Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HBA0_LEIBR

TriTrypDb:

LbrM.20.3400 , LBRM2903_200047900

Length:

356

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HBA0

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HBA0

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	145	149	PF00656	0.502
CLV_C14_Caspase3-7	31	35	PF00656	0.489
CLV_MEL_PAP_1	66	72	PF00089	0.538
CLV_NRD_NRD_1	145	147	PF00675	0.568
CLV_NRD_NRD_1	316	318	PF00675	0.533
CLV_NRD_NRD_1	4	6	PF00675	0.661
CLV_PCSK_FUR_1	2	6	PF00082	0.677
CLV_PCSK_KEX2_1	303	305	PF00082	0.486
CLV_PCSK_KEX2_1	32	34	PF00082	0.497
CLV_PCSK_KEX2_1	4	6	PF00082	0.607
CLV_PCSK_PC1ET2_1	303	305	PF00082	0.563
CLV_PCSK_PC1ET2_1	32	34	PF00082	0.497
CLV_PCSK_SKI1_1	118	122	PF00082	0.483
CLV_PCSK_SKI1_1	205	209	PF00082	0.464
CLV_PCSK_SKI1_1	303	307	PF00082	0.498
CLV_PCSK_SKI1_1	350	354	PF00082	0.482
DEG_Nend_UBRbox_1	1	4	PF02207	0.583
DOC_CYCLIN_RxL_1	202	211	PF00134	0.517
DOC_CYCLIN_yCln2_LP_2	316	322	PF00134	0.516
DOC_MAPK_gen_1	152	162	PF00069	0.476
DOC_MAPK_gen_1	317	328	PF00069	0.540
DOC_MAPK_gen_1	32	39	PF00069	0.570
DOC_MAPK_HePTP_8	29	41	PF00069	0.573
DOC_MAPK_MEF2A_6	194	203	PF00069	0.505
DOC_MAPK_MEF2A_6	32	41	PF00069	0.579
DOC_MAPK_RevD_3	17	33	PF00069	0.403
DOC_PP2B_LxvP_1	207	210	PF13499	0.507
DOC_PP2B_LxvP_1	54	57	PF13499	0.388
DOC_PP4_FxxP_1	76	79	PF00568	0.530
DOC_USP7_MATH_1	217	221	PF00917	0.565
DOC_USP7_MATH_1	224	228	PF00917	0.617
DOC_USP7_MATH_1	237	241	PF00917	0.544
DOC_USP7_MATH_1	3	7	PF00917	0.656
DOC_USP7_MATH_1	346	350	PF00917	0.519
DOC_USP7_MATH_1	49	53	PF00917	0.477
DOC_USP7_MATH_1	55	59	PF00917	0.457
DOC_USP7_MATH_1	88	92	PF00917	0.618
DOC_WW_Pin1_4	125	130	PF00397	0.432
DOC_WW_Pin1_4	233	238	PF00397	0.670
LIG_14-3-3_CanoR_1	155	161	PF00244	0.481
LIG_14-3-3_CanoR_1	2	12	PF00244	0.517
LIG_14-3-3_CanoR_1	321	328	PF00244	0.512
LIG_14-3-3_CanoR_1	60	70	PF00244	0.409
LIG_APCC_ABBA_1	246	251	PF00400	0.357
LIG_BRCT_BRCA1_1	5	9	PF00533	0.500
LIG_BRCT_BRCA1_1	57	61	PF00533	0.484
LIG_FHA_1	13	19	PF00498	0.398
LIG_FHA_1	157	163	PF00498	0.455
LIG_FHA_1	25	31	PF00498	0.375
LIG_FHA_1	334	340	PF00498	0.436
LIG_FHA_1	49	55	PF00498	0.378
LIG_FHA_1	62	68	PF00498	0.367
LIG_FHA_2	26	32	PF00498	0.557
LIG_FHA_2	269	275	PF00498	0.497
LIG_LIR_Apic_2	329	333	PF02991	0.535
LIG_LIR_Apic_2	74	79	PF02991	0.566
LIG_LIR_Gen_1	14	24	PF02991	0.392
LIG_LIR_Gen_1	271	280	PF02991	0.332
LIG_LIR_Gen_1	308	319	PF02991	0.394
LIG_LIR_Nem_3	109	115	PF02991	0.372
LIG_LIR_Nem_3	128	134	PF02991	0.264
LIG_LIR_Nem_3	14	19	PF02991	0.393
LIG_LIR_Nem_3	271	276	PF02991	0.340
LIG_LIR_Nem_3	308	314	PF02991	0.388
LIG_LIR_Nem_3	349	354	PF02991	0.505
LIG_LIR_Nem_3	6	12	PF02991	0.449
LIG_PCNA_PIPBox_1	99	108	PF02747	0.503
LIG_PDZ_Class_2	351	356	PF00595	0.373
LIG_Pex14_2	76	80	PF04695	0.532
LIG_SH2_CRK	16	20	PF00017	0.313
LIG_SH2_CRK	180	184	PF00017	0.561
LIG_SH2_STAT5	12	15	PF00017	0.411
LIG_SH2_STAT5	165	168	PF00017	0.426
LIG_SH2_STAT5	311	314	PF00017	0.467
LIG_SH2_STAT5	42	45	PF00017	0.448
LIG_SH3_3	250	256	PF00018	0.515
LIG_SH3_3	336	342	PF00018	0.322
LIG_SUMO_SIM_par_1	51	58	PF11976	0.375
LIG_TRAF2_1	139	142	PF00917	0.495
LIG_TRAF2_1	322	325	PF00917	0.421
LIG_UBA3_1	272	278	PF00899	0.297
LIG_WRC_WIRS_1	102	107	PF05994	0.492
MOD_CK1_1	136	142	PF00069	0.477
MOD_CK1_1	220	226	PF00069	0.728
MOD_CK1_1	238	244	PF00069	0.517
MOD_CK1_1	65	71	PF00069	0.411
MOD_CK1_1	91	97	PF00069	0.578
MOD_CK2_1	136	142	PF00069	0.452
MOD_CK2_1	224	230	PF00069	0.699
MOD_CK2_1	237	243	PF00069	0.620
MOD_CK2_1	25	31	PF00069	0.547
MOD_CK2_1	268	274	PF00069	0.480
MOD_DYRK1A_RPxSP_1	125	129	PF00069	0.441
MOD_GlcNHglycan	108	111	PF01048	0.240
MOD_GlcNHglycan	222	225	PF01048	0.679
MOD_GlcNHglycan	226	229	PF01048	0.622
MOD_GlcNHglycan	90	93	PF01048	0.597
MOD_GSK3_1	213	220	PF00069	0.644
MOD_GSK3_1	231	238	PF00069	0.605
MOD_GSK3_1	61	68	PF00069	0.491
MOD_NEK2_1	106	111	PF00069	0.430
MOD_NEK2_1	312	317	PF00069	0.504
MOD_NEK2_1	334	339	PF00069	0.463
MOD_NEK2_1	61	66	PF00069	0.429
MOD_NEK2_1	72	77	PF00069	0.434
MOD_PKA_1	4	10	PF00069	0.387
MOD_PKA_2	3	9	PF00069	0.597
MOD_PKA_2	320	326	PF00069	0.514
MOD_PKB_1	171	179	PF00069	0.552
MOD_PKB_1	2	10	PF00069	0.406
MOD_Plk_1	238	244	PF00069	0.373
MOD_Plk_2-3	268	274	PF00069	0.303
MOD_Plk_2-3	292	298	PF00069	0.585
MOD_Plk_4	101	107	PF00069	0.474
MOD_Plk_4	156	162	PF00069	0.481
MOD_Plk_4	25	31	PF00069	0.420
MOD_Plk_4	268	274	PF00069	0.412
MOD_Plk_4	49	55	PF00069	0.424
MOD_Plk_4	62	68	PF00069	0.491
MOD_ProDKin_1	125	131	PF00069	0.433
MOD_ProDKin_1	233	239	PF00069	0.667
MOD_SUMO_rev_2	139	149	PF00179	0.337
MOD_SUMO_rev_2	295	305	PF00179	0.569
TRG_ENDOCYTIC_2	16	19	PF00928	0.421
TRG_ENDOCYTIC_2	180	183	PF00928	0.480
TRG_ENDOCYTIC_2	311	314	PF00928	0.465
TRG_ER_diArg_1	1	4	PF00400	0.708
TRG_ER_diArg_1	169	172	PF00400	0.482

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P771	Leptomonas seymouri	57%	95%
A0A0S4KPS3	Bodo saltans	31%	100%
A0A1X0PA34	Trypanosomatidae	40%	100%
A0A3S7X8E4	Leishmania donovani	80%	100%
A0A422NT02	Trypanosoma rangeli	40%	100%
A4IAE8	Leishmania infantum	80%	100%
C9ZLU6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B5H2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2G3	Leishmania major	80%	100%
V5DMU4	Trypanosoma cruzi	42%	100%