Transmembrane 9 superfamily member

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

transmembrane/endomembrane-like protein

Species:

Leishmania braziliensis

UniProt:

A4HB85_LEIBR

TriTrypDb:

LbrM.20.3250 , LBRM2903_200046500

Length:

624

Annotations

LeishMANIAdb annotations

A compact protein with N-terminal signal peptide and 9 TM segments at the C-terminus. related to other Eukaryotic proteins of the same superfamily, sugguested to regulate vesicular pH. Localization: Endosomal (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 9, no: 1
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	11
GO:0110165	cellular anatomical entity	1	11

Expansion

Sequence features

A4HB85

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB85

Function

Biological processes
Term	Name	Level	Count
GO:0008104	protein localization	4	1
GO:0009987	cellular process	1	1
GO:0033036	macromolecule localization	2	1
GO:0051179	localization	1	1
GO:0051641	cellular localization	2	1
GO:0051668	localization within membrane	3	1
GO:0070727	cellular macromolecule localization	3	1
GO:0072657	protein localization to membrane	4	1

Could not find GO molecular_function term for this entry.

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	113	115	PF00675	0.534
CLV_NRD_NRD_1	147	149	PF00675	0.434
CLV_NRD_NRD_1	259	261	PF00675	0.518
CLV_NRD_NRD_1	288	290	PF00675	0.275
CLV_PCSK_KEX2_1	113	115	PF00082	0.537
CLV_PCSK_KEX2_1	147	149	PF00082	0.481
CLV_PCSK_KEX2_1	259	261	PF00082	0.475
CLV_PCSK_KEX2_1	573	575	PF00082	0.541
CLV_PCSK_KEX2_1	69	71	PF00082	0.549
CLV_PCSK_PC1ET2_1	573	575	PF00082	0.541
CLV_PCSK_PC1ET2_1	69	71	PF00082	0.384
CLV_PCSK_SKI1_1	126	130	PF00082	0.541
CLV_PCSK_SKI1_1	165	169	PF00082	0.384
CLV_PCSK_SKI1_1	383	387	PF00082	0.275
DEG_APCC_DBOX_1	44	52	PF00400	0.384
DEG_APCC_DBOX_1	478	486	PF00400	0.384
DEG_SCF_FBW7_1	129	136	PF00400	0.184
DOC_MAPK_gen_1	286	296	PF00069	0.513
DOC_MAPK_gen_1	69	75	PF00069	0.184
DOC_MAPK_HePTP_8	576	588	PF00069	0.332
DOC_MAPK_MEF2A_6	289	296	PF00069	0.541
DOC_MAPK_MEF2A_6	5	13	PF00069	0.539
DOC_MAPK_MEF2A_6	573	580	PF00069	0.274
DOC_PP4_FxxP_1	319	322	PF00568	0.461
DOC_USP7_MATH_1	133	137	PF00917	0.341
DOC_USP7_MATH_1	139	143	PF00917	0.331
DOC_USP7_MATH_1	41	45	PF00917	0.393
DOC_USP7_MATH_1	420	424	PF00917	0.364
DOC_USP7_MATH_1	601	605	PF00917	0.459
DOC_USP7_UBL2_3	160	164	PF12436	0.356
DOC_WW_Pin1_4	129	134	PF00397	0.310
DOC_WW_Pin1_4	27	32	PF00397	0.393
DOC_WW_Pin1_4	33	38	PF00397	0.403
DOC_WW_Pin1_4	46	51	PF00397	0.376
LIG_14-3-3_CanoR_1	106	110	PF00244	0.336
LIG_14-3-3_CanoR_1	390	394	PF00244	0.431
LIG_14-3-3_CanoR_1	43	49	PF00244	0.371
LIG_14-3-3_CanoR_1	479	483	PF00244	0.465
LIG_14-3-3_CanoR_1	552	558	PF00244	0.206
LIG_14-3-3_CanoR_1	579	585	PF00244	0.339
LIG_Actin_WH2_2	272	288	PF00022	0.387
LIG_APCC_ABBA_1	292	297	PF00400	0.513
LIG_BRCT_BRCA1_1	442	446	PF00533	0.366
LIG_BRCT_BRCA1_1	567	571	PF00533	0.426
LIG_BRCT_BRCA1_1	594	598	PF00533	0.364
LIG_BRCT_BRCA1_1	603	607	PF00533	0.301
LIG_BRCT_BRCA1_1	87	91	PF00533	0.248
LIG_BRCT_BRCA1_2	567	573	PF00533	0.426
LIG_deltaCOP1_diTrp_1	545	551	PF00928	0.463
LIG_EH1_1	369	377	PF00400	0.206
LIG_FHA_1	130	136	PF00498	0.296
LIG_FHA_1	16	22	PF00498	0.435
LIG_FHA_1	185	191	PF00498	0.291
LIG_FHA_1	233	239	PF00498	0.297
LIG_FHA_1	252	258	PF00498	0.369
LIG_FHA_1	363	369	PF00498	0.325
LIG_FHA_1	422	428	PF00498	0.314
LIG_FHA_1	457	463	PF00498	0.564
LIG_FHA_1	557	563	PF00498	0.420
LIG_FHA_2	208	214	PF00498	0.332
LIG_FHA_2	85	91	PF00498	0.327
LIG_Integrin_RGD_1	315	317	PF01839	0.275
LIG_IRF3_LxIS_1	436	443	PF10401	0.459
LIG_LIR_Apic_2	217	222	PF02991	0.299
LIG_LIR_Apic_2	317	322	PF02991	0.461
LIG_LIR_Gen_1	437	446	PF02991	0.426
LIG_LIR_Gen_1	553	562	PF02991	0.437
LIG_LIR_Nem_3	308	314	PF02991	0.473
LIG_LIR_Nem_3	437	442	PF02991	0.407
LIG_LIR_Nem_3	443	449	PF02991	0.395
LIG_LIR_Nem_3	481	486	PF02991	0.356
LIG_LIR_Nem_3	538	542	PF02991	0.419
LIG_LIR_Nem_3	553	557	PF02991	0.314
LIG_MLH1_MIPbox_1	567	571	PF16413	0.391
LIG_MYND_1	470	474	PF01753	0.541
LIG_Pex14_1	550	554	PF04695	0.461
LIG_Pex14_2	278	282	PF04695	0.206
LIG_Pex14_2	449	453	PF04695	0.441
LIG_Pex14_2	518	522	PF04695	0.399
LIG_PTB_Apo_2	101	108	PF02174	0.367
LIG_PTB_Apo_2	118	125	PF02174	0.315
LIG_PTB_Phospho_1	118	124	PF10480	0.341
LIG_Rb_LxCxE_1	523	546	PF01857	0.206
LIG_REV1ctd_RIR_1	568	578	PF16727	0.391
LIG_SH2_CRK	268	272	PF00017	0.426
LIG_SH2_CRK	516	520	PF00017	0.459
LIG_SH2_CRK	54	58	PF00017	0.341
LIG_SH2_CRK	554	558	PF00017	0.437
LIG_SH2_CRK	618	622	PF00017	0.534
LIG_SH2_SRC	514	517	PF00017	0.364
LIG_SH2_STAP1	124	128	PF00017	0.274
LIG_SH2_STAP1	236	240	PF00017	0.257
LIG_SH2_STAP1	554	558	PF00017	0.397
LIG_SH2_STAP1	567	571	PF00017	0.267
LIG_SH2_STAT5	219	222	PF00017	0.358
LIG_SH2_STAT5	295	298	PF00017	0.541
LIG_SH2_STAT5	484	487	PF00017	0.362
LIG_SH2_STAT5	514	517	PF00017	0.300
LIG_SH2_STAT5	539	542	PF00017	0.475
LIG_SH2_STAT5	575	578	PF00017	0.217
LIG_SH3_3	55	61	PF00018	0.364
LIG_SUMO_SIM_anti_2	364	370	PF11976	0.342
LIG_SUMO_SIM_anti_2	523	530	PF11976	0.380
LIG_SUMO_SIM_par_1	12	19	PF11976	0.377
LIG_SUMO_SIM_par_1	458	463	PF11976	0.541
LIG_TRAF2_1	61	64	PF00917	0.211
LIG_TYR_ITIM	51	56	PF00017	0.184
LIG_TYR_ITIM	537	542	PF00017	0.333
LIG_WRC_WIRS_1	518	523	PF05994	0.380
MOD_CDK_SPK_2	33	38	PF00069	0.329
MOD_CK1_1	155	161	PF00069	0.225
MOD_CK1_1	184	190	PF00069	0.367
MOD_CK1_1	19	25	PF00069	0.510
MOD_CK1_1	30	36	PF00069	0.354
MOD_CK1_1	44	50	PF00069	0.247
MOD_CK1_1	553	559	PF00069	0.236
MOD_CK2_1	207	213	PF00069	0.321
MOD_CK2_1	249	255	PF00069	0.294
MOD_CK2_1	84	90	PF00069	0.319
MOD_GlcNHglycan	135	138	PF01048	0.542
MOD_GlcNHglycan	22	25	PF01048	0.661
MOD_GlcNHglycan	307	311	PF01048	0.276
MOD_GlcNHglycan	376	379	PF01048	0.359
MOD_GlcNHglycan	66	69	PF01048	0.440
MOD_GSK3_1	129	136	PF00069	0.292
MOD_GSK3_1	15	22	PF00069	0.583
MOD_GSK3_1	203	210	PF00069	0.317
MOD_GSK3_1	228	235	PF00069	0.276
MOD_GSK3_1	236	243	PF00069	0.305
MOD_GSK3_1	338	345	PF00069	0.378
MOD_GSK3_1	354	361	PF00069	0.275
MOD_GSK3_1	389	396	PF00069	0.546
MOD_GSK3_1	456	463	PF00069	0.508
MOD_GSK3_1	517	524	PF00069	0.342
MOD_GSK3_1	553	560	PF00069	0.366
MOD_N-GLC_1	139	144	PF02516	0.569
MOD_NEK2_1	15	20	PF00069	0.533
MOD_NEK2_1	172	177	PF00069	0.263
MOD_NEK2_1	234	239	PF00069	0.328
MOD_NEK2_1	284	289	PF00069	0.321
MOD_NEK2_1	342	347	PF00069	0.421
MOD_NEK2_1	362	367	PF00069	0.128
MOD_NEK2_1	440	445	PF00069	0.385
MOD_NEK2_1	460	465	PF00069	0.328
MOD_NEK2_1	486	491	PF00069	0.459
MOD_NEK2_1	521	526	PF00069	0.245
MOD_NEK2_1	557	562	PF00069	0.323
MOD_NEK2_1	565	570	PF00069	0.330
MOD_NEK2_1	580	585	PF00069	0.301
MOD_NEK2_1	592	597	PF00069	0.167
MOD_NEK2_1	607	612	PF00069	0.325
MOD_NEK2_1	617	622	PF00069	0.551
MOD_NEK2_1	98	103	PF00069	0.281
MOD_NEK2_2	105	110	PF00069	0.364
MOD_NEK2_2	478	483	PF00069	0.471
MOD_NEK2_2	517	522	PF00069	0.426
MOD_PIKK_1	158	164	PF00454	0.336
MOD_PIKK_1	181	187	PF00454	0.364
MOD_PK_1	465	471	PF00069	0.475
MOD_PKA_2	105	111	PF00069	0.313
MOD_PKA_2	358	364	PF00069	0.364
MOD_PKA_2	389	395	PF00069	0.384
MOD_PKA_2	44	50	PF00069	0.390
MOD_PKA_2	478	484	PF00069	0.517
MOD_Plk_1	228	234	PF00069	0.222
MOD_Plk_2-3	85	91	PF00069	0.192
MOD_Plk_4	16	22	PF00069	0.511
MOD_Plk_4	270	276	PF00069	0.340
MOD_Plk_4	30	36	PF00069	0.201
MOD_Plk_4	327	333	PF00069	0.459
MOD_Plk_4	338	344	PF00069	0.380
MOD_Plk_4	358	364	PF00069	0.128
MOD_Plk_4	478	484	PF00069	0.541
MOD_Plk_4	486	492	PF00069	0.384
MOD_Plk_4	517	523	PF00069	0.408
MOD_Plk_4	535	541	PF00069	0.201
MOD_Plk_4	565	571	PF00069	0.364
MOD_Plk_4	580	586	PF00069	0.267
MOD_Plk_4	592	598	PF00069	0.314
MOD_Plk_4	607	613	PF00069	0.310
MOD_ProDKin_1	129	135	PF00069	0.310
MOD_ProDKin_1	27	33	PF00069	0.391
MOD_ProDKin_1	46	52	PF00069	0.375
MOD_SUMO_for_1	621	624	PF00179	0.687
MOD_SUMO_for_1	68	71	PF00179	0.234
MOD_SUMO_rev_2	297	305	PF00179	0.384
MOD_SUMO_rev_2	85	93	PF00179	0.356
TRG_DiLeu_BaEn_4	510	516	PF01217	0.364
TRG_DiLeu_BaLyEn_6	380	385	PF01217	0.426
TRG_DiLeu_BaLyEn_6	468	473	PF01217	0.526
TRG_ENDOCYTIC_2	124	127	PF00928	0.364
TRG_ENDOCYTIC_2	268	271	PF00928	0.421
TRG_ENDOCYTIC_2	452	455	PF00928	0.459
TRG_ENDOCYTIC_2	483	486	PF00928	0.388
TRG_ENDOCYTIC_2	516	519	PF00928	0.393
TRG_ENDOCYTIC_2	53	56	PF00928	0.339
TRG_ENDOCYTIC_2	539	542	PF00928	0.461
TRG_ENDOCYTIC_2	554	557	PF00928	0.314
TRG_ENDOCYTIC_2	567	570	PF00928	0.256
TRG_ENDOCYTIC_2	575	578	PF00928	0.281
TRG_ENDOCYTIC_2	618	621	PF00928	0.521
TRG_ER_diArg_1	112	114	PF00400	0.342
TRG_ER_diArg_1	146	148	PF00400	0.234
TRG_ER_diArg_1	222	225	PF00400	0.184
TRG_ER_diArg_1	42	45	PF00400	0.391
TRG_Pf-PMV_PEXEL_1	471	475	PF00026	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P948	Leptomonas seymouri	27%	94%
A0A0N1I2B1	Leptomonas seymouri	29%	98%
A0A0N1I6Y7	Leptomonas seymouri	56%	100%
A0A0N1IME8	Leptomonas seymouri	20%	100%
A0A0S4IV41	Bodo saltans	29%	98%
A0A0S4J9X2	Bodo saltans	27%	96%
A0A0S4JBB1	Bodo saltans	32%	98%
A0A0S4JCH7	Bodo saltans	26%	91%
A0A0S4JEU5	Bodo saltans	27%	97%
A0A0S4JIF4	Bodo saltans	34%	98%
A0A0S4JWZ9	Bodo saltans	23%	100%
A0A0S4JZ31	Bodo saltans	27%	100%
A0A1X0NJN3	Trypanosomatidae	24%	100%
A0A1X0NK64	Trypanosomatidae	29%	99%
A0A1X0NLM6	Trypanosomatidae	23%	100%
A0A1X0NZX5	Trypanosomatidae	31%	96%
A0A1X0P2G3	Trypanosomatidae	29%	98%
A0A1X0PA12	Trypanosomatidae	36%	98%
A0A3Q8IBT4	Leishmania donovani	23%	100%
A0A3Q8IFM1	Leishmania donovani	28%	97%
A0A3Q8IHT3	Leishmania donovani	75%	98%
A0A3R7MBZ3	Trypanosoma rangeli	36%	99%
A0A3S7X2L7	Leishmania donovani	27%	92%
A0A422NED2	Trypanosoma rangeli	31%	97%
A0A422NMS9	Trypanosoma rangeli	29%	95%
A0A422P482	Trypanosoma rangeli	23%	100%
A4HHH4	Leishmania braziliensis	29%	92%
A4HHY3	Leishmania braziliensis	29%	97%
A4HVR6	Leishmania infantum	23%	100%
A4I4M3	Leishmania infantum	28%	92%
A4I563	Leishmania infantum	28%	97%
A4IAD3	Leishmania infantum	75%	98%
A4IFE9	Bos taurus	28%	100%
A5D7E2	Bos taurus	31%	97%
C9ZLB0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	86%
C9ZLW2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	98%
C9ZUX0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	99%
D0A6H3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	24%	100%
E9AE21	Leishmania major	28%	100%
E9ALR2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	92%
E9APG2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	21%	100%
E9B0G0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	29%	95%
E9B5F7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	74%	98%
F4HW17	Arabidopsis thaliana	29%	100%
F4JRE0	Arabidopsis thaliana	29%	96%
F4KIB2	Arabidopsis thaliana	32%	96%
O15321	Homo sapiens	28%	100%
P32802	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	26%	94%
P40071	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	88%
P58021	Mus musculus	30%	94%
Q04562	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	27%	93%
Q4KLL4	Rattus norvegicus	30%	97%
Q4Q2H8	Leishmania major	75%	100%
Q4Q7S3	Leishmania major	29%	100%
Q4QG16	Leishmania major	22%	95%
Q54ZW0	Dictyostelium discoideum	25%	100%
Q55FP0	Dictyostelium discoideum	29%	97%
Q5R8F1	Pongo abelii	27%	100%
Q5R8Y6	Pongo abelii	30%	94%
Q5RDY2	Pongo abelii	30%	97%
Q66HF2	Rattus norvegicus	27%	100%
Q66HG5	Rattus norvegicus	30%	94%
Q7YTA6	Dictyostelium discoideum	21%	95%
Q8BH24	Mus musculus	30%	97%
Q8RWW1	Arabidopsis thaliana	32%	98%
Q92544	Homo sapiens	30%	97%
Q940G0	Arabidopsis thaliana	29%	100%
Q940S0	Arabidopsis thaliana	25%	100%
Q99805	Homo sapiens	30%	94%
Q9C5N2	Arabidopsis thaliana	32%	97%
Q9C720	Arabidopsis thaliana	32%	98%
Q9DBU0	Mus musculus	28%	100%
Q9ET30	Mus musculus	29%	100%
Q9FHT4	Arabidopsis thaliana	27%	100%
Q9FYQ8	Arabidopsis thaliana	31%	95%
Q9HD45	Homo sapiens	29%	100%
Q9LIC2	Arabidopsis thaliana	30%	97%
Q9Y819	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	29%	99%
Q9ZPS7	Arabidopsis thaliana	24%	100%
V5BCD5	Trypanosoma cruzi	28%	99%
V5BHS7	Trypanosoma cruzi	27%	100%
V5D9U0	Trypanosoma cruzi	31%	96%
V5DII3	Trypanosoma cruzi	23%	100%