TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

TPR repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HBA3_LEIBR

TriTrypDb:

LbrM.20.3430 , LBRM2903_200048200

Length:

288

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HBA3

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBA3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	199	201	PF00675	0.314
CLV_NRD_NRD_1	98	100	PF00675	0.387
CLV_PCSK_KEX2_1	199	201	PF00082	0.314
CLV_PCSK_PC7_1	195	201	PF00082	0.291
CLV_PCSK_SKI1_1	113	117	PF00082	0.544
CLV_PCSK_SKI1_1	99	103	PF00082	0.419
DEG_Kelch_Keap1_1	12	17	PF01344	0.470
DEG_SPOP_SBC_1	114	118	PF00917	0.514
DOC_PP2B_LxvP_1	20	23	PF13499	0.466
DOC_USP7_MATH_1	115	119	PF00917	0.547
DOC_USP7_MATH_1	120	124	PF00917	0.463
DOC_USP7_MATH_1	61	65	PF00917	0.660
DOC_USP7_UBL2_3	172	176	PF12436	0.535
DOC_USP7_UBL2_3	235	239	PF12436	0.380
DOC_WW_Pin1_4	116	121	PF00397	0.607
LIG_14-3-3_CanoR_1	113	120	PF00244	0.471
LIG_14-3-3_CanoR_1	124	131	PF00244	0.430
LIG_Actin_WH2_2	65	81	PF00022	0.507
LIG_BIR_III_4	228	232	PF00653	0.410
LIG_BRCT_BRCA1_1	282	286	PF00533	0.381
LIG_Clathr_ClatBox_1	170	174	PF01394	0.438
LIG_FHA_1	157	163	PF00498	0.288
LIG_FHA_2	137	143	PF00498	0.693
LIG_LIR_Gen_1	218	227	PF02991	0.393
LIG_LIR_Nem_3	211	217	PF02991	0.318
LIG_LIR_Nem_3	218	223	PF02991	0.402
LIG_MYND_1	18	22	PF01753	0.469
LIG_NRP_CendR_1	285	288	PF00754	0.459
LIG_Pex14_1	210	214	PF04695	0.295
LIG_PTB_Apo_2	162	169	PF02174	0.257
LIG_SH2_STAP1	156	160	PF00017	0.365
LIG_SH2_STAP1	282	286	PF00017	0.381
LIG_SH2_STAT3	205	208	PF00017	0.428
LIG_SH2_STAT5	156	159	PF00017	0.309
LIG_SH2_STAT5	163	166	PF00017	0.256
LIG_SH2_STAT5	193	196	PF00017	0.333
LIG_SH2_STAT5	197	200	PF00017	0.273
LIG_SH3_1	108	114	PF00018	0.365
LIG_SH3_3	103	109	PF00018	0.351
LIG_SUMO_SIM_par_1	67	74	PF11976	0.515
LIG_UBA3_1	170	176	PF00899	0.384
LIG_WW_3	110	114	PF00397	0.374
MOD_CK1_1	118	124	PF00069	0.607
MOD_CK2_1	61	67	PF00069	0.673
MOD_GlcNHglycan	120	123	PF01048	0.621
MOD_GlcNHglycan	211	214	PF01048	0.409
MOD_GlcNHglycan	64	67	PF01048	0.468
MOD_GSK3_1	114	121	PF00069	0.599
MOD_GSK3_1	150	157	PF00069	0.430
MOD_GSK3_1	276	283	PF00069	0.403
MOD_GSK3_1	89	96	PF00069	0.388
MOD_NEK2_2	280	285	PF00069	0.380
MOD_PKA_2	123	129	PF00069	0.579
MOD_Plk_1	154	160	PF00069	0.343
MOD_Plk_1	189	195	PF00069	0.458
MOD_Plk_1	31	37	PF00069	0.457
MOD_Plk_4	189	195	PF00069	0.523
MOD_Plk_4	93	99	PF00069	0.435
MOD_ProDKin_1	116	122	PF00069	0.609
MOD_SUMO_for_1	175	178	PF00179	0.453
TRG_DiLeu_BaEn_3	177	183	PF01217	0.436
TRG_DiLeu_BaEn_4	73	79	PF01217	0.557
TRG_ENDOCYTIC_2	204	207	PF00928	0.290
TRG_ENDOCYTIC_2	220	223	PF00928	0.320
TRG_ER_diArg_1	198	200	PF00400	0.324

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILM5	Leptomonas seymouri	59%	100%
A0A0S4KMF2	Bodo saltans	49%	100%
A0A1X0PA31	Trypanosomatidae	56%	100%
A0A3Q8IHU2	Leishmania donovani	78%	100%
A0A422NSX9	Trypanosoma rangeli	56%	100%
A4IAF1	Leishmania infantum	78%	100%
C9ZLU3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	54%	100%
E9B5H5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	77%	100%
Q3ZBR5	Bos taurus	30%	99%
Q4Q2G0	Leishmania major	78%	100%
Q91Z38	Mus musculus	30%	99%
Q99614	Homo sapiens	30%	99%