DUF659 domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Protein of unknown function (DUF501), putative

Species:

Leishmania braziliensis

UniProt:

A4HB91_LEIBR

TriTrypDb:

LbrM.20.3310 , LBRM2903_200047100

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB91

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB91

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	293	295	PF00675	0.552
CLV_NRD_NRD_1	5	7	PF00675	0.511
CLV_PCSK_FUR_1	290	294	PF00082	0.456
CLV_PCSK_KEX2_1	292	294	PF00082	0.651
CLV_PCSK_KEX2_1	5	7	PF00082	0.713
CLV_PCSK_SKI1_1	117	121	PF00082	0.352
CLV_PCSK_SKI1_1	281	285	PF00082	0.511
CLV_PCSK_SKI1_1	5	9	PF00082	0.636
DEG_APCC_DBOX_1	280	288	PF00400	0.534
DOC_CYCLIN_RxL_1	114	121	PF00134	0.348
DOC_MAPK_gen_1	27	36	PF00069	0.488
DOC_PP4_FxxP_1	244	247	PF00568	0.549
DOC_USP7_MATH_1	146	150	PF00917	0.454
DOC_USP7_MATH_1	171	175	PF00917	0.444
DOC_WW_Pin1_4	118	123	PF00397	0.485
LIG_14-3-3_CanoR_1	208	212	PF00244	0.466
LIG_14-3-3_CanoR_1	97	104	PF00244	0.301
LIG_BIR_II_1	1	5	PF00653	0.768
LIG_BRCT_BRCA1_1	212	216	PF00533	0.277
LIG_FHA_1	128	134	PF00498	0.233
LIG_FHA_1	188	194	PF00498	0.648
LIG_FHA_1	220	226	PF00498	0.523
LIG_FHA_1	58	64	PF00498	0.401
LIG_FHA_2	35	41	PF00498	0.484
LIG_Integrin_isoDGR_2	54	56	PF01839	0.355
LIG_Integrin_isoDGR_2	57	59	PF01839	0.334
LIG_LIR_Apic_2	241	247	PF02991	0.504
LIG_LIR_Gen_1	103	112	PF02991	0.463
LIG_LIR_Gen_1	214	225	PF02991	0.518
LIG_LIR_Nem_3	103	107	PF02991	0.463
LIG_LIR_Nem_3	214	220	PF02991	0.520
LIG_LIR_Nem_3	234	239	PF02991	0.575
LIG_LIR_Nem_3	241	246	PF02991	0.508
LIG_LIR_Nem_3	271	276	PF02991	0.434
LIG_LYPXL_S_1	272	276	PF13949	0.295
LIG_LYPXL_yS_3	273	276	PF13949	0.299
LIG_Pex14_2	128	132	PF04695	0.344
LIG_Pex14_2	216	220	PF04695	0.467
LIG_SH2_NCK_1	19	23	PF00017	0.592
LIG_SH2_PTP2	179	182	PF00017	0.411
LIG_SH2_SRC	19	22	PF00017	0.596
LIG_SH2_STAP1	112	116	PF00017	0.344
LIG_SH2_STAP1	19	23	PF00017	0.592
LIG_SH2_STAT5	179	182	PF00017	0.352
LIG_SH2_STAT5	243	246	PF00017	0.448
LIG_SH3_3	165	171	PF00018	0.485
LIG_SH3_3	243	249	PF00018	0.507
LIG_TRAF2_1	134	137	PF00917	0.344
LIG_TYR_ITIM	177	182	PF00017	0.411
LIG_UBA3_1	182	189	PF00899	0.298
LIG_WRC_WIRS_1	217	222	PF05994	0.263
MOD_CK1_1	219	225	PF00069	0.390
MOD_CK1_1	96	102	PF00069	0.396
MOD_CK2_1	131	137	PF00069	0.274
MOD_CK2_1	34	40	PF00069	0.488
MOD_CK2_1	77	83	PF00069	0.233
MOD_GSK3_1	123	130	PF00069	0.370
MOD_GSK3_1	131	138	PF00069	0.329
MOD_GSK3_1	203	210	PF00069	0.572
MOD_GSK3_1	264	271	PF00069	0.408
MOD_N-GLC_1	264	269	PF02516	0.297
MOD_NEK2_1	127	132	PF00069	0.405
MOD_NEK2_1	211	216	PF00069	0.505
MOD_NEK2_1	34	39	PF00069	0.485
MOD_NEK2_1	47	52	PF00069	0.257
MOD_NEK2_1	68	73	PF00069	0.344
MOD_NEK2_2	123	128	PF00069	0.339
MOD_PIKK_1	264	270	PF00454	0.555
MOD_PKA_1	5	11	PF00069	0.707
MOD_PKA_2	207	213	PF00069	0.413
MOD_PKA_2	5	11	PF00069	0.708
MOD_PKA_2	96	102	PF00069	0.421
MOD_Plk_1	135	141	PF00069	0.233
MOD_Plk_1	211	217	PF00069	0.520
MOD_Plk_1	264	270	PF00069	0.403
MOD_Plk_4	171	177	PF00069	0.441
MOD_Plk_4	211	217	PF00069	0.306
MOD_Plk_4	268	274	PF00069	0.479
MOD_Plk_4	63	69	PF00069	0.344
MOD_ProDKin_1	118	124	PF00069	0.485
MOD_SUMO_rev_2	149	157	PF00179	0.336
MOD_SUMO_rev_2	197	206	PF00179	0.573
TRG_DiLeu_BaEn_4	135	141	PF01217	0.233
TRG_ENDOCYTIC_2	179	182	PF00928	0.379
TRG_ENDOCYTIC_2	243	246	PF00928	0.342
TRG_ENDOCYTIC_2	273	276	PF00928	0.299
TRG_ER_diArg_1	290	293	PF00400	0.568
TRG_NES_CRM1_1	237	250	PF08389	0.320
TRG_NLS_MonoExtN_4	293	300	PF00514	0.598

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P6T1	Leptomonas seymouri	56%	100%
A0A1X0PAX3	Trypanosomatidae	40%	100%
A0A3Q8IIH7	Leishmania donovani	74%	100%
A0A422N2V1	Trypanosoma rangeli	39%	100%
A4IAD9	Leishmania infantum	74%	100%
C9ZLV6	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	41%	100%
E9B5G3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	100%
Q4Q2H2	Leishmania major	75%	100%