Complex I-B16.6

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Complex I-B16.6

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBA1_LEIBR

TriTrypDb:

LbrM.20.3410 , LBRM2903_200048000

Length:

197

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HBA1

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBA1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	139	141	PF00675	0.632
CLV_PCSK_KEX2_1	125	127	PF00082	0.625
CLV_PCSK_KEX2_1	139	141	PF00082	0.669
CLV_PCSK_KEX2_1	163	165	PF00082	0.619
CLV_PCSK_KEX2_1	39	41	PF00082	0.414
CLV_PCSK_PC1ET2_1	125	127	PF00082	0.616
CLV_PCSK_PC1ET2_1	139	141	PF00082	0.642
CLV_PCSK_PC1ET2_1	163	165	PF00082	0.619
CLV_PCSK_PC1ET2_1	39	41	PF00082	0.475
CLV_PCSK_SKI1_1	74	78	PF00082	0.625
DOC_MAPK_gen_1	9	17	PF00069	0.600
DOC_PP1_RVXF_1	123	130	PF00149	0.529
DOC_PP1_RVXF_1	180	187	PF00149	0.523
LIG_14-3-3_CanoR_1	11	17	PF00244	0.564
LIG_14-3-3_CanoR_1	187	195	PF00244	0.391
LIG_APCC_ABBAyCdc20_2	73	79	PF00400	0.312
LIG_BIR_II_1	1	5	PF00653	0.590
LIG_FHA_1	12	18	PF00498	0.561
LIG_LIR_Gen_1	130	138	PF02991	0.411
LIG_LIR_Gen_1	2	12	PF02991	0.573
LIG_LIR_Gen_1	59	68	PF02991	0.313
LIG_LIR_Nem_3	130	134	PF02991	0.490
LIG_LIR_Nem_3	35	41	PF02991	0.635
LIG_LIR_Nem_3	59	63	PF02991	0.313
LIG_LYPXL_S_1	68	72	PF13949	0.476
LIG_LYPXL_yS_3	100	103	PF13949	0.439
LIG_LYPXL_yS_3	69	72	PF13949	0.370
LIG_PDZ_Class_2	192	197	PF00595	0.396
LIG_SH2_STAT5	71	74	PF00017	0.425
LIG_SH2_STAT5	75	78	PF00017	0.427
LIG_SH3_3	31	37	PF00018	0.597
LIG_SUMO_SIM_anti_2	59	65	PF11976	0.344
LIG_SUMO_SIM_par_1	13	18	PF11976	0.630
LIG_TRAF2_1	118	121	PF00917	0.402
LIG_TYR_ITIM	67	72	PF00017	0.450
LIG_UBA3_1	159	163	PF00899	0.562
LIG_WRC_WIRS_1	20	25	PF05994	0.583
MOD_GlcNHglycan	112	115	PF01048	0.691
MOD_NEK2_1	1	6	PF00069	0.492
MOD_NEK2_1	10	15	PF00069	0.435
MOD_PKA_2	10	16	PF00069	0.445
MOD_PKA_2	186	192	PF00069	0.491
MOD_Plk_1	152	158	PF00069	0.534
MOD_Plk_4	56	62	PF00069	0.391
MOD_SUMO_for_1	162	165	PF00179	0.663
MOD_SUMO_for_1	45	48	PF00179	0.606
TRG_DiLeu_BaEn_1	180	185	PF01217	0.635
TRG_DiLeu_BaLyEn_6	37	42	PF01217	0.344
TRG_DiLeu_BaLyEn_6	62	67	PF01217	0.410
TRG_ENDOCYTIC_2	100	103	PF00928	0.534
TRG_ENDOCYTIC_2	170	173	PF00928	0.728
TRG_ENDOCYTIC_2	5	8	PF00928	0.556
TRG_ENDOCYTIC_2	69	72	PF00928	0.455
TRG_ER_diArg_1	88	91	PF00400	0.507

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6S8	Leptomonas seymouri	63%	100%
A0A0S4KIP5	Bodo saltans	37%	99%
A0A1X0PAY8	Trypanosomatidae	46%	100%
A0A3S7X8G4	Leishmania donovani	85%	100%
A4IAE9	Leishmania infantum	85%	100%
C9ZLU5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B5H3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q2G2	Leishmania major	85%	100%