IQ calmodulin-binding motif protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB92_LEIBR

TriTrypDb:

LbrM.20.3320

Length:

316

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB92

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB92

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	90	96	PF00089	0.534
CLV_NRD_NRD_1	108	110	PF00675	0.542
CLV_NRD_NRD_1	235	237	PF00675	0.485
CLV_NRD_NRD_1	268	270	PF00675	0.540
CLV_NRD_NRD_1	75	77	PF00675	0.472
CLV_NRD_NRD_1	80	82	PF00675	0.483
CLV_NRD_NRD_1	92	94	PF00675	0.466
CLV_PCSK_FUR_1	261	265	PF00082	0.650
CLV_PCSK_KEX2_1	108	110	PF00082	0.494
CLV_PCSK_KEX2_1	235	237	PF00082	0.485
CLV_PCSK_KEX2_1	263	265	PF00082	0.638
CLV_PCSK_KEX2_1	267	269	PF00082	0.528
CLV_PCSK_KEX2_1	75	77	PF00082	0.472
CLV_PCSK_KEX2_1	80	82	PF00082	0.483
CLV_PCSK_KEX2_1	92	94	PF00082	0.466
CLV_PCSK_PC1ET2_1	263	265	PF00082	0.446
CLV_PCSK_PC7_1	231	237	PF00082	0.527
CLV_PCSK_PC7_1	264	270	PF00082	0.514
CLV_PCSK_PC7_1	76	82	PF00082	0.552
CLV_PCSK_SKI1_1	103	107	PF00082	0.405
CLV_PCSK_SKI1_1	112	116	PF00082	0.493
CLV_PCSK_SKI1_1	235	239	PF00082	0.557
CLV_PCSK_SKI1_1	282	286	PF00082	0.533
CLV_PCSK_SKI1_1	64	68	PF00082	0.476
CLV_PCSK_SKI1_1	76	80	PF00082	0.483
DEG_APCC_DBOX_1	202	210	PF00400	0.541
DEG_APCC_DBOX_1	266	274	PF00400	0.370
DEG_APCC_DBOX_1	67	75	PF00400	0.500
DEG_MDM2_SWIB_1	258	266	PF02201	0.359
DEG_Nend_UBRbox_1	1	4	PF02207	0.496
DEG_SPOP_SBC_1	38	42	PF00917	0.386
DOC_CYCLIN_yCln2_LP_2	213	219	PF00134	0.532
DOC_MAPK_gen_1	148	156	PF00069	0.499
DOC_MAPK_gen_1	161	169	PF00069	0.443
DOC_MAPK_gen_1	180	190	PF00069	0.350
DOC_MAPK_gen_1	267	275	PF00069	0.375
DOC_MAPK_MEF2A_6	150	158	PF00069	0.534
DOC_MAPK_MEF2A_6	282	289	PF00069	0.495
DOC_MAPK_RevD_3	77	93	PF00069	0.384
DOC_PP1_RVXF_1	21	27	PF00149	0.415
DOC_USP7_MATH_1	18	22	PF00917	0.430
DOC_USP7_MATH_1	192	196	PF00917	0.542
DOC_USP7_MATH_1	25	29	PF00917	0.383
DOC_USP7_MATH_1	38	42	PF00917	0.502
DOC_WW_Pin1_4	14	19	PF00397	0.664
LIG_14-3-3_CanoR_1	103	110	PF00244	0.393
LIG_14-3-3_CanoR_1	198	202	PF00244	0.429
LIG_14-3-3_CanoR_1	205	210	PF00244	0.438
LIG_14-3-3_CanoR_1	253	259	PF00244	0.516
LIG_14-3-3_CanoR_1	37	47	PF00244	0.383
LIG_14-3-3_CterR_2	313	316	PF00244	0.583
LIG_Actin_WH2_2	67	82	PF00022	0.548
LIG_APCC_ABBAyCdc20_2	112	118	PF00400	0.503
LIG_deltaCOP1_diTrp_1	137	142	PF00928	0.504
LIG_deltaCOP1_diTrp_1	260	265	PF00928	0.565
LIG_FHA_1	171	177	PF00498	0.351
LIG_FHA_1	212	218	PF00498	0.601
LIG_FHA_1	241	247	PF00498	0.388
LIG_FHA_1	57	63	PF00498	0.443
LIG_FHA_2	132	138	PF00498	0.409
LIG_LIR_Gen_1	210	219	PF02991	0.570
LIG_LIR_Nem_3	210	215	PF02991	0.571
LIG_Pex14_2	258	262	PF04695	0.362
LIG_REV1ctd_RIR_1	256	265	PF16727	0.361
LIG_SH2_NCK_1	116	120	PF00017	0.366
LIG_SH2_SRC	116	119	PF00017	0.389
LIG_SH2_STAP1	116	120	PF00017	0.366
LIG_SH2_STAP1	302	306	PF00017	0.530
LIG_SH2_STAT3	302	305	PF00017	0.383
LIG_SH2_STAT5	166	169	PF00017	0.374
LIG_SH2_STAT5	212	215	PF00017	0.689
LIG_SUMO_SIM_anti_2	123	129	PF11976	0.373
MOD_CDK_SPK_2	14	19	PF00069	0.459
MOD_CK1_1	13	19	PF00069	0.549
MOD_CK1_1	42	48	PF00069	0.465
MOD_CK2_1	14	20	PF00069	0.454
MOD_CMANNOS	136	139	PF00535	0.500
MOD_CMANNOS	262	265	PF00535	0.436
MOD_GSK3_1	38	45	PF00069	0.385
MOD_GSK3_1	7	14	PF00069	0.640
MOD_LATS_1	35	41	PF00433	0.419
MOD_PIKK_1	7	13	PF00454	0.500
MOD_PK_1	269	275	PF00069	0.372
MOD_PKA_2	18	24	PF00069	0.553
MOD_PKA_2	197	203	PF00069	0.462
MOD_PKA_2	38	44	PF00069	0.475
MOD_PKB_1	168	176	PF00069	0.413
MOD_PKB_1	203	211	PF00069	0.411
MOD_PKB_1	267	275	PF00069	0.375
MOD_PKB_1	37	45	PF00069	0.387
MOD_Plk_1	19	25	PF00069	0.422
MOD_Plk_1	192	198	PF00069	0.531
MOD_Plk_4	254	260	PF00069	0.368
MOD_Plk_4	269	275	PF00069	0.363
MOD_Plk_4	27	33	PF00069	0.394
MOD_Plk_4	42	48	PF00069	0.629
MOD_Plk_4	56	62	PF00069	0.521
MOD_ProDKin_1	14	20	PF00069	0.659
TRG_DiLeu_BaEn_1	123	128	PF01217	0.465
TRG_DiLeu_BaEn_1	280	285	PF01217	0.518
TRG_DiLeu_BaLyEn_6	279	284	PF01217	0.516
TRG_ENDOCYTIC_2	166	169	PF00928	0.374
TRG_ENDOCYTIC_2	212	215	PF00928	0.640
TRG_ER_diArg_1	1	4	PF00400	0.561
TRG_ER_diArg_1	108	110	PF00400	0.541
TRG_ER_diArg_1	147	150	PF00400	0.484
TRG_ER_diArg_1	266	269	PF00400	0.533
TRG_ER_diArg_1	36	39	PF00400	0.400
TRG_ER_diArg_1	74	76	PF00400	0.506
TRG_ER_diArg_1	79	81	PF00400	0.475
TRG_ER_diArg_1	91	93	PF00400	0.411
TRG_Pf-PMV_PEXEL_1	108	113	PF00026	0.544
TRG_Pf-PMV_PEXEL_1	298	303	PF00026	0.387

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1ILB8	Leptomonas seymouri	57%	100%
A0A1X0PA21	Trypanosomatidae	27%	100%
A0A3Q8IFU3	Leishmania donovani	67%	91%
A4IAE0	Leishmania infantum	68%	91%
E9B5G4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	68%	93%
Q4Q2H1	Leishmania major	75%	100%