Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB95_LEIBR

TriTrypDb:

LbrM.20.3350 , LBRM2903_200047400

Length:

572

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB95

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB95

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	410	412	PF00675	0.651
CLV_NRD_NRD_1	44	46	PF00675	0.552
CLV_NRD_NRD_1	5	7	PF00675	0.557
CLV_PCSK_KEX2_1	102	104	PF00082	0.533
CLV_PCSK_KEX2_1	185	187	PF00082	0.534
CLV_PCSK_KEX2_1	198	200	PF00082	0.356
CLV_PCSK_KEX2_1	302	304	PF00082	0.394
CLV_PCSK_KEX2_1	412	414	PF00082	0.660
CLV_PCSK_KEX2_1	44	46	PF00082	0.530
CLV_PCSK_KEX2_1	5	7	PF00082	0.557
CLV_PCSK_KEX2_1	53	55	PF00082	0.784
CLV_PCSK_PC1ET2_1	102	104	PF00082	0.533
CLV_PCSK_PC1ET2_1	185	187	PF00082	0.529
CLV_PCSK_PC1ET2_1	198	200	PF00082	0.370
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.398
CLV_PCSK_PC1ET2_1	412	414	PF00082	0.660
CLV_PCSK_PC1ET2_1	53	55	PF00082	0.576
CLV_PCSK_SKI1_1	115	119	PF00082	0.666
CLV_PCSK_SKI1_1	227	231	PF00082	0.466
CLV_PCSK_SKI1_1	327	331	PF00082	0.533
CLV_PCSK_SKI1_1	385	389	PF00082	0.554
CLV_PCSK_SKI1_1	44	48	PF00082	0.597
CLV_PCSK_SKI1_1	480	484	PF00082	0.567
CLV_PCSK_SKI1_1	510	514	PF00082	0.464
CLV_PCSK_SKI1_1	60	64	PF00082	0.670
DEG_APCC_DBOX_1	274	282	PF00400	0.320
DEG_Nend_UBRbox_3	1	3	PF02207	0.606
DEG_SPOP_SBC_1	110	114	PF00917	0.770
DEG_SPOP_SBC_1	116	120	PF00917	0.683
DEG_SPOP_SBC_1	129	133	PF00917	0.540
DEG_SPOP_SBC_1	353	357	PF00917	0.662
DOC_CKS1_1	499	504	PF01111	0.486
DOC_CYCLIN_RxL_1	477	486	PF00134	0.539
DOC_CYCLIN_yCln2_LP_2	333	336	PF00134	0.525
DOC_CYCLIN_yCln2_LP_2	344	347	PF00134	0.540
DOC_MAPK_MEF2A_6	327	334	PF00069	0.532
DOC_MAPK_NFAT4_5	327	335	PF00069	0.531
DOC_MAPK_RevD_3	287	303	PF00069	0.371
DOC_PP2B_LxvP_1	247	250	PF13499	0.511
DOC_PP2B_LxvP_1	332	335	PF13499	0.577
DOC_PP2B_LxvP_1	343	346	PF13499	0.545
DOC_PP4_FxxP_1	287	290	PF00568	0.335
DOC_SPAK_OSR1_1	16	20	PF12202	0.433
DOC_SPAK_OSR1_1	286	290	PF12202	0.343
DOC_USP7_MATH_1	110	114	PF00917	0.658
DOC_USP7_MATH_1	116	120	PF00917	0.630
DOC_USP7_MATH_1	129	133	PF00917	0.558
DOC_USP7_MATH_1	203	207	PF00917	0.375
DOC_USP7_MATH_1	351	355	PF00917	0.623
DOC_USP7_MATH_1	360	364	PF00917	0.535
DOC_USP7_MATH_1	432	436	PF00917	0.567
DOC_USP7_MATH_1	474	478	PF00917	0.693
DOC_USP7_MATH_1	521	525	PF00917	0.554
DOC_USP7_MATH_1	561	565	PF00917	0.567
DOC_USP7_UBL2_3	240	244	PF12436	0.518
DOC_USP7_UBL2_3	425	429	PF12436	0.562
DOC_USP7_UBL2_3	556	560	PF12436	0.561
DOC_WW_Pin1_4	175	180	PF00397	0.436
DOC_WW_Pin1_4	228	233	PF00397	0.644
DOC_WW_Pin1_4	26	31	PF00397	0.488
DOC_WW_Pin1_4	414	419	PF00397	0.641
DOC_WW_Pin1_4	462	467	PF00397	0.592
DOC_WW_Pin1_4	495	500	PF00397	0.752
DOC_WW_Pin1_4	517	522	PF00397	0.639
DOC_WW_Pin1_4	565	570	PF00397	0.546
LIG_14-3-3_CanoR_1	115	124	PF00244	0.641
LIG_14-3-3_CanoR_1	141	145	PF00244	0.579
LIG_14-3-3_CanoR_1	158	168	PF00244	0.487
LIG_14-3-3_CanoR_1	192	197	PF00244	0.371
LIG_14-3-3_CanoR_1	199	207	PF00244	0.366
LIG_14-3-3_CanoR_1	227	232	PF00244	0.611
LIG_14-3-3_CanoR_1	338	346	PF00244	0.544
LIG_14-3-3_CanoR_1	5	14	PF00244	0.523
LIG_14-3-3_CanoR_1	545	549	PF00244	0.523
LIG_14-3-3_CanoR_1	60	66	PF00244	0.582
LIG_APCC_ABBA_1	38	43	PF00400	0.488
LIG_BRCT_BRCA1_1	135	139	PF00533	0.601
LIG_BRCT_BRCA1_1	210	214	PF00533	0.414
LIG_EABR_CEP55_1	484	494	PF12180	0.522
LIG_FHA_1	129	135	PF00498	0.660
LIG_FHA_1	151	157	PF00498	0.614
LIG_FHA_1	216	222	PF00498	0.488
LIG_FHA_1	234	240	PF00498	0.626
LIG_FHA_1	338	344	PF00498	0.539
LIG_FHA_1	71	77	PF00498	0.552
LIG_FHA_1	82	88	PF00498	0.534
LIG_FHA_2	103	109	PF00498	0.532
LIG_FHA_2	133	139	PF00498	0.516
LIG_FHA_2	141	147	PF00498	0.518
LIG_FHA_2	499	505	PF00498	0.654
LIG_FHA_2	50	56	PF00498	0.567
LIG_FHA_2	539	545	PF00498	0.627
LIG_LIR_Apic_2	284	290	PF02991	0.343
LIG_LIR_Gen_1	15	24	PF02991	0.480
LIG_LIR_Nem_3	15	20	PF02991	0.472
LIG_LIR_Nem_3	178	184	PF02991	0.401
LIG_LIR_Nem_3	202	207	PF02991	0.424
LIG_LIR_Nem_3	446	452	PF02991	0.531
LIG_MYND_1	331	335	PF01753	0.526
LIG_PDZ_Class_2	567	572	PF00595	0.476
LIG_PTAP_UEV_1	346	351	PF05743	0.529
LIG_SH2_CRK	181	185	PF00017	0.426
LIG_SH2_SRC	181	184	PF00017	0.501
LIG_SH2_STAP1	24	28	PF00017	0.521
LIG_SH2_STAP1	493	497	PF00017	0.602
LIG_SH2_STAT5	532	535	PF00017	0.480
LIG_SH3_3	249	255	PF00018	0.499
LIG_SH3_3	344	350	PF00018	0.657
LIG_SH3_3	460	466	PF00018	0.654
LIG_SH3_3	485	491	PF00018	0.516
LIG_SH3_3	496	502	PF00018	0.472
LIG_SH3_3	515	521	PF00018	0.641
LIG_TRAF2_1	501	504	PF00917	0.567
LIG_WW_2	350	353	PF00397	0.520
MOD_CDC14_SPxK_1	29	32	PF00782	0.525
MOD_CDK_SPK_2	462	467	PF00069	0.584
MOD_CDK_SPK_2	495	500	PF00069	0.674
MOD_CDK_SPxK_1	26	32	PF00069	0.521
MOD_CDK_SPxxK_3	462	469	PF00069	0.572
MOD_CK1_1	132	138	PF00069	0.597
MOD_CK1_1	140	146	PF00069	0.603
MOD_CK1_1	233	239	PF00069	0.552
MOD_CK1_1	337	343	PF00069	0.676
MOD_CK1_1	354	360	PF00069	0.551
MOD_CK1_1	404	410	PF00069	0.581
MOD_CK1_1	455	461	PF00069	0.656
MOD_CK1_1	95	101	PF00069	0.550
MOD_CK2_1	102	108	PF00069	0.531
MOD_CK2_1	49	55	PF00069	0.566
MOD_CK2_1	498	504	PF00069	0.568
MOD_DYRK1A_RPxSP_1	26	30	PF00069	0.483
MOD_GlcNHglycan	124	127	PF01048	0.655
MOD_GlcNHglycan	161	164	PF01048	0.664
MOD_GlcNHglycan	201	204	PF01048	0.408
MOD_GlcNHglycan	358	361	PF01048	0.538
MOD_GlcNHglycan	402	406	PF01048	0.573
MOD_GlcNHglycan	421	424	PF01048	0.600
MOD_GlcNHglycan	475	479	PF01048	0.622
MOD_GlcNHglycan	7	10	PF01048	0.533
MOD_GlcNHglycan	94	97	PF01048	0.567
MOD_GSK3_1	111	118	PF00069	0.533
MOD_GSK3_1	128	135	PF00069	0.649
MOD_GSK3_1	140	147	PF00069	0.614
MOD_GSK3_1	199	206	PF00069	0.363
MOD_GSK3_1	20	27	PF00069	0.451
MOD_GSK3_1	230	237	PF00069	0.589
MOD_GSK3_1	352	359	PF00069	0.542
MOD_GSK3_1	361	368	PF00069	0.499
MOD_GSK3_1	414	421	PF00069	0.607
MOD_GSK3_1	432	439	PF00069	0.820
MOD_GSK3_1	45	52	PF00069	0.684
MOD_GSK3_1	517	524	PF00069	0.661
MOD_GSK3_1	56	63	PF00069	0.599
MOD_GSK3_1	561	568	PF00069	0.553
MOD_GSK3_1	98	105	PF00069	0.692
MOD_N-GLC_1	432	437	PF02516	0.735
MOD_N-GLC_1	49	54	PF02516	0.564
MOD_NEK2_1	139	144	PF00069	0.574
MOD_NEK2_1	20	25	PF00069	0.453
MOD_NEK2_1	452	457	PF00069	0.560
MOD_NEK2_1	483	488	PF00069	0.609
MOD_NEK2_1	81	86	PF00069	0.518
MOD_PIKK_1	150	156	PF00454	0.646
MOD_PIKK_1	436	442	PF00454	0.575
MOD_PIKK_1	61	67	PF00454	0.572
MOD_PIKK_1	81	87	PF00454	0.521
MOD_PK_1	248	254	PF00069	0.505
MOD_PKA_1	102	108	PF00069	0.531
MOD_PKA_1	44	50	PF00069	0.540
MOD_PKA_1	5	11	PF00069	0.537
MOD_PKA_2	102	108	PF00069	0.584
MOD_PKA_2	140	146	PF00069	0.578
MOD_PKA_2	157	163	PF00069	0.524
MOD_PKA_2	337	343	PF00069	0.553
MOD_PKA_2	44	50	PF00069	0.609
MOD_PKA_2	5	11	PF00069	0.537
MOD_PKA_2	544	550	PF00069	0.543
MOD_PKA_2	70	76	PF00069	0.571
MOD_Plk_1	144	150	PF00069	0.553
MOD_Plk_1	436	442	PF00069	0.557
MOD_Plk_1	445	451	PF00069	0.497
MOD_Plk_1	506	512	PF00069	0.465
MOD_Plk_2-3	280	286	PF00069	0.515
MOD_Plk_4	234	240	PF00069	0.601
MOD_Plk_4	366	372	PF00069	0.522
MOD_ProDKin_1	175	181	PF00069	0.427
MOD_ProDKin_1	228	234	PF00069	0.645
MOD_ProDKin_1	26	32	PF00069	0.492
MOD_ProDKin_1	414	420	PF00069	0.640
MOD_ProDKin_1	462	468	PF00069	0.594
MOD_ProDKin_1	495	501	PF00069	0.746
MOD_ProDKin_1	517	523	PF00069	0.639
MOD_ProDKin_1	565	571	PF00069	0.542
MOD_SUMO_for_1	239	242	PF00179	0.522
MOD_SUMO_for_1	387	390	PF00179	0.550
MOD_SUMO_for_1	428	431	PF00179	0.563
MOD_SUMO_rev_2	242	250	PF00179	0.592
TRG_DiLeu_BaEn_4	151	157	PF01217	0.699
TRG_DiLeu_BaLyEn_6	165	170	PF01217	0.420
TRG_DiLeu_BaLyEn_6	328	333	PF01217	0.532
TRG_ENDOCYTIC_2	181	184	PF00928	0.416
TRG_ENDOCYTIC_2	204	207	PF00928	0.472
TRG_ENDOCYTIC_2	449	452	PF00928	0.539
TRG_ER_diArg_1	374	377	PF00400	0.626
TRG_ER_diArg_1	5	7	PF00400	0.557
TRG_NLS_MonoCore_2	410	415	PF00514	0.741
TRG_NLS_MonoExtC_3	410	415	PF00514	0.741
TRG_NLS_MonoExtN_4	409	416	PF00514	0.651
TRG_Pf-PMV_PEXEL_1	26	31	PF00026	0.488
TRG_Pf-PMV_PEXEL_1	32	36	PF00026	0.494
TRG_Pf-PMV_PEXEL_1	480	484	PF00026	0.683

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I5K2	Leptomonas seymouri	40%	99%
A0A3Q8INS4	Leishmania donovani	60%	100%
A4IAE3	Leishmania infantum	59%	100%
E9B5G7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q2G8	Leishmania major	60%	98%