A very conserved eukaryotic enzyme involved in sphingolipid biosynthesis. Localization: ER (by homology)
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Cuervo et al. | no | yes: 0 |
| Hassani et al. | no | yes: 0 |
| Forrest at al. (metacyclic) | no | yes: 0 |
| Forrest at al. (procyclic) | no | yes: 0 |
| Silverman et al. | no | yes: 0 |
| Pissara et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Pires et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Silverman et al. | no | yes: 0 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| Jamdhade et al. | no | yes: 9 |
| Source | Evidence on protein | Close homologs |
|---|---|---|
| DeepLoc | ||
| SignalP6 | no | yes: 0, no: 11 |
| NetGPI | no | yes: 0, no: 11 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0005783 | endoplasmic reticulum | 5 | 1 |
| GO:0043226 | organelle | 2 | 1 |
| GO:0043227 | membrane-bounded organelle | 3 | 1 |
| GO:0043229 | intracellular organelle | 3 | 1 |
| GO:0043231 | intracellular membrane-bounded organelle | 4 | 1 |
| GO:0110165 | cellular anatomical entity | 1 | 7 |
| GO:0016020 | membrane | 2 | 6 |
Related structures:
AlphaFold database: A4HB93
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0008152 | metabolic process | 1 | 12 |
| GO:0009058 | biosynthetic process | 2 | 12 |
| GO:0006066 | alcohol metabolic process | 3 | 1 |
| GO:0006629 | lipid metabolic process | 3 | 1 |
| GO:0006643 | membrane lipid metabolic process | 4 | 1 |
| GO:0006665 | sphingolipid metabolic process | 4 | 1 |
| GO:0006670 | sphingosine metabolic process | 6 | 1 |
| GO:0006672 | ceramide metabolic process | 4 | 1 |
| GO:0006807 | nitrogen compound metabolic process | 2 | 1 |
| GO:0008610 | lipid biosynthetic process | 4 | 1 |
| GO:0009987 | cellular process | 1 | 1 |
| GO:0019751 | polyol metabolic process | 4 | 1 |
| GO:0030148 | sphingolipid biosynthetic process | 5 | 1 |
| GO:0034311 | diol metabolic process | 5 | 1 |
| GO:0034312 | diol biosynthetic process | 6 | 1 |
| GO:0034641 | cellular nitrogen compound metabolic process | 3 | 1 |
| GO:0043603 | amide metabolic process | 3 | 1 |
| GO:0043604 | amide biosynthetic process | 4 | 1 |
| GO:0044237 | cellular metabolic process | 2 | 1 |
| GO:0044238 | primary metabolic process | 2 | 1 |
| GO:0044249 | cellular biosynthetic process | 3 | 1 |
| GO:0044255 | cellular lipid metabolic process | 3 | 1 |
| GO:0044271 | cellular nitrogen compound biosynthetic process | 4 | 1 |
| GO:0044281 | small molecule metabolic process | 2 | 1 |
| GO:0044283 | small molecule biosynthetic process | 3 | 1 |
| GO:0046165 | alcohol biosynthetic process | 4 | 1 |
| GO:0046173 | polyol biosynthetic process | 5 | 1 |
| GO:0046467 | membrane lipid biosynthetic process | 4 | 1 |
| GO:0046512 | sphingosine biosynthetic process | 5 | 1 |
| GO:0046513 | ceramide biosynthetic process | 5 | 1 |
| GO:0046519 | sphingoid metabolic process | 5 | 1 |
| GO:0046520 | sphingoid biosynthetic process | 6 | 1 |
| GO:0071704 | organic substance metabolic process | 2 | 1 |
| GO:1901564 | organonitrogen compound metabolic process | 3 | 1 |
| GO:1901566 | organonitrogen compound biosynthetic process | 4 | 1 |
| GO:1901576 | organic substance biosynthetic process | 3 | 1 |
| GO:1901615 | organic hydroxy compound metabolic process | 3 | 1 |
| GO:1901617 | organic hydroxy compound biosynthetic process | 4 | 1 |
| Term | Name | Level | Count |
|---|---|---|---|
| GO:0003824 | catalytic activity | 1 | 12 |
| GO:0004758 | serine C-palmitoyltransferase activity | 7 | 8 |
| GO:0005488 | binding | 1 | 12 |
| GO:0016408 | C-acyltransferase activity | 5 | 8 |
| GO:0016409 | palmitoyltransferase activity | 5 | 8 |
| GO:0016454 | C-palmitoyltransferase activity | 6 | 8 |
| GO:0016740 | transferase activity | 2 | 12 |
| GO:0016746 | acyltransferase activity | 3 | 8 |
| GO:0016747 | acyltransferase activity, transferring groups other than amino-acyl groups | 4 | 8 |
| GO:0019842 | vitamin binding | 3 | 12 |
| GO:0030170 | pyridoxal phosphate binding | 4 | 12 |
| GO:0036094 | small molecule binding | 2 | 12 |
| GO:0043167 | ion binding | 2 | 12 |
| GO:0043168 | anion binding | 3 | 12 |
| GO:0070279 | vitamin B6 binding | 3 | 12 |
| GO:0097159 | organic cyclic compound binding | 2 | 12 |
| GO:1901363 | heterocyclic compound binding | 2 | 12 |
| Leishmania | From | To | Domain/Motif | Score |
|---|---|---|---|---|
| CLV_NRD_NRD_1 | 246 | 248 | PF00675 | 0.242 |
| CLV_NRD_NRD_1 | 378 | 380 | PF00675 | 0.317 |
| CLV_NRD_NRD_1 | 59 | 61 | PF00675 | 0.358 |
| CLV_NRD_NRD_1 | 92 | 94 | PF00675 | 0.299 |
| CLV_PCSK_KEX2_1 | 246 | 248 | PF00082 | 0.239 |
| CLV_PCSK_KEX2_1 | 378 | 380 | PF00082 | 0.265 |
| CLV_PCSK_KEX2_1 | 59 | 61 | PF00082 | 0.358 |
| CLV_PCSK_SKI1_1 | 277 | 281 | PF00082 | 0.232 |
| CLV_PCSK_SKI1_1 | 365 | 369 | PF00082 | 0.246 |
| CLV_PCSK_SKI1_1 | 444 | 448 | PF00082 | 0.237 |
| DEG_COP1_1 | 74 | 84 | PF00400 | 0.682 |
| DOC_MAPK_gen_1 | 42 | 51 | PF00069 | 0.527 |
| DOC_MAPK_gen_1 | 93 | 100 | PF00069 | 0.411 |
| DOC_PP4_FxxP_1 | 300 | 303 | PF00568 | 0.443 |
| DOC_SPAK_OSR1_1 | 247 | 251 | PF12202 | 0.411 |
| DOC_USP7_MATH_1 | 103 | 107 | PF00917 | 0.641 |
| DOC_USP7_MATH_1 | 326 | 330 | PF00917 | 0.520 |
| DOC_USP7_MATH_1 | 354 | 358 | PF00917 | 0.461 |
| DOC_USP7_MATH_1 | 63 | 67 | PF00917 | 0.597 |
| DOC_WW_Pin1_4 | 293 | 298 | PF00397 | 0.485 |
| DOC_WW_Pin1_4 | 401 | 406 | PF00397 | 0.418 |
| LIG_14-3-3_CanoR_1 | 247 | 255 | PF00244 | 0.418 |
| LIG_14-3-3_CanoR_1 | 336 | 344 | PF00244 | 0.429 |
| LIG_14-3-3_CanoR_1 | 444 | 453 | PF00244 | 0.478 |
| LIG_BIR_II_1 | 1 | 5 | PF00653 | 0.374 |
| LIG_BRCT_BRCA1_1 | 282 | 286 | PF00533 | 0.418 |
| LIG_BRCT_BRCA1_1 | 65 | 69 | PF00533 | 0.569 |
| LIG_FHA_1 | 249 | 255 | PF00498 | 0.418 |
| LIG_FHA_1 | 256 | 262 | PF00498 | 0.418 |
| LIG_FHA_1 | 302 | 308 | PF00498 | 0.461 |
| LIG_FHA_1 | 338 | 344 | PF00498 | 0.451 |
| LIG_FHA_1 | 351 | 357 | PF00498 | 0.377 |
| LIG_FHA_1 | 471 | 477 | PF00498 | 0.503 |
| LIG_FHA_1 | 74 | 80 | PF00498 | 0.662 |
| LIG_FHA_1 | 86 | 92 | PF00498 | 0.541 |
| LIG_FHA_2 | 122 | 128 | PF00498 | 0.435 |
| LIG_FHA_2 | 163 | 169 | PF00498 | 0.359 |
| LIG_FHA_2 | 446 | 452 | PF00498 | 0.482 |
| LIG_FHA_2 | 466 | 472 | PF00498 | 0.324 |
| LIG_Integrin_RGD_1 | 192 | 194 | PF01839 | 0.261 |
| LIG_LIR_Apic_2 | 239 | 244 | PF02991 | 0.476 |
| LIG_LIR_Apic_2 | 298 | 303 | PF02991 | 0.418 |
| LIG_LIR_Gen_1 | 116 | 126 | PF02991 | 0.422 |
| LIG_LIR_Gen_1 | 176 | 186 | PF02991 | 0.443 |
| LIG_LIR_Nem_3 | 116 | 122 | PF02991 | 0.423 |
| LIG_LIR_Nem_3 | 148 | 153 | PF02991 | 0.520 |
| LIG_LIR_Nem_3 | 176 | 182 | PF02991 | 0.443 |
| LIG_LIR_Nem_3 | 194 | 198 | PF02991 | 0.454 |
| LIG_LIR_Nem_3 | 273 | 279 | PF02991 | 0.422 |
| LIG_LIR_Nem_3 | 283 | 289 | PF02991 | 0.435 |
| LIG_LIR_Nem_3 | 83 | 87 | PF02991 | 0.648 |
| LIG_NRBOX | 28 | 34 | PF00104 | 0.273 |
| LIG_PDZ_Class_3 | 483 | 488 | PF00595 | 0.509 |
| LIG_SH2_CRK | 150 | 154 | PF00017 | 0.418 |
| LIG_SH2_CRK | 179 | 183 | PF00017 | 0.520 |
| LIG_SH2_CRK | 241 | 245 | PF00017 | 0.476 |
| LIG_SH2_CRK | 84 | 88 | PF00017 | 0.644 |
| LIG_SH2_NCK_1 | 179 | 183 | PF00017 | 0.520 |
| LIG_SH2_SRC | 198 | 201 | PF00017 | 0.467 |
| LIG_SH2_STAP1 | 175 | 179 | PF00017 | 0.461 |
| LIG_SH2_STAT5 | 179 | 182 | PF00017 | 0.474 |
| LIG_SH2_STAT5 | 195 | 198 | PF00017 | 0.436 |
| LIG_SH2_STAT5 | 31 | 34 | PF00017 | 0.325 |
| LIG_SH2_STAT5 | 310 | 313 | PF00017 | 0.418 |
| LIG_SH2_STAT5 | 342 | 345 | PF00017 | 0.418 |
| LIG_SH2_STAT5 | 351 | 354 | PF00017 | 0.418 |
| LIG_SH2_STAT5 | 415 | 418 | PF00017 | 0.456 |
| LIG_SH3_3 | 76 | 82 | PF00018 | 0.638 |
| LIG_SUMO_SIM_anti_2 | 359 | 364 | PF11976 | 0.520 |
| LIG_SUMO_SIM_anti_2 | 404 | 410 | PF11976 | 0.437 |
| LIG_SUMO_SIM_par_1 | 50 | 56 | PF11976 | 0.484 |
| LIG_TRAF2_1 | 227 | 230 | PF00917 | 0.520 |
| LIG_TRAF2_1 | 53 | 56 | PF00917 | 0.525 |
| LIG_TYR_ITIM | 29 | 34 | PF00017 | 0.398 |
| LIG_UBA3_1 | 267 | 275 | PF00899 | 0.429 |
| LIG_WRC_WIRS_1 | 119 | 124 | PF05994 | 0.427 |
| LIG_WRC_WIRS_1 | 163 | 168 | PF05994 | 0.459 |
| LIG_WRC_WIRS_1 | 174 | 179 | PF05994 | 0.434 |
| MOD_CK1_1 | 121 | 127 | PF00069 | 0.418 |
| MOD_CK1_1 | 187 | 193 | PF00069 | 0.449 |
| MOD_CK1_1 | 2 | 8 | PF00069 | 0.409 |
| MOD_CK1_1 | 301 | 307 | PF00069 | 0.448 |
| MOD_CK1_1 | 313 | 319 | PF00069 | 0.420 |
| MOD_CK1_1 | 465 | 471 | PF00069 | 0.473 |
| MOD_CK1_1 | 74 | 80 | PF00069 | 0.683 |
| MOD_CK2_1 | 103 | 109 | PF00069 | 0.583 |
| MOD_CK2_1 | 121 | 127 | PF00069 | 0.464 |
| MOD_CK2_1 | 162 | 168 | PF00069 | 0.359 |
| MOD_CK2_1 | 202 | 208 | PF00069 | 0.508 |
| MOD_CK2_1 | 224 | 230 | PF00069 | 0.443 |
| MOD_CK2_1 | 35 | 41 | PF00069 | 0.547 |
| MOD_CK2_1 | 445 | 451 | PF00069 | 0.429 |
| MOD_CK2_1 | 465 | 471 | PF00069 | 0.324 |
| MOD_CK2_1 | 50 | 56 | PF00069 | 0.560 |
| MOD_Cter_Amidation | 91 | 94 | PF01082 | 0.229 |
| MOD_GlcNHglycan | 189 | 192 | PF01048 | 0.306 |
| MOD_GlcNHglycan | 255 | 258 | PF01048 | 0.204 |
| MOD_GlcNHglycan | 291 | 294 | PF01048 | 0.276 |
| MOD_GlcNHglycan | 344 | 347 | PF01048 | 0.238 |
| MOD_GlcNHglycan | 456 | 459 | PF01048 | 0.258 |
| MOD_GSK3_1 | 145 | 152 | PF00069 | 0.527 |
| MOD_GSK3_1 | 162 | 169 | PF00069 | 0.438 |
| MOD_GSK3_1 | 173 | 180 | PF00069 | 0.361 |
| MOD_GSK3_1 | 212 | 219 | PF00069 | 0.390 |
| MOD_GSK3_1 | 289 | 296 | PF00069 | 0.420 |
| MOD_GSK3_1 | 310 | 317 | PF00069 | 0.429 |
| MOD_GSK3_1 | 350 | 357 | PF00069 | 0.418 |
| MOD_GSK3_1 | 361 | 368 | PF00069 | 0.418 |
| MOD_NEK2_1 | 149 | 154 | PF00069 | 0.426 |
| MOD_NEK2_1 | 177 | 182 | PF00069 | 0.453 |
| MOD_NEK2_1 | 280 | 285 | PF00069 | 0.429 |
| MOD_NEK2_1 | 289 | 294 | PF00069 | 0.440 |
| MOD_NEK2_1 | 314 | 319 | PF00069 | 0.429 |
| MOD_NEK2_1 | 337 | 342 | PF00069 | 0.418 |
| MOD_NEK2_1 | 344 | 349 | PF00069 | 0.402 |
| MOD_PIKK_1 | 354 | 360 | PF00454 | 0.506 |
| MOD_PKA_2 | 35 | 41 | PF00069 | 0.554 |
| MOD_Plk_1 | 169 | 175 | PF00069 | 0.443 |
| MOD_Plk_1 | 280 | 286 | PF00069 | 0.422 |
| MOD_Plk_1 | 365 | 371 | PF00069 | 0.429 |
| MOD_Plk_1 | 71 | 77 | PF00069 | 0.689 |
| MOD_Plk_2-3 | 113 | 119 | PF00069 | 0.427 |
| MOD_Plk_2-3 | 162 | 168 | PF00069 | 0.359 |
| MOD_Plk_4 | 162 | 168 | PF00069 | 0.453 |
| MOD_Plk_4 | 169 | 175 | PF00069 | 0.435 |
| MOD_Plk_4 | 181 | 187 | PF00069 | 0.438 |
| MOD_Plk_4 | 202 | 208 | PF00069 | 0.520 |
| MOD_Plk_4 | 365 | 371 | PF00069 | 0.487 |
| MOD_ProDKin_1 | 293 | 299 | PF00069 | 0.485 |
| MOD_ProDKin_1 | 401 | 407 | PF00069 | 0.418 |
| MOD_SUMO_for_1 | 237 | 240 | PF00179 | 0.351 |
| MOD_SUMO_for_1 | 416 | 419 | PF00179 | 0.439 |
| MOD_SUMO_for_1 | 483 | 486 | PF00179 | 0.560 |
| MOD_SUMO_rev_2 | 227 | 232 | PF00179 | 0.406 |
| MOD_SUMO_rev_2 | 269 | 276 | PF00179 | 0.359 |
| TRG_DiLeu_BaEn_1 | 392 | 397 | PF01217 | 0.485 |
| TRG_DiLeu_BaEn_4 | 109 | 115 | PF01217 | 0.458 |
| TRG_ENDOCYTIC_2 | 150 | 153 | PF00928 | 0.418 |
| TRG_ENDOCYTIC_2 | 179 | 182 | PF00928 | 0.497 |
| TRG_ENDOCYTIC_2 | 31 | 34 | PF00928 | 0.381 |
| TRG_ENDOCYTIC_2 | 84 | 87 | PF00928 | 0.654 |
| TRG_ER_diArg_1 | 246 | 248 | PF00400 | 0.441 |
| TRG_ER_diArg_1 | 378 | 381 | PF00400 | 0.459 |
| TRG_ER_diArg_1 | 59 | 61 | PF00400 | 0.540 |
| TRG_NLS_Bipartite_1 | 422 | 441 | PF00514 | 0.359 |
| TRG_Pf-PMV_PEXEL_1 | 226 | 230 | PF00026 | 0.177 |
| Protein | Taxonomy | Sequence identity | Coverage |
|---|---|---|---|
| A0A0H3C7E9 | Caulobacter vibrioides (strain NA1000 / CB15N) | 26% | 100% |
| A0A0N1HYL3 | Leptomonas seymouri | 74% | 99% |
| A0A0S4KPJ9 | Bodo saltans | 46% | 96% |
| A0A1X0PAD7 | Trypanosomatidae | 50% | 99% |
| A0A3R7KRA6 | Trypanosoma rangeli | 49% | 99% |
| A0A3S7X8D9 | Leishmania donovani | 84% | 100% |
| A1ITK1 | Neisseria meningitidis serogroup A / serotype 4A (strain DSM 15465 / Z2491) | 22% | 100% |
| A1KVF6 | Neisseria meningitidis serogroup C / serotype 2a (strain ATCC 700532 / DSM 15464 / FAM18) | 21% | 100% |
| A4IAE1 | Leishmania infantum | 84% | 100% |
| A4VR87 | Pseudomonas stutzeri (strain A1501) | 25% | 100% |
| A6UYW1 | Pseudomonas aeruginosa (strain PA7) | 26% | 100% |
| A7Z4X1 | Bacillus velezensis (strain DSM 23117 / BGSC 10A6 / LMG 26770 / FZB42) | 28% | 100% |
| A9M251 | Neisseria meningitidis serogroup C (strain 053442) | 22% | 100% |
| A9W106 | Methylorubrum extorquens (strain PA1) | 23% | 100% |
| B3PI88 | Cellvibrio japonicus (strain Ueda107) | 26% | 100% |
| B4RP93 | Neisseria gonorrhoeae (strain NCCP11945) | 21% | 100% |
| B5Y9Z4 | Coprothermobacter proteolyticus (strain ATCC 35245 / DSM 5265 / OCM 4 / BT) | 28% | 100% |
| B7GHW7 | Anoxybacillus flavithermus (strain DSM 21510 / WK1) | 24% | 100% |
| B7K0L9 | Rippkaea orientalis (strain PCC 8801) | 25% | 100% |
| B7L0L2 | Methylorubrum extorquens (strain CM4 / NCIMB 13688) | 23% | 100% |
| B7V486 | Pseudomonas aeruginosa (strain LESB58) | 27% | 100% |
| B8GTH6 | Thioalkalivibrio sulfidiphilus (strain HL-EbGR7) | 23% | 100% |
| C4LK80 | Corynebacterium kroppenstedtii (strain DSM 44385 / JCM 11950 / CIP 105744 / CCUG 35717) | 26% | 68% |
| C9ZLV5 | Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) | 51% | 100% |
| D4A2H2 | Rattus norvegicus | 31% | 100% |
| E9B5G5 | Leishmania mexicana (strain MHOM/GT/2001/U1103) | 83% | 100% |
| O15269 | Homo sapiens | 32% | 100% |
| O35704 | Mus musculus | 31% | 100% |
| O54695 | Cricetulus griseus | 31% | 100% |
| O59682 | Schizosaccharomyces pombe (strain 972 / ATCC 24843) | 31% | 96% |
| P25045 | Saccharomyces cerevisiae (strain ATCC 204508 / S288c) | 36% | 87% |
| P43089 | Paracoccus denitrificans (strain Pd 1222) | 25% | 100% |
| P48241 | Kluyveromyces lactis (strain ATCC 8585 / CBS 2359 / DSM 70799 / NBRC 1267 / NRRL Y-1140 / WM37) | 30% | 87% |
| P91079 | Caenorhabditis elegans | 33% | 100% |
| Q02TR5 | Pseudomonas aeruginosa (strain UCBPP-PA14) | 27% | 100% |
| Q10P01 | Oryza sativa subsp. japonica | 31% | 100% |
| Q12F38 | Polaromonas sp. (strain JS666 / ATCC BAA-500) | 24% | 100% |
| Q1QYD6 | Chromohalobacter salexigens (strain ATCC BAA-138 / DSM 3043 / CIP 106854 / NCIMB 13768 / 1H11) | 24% | 100% |
| Q2W3L2 | Magnetospirillum magneticum (strain AMB-1 / ATCC 700264) | 24% | 100% |
| Q31E54 | Hydrogenovibrio crunogenus (strain DSM 25203 / XCL-2) | 25% | 100% |
| Q3SLX9 | Thiobacillus denitrificans (strain ATCC 25259) | 26% | 100% |
| Q55FL5 | Dictyostelium discoideum | 32% | 100% |
| Q5F6R6 | Neisseria gonorrhoeae (strain ATCC 700825 / FA 1090) | 21% | 100% |
| Q5R9T5 | Pongo abelii | 32% | 100% |
| Q60HD1 | Macaca fascicularis | 32% | 100% |
| Q6FXE3 | Candida glabrata (strain ATCC 2001 / CBS 138 / JCM 3761 / NBRC 0622 / NRRL Y-65) | 23% | 92% |
| Q6LPR3 | Photobacterium profundum (strain SS9) | 24% | 100% |
| Q6XFB3 | Leishmania major | 85% | 100% |
| Q7G4P2 | Oryza sativa subsp. japonica | 33% | 100% |
| Q88A97 | Pseudomonas syringae pv. tomato (strain ATCC BAA-871 / DC3000) | 25% | 100% |
| Q89AK6 | Buchnera aphidicola subsp. Baizongia pistaciae (strain Bp) | 23% | 100% |
| Q9I617 | Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) | 27% | 100% |
| Q9K0U0 | Neisseria meningitidis serogroup B (strain MC58) | 21% | 100% |
| V5BLV3 | Trypanosoma cruzi | 50% | 99% |