J domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

DnaJ domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HBA8_LEIBR

TriTrypDb:

LbrM.20.3480 , LBRM2903_200048700

Length:

691

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	2
GO:0110165	cellular anatomical entity	1	2

Expansion

Sequence features

A4HBA8

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBA8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	540	544	PF00656	0.306
CLV_NRD_NRD_1	186	188	PF00675	0.468
CLV_NRD_NRD_1	303	305	PF00675	0.352
CLV_NRD_NRD_1	488	490	PF00675	0.386
CLV_NRD_NRD_1	587	589	PF00675	0.705
CLV_NRD_NRD_1	596	598	PF00675	0.783
CLV_NRD_NRD_1	633	635	PF00675	0.344
CLV_NRD_NRD_1	84	86	PF00675	0.674
CLV_PCSK_KEX2_1	185	187	PF00082	0.423
CLV_PCSK_KEX2_1	303	305	PF00082	0.443
CLV_PCSK_KEX2_1	488	490	PF00082	0.386
CLV_PCSK_KEX2_1	566	568	PF00082	0.493
CLV_PCSK_KEX2_1	589	591	PF00082	0.616
CLV_PCSK_KEX2_1	596	598	PF00082	0.630
CLV_PCSK_KEX2_1	635	637	PF00082	0.352
CLV_PCSK_KEX2_1	84	86	PF00082	0.571
CLV_PCSK_PC1ET2_1	566	568	PF00082	0.515
CLV_PCSK_PC1ET2_1	589	591	PF00082	0.513
CLV_PCSK_PC1ET2_1	635	637	PF00082	0.203
CLV_PCSK_PC7_1	80	86	PF00082	0.726
CLV_PCSK_SKI1_1	212	216	PF00082	0.386
CLV_PCSK_SKI1_1	351	355	PF00082	0.407
CLV_PCSK_SKI1_1	507	511	PF00082	0.256
CLV_PCSK_SKI1_1	638	642	PF00082	0.298
CLV_PCSK_SKI1_1	658	662	PF00082	0.179
CLV_Separin_Metazoa	462	466	PF03568	0.441
DEG_APCC_DBOX_1	184	192	PF00400	0.272
DEG_APCC_DBOX_1	488	496	PF00400	0.395
DEG_SPOP_SBC_1	389	393	PF00917	0.376
DOC_CYCLIN_RxL_1	413	423	PF00134	0.422
DOC_CYCLIN_yCln2_LP_2	353	359	PF00134	0.435
DOC_MAPK_gen_1	488	494	PF00069	0.389
DOC_MAPK_gen_1	634	642	PF00069	0.400
DOC_MAPK_MEF2A_6	156	164	PF00069	0.485
DOC_MAPK_MEF2A_6	224	232	PF00069	0.563
DOC_PP2B_LxvP_1	263	266	PF13499	0.373
DOC_PP2B_LxvP_1	353	356	PF13499	0.565
DOC_PP2B_LxvP_1	41	44	PF13499	0.489
DOC_PP2B_LxvP_1	464	467	PF13499	0.497
DOC_PP2B_LxvP_1	610	613	PF13499	0.494
DOC_PP4_FxxP_1	281	284	PF00568	0.394
DOC_USP7_MATH_1	107	111	PF00917	0.710
DOC_USP7_MATH_1	149	153	PF00917	0.416
DOC_USP7_MATH_1	291	295	PF00917	0.490
DOC_USP7_MATH_1	396	400	PF00917	0.421
DOC_USP7_MATH_1	446	450	PF00917	0.501
DOC_USP7_MATH_1	572	576	PF00917	0.641
DOC_USP7_MATH_1	63	67	PF00917	0.708
DOC_WW_Pin1_4	224	229	PF00397	0.414
DOC_WW_Pin1_4	328	333	PF00397	0.363
DOC_WW_Pin1_4	34	39	PF00397	0.776
DOC_WW_Pin1_4	83	88	PF00397	0.653
LIG_14-3-3_CanoR_1	189	194	PF00244	0.360
LIG_14-3-3_CanoR_1	310	318	PF00244	0.459
LIG_14-3-3_CanoR_1	32	41	PF00244	0.642
LIG_14-3-3_CanoR_1	52	58	PF00244	0.773
LIG_14-3-3_CanoR_1	567	571	PF00244	0.544
LIG_14-3-3_CanoR_1	638	643	PF00244	0.359
LIG_Actin_WH2_2	247	264	PF00022	0.288
LIG_APCC_ABBA_1	129	134	PF00400	0.517
LIG_BRCT_BRCA1_1	276	280	PF00533	0.615
LIG_DLG_GKlike_1	189	196	PF00625	0.244
LIG_EH1_1	163	171	PF00400	0.284
LIG_eIF4E_1	424	430	PF01652	0.453
LIG_EVH1_1	361	365	PF00568	0.480
LIG_FHA_1	109	115	PF00498	0.766
LIG_FHA_1	370	376	PF00498	0.464
LIG_FHA_1	390	396	PF00498	0.314
LIG_FHA_1	468	474	PF00498	0.557
LIG_FHA_1	556	562	PF00498	0.338
LIG_FHA_2	25	31	PF00498	0.474
LIG_FHA_2	269	275	PF00498	0.636
LIG_FHA_2	557	563	PF00498	0.344
LIG_FHA_2	615	621	PF00498	0.280
LIG_FHA_2	72	78	PF00498	0.540
LIG_GBD_Chelix_1	241	249	PF00786	0.406
LIG_LIR_Apic_2	279	284	PF02991	0.406
LIG_LIR_Gen_1	198	204	PF02991	0.347
LIG_LIR_Gen_1	253	263	PF02991	0.340
LIG_LIR_Gen_1	366	375	PF02991	0.493
LIG_LIR_Gen_1	404	414	PF02991	0.344
LIG_LIR_Gen_1	517	526	PF02991	0.452
LIG_LIR_Gen_1	543	551	PF02991	0.378
LIG_LIR_Gen_1	617	624	PF02991	0.286
LIG_LIR_Gen_1	662	671	PF02991	0.425
LIG_LIR_Nem_3	161	166	PF02991	0.474
LIG_LIR_Nem_3	192	196	PF02991	0.365
LIG_LIR_Nem_3	198	202	PF02991	0.338
LIG_LIR_Nem_3	253	258	PF02991	0.423
LIG_LIR_Nem_3	277	283	PF02991	0.702
LIG_LIR_Nem_3	366	370	PF02991	0.511
LIG_LIR_Nem_3	404	409	PF02991	0.364
LIG_LIR_Nem_3	452	456	PF02991	0.333
LIG_LIR_Nem_3	543	549	PF02991	0.313
LIG_LIR_Nem_3	617	622	PF02991	0.286
LIG_LIR_Nem_3	662	667	PF02991	0.284
LIG_LIR_Nem_3	669	674	PF02991	0.284
LIG_LYPXL_yS_3	453	456	PF13949	0.330
LIG_PCNA_yPIPBox_3	236	250	PF02747	0.458
LIG_Pex14_2	298	302	PF04695	0.352
LIG_PTB_Apo_2	418	425	PF02174	0.275
LIG_PTB_Phospho_1	418	424	PF10480	0.275
LIG_SH2_CRK	193	197	PF00017	0.415
LIG_SH2_CRK	199	203	PF00017	0.462
LIG_SH2_CRK	637	641	PF00017	0.295
LIG_SH2_CRK	671	675	PF00017	0.400
LIG_SH2_GRB2like	406	409	PF00017	0.471
LIG_SH2_NCK_1	255	259	PF00017	0.487
LIG_SH2_PTP2	159	162	PF00017	0.415
LIG_SH2_SRC	100	103	PF00017	0.504
LIG_SH2_SRC	159	162	PF00017	0.415
LIG_SH2_SRC	406	409	PF00017	0.471
LIG_SH2_SRC	424	427	PF00017	0.448
LIG_SH2_STAT3	33	36	PF00017	0.484
LIG_SH2_STAT3	437	440	PF00017	0.330
LIG_SH2_STAT5	100	103	PF00017	0.542
LIG_SH2_STAT5	159	162	PF00017	0.480
LIG_SH2_STAT5	163	166	PF00017	0.402
LIG_SH2_STAT5	33	36	PF00017	0.484
LIG_SH2_STAT5	357	360	PF00017	0.383
LIG_SH2_STAT5	388	391	PF00017	0.302
LIG_SH2_STAT5	406	409	PF00017	0.355
LIG_SH2_STAT5	478	481	PF00017	0.397
LIG_SH2_STAT5	68	71	PF00017	0.641
LIG_SH3_1	96	102	PF00018	0.513
LIG_SH3_2	583	588	PF14604	0.475
LIG_SH3_3	281	287	PF00018	0.591
LIG_SH3_3	359	365	PF00018	0.405
LIG_SH3_3	580	586	PF00018	0.466
LIG_SH3_3	96	102	PF00018	0.586
LIG_SH3_CIN85_PxpxPR_1	583	588	PF14604	0.475
LIG_SUMO_SIM_par_1	455	460	PF11976	0.321
LIG_TYR_ITIM	191	196	PF00017	0.316
LIG_WRC_WIRS_1	299	304	PF05994	0.495
LIG_WRC_WIRS_1	573	578	PF05994	0.483
LIG_WW_3	37	41	PF00397	0.485
LIG_WW_3	581	585	PF00397	0.469
MOD_CDK_SPK_2	83	88	PF00069	0.653
MOD_CDK_SPxK_1	34	40	PF00069	0.486
MOD_CK1_1	142	148	PF00069	0.415
MOD_CK1_1	152	158	PF00069	0.504
MOD_CK1_1	168	174	PF00069	0.489
MOD_CK1_1	226	232	PF00069	0.567
MOD_CK1_1	273	279	PF00069	0.476
MOD_CK1_1	382	388	PF00069	0.345
MOD_CK1_1	399	405	PF00069	0.518
MOD_CK1_1	575	581	PF00069	0.703
MOD_CK1_1	672	678	PF00069	0.344
MOD_CK1_1	70	76	PF00069	0.776
MOD_CK2_1	100	106	PF00069	0.520
MOD_CK2_1	145	151	PF00069	0.434
MOD_CK2_1	24	30	PF00069	0.473
MOD_CK2_1	268	274	PF00069	0.560
MOD_CK2_1	357	363	PF00069	0.454
MOD_CK2_1	556	562	PF00069	0.338
MOD_CK2_1	614	620	PF00069	0.379
MOD_CK2_1	71	77	PF00069	0.539
MOD_GlcNHglycan	147	150	PF01048	0.524
MOD_GlcNHglycan	16	19	PF01048	0.644
MOD_GlcNHglycan	293	296	PF01048	0.436
MOD_GlcNHglycan	319	323	PF01048	0.609
MOD_GlcNHglycan	401	404	PF01048	0.445
MOD_GlcNHglycan	409	412	PF01048	0.411
MOD_GlcNHglycan	41	44	PF01048	0.729
MOD_GlcNHglycan	448	451	PF01048	0.556
MOD_GlcNHglycan	562	566	PF01048	0.422
MOD_GlcNHglycan	577	580	PF01048	0.557
MOD_GlcNHglycan	59	62	PF01048	0.718
MOD_GSK3_1	115	122	PF00069	0.642
MOD_GSK3_1	145	152	PF00069	0.455
MOD_GSK3_1	164	171	PF00069	0.444
MOD_GSK3_1	226	233	PF00069	0.499
MOD_GSK3_1	269	276	PF00069	0.688
MOD_GSK3_1	314	321	PF00069	0.410
MOD_GSK3_1	379	386	PF00069	0.341
MOD_GSK3_1	53	60	PF00069	0.650
MOD_GSK3_1	551	558	PF00069	0.509
MOD_GSK3_1	571	578	PF00069	0.561
MOD_GSK3_1	591	598	PF00069	0.570
MOD_GSK3_1	63	70	PF00069	0.597
MOD_N-GLC_1	108	113	PF02516	0.487
MOD_N-GLC_1	115	120	PF02516	0.479
MOD_N-GLC_1	407	412	PF02516	0.416
MOD_NEK2_1	114	119	PF00069	0.753
MOD_NEK2_1	164	169	PF00069	0.482
MOD_NEK2_1	268	273	PF00069	0.614
MOD_NEK2_1	298	303	PF00069	0.426
MOD_NEK2_1	390	395	PF00069	0.390
MOD_NEK2_1	401	406	PF00069	0.312
MOD_NEK2_1	407	412	PF00069	0.250
MOD_NEK2_1	479	484	PF00069	0.387
MOD_NEK2_1	591	596	PF00069	0.541
MOD_NEK2_2	63	68	PF00069	0.729
MOD_NEK2_2	686	691	PF00069	0.375
MOD_PIKK_1	32	38	PF00454	0.484
MOD_PIKK_1	479	485	PF00454	0.445
MOD_PIKK_1	50	56	PF00454	0.619
MOD_PIKK_1	556	562	PF00454	0.372
MOD_PIKK_1	599	605	PF00454	0.459
MOD_PK_1	455	461	PF00069	0.421
MOD_PK_1	566	572	PF00069	0.474
MOD_PKA_1	566	572	PF00069	0.590
MOD_PKA_2	14	20	PF00069	0.670
MOD_PKA_2	2	8	PF00069	0.640
MOD_PKA_2	309	315	PF00069	0.428
MOD_PKA_2	39	45	PF00069	0.680
MOD_PKA_2	566	572	PF00069	0.565
MOD_PKA_2	595	601	PF00069	0.583
MOD_PKB_1	187	195	PF00069	0.252
MOD_PKB_1	553	561	PF00069	0.328
MOD_PKB_1	588	596	PF00069	0.507
MOD_PKB_1	636	644	PF00069	0.336
MOD_Plk_1	467	473	PF00069	0.518
MOD_Plk_1	556	562	PF00069	0.547
MOD_Plk_1	63	69	PF00069	0.589
MOD_Plk_1	70	76	PF00069	0.623
MOD_Plk_2-3	363	369	PF00069	0.475
MOD_Plk_2-3	71	77	PF00069	0.486
MOD_Plk_4	125	131	PF00069	0.748
MOD_Plk_4	149	155	PF00069	0.570
MOD_Plk_4	165	171	PF00069	0.504
MOD_Plk_4	323	329	PF00069	0.524
MOD_Plk_4	390	396	PF00069	0.345
MOD_Plk_4	53	59	PF00069	0.710
MOD_Plk_4	63	69	PF00069	0.638
MOD_Plk_4	669	675	PF00069	0.344
MOD_ProDKin_1	224	230	PF00069	0.408
MOD_ProDKin_1	328	334	PF00069	0.358
MOD_ProDKin_1	34	40	PF00069	0.780
MOD_ProDKin_1	83	89	PF00069	0.652
MOD_SUMO_rev_2	134	140	PF00179	0.501
MOD_SUMO_rev_2	343	350	PF00179	0.427
MOD_SUMO_rev_2	499	509	PF00179	0.368
MOD_SUMO_rev_2	593	602	PF00179	0.532
TRG_AP2beta_CARGO_1	543	553	PF09066	0.300
TRG_DiLeu_BaEn_1	259	264	PF01217	0.338
TRG_DiLeu_BaEn_1	468	473	PF01217	0.440
TRG_DiLeu_BaEn_1	662	667	PF01217	0.344
TRG_DiLeu_BaEn_3	259	265	PF01217	0.336
TRG_DiLeu_BaEn_4	183	189	PF01217	0.318
TRG_DiLeu_BaLyEn_6	186	191	PF01217	0.506
TRG_DiLeu_BaLyEn_6	284	289	PF01217	0.534
TRG_DiLeu_LyEn_5	259	264	PF01217	0.338
TRG_ENDOCYTIC_2	159	162	PF00928	0.420
TRG_ENDOCYTIC_2	163	166	PF00928	0.384
TRG_ENDOCYTIC_2	193	196	PF00928	0.451
TRG_ENDOCYTIC_2	199	202	PF00928	0.475
TRG_ENDOCYTIC_2	218	221	PF00928	0.386
TRG_ENDOCYTIC_2	255	258	PF00928	0.285
TRG_ENDOCYTIC_2	406	409	PF00928	0.379
TRG_ENDOCYTIC_2	453	456	PF00928	0.330
TRG_ENDOCYTIC_2	619	622	PF00928	0.284
TRG_ENDOCYTIC_2	637	640	PF00928	0.284
TRG_ENDOCYTIC_2	671	674	PF00928	0.400
TRG_ER_diArg_1	185	187	PF00400	0.459
TRG_ER_diArg_1	302	304	PF00400	0.520
TRG_ER_diArg_1	487	489	PF00400	0.369
TRG_ER_diArg_1	512	515	PF00400	0.391
TRG_ER_diArg_1	553	556	PF00400	0.466
TRG_ER_diArg_1	587	590	PF00400	0.761
TRG_ER_diArg_1	633	636	PF00400	0.400
TRG_ER_diArg_1	83	85	PF00400	0.651
TRG_NLS_MonoExtC_3	633	638	PF00514	0.203
TRG_NLS_MonoExtN_4	586	592	PF00514	0.499
TRG_NLS_MonoExtN_4	634	639	PF00514	0.203
TRG_Pf-PMV_PEXEL_1	219	223	PF00026	0.484
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.581
TRG_Pf-PMV_PEXEL_1	638	643	PF00026	0.437

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD42	Leptomonas seymouri	45%	99%
A0A1X0PA46	Trypanosomatidae	27%	100%
A0A3S7X8I0	Leishmania donovani	68%	89%
A4IAF6	Leishmania infantum	68%	89%
C9ZLT8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	27%	100%
E9B5I0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	88%
Q4Q2F5	Leishmania major	69%	100%
V5BRG9	Trypanosoma cruzi	27%	100%