Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB90_LEIBR

TriTrypDb:

LbrM.20.3300 , LBRM2903_200047000

Length:

183

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005930	axoneme	2	1
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB90

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB90

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	112	116	PF00656	0.371
CLV_NRD_NRD_1	105	107	PF00675	0.622
CLV_NRD_NRD_1	119	121	PF00675	0.481
CLV_NRD_NRD_1	127	129	PF00675	0.419
CLV_NRD_NRD_1	77	79	PF00675	0.506
CLV_PCSK_KEX2_1	119	121	PF00082	0.570
CLV_PCSK_KEX2_1	77	79	PF00082	0.503
CLV_PCSK_SKI1_1	100	104	PF00082	0.628
CLV_PCSK_SKI1_1	107	111	PF00082	0.618
CLV_PCSK_SKI1_1	129	133	PF00082	0.429
CLV_PCSK_SKI1_1	148	152	PF00082	0.581
CLV_PCSK_SKI1_1	154	158	PF00082	0.544
DOC_MAPK_RevD_3	116	130	PF00069	0.602
DOC_USP7_UBL2_3	151	155	PF12436	0.450
LIG_14-3-3_CanoR_1	106	110	PF00244	0.598
LIG_14-3-3_CanoR_1	29	36	PF00244	0.539
LIG_BIR_II_1	1	5	PF00653	0.706
LIG_Clathr_ClatBox_1	42	46	PF01394	0.342
LIG_FHA_1	30	36	PF00498	0.540
LIG_FHA_2	108	114	PF00498	0.595
LIG_FHA_2	171	177	PF00498	0.466
LIG_FHA_2	71	77	PF00498	0.611
LIG_LIR_Gen_1	6	16	PF02991	0.438
LIG_LIR_Nem_3	46	52	PF02991	0.591
LIG_LIR_Nem_3	6	11	PF02991	0.444
LIG_PDZ_Class_2	178	183	PF00595	0.564
LIG_Rb_pABgroove_1	116	124	PF01858	0.552
LIG_SH2_CRK	8	12	PF00017	0.620
LIG_SH2_GRB2like	96	99	PF00017	0.422
LIG_SH2_NCK_1	8	12	PF00017	0.442
LIG_SH2_SRC	96	99	PF00017	0.422
LIG_SH2_STAP1	122	126	PF00017	0.443
LIG_SH2_STAP1	31	35	PF00017	0.542
LIG_SH2_STAP1	8	12	PF00017	0.671
LIG_SH2_STAT5	17	20	PF00017	0.563
LIG_SH2_STAT5	31	34	PF00017	0.540
LIG_TRAF2_1	110	113	PF00917	0.508
LIG_TRAF2_1	20	23	PF00917	0.516
MOD_CK1_1	59	65	PF00069	0.595
MOD_CK2_1	107	113	PF00069	0.536
MOD_CK2_1	170	176	PF00069	0.476
MOD_CK2_1	70	76	PF00069	0.382
MOD_GlcNHglycan	148	151	PF01048	0.664
MOD_GSK3_1	107	114	PF00069	0.635
MOD_GSK3_1	146	153	PF00069	0.653
MOD_GSK3_1	52	59	PF00069	0.590
MOD_NEK2_1	157	162	PF00069	0.626
MOD_NEK2_1	63	68	PF00069	0.576
MOD_PIKK_1	29	35	PF00454	0.573
MOD_PIKK_1	52	58	PF00454	0.632
MOD_PKA_2	105	111	PF00069	0.597
MOD_PKA_2	162	168	PF00069	0.594
MOD_Plk_1	114	120	PF00069	0.487
MOD_Plk_1	122	128	PF00069	0.455
MOD_Plk_1	170	176	PF00069	0.520
MOD_Plk_1	38	44	PF00069	0.507
MOD_Plk_4	122	128	PF00069	0.493
MOD_Plk_4	31	37	PF00069	0.573
MOD_Plk_4	38	44	PF00069	0.576
MOD_SUMO_rev_2	145	150	PF00179	0.636
TRG_ENDOCYTIC_2	49	52	PF00928	0.549
TRG_ENDOCYTIC_2	8	11	PF00928	0.640
TRG_ER_diArg_1	118	120	PF00400	0.559
TRG_ER_diArg_1	77	80	PF00400	0.448
TRG_NLS_Bipartite_1	119	133	PF00514	0.615
TRG_NLS_MonoExtC_3	127	132	PF00514	0.555
TRG_NLS_MonoExtN_4	128	133	PF00514	0.460
TRG_Pf-PMV_PEXEL_1	119	123	PF00026	0.543

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P774	Leptomonas seymouri	64%	100%
A0A0S4J6R9	Bodo saltans	29%	98%
A0A0S4KRE5	Bodo saltans	31%	100%
A0A1X0PA28	Trypanosomatidae	41%	100%
A0A3Q8IIW0	Leishmania donovani	76%	100%
A0A3R7M5H7	Trypanosoma rangeli	39%	92%
A0A422NMA5	Trypanosoma rangeli	32%	96%
A4IAD8	Leishmania infantum	76%	100%
C9ZLV7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	40%	100%
E9B5G2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q2H3	Leishmania major	75%	100%