Inositol-pentakisphosphate 2-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

inositol-pentakisphosphate 2-kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB89_LEIBR

TriTrypDb:

LbrM.20.3290 , LBRM2903_200046900

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HB89

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB89

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	12
GO:0006796	phosphate-containing compound metabolic process	4	12
GO:0008152	metabolic process	1	12
GO:0009987	cellular process	1	12
GO:0016310	phosphorylation	5	12
GO:0044237	cellular metabolic process	2	12
GO:0005975	carbohydrate metabolic process	3	1
GO:0006020	inositol metabolic process	4	1
GO:0006066	alcohol metabolic process	3	1
GO:0009058	biosynthetic process	2	1
GO:0019637	organophosphate metabolic process	3	1
GO:0019751	polyol metabolic process	4	1
GO:0032958	inositol phosphate biosynthetic process	5	1
GO:0043647	inositol phosphate metabolic process	4	1
GO:0044238	primary metabolic process	2	1
GO:0044262	obsolete cellular carbohydrate metabolic process	3	1
GO:0044281	small molecule metabolic process	2	1
GO:0044283	small molecule biosynthetic process	3	1
GO:0046165	alcohol biosynthetic process	4	1
GO:0046173	polyol biosynthetic process	5	1
GO:0046835	carbohydrate phosphorylation	4	1
GO:0052746	obsolete inositol phosphorylation	5	1
GO:0071704	organic substance metabolic process	2	1
GO:0090407	organophosphate biosynthetic process	4	1
GO:1901576	organic substance biosynthetic process	3	1
GO:1901615	organic hydroxy compound metabolic process	3	1
GO:1901617	organic hydroxy compound biosynthetic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016301	kinase activity	4	12
GO:0016740	transferase activity	2	12
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	12
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	12
GO:0017076	purine nucleotide binding	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035299	inositol pentakisphosphate 2-kinase activity	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	218	222	PF00656	0.497
CLV_C14_Caspase3-7	264	268	PF00656	0.546
CLV_NRD_NRD_1	242	244	PF00675	0.391
CLV_NRD_NRD_1	386	388	PF00675	0.266
CLV_NRD_NRD_1	69	71	PF00675	0.552
CLV_PCSK_KEX2_1	175	177	PF00082	0.217
CLV_PCSK_KEX2_1	386	388	PF00082	0.200
CLV_PCSK_KEX2_1	456	458	PF00082	0.617
CLV_PCSK_PC1ET2_1	175	177	PF00082	0.230
CLV_PCSK_PC1ET2_1	456	458	PF00082	0.708
CLV_PCSK_SKI1_1	43	47	PF00082	0.477
CLV_PCSK_SKI1_1	443	447	PF00082	0.349
DEG_APCC_DBOX_1	219	227	PF00400	0.562
DEG_Nend_UBRbox_2	1	3	PF02207	0.554
DEG_SPOP_SBC_1	28	32	PF00917	0.410
DOC_MAPK_gen_1	317	325	PF00069	0.400
DOC_MAPK_MEF2A_6	13	22	PF00069	0.460
DOC_MAPK_MEF2A_6	318	327	PF00069	0.400
DOC_MAPK_MEF2A_6	375	383	PF00069	0.501
DOC_MAPK_MEF2A_6	421	429	PF00069	0.400
DOC_PP1_RVXF_1	316	323	PF00149	0.400
DOC_SPAK_OSR1_1	367	371	PF12202	0.517
DOC_USP7_MATH_1	28	32	PF00917	0.410
DOC_USP7_MATH_1	82	86	PF00917	0.477
DOC_USP7_MATH_2	292	298	PF00917	0.553
DOC_WW_Pin1_4	226	231	PF00397	0.400
LIG_14-3-3_CanoR_1	116	122	PF00244	0.513
LIG_14-3-3_CanoR_1	214	223	PF00244	0.528
LIG_14-3-3_CanoR_1	235	240	PF00244	0.400
LIG_14-3-3_CanoR_1	367	377	PF00244	0.494
LIG_14-3-3_CanoR_1	386	394	PF00244	0.401
LIG_14-3-3_CanoR_1	414	422	PF00244	0.491
LIG_Actin_WH2_2	219	237	PF00022	0.537
LIG_BIR_III_2	289	293	PF00653	0.581
LIG_BIR_III_4	267	271	PF00653	0.400
LIG_eIF4E_1	207	213	PF01652	0.483
LIG_FHA_1	130	136	PF00498	0.508
LIG_FHA_1	251	257	PF00498	0.565
LIG_FHA_2	118	124	PF00498	0.500
LIG_FHA_2	253	259	PF00498	0.581
LIG_FHA_2	337	343	PF00498	0.491
LIG_FHA_2	371	377	PF00498	0.481
LIG_LIR_Apic_2	139	144	PF02991	0.562
LIG_LIR_Gen_1	2	11	PF02991	0.532
LIG_LIR_Gen_1	319	327	PF02991	0.505
LIG_LIR_Gen_1	395	405	PF02991	0.549
LIG_LIR_Gen_1	78	88	PF02991	0.462
LIG_LIR_Nem_3	2	8	PF02991	0.536
LIG_LIR_Nem_3	319	325	PF02991	0.505
LIG_LIR_Nem_3	341	347	PF02991	0.580
LIG_LIR_Nem_3	395	400	PF02991	0.549
LIG_LIR_Nem_3	58	63	PF02991	0.419
LIG_LIR_Nem_3	78	83	PF02991	0.439
LIG_PTB_Apo_2	348	355	PF02174	0.497
LIG_PTB_Phospho_1	348	354	PF10480	0.497
LIG_SH2_CRK	174	178	PF00017	0.400
LIG_SH2_CRK	344	348	PF00017	0.400
LIG_SH2_CRK	397	401	PF00017	0.400
LIG_SH2_CRK	80	84	PF00017	0.523
LIG_SH2_NCK_1	80	84	PF00017	0.499
LIG_SH2_PTP2	354	357	PF00017	0.562
LIG_SH2_STAP1	131	135	PF00017	0.540
LIG_SH2_STAP1	168	172	PF00017	0.581
LIG_SH2_STAP1	361	365	PF00017	0.566
LIG_SH2_STAP1	80	84	PF00017	0.526
LIG_SH2_STAT5	131	134	PF00017	0.549
LIG_SH2_STAT5	207	210	PF00017	0.468
LIG_SH2_STAT5	211	214	PF00017	0.464
LIG_SH2_STAT5	354	357	PF00017	0.528
LIG_SH2_STAT5	369	372	PF00017	0.420
LIG_SH3_3	116	122	PF00018	0.400
LIG_SH3_3	15	21	PF00018	0.445
LIG_SH3_3	203	209	PF00018	0.525
LIG_SH3_3	242	248	PF00018	0.535
LIG_SH3_3	268	274	PF00018	0.552
LIG_SH3_5	357	361	PF00018	0.581
LIG_SUMO_SIM_anti_2	376	381	PF11976	0.487
LIG_SUMO_SIM_par_1	252	258	PF11976	0.581
LIG_SUMO_SIM_par_1	323	331	PF11976	0.400
LIG_SUMO_SIM_par_1	378	384	PF11976	0.502
LIG_SUMO_SIM_par_1	423	428	PF11976	0.501
LIG_TRAF2_1	121	124	PF00917	0.400
LIG_TRAF2_1	180	183	PF00917	0.400
LIG_TRAF2_1	255	258	PF00917	0.581
LIG_TRAF2_1	339	342	PF00917	0.554
LIG_TYR_ITIM	172	177	PF00017	0.581
LIG_UBA3_1	6	13	PF00899	0.474
MOD_CK1_1	196	202	PF00069	0.569
MOD_CK1_1	27	33	PF00069	0.670
MOD_CK1_1	334	340	PF00069	0.586
MOD_CK1_1	34	40	PF00069	0.572
MOD_CK1_1	390	396	PF00069	0.516
MOD_CK1_1	398	404	PF00069	0.497
MOD_CK1_1	99	105	PF00069	0.581
MOD_CK2_1	117	123	PF00069	0.400
MOD_CK2_1	177	183	PF00069	0.521
MOD_CK2_1	252	258	PF00069	0.560
MOD_CK2_1	336	342	PF00069	0.472
MOD_CK2_1	385	391	PF00069	0.468
MOD_Cter_Amidation	68	71	PF01082	0.523
MOD_GlcNHglycan	138	141	PF01048	0.376
MOD_GlcNHglycan	179	182	PF01048	0.383
MOD_GlcNHglycan	195	198	PF01048	0.385
MOD_GlcNHglycan	203	206	PF01048	0.346
MOD_GlcNHglycan	26	29	PF01048	0.585
MOD_GlcNHglycan	267	271	PF01048	0.227
MOD_GlcNHglycan	75	78	PF01048	0.449
MOD_GSK3_1	23	30	PF00069	0.480
MOD_GSK3_1	235	242	PF00069	0.539
MOD_GSK3_1	34	41	PF00069	0.654
MOD_GSK3_1	381	388	PF00069	0.518
MOD_LATS_1	441	447	PF00433	0.466
MOD_N-GLC_1	105	110	PF02516	0.342
MOD_N-GLC_1	215	220	PF02516	0.200
MOD_N-GLC_1	443	448	PF02516	0.482
MOD_NEK2_1	1	6	PF00069	0.515
MOD_NEK2_1	193	198	PF00069	0.529
MOD_NEK2_1	24	29	PF00069	0.484
MOD_NEK2_1	368	373	PF00069	0.476
MOD_PIKK_1	38	44	PF00454	0.586
MOD_PKA_2	177	183	PF00069	0.436
MOD_PKA_2	34	40	PF00069	0.524
MOD_PKA_2	385	391	PF00069	0.558
MOD_PKA_2	413	419	PF00069	0.573
MOD_Plk_1	1	7	PF00069	0.565
MOD_Plk_1	129	135	PF00069	0.565
MOD_Plk_1	375	381	PF00069	0.476
MOD_Plk_1	390	396	PF00069	0.476
MOD_Plk_1	99	105	PF00069	0.542
MOD_Plk_2-3	252	258	PF00069	0.400
MOD_Plk_4	1	7	PF00069	0.508
MOD_Plk_4	375	381	PF00069	0.482
MOD_Plk_4	395	401	PF00069	0.506
MOD_Plk_4	82	88	PF00069	0.504
MOD_Plk_4	90	96	PF00069	0.484
MOD_Plk_4	99	105	PF00069	0.520
MOD_ProDKin_1	226	232	PF00069	0.400
MOD_SUMO_rev_2	130	137	PF00179	0.505
MOD_SUMO_rev_2	426	431	PF00179	0.518
TRG_ENDOCYTIC_2	168	171	PF00928	0.537
TRG_ENDOCYTIC_2	174	177	PF00928	0.537
TRG_ENDOCYTIC_2	344	347	PF00928	0.400
TRG_ENDOCYTIC_2	397	400	PF00928	0.400
TRG_ENDOCYTIC_2	60	63	PF00928	0.496
TRG_ENDOCYTIC_2	80	83	PF00928	0.458
TRG_ER_diArg_1	46	49	PF00400	0.484

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PDW9	Leptomonas seymouri	54%	100%
A0A0S4KLU4	Bodo saltans	26%	92%
A0A1X0PAD2	Trypanosomatidae	31%	100%
A0A3Q8IEN4	Leishmania donovani	75%	100%
A0A3R7K0N1	Trypanosoma rangeli	30%	99%
A4IAD7	Leishmania infantum	75%	100%
C9ZLV8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B5G1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	100%
Q4Q2H4	Leishmania major	75%	100%
V5B6A7	Trypanosoma cruzi	31%	90%