H(+)-transporting two-sector ATPase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

vacuolar ATP synthase catalytic subunit A, putative

Species:

Leishmania braziliensis

UniProt:

A4HB86_LEIBR

TriTrypDb:

LbrM.20.3260 , LBRM2903_200046600

Length:

610

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 7

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 14

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0032991	protein-containing complex	1	12
GO:0033178	proton-transporting two-sector ATPase complex, catalytic domain	3	12
GO:0033180	proton-transporting V-type ATPase, V1 domain	4	12
GO:0098796	membrane protein complex	2	12

Expansion

Sequence features

A4HB86

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB86

Function

Biological processes
Term	Name	Level	Count
GO:0006810	transport	3	1
GO:0006811	monoatomic ion transport	4	1
GO:0006812	monoatomic cation transport	5	1
GO:0009987	cellular process	1	1
GO:0034220	monoatomic ion transmembrane transport	3	1
GO:0051179	localization	1	1
GO:0051234	establishment of localization	2	1
GO:0055085	transmembrane transport	2	1
GO:0098655	monoatomic cation transmembrane transport	4	1
GO:0098660	inorganic ion transmembrane transport	4	1
GO:0098662	inorganic cation transmembrane transport	5	1
GO:1902600	proton transmembrane transport	6	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005215	transporter activity	1	12
GO:0005216	monoatomic ion channel activity	4	12
GO:0005261	monoatomic cation channel activity	5	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008324	monoatomic cation transmembrane transporter activity	4	12
GO:0009678	pyrophosphate hydrolysis-driven proton transmembrane transporter activity	5	12
GO:0015075	monoatomic ion transmembrane transporter activity	3	12
GO:0015078	proton transmembrane transporter activity	5	12
GO:0015252	proton channel activity	6	12
GO:0015267	channel activity	4	12
GO:0015318	inorganic molecular entity transmembrane transporter activity	3	12
GO:0015399	primary active transmembrane transporter activity	4	12
GO:0016787	hydrolase activity	2	8
GO:0016874	ligase activity	2	12
GO:0017076	purine nucleotide binding	4	12
GO:0019829	ATPase-coupled monoatomic cation transmembrane transporter activity	3	12
GO:0022803	passive transmembrane transporter activity	3	12
GO:0022804	active transmembrane transporter activity	3	12
GO:0022853	active monoatomic ion transmembrane transporter activity	4	12
GO:0022857	transmembrane transporter activity	2	12
GO:0022890	inorganic cation transmembrane transporter activity	4	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0042625	ATPase-coupled ion transmembrane transporter activity	3	12
GO:0042626	ATPase-coupled transmembrane transporter activity	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0044769	ATPase activity, coupled to transmembrane movement of ions, rotational mechanism	4	12
GO:0046933	proton-transporting ATP synthase activity, rotational mechanism	3	12
GO:0046961	proton-transporting ATPase activity, rotational mechanism	4	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:0140657	ATP-dependent activity	1	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	291	295	PF00656	0.304
CLV_NRD_NRD_1	436	438	PF00675	0.289
CLV_PCSK_KEX2_1	302	304	PF00082	0.289
CLV_PCSK_KEX2_1	394	396	PF00082	0.289
CLV_PCSK_KEX2_1	432	434	PF00082	0.289
CLV_PCSK_PC1ET2_1	302	304	PF00082	0.289
CLV_PCSK_PC1ET2_1	394	396	PF00082	0.304
CLV_PCSK_PC1ET2_1	432	434	PF00082	0.289
CLV_PCSK_SKI1_1	5	9	PF00082	0.574
CLV_PCSK_SKI1_1	501	505	PF00082	0.328
DEG_SPOP_SBC_1	343	347	PF00917	0.289
DOC_CKS1_1	206	211	PF01111	0.289
DOC_CYCLIN_RxL_1	77	85	PF00134	0.389
DOC_MAPK_gen_1	394	401	PF00069	0.289
DOC_MAPK_JIP1_4	80	86	PF00069	0.375
DOC_PP1_RVXF_1	556	562	PF00149	0.413
DOC_PP4_FxxP_1	412	415	PF00568	0.289
DOC_PP4_FxxP_1	580	583	PF00568	0.401
DOC_PP4_MxPP_1	162	165	PF00568	0.304
DOC_USP7_MATH_1	151	155	PF00917	0.389
DOC_USP7_MATH_1	308	312	PF00917	0.329
DOC_USP7_MATH_1	415	419	PF00917	0.289
DOC_USP7_MATH_1	472	476	PF00917	0.500
DOC_USP7_MATH_1	519	523	PF00917	0.299
DOC_USP7_MATH_1	7	11	PF00917	0.618
DOC_WW_Pin1_4	129	134	PF00397	0.457
DOC_WW_Pin1_4	205	210	PF00397	0.289
DOC_WW_Pin1_4	403	408	PF00397	0.289
LIG_14-3-3_CanoR_1	170	175	PF00244	0.304
LIG_14-3-3_CanoR_1	376	381	PF00244	0.289
LIG_14-3-3_CanoR_1	537	543	PF00244	0.313
LIG_APCC_ABBA_1	60	65	PF00400	0.304
LIG_BIR_II_1	1	5	PF00653	0.623
LIG_BRCT_BRCA1_1	91	95	PF00533	0.357
LIG_eIF4E_1	381	387	PF01652	0.434
LIG_FHA_1	130	136	PF00498	0.434
LIG_FHA_1	193	199	PF00498	0.327
LIG_FHA_1	238	244	PF00498	0.289
LIG_FHA_1	288	294	PF00498	0.334
LIG_FHA_1	302	308	PF00498	0.334
LIG_FHA_1	418	424	PF00498	0.289
LIG_FHA_1	55	61	PF00498	0.304
LIG_FHA_1	64	70	PF00498	0.304
LIG_FHA_2	140	146	PF00498	0.304
LIG_FHA_2	147	153	PF00498	0.304
LIG_FHA_2	179	185	PF00498	0.289
LIG_FHA_2	289	295	PF00498	0.304
LIG_FHA_2	325	331	PF00498	0.289
LIG_FHA_2	519	525	PF00498	0.369
LIG_FHA_2	539	545	PF00498	0.201
LIG_FHA_2	68	74	PF00498	0.304
LIG_LIR_Apic_2	411	415	PF02991	0.289
LIG_LIR_Apic_2	577	583	PF02991	0.393
LIG_LIR_Gen_1	103	114	PF02991	0.434
LIG_LIR_Gen_1	33	44	PF02991	0.304
LIG_LIR_Gen_1	457	468	PF02991	0.378
LIG_LIR_Gen_1	521	530	PF02991	0.358
LIG_LIR_Gen_1	560	569	PF02991	0.382
LIG_LIR_Gen_1	603	609	PF02991	0.467
LIG_LIR_Nem_3	103	109	PF02991	0.289
LIG_LIR_Nem_3	130	134	PF02991	0.219
LIG_LIR_Nem_3	230	236	PF02991	0.289
LIG_LIR_Nem_3	285	289	PF02991	0.289
LIG_LIR_Nem_3	321	326	PF02991	0.289
LIG_LIR_Nem_3	33	39	PF02991	0.304
LIG_LIR_Nem_3	366	372	PF02991	0.289
LIG_LIR_Nem_3	43	47	PF02991	0.371
LIG_LIR_Nem_3	448	452	PF02991	0.289
LIG_LIR_Nem_3	457	463	PF02991	0.372
LIG_LIR_Nem_3	464	470	PF02991	0.348
LIG_LIR_Nem_3	521	526	PF02991	0.358
LIG_LIR_Nem_3	560	564	PF02991	0.373
LIG_LIR_Nem_3	570	575	PF02991	0.372
LIG_LIR_Nem_3	603	608	PF02991	0.462
LIG_LIR_Nem_3	92	98	PF02991	0.289
LIG_LRP6_Inhibitor_1	559	565	PF00058	0.376
LIG_PCNA_PIPBox_1	226	235	PF02747	0.289
LIG_Pex14_1	445	449	PF04695	0.304
LIG_Pex14_2	459	463	PF04695	0.383
LIG_SH2_CRK	106	110	PF00017	0.383
LIG_SH2_CRK	323	327	PF00017	0.289
LIG_SH2_CRK	467	471	PF00017	0.336
LIG_SH2_CRK	572	576	PF00017	0.373
LIG_SH2_GRB2like	261	264	PF00017	0.304
LIG_SH2_GRB2like	452	455	PF00017	0.451
LIG_SH2_NCK_1	36	40	PF00017	0.304
LIG_SH2_NCK_1	381	385	PF00017	0.289
LIG_SH2_NCK_1	543	547	PF00017	0.433
LIG_SH2_SRC	452	455	PF00017	0.451
LIG_SH2_SRC	543	546	PF00017	0.335
LIG_SH2_STAP1	449	453	PF00017	0.339
LIG_SH2_STAT5	180	183	PF00017	0.295
LIG_SH2_STAT5	269	272	PF00017	0.299
LIG_SH2_STAT5	323	326	PF00017	0.289
LIG_SH2_STAT5	372	375	PF00017	0.289
LIG_SH2_STAT5	452	455	PF00017	0.357
LIG_SH2_STAT5	563	566	PF00017	0.389
LIG_SH2_STAT5	572	575	PF00017	0.370
LIG_SH2_STAT5	593	596	PF00017	0.402
LIG_SH2_STAT5	76	79	PF00017	0.348
LIG_SH3_3	109	115	PF00018	0.289
LIG_SH3_3	17	23	PF00018	0.304
LIG_SH3_3	203	209	PF00018	0.329
LIG_SH3_3	402	408	PF00018	0.289
LIG_SH3_3	68	74	PF00018	0.304
LIG_SUMO_SIM_anti_2	398	403	PF11976	0.289
LIG_SUMO_SIM_anti_2	420	425	PF11976	0.383
LIG_SUMO_SIM_par_1	183	190	PF11976	0.291
LIG_SUMO_SIM_par_1	21	28	PF11976	0.304
LIG_SUMO_SIM_par_1	210	217	PF11976	0.348
LIG_SUMO_SIM_par_1	80	85	PF11976	0.400
LIG_TYR_ITSM	102	109	PF00017	0.289
LIG_WRC_WIRS_1	377	382	PF05994	0.289
LIG_WRC_WIRS_1	41	46	PF05994	0.323
LIG_WRC_WIRS_1	460	465	PF05994	0.384
LIG_WRC_WIRS_1	539	544	PF05994	0.320
LIG_WRC_WIRS_1	602	607	PF05994	0.436
MOD_CDK_SPK_2	205	210	PF00069	0.289
MOD_CDK_SPxxK_3	129	136	PF00069	0.434
MOD_CK1_1	154	160	PF00069	0.212
MOD_CK1_1	259	265	PF00069	0.292
MOD_CK1_1	321	327	PF00069	0.302
MOD_CK1_1	603	609	PF00069	0.430
MOD_CK2_1	146	152	PF00069	0.207
MOD_CK2_1	182	188	PF00069	0.212
MOD_CK2_1	324	330	PF00069	0.289
MOD_CK2_1	376	382	PF00069	0.289
MOD_CK2_1	492	498	PF00069	0.378
MOD_CK2_1	538	544	PF00069	0.318
MOD_CK2_1	581	587	PF00069	0.339
MOD_GlcNHglycan	120	123	PF01048	0.212
MOD_GlcNHglycan	20	23	PF01048	0.304
MOD_GlcNHglycan	216	219	PF01048	0.434
MOD_GlcNHglycan	30	33	PF01048	0.304
MOD_GlcNHglycan	355	359	PF01048	0.289
MOD_GlcNHglycan	373	376	PF01048	0.289
MOD_GlcNHglycan	417	420	PF01048	0.289
MOD_GlcNHglycan	552	555	PF01048	0.429
MOD_GSK3_1	178	185	PF00069	0.251
MOD_GSK3_1	252	259	PF00069	0.289
MOD_GSK3_1	410	417	PF00069	0.289
MOD_GSK3_1	458	465	PF00069	0.292
MOD_GSK3_1	492	499	PF00069	0.376
MOD_GSK3_1	600	607	PF00069	0.460
MOD_GSK3_1	63	70	PF00069	0.304
MOD_N-GLC_1	157	162	PF02516	0.348
MOD_N-GLC_1	178	183	PF02516	0.289
MOD_N-GLC_1	28	33	PF02516	0.304
MOD_N-GLC_1	308	313	PF02516	0.289
MOD_NEK2_1	182	187	PF00069	0.212
MOD_NEK2_1	30	35	PF00069	0.304
MOD_NEK2_1	301	306	PF00069	0.289
MOD_NEK2_1	342	347	PF00069	0.289
MOD_NEK2_1	529	534	PF00069	0.329
MOD_NEK2_2	101	106	PF00069	0.289
MOD_OFUCOSY	527	533	PF10250	0.314
MOD_PIKK_1	252	258	PF00454	0.289
MOD_PK_1	170	176	PF00069	0.289
MOD_PK_1	296	302	PF00069	0.289
MOD_PK_1	318	324	PF00069	0.289
MOD_PK_1	395	401	PF00069	0.289
MOD_Plk_1	151	157	PF00069	0.289
MOD_Plk_1	178	184	PF00069	0.289
MOD_Plk_1	296	302	PF00069	0.323
MOD_Plk_1	318	324	PF00069	0.289
MOD_Plk_2-3	494	500	PF00069	0.370
MOD_Plk_4	101	107	PF00069	0.332
MOD_Plk_4	151	157	PF00069	0.313
MOD_Plk_4	182	188	PF00069	0.256
MOD_Plk_4	249	255	PF00069	0.323
MOD_Plk_4	288	294	PF00069	0.337
MOD_Plk_4	296	302	PF00069	0.337
MOD_Plk_4	318	324	PF00069	0.289
MOD_Plk_4	376	382	PF00069	0.289
MOD_Plk_4	397	403	PF00069	0.289
MOD_Plk_4	419	425	PF00069	0.383
MOD_Plk_4	538	544	PF00069	0.318
MOD_Plk_4	567	573	PF00069	0.525
MOD_Plk_4	604	610	PF00069	0.384
MOD_ProDKin_1	129	135	PF00069	0.457
MOD_ProDKin_1	205	211	PF00069	0.289
MOD_ProDKin_1	403	409	PF00069	0.289
MOD_SUMO_rev_2	552	560	PF00179	0.428
TRG_DiLeu_BaEn_1	382	387	PF01217	0.434
TRG_DiLeu_BaEn_1	486	491	PF01217	0.410
TRG_DiLeu_BaEn_3	482	488	PF01217	0.378
TRG_DiLeu_BaEn_4	64	70	PF01217	0.304
TRG_DiLeu_BaLyEn_6	218	223	PF01217	0.386
TRG_ENDOCYTIC_2	106	109	PF00928	0.289
TRG_ENDOCYTIC_2	323	326	PF00928	0.289
TRG_ENDOCYTIC_2	332	335	PF00928	0.289
TRG_ENDOCYTIC_2	36	39	PF00928	0.304
TRG_ENDOCYTIC_2	467	470	PF00928	0.375
TRG_ENDOCYTIC_2	523	526	PF00928	0.368
TRG_ENDOCYTIC_2	572	575	PF00928	0.370
TRG_ER_diArg_1	468	471	PF00400	0.341
TRG_NES_CRM1_1	37	49	PF08389	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I8L6	Leptomonas seymouri	95%	100%
A0A0S4JL32	Bodo saltans	88%	100%
A0A1X0PA64	Trypanosomatidae	90%	100%
A0A3Q8IUV8	Leishmania donovani	96%	100%
A0A422N2Z1	Trypanosoma rangeli	90%	100%
A0B9K2	Methanothrix thermoacetophila (strain DSM 6194 / JCM 14653 / NBRC 101360 / PT)	52%	100%
A0PZC6	Clostridium novyi (strain NT)	53%	100%
A0RXK1	Cenarchaeum symbiosum (strain A)	52%	100%
A1QYP3	Borrelia turicatae (strain 91E135)	42%	100%
A1RSF1	Pyrobaculum islandicum (strain DSM 4184 / JCM 9189 / GEO3)	46%	100%
A1RX21	Thermofilum pendens (strain DSM 2475 / Hrk 5)	45%	100%
A1SHJ1	Nocardioides sp. (strain ATCC BAA-499 / JS614)	27%	100%
A2BKX6	Hyperthermus butylicus (strain DSM 5456 / JCM 9403 / PLM1-5)	50%	100%
A2RC97	Streptococcus pyogenes serotype M5 (strain Manfredo)	51%	100%
A2SST5	Methanocorpusculum labreanum (strain ATCC 43576 / DSM 4855 / Z)	53%	100%
A3CK48	Streptococcus sanguinis (strain SK36)	52%	100%
A3CS71	Methanoculleus marisnigri (strain ATCC 35101 / DSM 1498 / JR1)	51%	100%
A3DHP0	Acetivibrio thermocellus (strain ATCC 27405 / DSM 1237 / JCM 9322 / NBRC 103400 / NCIMB 10682 / NRRL B-4536 / VPI 7372)	53%	100%
A3DNQ6	Staphylothermus marinus (strain ATCC 43588 / DSM 3639 / JCM 9404 / F1)	50%	100%
A3MXY7	Pyrobaculum calidifontis (strain DSM 21063 / JCM 11548 / VA1)	46%	100%
A4FXD4	Methanococcus maripaludis (strain C5 / ATCC BAA-1333)	49%	100%
A4IAD4	Leishmania infantum	96%	100%
A4WN96	Pyrobaculum arsenaticum (strain DSM 13514 / JCM 11321 / PZ6)	45%	100%
A4YI05	Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2)	50%	100%
A5I557	Clostridium botulinum (strain Hall / ATCC 3502 / NCTC 13319 / Type A)	54%	100%
A5UKB2	Methanobrevibacter smithii (strain ATCC 35061 / DSM 861 / OCM 144 / PS)	52%	100%
A6UP54	Methanococcus vannielii (strain ATCC 35089 / DSM 1224 / JCM 13029 / OCM 148 / SB)	53%	100%
A6UT35	Methanococcus aeolicus (strain ATCC BAA-1280 / DSM 17508 / OCM 812 / Nankai-3)	53%	100%
A6VFZ2	Methanococcus maripaludis (strain C7 / ATCC BAA-1331)	49%	100%
A7FWQ7	Clostridium botulinum (strain ATCC 19397 / Type A)	54%	100%
A7GGL4	Clostridium botulinum (strain Langeland / NCTC 10281 / Type F)	53%	100%
A7HDG9	Anaeromyxobacter sp. (strain Fw109-5)	48%	100%
A7IAU8	Methanoregula boonei (strain DSM 21154 / JCM 14090 / 6A8)	51%	100%
A8AC29	Ignicoccus hospitalis (strain KIN4/I / DSM 18386 / JCM 14125)	52%	100%
A8AUJ7	Streptococcus gordonii (strain Challis / ATCC 35105 / BCRC 15272 / CH1 / DL1 / V288)	52%	100%
A9A2R0	Nitrosopumilus maritimus (strain SCM1)	51%	100%
A9AAQ4	Methanococcus maripaludis (strain C6 / ATCC BAA-1332)	49%	100%
A9AVV4	Herpetosiphon aurantiacus (strain ATCC 23779 / DSM 785 / 114-95)	28%	100%
B0B7M4	Chlamydia trachomatis serovar L2 (strain 434/Bu / ATCC VR-902B)	42%	100%
B0BBT9	Chlamydia trachomatis serovar L2b (strain UCH-1/proctitis)	42%	100%
B0K5J0	Thermoanaerobacter sp. (strain X514)	54%	100%
B0K8E8	Thermoanaerobacter pseudethanolicus (strain ATCC 33223 / 39E)	54%	100%
B0R755	Halobacterium salinarum (strain ATCC 29341 / DSM 671 / R1)	51%	100%
B1ICC9	Streptococcus pneumoniae (strain Hungary19A-6)	53%	100%
B1IJM8	Clostridium botulinum (strain Okra / Type B1)	54%	100%
B1KXT6	Clostridium botulinum (strain Loch Maree / Type A3)	53%	100%
B1YC22	Pyrobaculum neutrophilum (strain DSM 2338 / JCM 9278 / NBRC 100436 / V24Sta)	45%	100%
B2S1S8	Borrelia hermsii (strain HS1 / DAH)	42%	100%
B2TP91	Clostridium botulinum (strain Eklund 17B / Type B)	51%	100%
B2UWY4	Clostridium botulinum (strain Alaska E43 / Type E3)	52%	100%
B4UH39	Anaeromyxobacter sp. (strain K)	49%	100%
B5E552	Streptococcus pneumoniae serotype 19F (strain G54)	53%	100%
B5RLG8	Borrelia duttonii (strain Ly)	42%	100%
B5RQS2	Borrelia recurrentis (strain A1)	41%	100%
B5XJH3	Streptococcus pyogenes serotype M49 (strain NZ131)	52%	100%
B6YV14	Thermococcus onnurineus (strain NA1)	52%	100%
B7J127	Borreliella burgdorferi (strain ZS7)	41%	100%
B8CZG8	Halothermothrix orenii (strain H 168 / OCM 544 / DSM 9562)	53%	100%
B8JE35	Anaeromyxobacter dehalogenans (strain 2CP-1 / ATCC BAA-258)	49%	100%
B8ZK31	Streptococcus pneumoniae (strain ATCC 700669 / Spain 23F-1)	53%	100%
C1CES2	Streptococcus pneumoniae (strain JJA)	53%	100%
C1CXU3	Deinococcus deserti (strain DSM 17065 / CIP 109153 / LMG 22923 / VCD115)	51%	100%
C3MQL5	Sulfolobus islandicus (strain L.S.2.15 / Lassen #1)	48%	100%
C3MW93	Sulfolobus islandicus (strain M.14.25 / Kamchatka #1)	48%	100%
C3N6D5	Sulfolobus islandicus (strain M.16.27)	48%	100%
C3NEU3	Sulfolobus islandicus (strain Y.G.57.14 / Yellowstone #1)	51%	100%
C3NGV1	Sulfolobus islandicus (strain Y.N.15.51 / Yellowstone #2)	49%	100%
C4KHV0	Sulfolobus islandicus (strain M.16.4 / Kamchatka #3)	48%	100%
C5A336	Thermococcus gammatolerans (strain DSM 15229 / JCM 11827 / EJ3)	49%	100%
C6A5E8	Thermococcus sibiricus (strain DSM 12597 / MM 739)	50%	100%
C9ZLW1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	87%	100%
E9B5F8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	96%	100%
O06504	Desulfurococcus sp. (strain SY)	52%	100%
O16109	Aedes aegypti	65%	99%
O23654	Arabidopsis thaliana	67%	98%
O27036	Methanothermobacter thermautotrophicus (strain ATCC 29096 / DSM 1053 / JCM 10044 / NBRC 100330 / Delta H)	52%	100%
O29101	Archaeoglobus fulgidus (strain ATCC 49558 / DSM 4304 / JCM 9628 / NBRC 100126 / VC-16)	51%	100%
O32466	Thermococcus sp. (strain KI)	50%	100%
O51121	Borreliella burgdorferi (strain ATCC 35210 / DSM 4680 / CIP 102532 / B31)	41%	100%
O83441	Treponema pallidum (strain Nichols)	42%	100%
O83541	Treponema pallidum (strain Nichols)	49%	100%
O84310	Chlamydia trachomatis (strain D/UW-3/Cx)	42%	100%
P09469	Daucus carota	67%	98%
P0DA06	Streptococcus pyogenes serotype M3 (strain ATCC BAA-595 / MGAS315)	52%	100%
P0DA07	Streptococcus pyogenes serotype M3 (strain SSI-1)	52%	100%
P11592	Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987)	59%	100%
P13548	Vigna radiata var. radiata	66%	98%
P22662	Methanosarcina barkeri	53%	100%
P31400	Manduca sexta	65%	99%
P31404	Bos taurus	66%	99%
P31405	Gossypium hirsutum	67%	98%
P31406	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	59%	99%
P38606	Homo sapiens	66%	99%
P42466	Herpetosiphon aurantiacus	28%	100%
P48414	Cyanidium caldarium	68%	100%
P48602	Drosophila melanogaster	66%	99%
P49087	Zea mays	66%	100%
P50516	Mus musculus	65%	99%
P54647	Dictyostelium discoideum	65%	99%
Q08636	Enterococcus hirae (strain ATCC 9790 / DSM 20160 / JCM 8729 / LMG 6399 / NBRC 3181 / NCIMB 6459 / NCDO 1258 / NCTC 12367 / WDCM 00089 / R)	51%	100%
Q0SP70	Borreliella afzelii (strain PKo)	40%	100%
Q0SSI2	Clostridium perfringens (strain SM101 / Type A)	52%	100%
Q0TPW7	Clostridium perfringens (strain ATCC 13124 / DSM 756 / JCM 1290 / NCIMB 6125 / NCTC 8237 / Type A)	52%	100%
Q0W363	Methanocella arvoryzae (strain DSM 22066 / NBRC 105507 / MRE50)	51%	100%
Q11DD5	Chelativorans sp. (strain BNC1)	28%	100%
Q12WL1	Methanococcoides burtonii (strain DSM 6242 / NBRC 107633 / OCM 468 / ACE-M)	52%	100%
Q184E7	Clostridioides difficile (strain 630)	51%	100%
Q18FB7	Haloquadratum walsbyi (strain DSM 16790 / HBSQ001)	50%	100%
Q1IWP3	Deinococcus geothermalis (strain DSM 11300 / AG-3a)	52%	100%
Q1J8S5	Streptococcus pyogenes serotype M4 (strain MGAS10750)	52%	100%
Q1JDX0	Streptococcus pyogenes serotype M12 (strain MGAS2096)	54%	100%
Q1JIX5	Streptococcus pyogenes serotype M2 (strain MGAS10270)	52%	100%
Q1JNS8	Streptococcus pyogenes serotype M12 (strain MGAS9429)	54%	100%
Q26975	Trypanosoma congolense	87%	100%
Q27331	Drosophila melanogaster	66%	99%
Q29048	Sus scrofa	65%	99%
Q2FL43	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	54%	100%
Q2FP52	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	50%	100%
Q2FQE9	Methanospirillum hungatei JF-1 (strain ATCC 27890 / DSM 864 / NBRC 100397 / JF-1)	53%	100%
Q2IQ95	Anaeromyxobacter dehalogenans (strain 2CP-C)	49%	100%
Q2NF87	Methanosphaera stadtmanae (strain ATCC 43021 / DSM 3091 / JCM 11832 / MCB-3)	53%	100%
Q2TJ56	Aedes albopictus	65%	99%
Q38676	Acetabularia acetabulum	68%	100%
Q38677	Acetabularia acetabulum	66%	100%
Q39291	Brassica napus	67%	98%
Q39442	Beta vulgaris	66%	98%
Q3ITC8	Natronomonas pharaonis (strain ATCC 35678 / DSM 2160 / CIP 103997 / JCM 8858 / NBRC 14720 / NCIMB 2260 / Gabara)	52%	100%
Q3J9F3	Nitrosococcus oceani (strain ATCC 19707 / BCRC 17464 / JCM 30415 / NCIMB 11848 / C-107)	47%	100%
Q3KM54	Chlamydia trachomatis serovar A (strain ATCC VR-571B / DSM 19440 / HAR-13)	42%	100%
Q40002	Hordeum vulgare	66%	100%
Q46FH3	Methanosarcina barkeri (strain Fusaro / DSM 804)	52%	100%
Q48332	Haloferax volcanii (strain ATCC 29605 / DSM 3757 / JCM 8879 / NBRC 14742 / NCIMB 2012 / VKM B-1768 / DS2)	51%	100%
Q48VL3	Streptococcus pyogenes serotype M28 (strain MGAS6180)	52%	100%
Q494C3	Blochmannia pennsylvanicus (strain BPEN)	29%	100%
Q4J8L9	Sulfolobus acidocaldarius (strain ATCC 33909 / DSM 639 / JCM 8929 / NBRC 15157 / NCIMB 11770)	48%	100%
Q4L7Y4	Staphylococcus haemolyticus (strain JCSC1435)	29%	100%
Q4Q2H7	Leishmania major	96%	100%
Q56403	Thermus thermophilus (strain ATCC 27634 / DSM 579 / HB8)	52%	100%
Q57670	Methanocaldococcus jannaschii (strain ATCC 43067 / DSM 2661 / JAL-1 / JCM 10045 / NBRC 100440)	53%	100%
Q5AJB1	Candida albicans (strain SC5314 / ATCC MYA-2876)	61%	99%
Q5JIR3	Thermococcus kodakarensis (strain ATCC BAA-918 / JCM 12380 / KOD1)	49%	100%
Q5L5J0	Chlamydia abortus (strain DSM 27085 / S26/3)	41%	100%
Q5R5H2	Pongo abelii	66%	99%
Q5TTG1	Anopheles gambiae	65%	99%
Q5UXY8	Haloarcula marismortui (strain ATCC 43049 / DSM 3752 / JCM 8966 / VKM B-1809)	52%	100%
Q5XE50	Streptococcus pyogenes serotype M6 (strain ATCC BAA-946 / MGAS10394)	52%	100%
Q60186	Methanosarcina mazei (strain ATCC BAA-159 / DSM 3647 / Goe1 / Go1 / JCM 11833 / OCM 88)	51%	100%
Q61VZ4	Caenorhabditis briggsae	65%	100%
Q662R8	Borrelia garinii subsp. bavariensis (strain ATCC BAA-2496 / DSM 23469 / PBi)	41%	100%
Q6LYE7	Methanococcus maripaludis (strain S2 / LL)	49%	100%
Q6MAJ5	Protochlamydia amoebophila (strain UWE25)	42%	100%
Q72J72	Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27)	52%	100%
Q73M28	Treponema denticola (strain ATCC 35405 / DSM 14222 / CIP 103919 / JCM 8153 / KCTC 15104)	43%	100%
Q74MJ7	Nanoarchaeum equitans (strain Kin4-M)	48%	100%
Q76NM6	Plasmodium falciparum (isolate 3D7)	62%	100%
Q822J8	Chlamydia caviae (strain ATCC VR-813 / DSM 19441 / 03DC25 / GPIC)	42%	100%
Q834X9	Enterococcus faecalis (strain ATCC 700802 / V583)	51%	100%
Q891P1	Clostridium tetani (strain Massachusetts / E88)	49%	100%
Q896K4	Clostridium tetani (strain Massachusetts / E88)	53%	100%
Q8P2U6	Streptococcus pyogenes serotype M18 (strain MGAS8232)	52%	100%
Q8SQU9	Encephalitozoon cuniculi (strain GB-M1)	60%	100%
Q8TIJ1	Methanosarcina acetivorans (strain ATCC 35395 / DSM 2834 / JCM 12185 / C2A)	49%	100%
Q8TWL6	Methanopyrus kandleri (strain AV19 / DSM 6324 / JCM 9639 / NBRC 100938)	57%	100%
Q8XJW5	Clostridium perfringens (strain 13 / Type A)	52%	100%
Q8ZYR1	Pyrobaculum aerophilum (strain ATCC 51768 / DSM 7523 / JCM 9630 / CIP 104966 / NBRC 100827 / IM2)	45%	100%
Q90647	Gallus gallus	65%	99%
Q971B7	Sulfurisphaera tokodaii (strain DSM 16993 / JCM 10545 / NBRC 100140 / 7)	47%	100%
Q97QA8	Streptococcus pneumoniae serotype 4 (strain ATCC BAA-334 / TIGR4)	53%	100%
Q98EV8	Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099)	28%	100%
Q9A1Q3	Streptococcus pyogenes serotype M1	52%	100%
Q9HNE3	Halobacterium salinarum (strain ATCC 700922 / JCM 11081 / NRC-1)	51%	100%
Q9PK85	Chlamydia muridarum (strain MoPn / Nigg)	42%	100%
Q9RWG8	Deinococcus radiodurans (strain ATCC 13939 / DSM 20539 / JCM 16871 / LMG 4051 / NBRC 15346 / NCIMB 9279 / R1 / VKM B-1422)	53%	100%
Q9SM09	Citrus unshiu	67%	98%
Q9UVJ8	Ashbya gossypii (strain ATCC 10895 / CBS 109.51 / FGSC 9923 / NRRL Y-1056)	60%	99%
Q9UWW6	Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2)	51%	100%
Q9XW92	Caenorhabditis elegans	64%	100%
Q9YF35	Aeropyrum pernix (strain ATCC 700893 / DSM 11879 / JCM 9820 / NBRC 100138 / K1)	49%	100%
Q9Z993	Chlamydia pneumoniae	40%	100%
V5BW59	Trypanosoma cruzi	89%	100%