Pro-kuma_activ domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBB0_LEIBR

TriTrypDb:

LbrM.20.3500 , LBRM2903_200048900

Length:

304

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0020022	acidocalcisome	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1

Expansion

Sequence features

A4HBB0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBB0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	276	280	PF00656	0.235
CLV_NRD_NRD_1	122	124	PF00675	0.591
CLV_NRD_NRD_1	21	23	PF00675	0.389
CLV_NRD_NRD_1	84	86	PF00675	0.584
CLV_PCSK_KEX2_1	122	124	PF00082	0.585
CLV_PCSK_KEX2_1	20	22	PF00082	0.396
CLV_PCSK_KEX2_1	84	86	PF00082	0.567
CLV_PCSK_SKI1_1	134	138	PF00082	0.583
CLV_PCSK_SKI1_1	22	26	PF00082	0.297
CLV_PCSK_SKI1_1	239	243	PF00082	0.579
CLV_PCSK_SKI1_1	268	272	PF00082	0.559
CLV_PCSK_SKI1_1	284	288	PF00082	0.412
CLV_PCSK_SKI1_1	85	89	PF00082	0.459
DOC_CYCLIN_RxL_1	159	173	PF00134	0.255
DOC_CYCLIN_RxL_1	281	291	PF00134	0.277
DOC_MAPK_gen_1	20	29	PF00069	0.502
DOC_MAPK_gen_1	84	90	PF00069	0.429
DOC_PP1_RVXF_1	249	255	PF00149	0.317
DOC_USP7_MATH_1	290	294	PF00917	0.489
DOC_WW_Pin1_4	231	236	PF00397	0.405
DOC_WW_Pin1_4	94	99	PF00397	0.421
LIG_14-3-3_CanoR_1	122	129	PF00244	0.393
LIG_14-3-3_CanoR_1	159	163	PF00244	0.394
LIG_14-3-3_CanoR_1	189	194	PF00244	0.336
LIG_14-3-3_CanoR_1	21	27	PF00244	0.470
LIG_eIF4E_1	131	137	PF01652	0.215
LIG_FHA_1	108	114	PF00498	0.426
LIG_FHA_1	159	165	PF00498	0.411
LIG_FHA_1	224	230	PF00498	0.358
LIG_FHA_1	23	29	PF00498	0.382
LIG_FHA_1	259	265	PF00498	0.350
LIG_FHA_1	281	287	PF00498	0.387
LIG_FHA_1	95	101	PF00498	0.450
LIG_FHA_2	133	139	PF00498	0.236
LIG_FHA_2	220	226	PF00498	0.398
LIG_FHA_2	67	73	PF00498	0.398
LIG_GBD_Chelix_1	73	81	PF00786	0.556
LIG_LIR_Gen_1	135	145	PF02991	0.265
LIG_LIR_Gen_1	156	164	PF02991	0.400
LIG_LIR_Gen_1	218	229	PF02991	0.305
LIG_LIR_Gen_1	25	34	PF02991	0.330
LIG_LIR_Gen_1	40	49	PF02991	0.464
LIG_LIR_Gen_1	57	64	PF02991	0.401
LIG_LIR_Nem_3	135	140	PF02991	0.424
LIG_LIR_Nem_3	143	147	PF02991	0.422
LIG_LIR_Nem_3	156	160	PF02991	0.341
LIG_LIR_Nem_3	198	203	PF02991	0.339
LIG_LIR_Nem_3	25	29	PF02991	0.330
LIG_LIR_Nem_3	40	44	PF02991	0.427
LIG_LYPXL_yS_3	144	147	PF13949	0.439
LIG_Pex14_2	26	30	PF04695	0.344
LIG_PTB_Apo_2	151	158	PF02174	0.376
LIG_PTB_Phospho_1	151	157	PF10480	0.383
LIG_Rb_pABgroove_1	131	139	PF01858	0.229
LIG_SH2_GRB2like	230	233	PF00017	0.416
LIG_SH2_NCK_1	157	161	PF00017	0.360
LIG_SH2_SRC	13	16	PF00017	0.498
LIG_SH2_STAP1	10	14	PF00017	0.658
LIG_SH2_STAT3	176	179	PF00017	0.329
LIG_SH2_STAT5	13	16	PF00017	0.691
LIG_SH2_STAT5	176	179	PF00017	0.374
LIG_SH2_STAT5	221	224	PF00017	0.415
LIG_SUMO_SIM_anti_2	31	36	PF11976	0.426
LIG_SUMO_SIM_par_1	269	276	PF11976	0.420
LIG_TYR_ITIM	155	160	PF00017	0.516
LIG_UBA3_1	270	274	PF00899	0.285
LIG_WRC_WIRS_1	23	28	PF05994	0.363
LIG_WRC_WIRS_1	38	43	PF05994	0.363
MOD_CK1_1	181	187	PF00069	0.491
MOD_CK1_1	272	278	PF00069	0.519
MOD_CK1_1	66	72	PF00069	0.511
MOD_CK2_1	219	225	PF00069	0.478
MOD_CK2_1	65	71	PF00069	0.567
MOD_GlcNHglycan	217	220	PF01048	0.527
MOD_GlcNHglycan	41	44	PF01048	0.484
MOD_GlcNHglycan	65	68	PF01048	0.425
MOD_GSK3_1	121	128	PF00069	0.326
MOD_GSK3_1	165	172	PF00069	0.505
MOD_GSK3_1	177	184	PF00069	0.365
MOD_GSK3_1	211	218	PF00069	0.412
MOD_GSK3_1	219	226	PF00069	0.459
MOD_GSK3_1	269	276	PF00069	0.499
MOD_N-GLC_1	170	175	PF02516	0.581
MOD_N-GLC_1	231	236	PF02516	0.510
MOD_N-GLC_1	288	293	PF02516	0.610
MOD_NEK2_1	14	19	PF00069	0.469
MOD_NEK2_1	140	145	PF00069	0.464
MOD_NEK2_1	169	174	PF00069	0.530
MOD_NEK2_1	177	182	PF00069	0.424
MOD_NEK2_1	206	211	PF00069	0.367
MOD_NEK2_1	213	218	PF00069	0.295
MOD_NEK2_1	224	229	PF00069	0.224
MOD_NEK2_1	273	278	PF00069	0.447
MOD_NEK2_1	28	33	PF00069	0.314
MOD_NEK2_1	37	42	PF00069	0.320
MOD_NEK2_1	63	68	PF00069	0.531
MOD_PIKK_1	211	217	PF00454	0.326
MOD_PIKK_1	224	230	PF00454	0.506
MOD_PIKK_1	258	264	PF00454	0.495
MOD_PKA_2	121	127	PF00069	0.437
MOD_PKA_2	158	164	PF00069	0.470
MOD_PKA_2	188	194	PF00069	0.419
MOD_PKA_2	211	217	PF00069	0.556
MOD_PKB_1	20	28	PF00069	0.338
MOD_Plk_1	14	20	PF00069	0.608
MOD_Plk_1	170	176	PF00069	0.554
MOD_Plk_1	219	225	PF00069	0.418
MOD_Plk_2-3	132	138	PF00069	0.257
MOD_Plk_4	14	20	PF00069	0.507
MOD_Plk_4	165	171	PF00069	0.544
MOD_Plk_4	178	184	PF00069	0.394
MOD_Plk_4	195	201	PF00069	0.235
MOD_Plk_4	219	225	PF00069	0.344
MOD_Plk_4	22	28	PF00069	0.280
MOD_Plk_4	96	102	PF00069	0.551
MOD_ProDKin_1	231	237	PF00069	0.508
MOD_ProDKin_1	94	100	PF00069	0.523
MOD_SUMO_rev_2	247	252	PF00179	0.565
TRG_DiLeu_BaEn_1	83	88	PF01217	0.298
TRG_ENDOCYTIC_2	144	147	PF00928	0.531
TRG_ENDOCYTIC_2	157	160	PF00928	0.402
TRG_ENDOCYTIC_2	221	224	PF00928	0.372
TRG_ER_diArg_1	121	123	PF00400	0.484
TRG_ER_diArg_1	19	22	PF00400	0.532
TRG_Pf-PMV_PEXEL_1	134	138	PF00026	0.341
TRG_Pf-PMV_PEXEL_1	85	89	PF00026	0.466

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5I4	Leptomonas seymouri	58%	100%
A0A0S4JKH0	Bodo saltans	24%	100%
A0A1X0PA82	Trypanosomatidae	34%	100%
A0A3S7X8F5	Leishmania donovani	76%	100%
A0A422NSU6	Trypanosoma rangeli	31%	100%
A4IAF8	Leishmania infantum	76%	100%
C9ZLT6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
E9B5I2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q2F3	Leishmania major	76%	100%
V5B695	Trypanosoma cruzi	33%	100%