Transmembrane protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB82_LEIBR

TriTrypDb:

LbrM.20.3220 , LBRM2903_200046200

Length:

233

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 2
Forrest at al. (procyclic)	no	yes: 2
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 15

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 6

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 1, no: 6
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	7
GO:0110165	cellular anatomical entity	1	7

Expansion

Sequence features

A4HB82

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB82

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	166	168	PF00675	0.488
CLV_NRD_NRD_1	216	218	PF00675	0.479
CLV_PCSK_KEX2_1	166	168	PF00082	0.488
CLV_PCSK_SKI1_1	62	66	PF00082	0.224
DEG_APCC_DBOX_1	198	206	PF00400	0.608
DEG_SCF_FBW7_2	149	156	PF00400	0.685
DEG_SPOP_SBC_1	86	90	PF00917	0.576
DOC_CYCLIN_RxL_1	16	24	PF00134	0.253
DOC_MAPK_gen_1	129	137	PF00069	0.678
DOC_PP1_RVXF_1	137	143	PF00149	0.677
DOC_PP2B_LxvP_1	32	35	PF13499	0.269
DOC_USP7_MATH_1	192	196	PF00917	0.652
DOC_USP7_UBL2_3	125	129	PF12436	0.552
DOC_WW_Pin1_4	149	154	PF00397	0.681
LIG_14-3-3_CanoR_1	19	24	PF00244	0.207
LIG_14-3-3_CanoR_1	7	15	PF00244	0.381
LIG_BIR_II_1	1	5	PF00653	0.380
LIG_CtBP_PxDLS_1	97	101	PF00389	0.461
LIG_DLG_GKlike_1	19	26	PF00625	0.240
LIG_FHA_1	104	110	PF00498	0.406
LIG_FHA_1	16	22	PF00498	0.224
LIG_FHA_1	44	50	PF00498	0.577
LIG_FHA_1	59	65	PF00498	0.535
LIG_GBD_Chelix_1	115	123	PF00786	0.414
LIG_LIR_Gen_1	134	142	PF02991	0.650
LIG_LIR_Gen_1	9	15	PF02991	0.381
LIG_LIR_Nem_3	134	140	PF02991	0.622
LIG_LIR_Nem_3	9	14	PF02991	0.382
LIG_SH2_STAT5	13	16	PF00017	0.382
LIG_SH2_STAT5	183	186	PF00017	0.628
LIG_SH3_3	225	231	PF00018	0.749
LIG_SH3_3	71	77	PF00018	0.289
LIG_SUMO_SIM_anti_2	106	112	PF11976	0.414
LIG_UBA3_1	119	125	PF00899	0.269
LIG_UBA3_1	54	62	PF00899	0.419
MOD_CDK_SPK_2	149	154	PF00069	0.636
MOD_CDK_SPxK_1	149	155	PF00069	0.603
MOD_CK1_1	37	43	PF00069	0.456
MOD_CK1_1	47	53	PF00069	0.414
MOD_CK2_1	209	215	PF00069	0.661
MOD_Cter_Amidation	215	218	PF01082	0.533
MOD_GlcNHglycan	131	134	PF01048	0.705
MOD_GlcNHglycan	23	26	PF01048	0.422
MOD_GSK3_1	129	136	PF00069	0.605
MOD_GSK3_1	15	22	PF00069	0.449
MOD_GSK3_1	222	229	PF00069	0.806
MOD_GSK3_1	40	47	PF00069	0.459
MOD_GSK3_1	49	56	PF00069	0.409
MOD_GSK3_1	85	92	PF00069	0.608
MOD_N-GLC_1	149	154	PF02516	0.599
MOD_N-GLC_1	98	103	PF02516	0.440
MOD_NEK2_1	1	6	PF00069	0.455
MOD_NEK2_1	111	116	PF00069	0.383
MOD_NEK2_1	135	140	PF00069	0.524
MOD_NEK2_1	21	26	PF00069	0.185
MOD_NEK2_1	49	54	PF00069	0.441
MOD_NEK2_1	58	63	PF00069	0.391
MOD_NEK2_1	85	90	PF00069	0.565
MOD_PIKK_1	193	199	PF00454	0.682
MOD_PIKK_1	6	12	PF00454	0.456
MOD_PKA_2	40	46	PF00069	0.504
MOD_PKA_2	6	12	PF00069	0.456
MOD_Plk_1	133	139	PF00069	0.607
MOD_Plk_1	222	228	PF00069	0.806
MOD_Plk_1	86	92	PF00069	0.479
MOD_Plk_1	98	104	PF00069	0.375
MOD_Plk_4	1	7	PF00069	0.457
MOD_Plk_4	104	110	PF00069	0.240
MOD_Plk_4	204	210	PF00069	0.567
MOD_ProDKin_1	149	155	PF00069	0.603
MOD_SUMO_for_1	153	156	PF00179	0.747
TRG_DiLeu_BaEn_1	204	209	PF01217	0.509

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PA23	Leptomonas seymouri	51%	100%
A0A3S7X8E8	Leishmania donovani	67%	100%
A4IAD0	Leishmania infantum	67%	100%
E9B5F3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	62%	100%
E9B5F5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	60%	100%
Q4Q2I0	Leishmania major	61%	99%