Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBA5_LEIBR

TriTrypDb:

LbrM.20.3450 , LBRM2903_200048400

Length:

271

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBA5

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBA5

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_SKI1_1	104	108	PF00082	0.511
CLV_PCSK_SKI1_1	21	25	PF00082	0.375
CLV_PCSK_SKI1_1	62	66	PF00082	0.558
CLV_PCSK_SKI1_1	93	97	PF00082	0.575
DEG_Nend_Nbox_1	1	3	PF02207	0.468
DOC_CDC14_PxL_1	124	132	PF14671	0.436
DOC_PP2B_LxvP_1	13	16	PF13499	0.392
DOC_PP2B_LxvP_1	185	188	PF13499	0.474
DOC_PP4_FxxP_1	152	155	PF00568	0.465
DOC_USP7_MATH_1	188	192	PF00917	0.480
DOC_USP7_MATH_1	263	267	PF00917	0.431
DOC_WW_Pin1_4	136	141	PF00397	0.694
DOC_WW_Pin1_4	144	149	PF00397	0.695
DOC_WW_Pin1_4	4	9	PF00397	0.594
LIG_14-3-3_CanoR_1	3	9	PF00244	0.554
LIG_BRCT_BRCA1_1	155	159	PF00533	0.537
LIG_BRCT_BRCA1_1	190	194	PF00533	0.351
LIG_DCNL_PONY_1	1	4	PF03556	0.459
LIG_DLG_GKlike_1	153	161	PF00625	0.265
LIG_FHA_1	116	122	PF00498	0.453
LIG_FHA_1	27	33	PF00498	0.479
LIG_FHA_1	41	47	PF00498	0.418
LIG_FHA_2	230	236	PF00498	0.504
LIG_FHA_2	58	64	PF00498	0.486
LIG_FHA_2	81	87	PF00498	0.417
LIG_LIR_Apic_2	149	155	PF02991	0.464
LIG_LIR_Gen_1	156	167	PF02991	0.413
LIG_LIR_Gen_1	168	177	PF02991	0.459
LIG_LIR_Nem_3	156	162	PF02991	0.414
LIG_LIR_Nem_3	168	174	PF02991	0.328
LIG_LIR_Nem_3	17	22	PF02991	0.449
LIG_LIR_Nem_3	191	196	PF02991	0.344
LIG_LIR_Nem_3	222	226	PF02991	0.325
LIG_MLH1_MIPbox_1	190	194	PF16413	0.464
LIG_NRBOX	108	114	PF00104	0.433
LIG_NRBOX	206	212	PF00104	0.412
LIG_PCNA_PIPBox_1	187	196	PF02747	0.258
LIG_PTAP_UEV_1	124	129	PF05743	0.430
LIG_RPA_C_Fungi	111	123	PF08784	0.367
LIG_SH2_SRC	9	12	PF00017	0.405
LIG_SH2_STAP1	9	13	PF00017	0.388
LIG_SH2_STAT5	22	25	PF00017	0.328
LIG_SH2_STAT5	80	83	PF00017	0.631
LIG_SH3_3	122	128	PF00018	0.655
LIG_SH3_3	252	258	PF00018	0.538
LIG_SUMO_SIM_anti_2	29	36	PF11976	0.432
LIG_TRAF2_1	166	169	PF00917	0.432
LIG_TRAF2_1	8	11	PF00917	0.574
MOD_CK1_1	108	114	PF00069	0.482
MOD_CK1_1	139	145	PF00069	0.608
MOD_CK1_1	26	32	PF00069	0.490
MOD_CK2_1	108	114	PF00069	0.421
MOD_CK2_1	11	17	PF00069	0.526
MOD_CK2_1	229	235	PF00069	0.471
MOD_CK2_1	4	10	PF00069	0.731
MOD_CK2_1	57	63	PF00069	0.453
MOD_CK2_1	80	86	PF00069	0.426
MOD_CMANNOS	181	184	PF00535	0.330
MOD_GlcNHglycan	125	128	PF01048	0.581
MOD_GlcNHglycan	245	250	PF01048	0.482
MOD_GlcNHglycan	265	268	PF01048	0.395
MOD_GlcNHglycan	4	7	PF01048	0.682
MOD_GlcNHglycan	74	77	PF01048	0.548
MOD_GSK3_1	104	111	PF00069	0.476
MOD_GSK3_1	153	160	PF00069	0.533
MOD_GSK3_1	74	81	PF00069	0.594
MOD_N-GLC_2	176	178	PF02516	0.410
MOD_NEK2_1	105	110	PF00069	0.467
MOD_NEK2_1	157	162	PF00069	0.498
MOD_NEK2_1	2	7	PF00069	0.705
MOD_NEK2_1	210	215	PF00069	0.536
MOD_NEK2_1	23	28	PF00069	0.334
MOD_PIKK_1	80	86	PF00454	0.693
MOD_PKA_2	115	121	PF00069	0.514
MOD_PKA_2	2	8	PF00069	0.590
MOD_Plk_1	188	194	PF00069	0.512
MOD_Plk_1	9	15	PF00069	0.388
MOD_Plk_1	97	103	PF00069	0.400
MOD_Plk_2-3	11	17	PF00069	0.323
MOD_Plk_4	108	114	PF00069	0.364
MOD_Plk_4	153	159	PF00069	0.375
MOD_Plk_4	97	103	PF00069	0.386
MOD_ProDKin_1	136	142	PF00069	0.695
MOD_ProDKin_1	144	150	PF00069	0.681
MOD_ProDKin_1	4	10	PF00069	0.592
MOD_SUMO_rev_2	58	67	PF00179	0.543
MOD_SUMO_rev_2	86	95	PF00179	0.562
TRG_DiLeu_BaEn_1	91	96	PF01217	0.500
TRG_DiLeu_BaLyEn_6	252	257	PF01217	0.430
TRG_DiLeu_BaLyEn_6	36	41	PF01217	0.302

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PE51	Leptomonas seymouri	55%	100%
A0A0S4KKN8	Bodo saltans	28%	96%
A0A1X0ND66	Trypanosomatidae	32%	100%
A0A3Q8IEP6	Leishmania donovani	69%	100%
A0A422NSY2	Trypanosoma rangeli	35%	100%
A4IAF3	Leishmania infantum	69%	100%
C9ZLU1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	32%	100%
E9B5H7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	69%	100%
Q4Q2F8	Leishmania major	66%	100%