Metallophos domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB81_LEIBR

TriTrypDb:

LbrM.20.3210 , LBRM2903_200046100

Length:

511

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 14, no: 2
NetGPI	no	yes: 0, no: 16

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	14
GO:0110165	cellular anatomical entity	1	14

Expansion

Sequence features

A4HB81

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB81

Function

Biological processes
Term	Name	Level	Count
GO:0008152	metabolic process	1	1

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	14
GO:0016787	hydrolase activity	2	14
GO:0004553	hydrolase activity, hydrolyzing O-glycosyl compounds	4	1
GO:0004564	beta-fructofuranosidase activity	5	1
GO:0016798	hydrolase activity, acting on glycosyl bonds	3	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	110	112	PF00675	0.514
CLV_NRD_NRD_1	226	228	PF00675	0.432
CLV_NRD_NRD_1	470	472	PF00675	0.380
CLV_PCSK_FUR_1	468	472	PF00082	0.291
CLV_PCSK_KEX2_1	110	112	PF00082	0.514
CLV_PCSK_KEX2_1	226	228	PF00082	0.523
CLV_PCSK_KEX2_1	230	232	PF00082	0.522
CLV_PCSK_KEX2_1	249	251	PF00082	0.395
CLV_PCSK_KEX2_1	392	394	PF00082	0.615
CLV_PCSK_KEX2_1	468	470	PF00082	0.323
CLV_PCSK_PC1ET2_1	230	232	PF00082	0.542
CLV_PCSK_PC1ET2_1	249	251	PF00082	0.542
CLV_PCSK_PC1ET2_1	392	394	PF00082	0.531
CLV_PCSK_PC7_1	226	232	PF00082	0.542
CLV_PCSK_SKI1_1	113	117	PF00082	0.531
CLV_PCSK_SKI1_1	250	254	PF00082	0.397
CLV_PCSK_SKI1_1	292	296	PF00082	0.442
CLV_PCSK_SKI1_1	336	340	PF00082	0.494
CLV_PCSK_SKI1_1	351	355	PF00082	0.573
CLV_PCSK_SKI1_1	382	386	PF00082	0.537
CLV_PCSK_SKI1_1	471	475	PF00082	0.444
DOC_CYCLIN_yClb1_LxF_4	212	218	PF00134	0.168
DOC_MAPK_gen_1	110	117	PF00069	0.168
DOC_MAPK_HePTP_8	348	360	PF00069	0.197
DOC_MAPK_MEF2A_6	277	284	PF00069	0.327
DOC_MAPK_MEF2A_6	298	306	PF00069	0.356
DOC_MAPK_MEF2A_6	351	360	PF00069	0.360
DOC_MAPK_NFAT4_5	351	359	PF00069	0.203
DOC_MAPK_RevD_3	455	469	PF00069	0.339
DOC_PP2B_LxvP_1	200	203	PF13499	0.309
DOC_PP2B_LxvP_1	294	297	PF13499	0.352
DOC_PP2B_LxvP_1	304	307	PF13499	0.274
DOC_USP7_MATH_1	168	172	PF00917	0.331
DOC_USP7_MATH_1	203	207	PF00917	0.273
DOC_USP7_MATH_1	268	272	PF00917	0.181
DOC_USP7_MATH_1	433	437	PF00917	0.463
DOC_USP7_UBL2_3	249	253	PF12436	0.168
DOC_WW_Pin1_4	307	312	PF00397	0.261
DOC_WW_Pin1_4	61	66	PF00397	0.240
LIG_14-3-3_CanoR_1	113	118	PF00244	0.331
LIG_14-3-3_CanoR_1	250	260	PF00244	0.227
LIG_14-3-3_CanoR_1	27	31	PF00244	0.298
LIG_14-3-3_CanoR_1	292	297	PF00244	0.290
LIG_14-3-3_CanoR_1	407	411	PF00244	0.237
LIG_14-3-3_CanoR_1	468	477	PF00244	0.673
LIG_14-3-3_CanoR_1	91	95	PF00244	0.266
LIG_Actin_RPEL_3	360	379	PF02755	0.200
LIG_BRCT_BRCA1_1	108	112	PF00533	0.335
LIG_BRCT_BRCA1_1	309	313	PF00533	0.368
LIG_BRCT_BRCA1_1	348	352	PF00533	0.197
LIG_deltaCOP1_diTrp_1	88	94	PF00928	0.323
LIG_FHA_1	151	157	PF00498	0.275
LIG_FHA_1	355	361	PF00498	0.304
LIG_FHA_1	373	379	PF00498	0.386
LIG_FHA_1	494	500	PF00498	0.737
LIG_FHA_1	78	84	PF00498	0.214
LIG_FHA_2	265	271	PF00498	0.168
LIG_IBAR_NPY_1	316	318	PF08397	0.176
LIG_LIR_Apic_2	54	59	PF02991	0.285
LIG_LIR_Gen_1	243	252	PF02991	0.325
LIG_LIR_Gen_1	267	276	PF02991	0.269
LIG_LIR_Gen_1	377	387	PF02991	0.315
LIG_LIR_Gen_1	416	427	PF02991	0.246
LIG_LIR_Nem_3	102	108	PF02991	0.271
LIG_LIR_Nem_3	109	115	PF02991	0.297
LIG_LIR_Nem_3	243	248	PF02991	0.308
LIG_LIR_Nem_3	267	272	PF02991	0.237
LIG_LIR_Nem_3	274	279	PF02991	0.237
LIG_LIR_Nem_3	288	294	PF02991	0.229
LIG_LIR_Nem_3	33	39	PF02991	0.298
LIG_LIR_Nem_3	377	383	PF02991	0.297
LIG_LIR_Nem_3	416	422	PF02991	0.249
LIG_LIR_Nem_3	428	432	PF02991	0.298
LIG_LIR_Nem_3	482	488	PF02991	0.658
LIG_NRBOX	190	196	PF00104	0.307
LIG_NRBOX	450	456	PF00104	0.189
LIG_Pex14_1	261	265	PF04695	0.243
LIG_Pex14_1	484	488	PF04695	0.566
LIG_Pex14_2	324	328	PF04695	0.388
LIG_Pex14_2	383	387	PF04695	0.352
LIG_PTB_Apo_2	312	319	PF02174	0.194
LIG_PTB_Phospho_1	312	318	PF10480	0.196
LIG_SH2_CRK	245	249	PF00017	0.339
LIG_SH2_CRK	269	273	PF00017	0.295
LIG_SH2_CRK	36	40	PF00017	0.260
LIG_SH2_CRK	419	423	PF00017	0.240
LIG_SH2_NCK_1	419	423	PF00017	0.197
LIG_SH2_STAP1	179	183	PF00017	0.323
LIG_SH2_STAP1	269	273	PF00017	0.326
LIG_SH2_STAT5	179	182	PF00017	0.273
LIG_SH2_STAT5	265	268	PF00017	0.222
LIG_SH3_3	205	211	PF00018	0.249
LIG_Sin3_3	301	308	PF02671	0.175
LIG_SUMO_SIM_anti_2	278	283	PF11976	0.355
LIG_SUMO_SIM_anti_2	453	458	PF11976	0.324
LIG_SUMO_SIM_par_1	187	193	PF11976	0.239
LIG_SUMO_SIM_par_1	447	453	PF11976	0.349
LIG_SUMO_SIM_par_1	461	467	PF11976	0.399
LIG_TYR_ITIM	34	39	PF00017	0.286
LIG_TYR_ITSM	265	272	PF00017	0.168
LIG_WRC_WIRS_1	321	326	PF05994	0.194
MOD_CK1_1	271	277	PF00069	0.303
MOD_CK1_1	346	352	PF00069	0.328
MOD_CK1_1	4	10	PF00069	0.189
MOD_CK1_1	436	442	PF00069	0.501
MOD_CK2_1	117	123	PF00069	0.251
MOD_CK2_1	163	169	PF00069	0.184
MOD_CK2_1	410	416	PF00069	0.332
MOD_CK2_1	90	96	PF00069	0.226
MOD_GlcNHglycan	298	301	PF01048	0.590
MOD_GlcNHglycan	3	6	PF01048	0.352
MOD_GlcNHglycan	345	348	PF01048	0.577
MOD_GlcNHglycan	441	444	PF01048	0.619
MOD_GlcNHglycan	73	78	PF01048	0.517
MOD_GlcNHglycan	96	99	PF01048	0.430
MOD_GSK3_1	113	120	PF00069	0.294
MOD_GSK3_1	264	271	PF00069	0.219
MOD_GSK3_1	292	299	PF00069	0.233
MOD_GSK3_1	322	329	PF00069	0.293
MOD_GSK3_1	406	413	PF00069	0.219
MOD_GSK3_1	61	68	PF00069	0.217
MOD_GSK3_1	73	80	PF00069	0.191
MOD_GSK3_1	90	97	PF00069	0.156
MOD_LATS_1	290	296	PF00433	0.180
MOD_N-GLC_1	113	118	PF02516	0.409
MOD_N-GLC_1	144	149	PF02516	0.451
MOD_N-GLC_1	354	359	PF02516	0.461
MOD_N-GLC_1	417	422	PF02516	0.565
MOD_N-GLC_1	493	498	PF02516	0.429
MOD_N-GLC_1	78	83	PF02516	0.446
MOD_N-GLC_2	404	406	PF02516	0.413
MOD_NEK2_1	1	6	PF00069	0.414
MOD_NEK2_1	126	131	PF00069	0.313
MOD_NEK2_1	204	209	PF00069	0.222
MOD_NEK2_1	285	290	PF00069	0.281
MOD_NEK2_1	320	325	PF00069	0.251
MOD_NEK2_1	354	359	PF00069	0.262
MOD_NEK2_1	410	415	PF00069	0.247
MOD_NEK2_1	464	469	PF00069	0.490
MOD_NEK2_1	94	99	PF00069	0.291
MOD_NEK2_2	196	201	PF00069	0.224
MOD_NMyristoyl	1	7	PF02799	0.368
MOD_PKA_1	469	475	PF00069	0.503
MOD_PKA_2	26	32	PF00069	0.168
MOD_PKA_2	406	412	PF00069	0.265
MOD_PKA_2	436	442	PF00069	0.515
MOD_PKA_2	469	475	PF00069	0.634
MOD_PKA_2	90	96	PF00069	0.295
MOD_PKB_1	111	119	PF00069	0.331
MOD_Plk_1	113	119	PF00069	0.242
MOD_Plk_1	144	150	PF00069	0.282
MOD_Plk_1	168	174	PF00069	0.303
MOD_Plk_1	354	360	PF00069	0.237
MOD_Plk_1	417	423	PF00069	0.342
MOD_Plk_1	49	55	PF00069	0.285
MOD_Plk_1	492	498	PF00069	0.565
MOD_Plk_1	78	84	PF00069	0.251
MOD_Plk_4	168	174	PF00069	0.359
MOD_Plk_4	190	196	PF00069	0.242
MOD_Plk_4	213	219	PF00069	0.261
MOD_Plk_4	26	32	PF00069	0.202
MOD_Plk_4	268	274	PF00069	0.304
MOD_Plk_4	406	412	PF00069	0.272
MOD_Plk_4	450	456	PF00069	0.322
MOD_Plk_4	480	486	PF00069	0.635
MOD_Plk_4	51	57	PF00069	0.237
MOD_Plk_4	78	84	PF00069	0.299
MOD_Plk_4	90	96	PF00069	0.289
MOD_ProDKin_1	307	313	PF00069	0.267
MOD_ProDKin_1	61	67	PF00069	0.240
MOD_SUMO_for_1	252	255	PF00179	0.168
MOD_SUMO_for_1	398	401	PF00179	0.440
MOD_SUMO_rev_2	270	279	PF00179	0.332
TRG_DiLeu_BaEn_1	275	280	PF01217	0.339
TRG_DiLeu_BaLyEn_6	289	294	PF01217	0.183
TRG_ENDOCYTIC_2	245	248	PF00928	0.301
TRG_ENDOCYTIC_2	269	272	PF00928	0.257
TRG_ENDOCYTIC_2	318	321	PF00928	0.247
TRG_ENDOCYTIC_2	36	39	PF00928	0.268
TRG_ENDOCYTIC_2	419	422	PF00928	0.343
TRG_ER_diArg_1	110	112	PF00400	0.314
TRG_ER_diArg_1	468	471	PF00400	0.522
TRG_NES_CRM1_1	107	118	PF08389	0.329
TRG_NES_CRM1_1	270	283	PF08389	0.168
TRG_Pf-PMV_PEXEL_1	70	74	PF00026	0.526

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYJ4	Leptomonas seymouri	52%	100%
A0A0S4JMD5	Bodo saltans	30%	100%
A0A0S4JQJ5	Bodo saltans	32%	90%
A0A1X0PA11	Trypanosomatidae	29%	100%
A0A1X0PAC3	Trypanosomatidae	32%	98%
A0A3Q8IHH9	Leishmania donovani	64%	100%
A0A3R7K6I9	Trypanosoma rangeli	31%	100%
A0A3R7KT12	Trypanosoma rangeli	27%	99%
A4IAC9	Leishmania infantum	64%	100%
C9ZLW4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	30%	100%
C9ZLW5	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9AHU3	Leishmania infantum	39%	100%
E9B5F2	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	100%
P58242	Mus musculus	22%	100%
P70158	Mus musculus	22%	100%
Q04519	Mus musculus	23%	81%
Q4Q2I1	Leishmania major	63%	100%
Q54SR8	Dictyostelium discoideum	23%	100%
Q55C09	Dictyostelium discoideum	24%	88%
Q55GC7	Dictyostelium discoideum	24%	100%
Q641Z7	Rattus norvegicus	22%	100%
Q92485	Homo sapiens	23%	100%
V5DMV6	Trypanosoma cruzi	27%	100%