-3_CanoR_1	318	324	PF00244	0.527
LIG_14-3-3_CanoR_1	389	398	PF00244	0.360
LIG_14-3-3_CanoR_1	56	62	PF00244	0.403
LIG_14-3-3_CanoR_1	79	85	PF00244	0.383
LIG_Actin_WH2_2	355	373	PF00022	0.421
LIG_Actin_WH2_2	63	81	PF00022	0.381
LIG_APCC_ABBA_1	309	314	PF00400	0.449
LIG_BIR_II_1	1	5	PF00653	0.551
LIG_BIR_III_4	160	164	PF00653	0.509
LIG_deltaCOP1_diTrp_1	393	401	PF00928	0.382
LIG_FHA_1	209	215	PF00498	0.498
LIG_FHA_1	270	276	PF00498	0.441
LIG_FHA_1	278	284	PF00498	0.360
LIG_FHA_1	331	337	PF00498	0.595
LIG_FHA_1	375	381	PF00498	0.300
LIG_FHA_1	393	399	PF00498	0.358
LIG_FHA_1	438	444	PF00498	0.381
LIG_FHA_1	455	461	PF00498	0.317
LIG_FHA_2	132	138	PF00498	0.585
LIG_FHA_2	192	198	PF00498	0.580
LIG_FHA_2	21	27	PF00498	0.479
LIG_FHA_2	420	426	PF00498	0.382
LIG_GBD_Chelix_1	42	50	PF00786	0.452
LIG_LIR_Apic_2	60	64	PF02991	0.459
LIG_LIR_Gen_1	126	135	PF02991	0.448
LIG_LIR_Gen_1	295	301	PF02991	0.451
LIG_LIR_Gen_1	393	404	PF02991	0.382
LIG_LIR_Gen_1	453	460	PF02991	0.399
LIG_LIR_Gen_1	55	66	PF02991	0.461
LIG_LIR_Nem_3	126	131	PF02991	0.576
LIG_LIR_Nem_3	179	185	PF02991	0.626
LIG_LIR_Nem_3	295	300	PF02991	0.474
LIG_LIR_Nem_3	363	369	PF02991	0.360
LIG_LIR_Nem_3	393	399	PF02991	0.382
LIG_LIR_Nem_3	400	404	PF02991	0.382
LIG_LIR_Nem_3	453	458	PF02991	0.420
LIG_LIR_Nem_3	55	61	PF02991	0.365
LIG_NRBOX	281	287	PF00104	0.257
LIG_PCNA_yPIPBox_3	279	288	PF02747	0.264
LIG_Pex14_1	245	249	PF04695	0.349
LIG_Pex14_1	80	84	PF04695	0.461
LIG_Pex14_2	413	417	PF04695	0.382
LIG_SH2_STAP1	427	431	PF00017	0.382
LIG_SH2_STAT5	17	20	PF00017	0.405
LIG_SH2_STAT5	265	268	PF00017	0.479
LIG_SH2_STAT5	364	367	PF00017	0.288
LIG_SH2_STAT5	455	458	PF00017	0.203
LIG_SH2_STAT5	84	87	PF00017	0.464
LIG_SH2_STAT5	91	94	PF00017	0.387
LIG_SH3_3	18	24	PF00018	0.412
LIG_SH3_3	463	469	PF00018	0.331
LIG_SH3_3	472	478	PF00018	0.398
LIG_SUMO_SIM_anti_2	225	232	PF11976	0.499
LIG_SUMO_SIM_anti_2	280	287	PF11976	0.364
LIG_SUMO_SIM_anti_2	383	388	PF11976	0.353
LIG_SUMO_SIM_par_1	291	299	PF11976	0.406
LIG_WRC_WIRS_1	455	460	PF05994	0.209
LIG_WRC_WIRS_1	58	63	PF05994	0.438
MOD_CK1_1	123	129	PF00069	0.604
MOD_CK1_1	149	155	PF00069	0.759
MOD_CK1_1	171	177	PF00069	0.635
MOD_CK1_1	305	311	PF00069	0.410
MOD_CK1_1	330	336	PF00069	0.528
MOD_CK1_1	392	398	PF00069	0.372
MOD_CK2_1	191	197	PF00069	0.597
MOD_CK2_1	296	302	PF00069	0.315
MOD_CK2_1	33	39	PF00069	0.328
MOD_GlcNHglycan	174	177	PF01048	0.602
MOD_GlcNHglycan	290	293	PF01048	0.342
MOD_GSK3_1	131	138	PF00069	0.594
MOD_GSK3_1	141	148	PF00069	0.532
MOD_GSK3_1	16	23	PF00069	0.308
MOD_GSK3_1	165	172	PF00069	0.583
MOD_GSK3_1	174	181	PF00069	0.583
MOD_GSK3_1	208	215	PF00069	0.491
MOD_GSK3_1	296	303	PF00069	0.398
MOD_GSK3_1	327	334	PF00069	0.487
MOD_GSK3_1	345	352	PF00069	0.520
MOD_GSK3_1	485	492	PF00069	0.487
MOD_N-GLC_1	9	14	PF02516	0.322
MOD_N-GLC_2	372	374	PF02516	0.323
MOD_N-GLC_2	90	92	PF02516	0.450
MOD_NEK2_1	1	6	PF00069	0.705
MOD_NEK2_1	264	269	PF00069	0.444
MOD_NEK2_1	328	333	PF00069	0.426
MOD_NEK2_1	419	424	PF00069	0.288
MOD_NEK2_1	438	443	PF00069	0.249
MOD_NEK2_1	487	492	PF00069	0.498
MOD_NEK2_2	374	379	PF00069	0.360
MOD_PIKK_1	269	275	PF00454	0.451
MOD_PIKK_1	33	39	PF00454	0.328
MOD_PKA_1	208	214	PF00069	0.386
MOD_PKA_2	109	115	PF00069	0.416
MOD_PKA_2	131	137	PF00069	0.646
MOD_PKA_2	223	229	PF00069	0.406
MOD_PKA_2	52	58	PF00069	0.420
MOD_Plk_1	135	141	PF00069	0.639
MOD_Plk_1	392	398	PF00069	0.331
MOD_Plk_1	460	466	PF00069	0.360
MOD_Plk_1	9	15	PF00069	0.377
MOD_Plk_2-3	135	141	PF00069	0.414
MOD_Plk_4	123	129	PF00069	0.565
MOD_Plk_4	135	141	PF00069	0.566
MOD_Plk_4	223	229	PF00069	0.548
MOD_Plk_4	296	302	PF00069	0.607
MOD_Plk_4	305	311	PF00069	0.410
MOD_Plk_4	360	366	PF00069	0.428
MOD_Plk_4	392	398	PF00069	0.459
MOD_Plk_4	80	86	PF00069	0.454
MOD_ProDKin_1	20	26	PF00069	0.379
MOD_ProDKin_1	320	326	PF00069	0.308
MOD_ProDKin_1	331	337	PF00069	0.630
MOD_ProDKin_1	345	351	PF00069	0.531
MOD_SUMO_rev_2	314	319	PF00179	0.405
TRG_DiLeu_BaEn_1	383	388	PF01217	0.209
TRG_DiLeu_BaEn_3	314	320	PF01217	0.456
TRG_ENDOCYTIC_2	17	20	PF00928	0.456
TRG_ENDOCYTIC_2	444	447	PF00928	0.331
TRG_ENDOCYTIC_2	455	458	PF00928	0.331
TRG_ENDOCYTIC_2	58	61	PF00928	0.356
TRG_ER_diArg_1	221	224	PF00400	0.385
TRG_ER_diArg_1	251	253	PF00400	0.364
TRG_ER_diArg_1	286	288	PF00400	0.471
TRG_ER_diArg_1	464	467	PF00400	0.382
TRG_ER_diArg_1	5	7	PF00400	0.569
TRG_ER_diArg_1	77	80	PF00400	0.479
TRG_Pf-PMV_PEXEL_1	257	261	PF00026	0.313
TRG_Pf-PMV_PEXEL_1	97	101	PF00026	0.557

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P768	Leptomonas seymouri	54%	100%
A0A1X0PBH1	Trypanosomatidae	36%	100%
A0A3Q8III9	Leishmania donovani	82%	98%
A0A3S5IRS7	Trypanosoma rangeli	35%	100%
A4IAF9	Leishmania infantum	82%	98%
E9B5I3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q2F2	Leishmania major	81%	100%