Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBA4_LEIBR

TriTrypDb:

LbrM.20.3440 , LBRM2903_200048300

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 5
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBA4

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBA4

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	117	119	PF00675	0.387
CLV_NRD_NRD_1	40	42	PF00675	0.681
CLV_NRD_NRD_1	97	99	PF00675	0.665
CLV_PCSK_KEX2_1	117	119	PF00082	0.581
CLV_PCSK_KEX2_1	191	193	PF00082	0.513
CLV_PCSK_KEX2_1	40	42	PF00082	0.681
CLV_PCSK_KEX2_1	96	98	PF00082	0.685
CLV_PCSK_PC1ET2_1	191	193	PF00082	0.412
CLV_PCSK_PC7_1	93	99	PF00082	0.669
CLV_PCSK_SKI1_1	201	205	PF00082	0.418
CLV_PCSK_SKI1_1	40	44	PF00082	0.500
CLV_PCSK_SKI1_1	62	66	PF00082	0.594
DEG_APCC_DBOX_1	200	208	PF00400	0.412
DOC_MAPK_gen_1	117	123	PF00069	0.502
DOC_MAPK_gen_1	195	204	PF00069	0.573
DOC_MAPK_MEF2A_6	48	57	PF00069	0.662
DOC_USP7_MATH_1	150	154	PF00917	0.799
DOC_USP7_MATH_1	163	167	PF00917	0.614
DOC_USP7_MATH_1	86	90	PF00917	0.654
DOC_WW_Pin1_4	1	6	PF00397	0.529
DOC_WW_Pin1_4	126	131	PF00397	0.763
LIG_14-3-3_CanoR_1	181	185	PF00244	0.674
LIG_14-3-3_CanoR_1	40	50	PF00244	0.633
LIG_Actin_WH2_2	189	207	PF00022	0.621
LIG_Actin_WH2_2	217	233	PF00022	0.440
LIG_Actin_WH2_2	50	67	PF00022	0.411
LIG_BIR_II_1	1	5	PF00653	0.534
LIG_BRCT_BRCA1_1	225	229	PF00533	0.443
LIG_FHA_1	2	8	PF00498	0.559
LIG_FHA_1	86	92	PF00498	0.659
LIG_FHA_2	107	113	PF00498	0.538
LIG_GSK3_LRP6_1	126	131	PF00069	0.548
LIG_Integrin_RGD_1	212	214	PF01839	0.672
LIG_SH2_SRC	102	105	PF00017	0.662
LIG_SH2_STAP1	102	106	PF00017	0.664
LIG_SH3_3	120	126	PF00018	0.593
LIG_SH3_3	153	159	PF00018	0.751
LIG_SUMO_SIM_anti_2	206	211	PF11976	0.647
MOD_CK1_1	131	137	PF00069	0.642
MOD_CK2_1	106	112	PF00069	0.445
MOD_GlcNHglycan	130	133	PF01048	0.651
MOD_GlcNHglycan	144	147	PF01048	0.502
MOD_GlcNHglycan	216	219	PF01048	0.417
MOD_GlcNHglycan	25	28	PF01048	0.386
MOD_GSK3_1	138	145	PF00069	0.621
MOD_N-GLC_1	142	147	PF02516	0.663
MOD_NEK2_1	137	142	PF00069	0.549
MOD_PKA_2	163	169	PF00069	0.742
MOD_PKA_2	180	186	PF00069	0.391
MOD_PKA_2	86	92	PF00069	0.659
MOD_Plk_1	137	143	PF00069	0.582
MOD_Plk_4	180	186	PF00069	0.419
MOD_ProDKin_1	1	7	PF00069	0.519
MOD_ProDKin_1	126	132	PF00069	0.762
MOD_SUMO_for_1	100	103	PF00179	0.415
MOD_SUMO_rev_2	26	34	PF00179	0.423
TRG_DiLeu_BaEn_1	199	204	PF01217	0.409
TRG_DiLeu_BaEn_2	224	230	PF01217	0.442
TRG_DiLeu_BaLyEn_6	87	92	PF01217	0.663
TRG_ENDOCYTIC_2	221	224	PF00928	0.514
TRG_ER_diArg_1	116	118	PF00400	0.371
TRG_ER_diArg_1	96	98	PF00400	0.685
TRG_Pf-PMV_PEXEL_1	108	112	PF00026	0.657
TRG_Pf-PMV_PEXEL_1	41	45	PF00026	0.421

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3Q8IUX1	Leishmania donovani	70%	100%
A4IAF2	Leishmania infantum	70%	100%
E9B5H6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	100%
Q4Q2F9	Leishmania major	67%	100%