PNPLA domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Domain of unknown function (DUF3336)/Patatin-like phospholipase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB80_LEIBR

TriTrypDb:

LbrM.20.3200 , LBRM2903_200046000

Length:

570

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HB80

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB80

Function

Biological processes
Term	Name	Level	Count
GO:0006629	lipid metabolic process	3	13
GO:0008152	metabolic process	1	13
GO:0044238	primary metabolic process	2	13
GO:0071704	organic substance metabolic process	2	13
GO:0009056	catabolic process	2	2
GO:0016042	lipid catabolic process	4	2
GO:1901575	organic substance catabolic process	3	2

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	13
GO:0004806	triglyceride lipase activity	5	12
GO:0016298	lipase activity	4	12
GO:0016787	hydrolase activity	2	13
GO:0016788	hydrolase activity, acting on ester bonds	3	12
GO:0052689	carboxylic ester hydrolase activity	4	12

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.508
CLV_C14_Caspase3-7	74	78	PF00656	0.508
CLV_MEL_PAP_1	156	162	PF00089	0.327
CLV_NRD_NRD_1	133	135	PF00675	0.350
CLV_NRD_NRD_1	168	170	PF00675	0.368
CLV_NRD_NRD_1	322	324	PF00675	0.349
CLV_PCSK_KEX2_1	133	135	PF00082	0.336
CLV_PCSK_KEX2_1	168	170	PF00082	0.358
CLV_PCSK_KEX2_1	322	324	PF00082	0.322
CLV_PCSK_KEX2_1	564	566	PF00082	0.404
CLV_PCSK_PC1ET2_1	564	566	PF00082	0.404
CLV_PCSK_SKI1_1	175	179	PF00082	0.364
CLV_PCSK_SKI1_1	375	379	PF00082	0.390
CLV_PCSK_SKI1_1	419	423	PF00082	0.331
CLV_PCSK_SKI1_1	462	466	PF00082	0.273
CLV_PCSK_SKI1_1	497	501	PF00082	0.410
DEG_APCC_DBOX_1	434	442	PF00400	0.593
DEG_Nend_UBRbox_2	1	3	PF02207	0.430
DEG_SPOP_SBC_1	358	362	PF00917	0.492
DOC_CYCLIN_RxL_1	372	381	PF00134	0.557
DOC_CYCLIN_yCln2_LP_2	214	220	PF00134	0.332
DOC_CYCLIN_yCln2_LP_2	309	315	PF00134	0.373
DOC_MAPK_DCC_7	307	316	PF00069	0.397
DOC_MAPK_gen_1	322	331	PF00069	0.497
DOC_MAPK_gen_1	417	426	PF00069	0.587
DOC_MAPK_MEF2A_6	307	316	PF00069	0.536
DOC_MAPK_MEF2A_6	322	331	PF00069	0.438
DOC_MAPK_RevD_3	309	324	PF00069	0.469
DOC_PP1_RVXF_1	476	483	PF00149	0.627
DOC_PP2B_LxvP_1	309	312	PF13499	0.536
DOC_PP2B_LxvP_1	41	44	PF13499	0.650
DOC_SPAK_OSR1_1	425	429	PF12202	0.565
DOC_USP7_MATH_1	315	319	PF00917	0.538
DOC_USP7_MATH_1	358	362	PF00917	0.543
DOC_USP7_MATH_1	512	516	PF00917	0.540
DOC_USP7_MATH_1	68	72	PF00917	0.537
DOC_WW_Pin1_4	334	339	PF00397	0.522
DOC_WW_Pin1_4	349	354	PF00397	0.475
DOC_WW_Pin1_4	489	494	PF00397	0.666
DOC_WW_Pin1_4	522	527	PF00397	0.573
LIG_14-3-3_CanoR_1	133	139	PF00244	0.466
LIG_14-3-3_CanoR_1	550	556	PF00244	0.556
LIG_14-3-3_CterR_2	565	570	PF00244	0.503
LIG_Actin_WH2_2	93	109	PF00022	0.469
LIG_BRCT_BRCA1_1	199	203	PF00533	0.421
LIG_BRCT_BRCA1_1	27	31	PF00533	0.463
LIG_BRCT_BRCA1_1	87	91	PF00533	0.536
LIG_deltaCOP1_diTrp_1	264	270	PF00928	0.509
LIG_deltaCOP1_diTrp_1	459	465	PF00928	0.594
LIG_eIF4E_1	185	191	PF01652	0.469
LIG_FAT_LD_1	112	120	PF03623	0.469
LIG_FHA_1	172	178	PF00498	0.563
LIG_FHA_1	185	191	PF00498	0.449
LIG_FHA_1	274	280	PF00498	0.555
LIG_FHA_1	303	309	PF00498	0.455
LIG_FHA_1	372	378	PF00498	0.638
LIG_FHA_1	382	388	PF00498	0.572
LIG_FHA_2	290	296	PF00498	0.460
LIG_FHA_2	334	340	PF00498	0.532
LIG_FHA_2	496	502	PF00498	0.727
LIG_FHA_2	59	65	PF00498	0.472
LIG_FHA_2	70	76	PF00498	0.536
LIG_FHA_2	97	103	PF00498	0.536
LIG_GBD_Chelix_1	22	30	PF00786	0.392
LIG_GBD_Chelix_1	472	480	PF00786	0.371
LIG_LIR_Gen_1	148	157	PF02991	0.457
LIG_LIR_Gen_1	176	185	PF02991	0.515
LIG_LIR_Gen_1	514	524	PF02991	0.572
LIG_LIR_Nem_3	148	152	PF02991	0.457
LIG_LIR_Nem_3	179	185	PF02991	0.550
LIG_LIR_Nem_3	20	24	PF02991	0.412
LIG_LIR_Nem_3	264	270	PF02991	0.522
LIG_LIR_Nem_3	459	463	PF02991	0.580
LIG_LIR_Nem_3	514	520	PF02991	0.567
LIG_LIR_Nem_3	64	69	PF02991	0.451
LIG_LIR_Nem_3	88	93	PF02991	0.471
LIG_MLH1_MIPbox_1	87	91	PF16413	0.536
LIG_NRBOX	437	443	PF00104	0.594
LIG_NRBOX	475	481	PF00104	0.478
LIG_Pex14_2	422	426	PF04695	0.573
LIG_Pex14_2	465	469	PF04695	0.511
LIG_PTB_Apo_2	307	314	PF02174	0.465
LIG_SH2_CRK	149	153	PF00017	0.492
LIG_SH2_CRK	27	31	PF00017	0.392
LIG_SH2_CRK	485	489	PF00017	0.635
LIG_SH2_CRK	50	54	PF00017	0.536
LIG_SH2_NCK_1	485	489	PF00017	0.635
LIG_SH2_SRC	390	393	PF00017	0.554
LIG_SH2_STAP1	27	31	PF00017	0.392
LIG_SH2_STAP1	399	403	PF00017	0.644
LIG_SH2_STAP1	63	67	PF00017	0.477
LIG_SH2_STAT3	437	440	PF00017	0.538
LIG_SH2_STAT5	21	24	PF00017	0.403
LIG_SH2_STAT5	334	337	PF00017	0.469
LIG_SH2_STAT5	437	440	PF00017	0.628
LIG_SH2_STAT5	463	466	PF00017	0.587
LIG_SH2_STAT5	468	471	PF00017	0.567
LIG_SH2_STAT5	519	522	PF00017	0.602
LIG_SH2_STAT5	90	93	PF00017	0.508
LIG_SH3_3	276	282	PF00018	0.532
LIG_SUMO_SIM_par_1	101	108	PF11976	0.504
LIG_SUMO_SIM_par_1	281	287	PF11976	0.492
LIG_SUMO_SIM_par_1	39	45	PF11976	0.612
LIG_SUMO_SIM_par_1	532	537	PF11976	0.522
LIG_TRAF2_1	62	65	PF00917	0.508
LIG_TRAF2_1	99	102	PF00917	0.524
LIG_TYR_ITIM	25	30	PF00017	0.392
LIG_TYR_ITIM	483	488	PF00017	0.357
LIG_UBA3_1	115	121	PF00899	0.391
LIG_WRC_WIRS_1	496	501	PF05994	0.622
LIG_WRC_WIRS_1	90	95	PF05994	0.421
MOD_CK1_1	137	143	PF00069	0.392
MOD_CK1_1	148	154	PF00069	0.394
MOD_CK1_1	351	357	PF00069	0.302
MOD_CK1_1	360	366	PF00069	0.627
MOD_CK1_1	430	436	PF00069	0.386
MOD_CK1_1	492	498	PF00069	0.676
MOD_CK1_1	515	521	PF00069	0.469
MOD_CK1_1	525	531	PF00069	0.527
MOD_CK2_1	247	253	PF00069	0.418
MOD_CK2_1	294	300	PF00069	0.293
MOD_CK2_1	495	501	PF00069	0.674
MOD_CK2_1	58	64	PF00069	0.330
MOD_CK2_1	96	102	PF00069	0.403
MOD_GlcNHglycan	199	202	PF01048	0.389
MOD_GlcNHglycan	221	224	PF01048	0.378
MOD_GlcNHglycan	244	247	PF01048	0.373
MOD_GlcNHglycan	343	346	PF01048	0.326
MOD_GlcNHglycan	366	369	PF01048	0.654
MOD_GlcNHglycan	444	447	PF01048	0.600
MOD_GSK3_1	137	144	PF00069	0.397
MOD_GSK3_1	233	240	PF00069	0.458
MOD_GSK3_1	242	249	PF00069	0.437
MOD_GSK3_1	258	265	PF00069	0.264
MOD_GSK3_1	348	355	PF00069	0.344
MOD_GSK3_1	359	366	PF00069	0.589
MOD_GSK3_1	395	402	PF00069	0.421
MOD_GSK3_1	491	498	PF00069	0.657
MOD_GSK3_1	511	518	PF00069	0.297
MOD_GSK3_1	81	88	PF00069	0.393
MOD_LATS_1	132	138	PF00433	0.395
MOD_N-GLC_1	57	62	PF02516	0.293
MOD_NEK2_1	1	6	PF00069	0.510
MOD_NEK2_1	197	202	PF00069	0.400
MOD_NEK2_1	219	224	PF00069	0.379
MOD_NEK2_1	227	232	PF00069	0.467
MOD_NEK2_1	242	247	PF00069	0.321
MOD_NEK2_1	258	263	PF00069	0.311
MOD_NEK2_1	289	294	PF00069	0.379
MOD_NEK2_1	341	346	PF00069	0.345
MOD_NEK2_1	378	383	PF00069	0.463
MOD_NEK2_1	442	447	PF00069	0.618
MOD_NEK2_1	549	554	PF00069	0.421
MOD_NEK2_1	559	564	PF00069	0.416
MOD_PKA_2	381	387	PF00069	0.523
MOD_PKA_2	549	555	PF00069	0.435
MOD_Plk_1	1	7	PF00069	0.506
MOD_Plk_1	236	242	PF00069	0.335
MOD_Plk_1	294	300	PF00069	0.306
MOD_Plk_1	430	436	PF00069	0.395
MOD_Plk_1	85	91	PF00069	0.423
MOD_Plk_4	141	147	PF00069	0.337
MOD_Plk_4	148	154	PF00069	0.282
MOD_Plk_4	17	23	PF00069	0.357
MOD_Plk_4	227	233	PF00069	0.399
MOD_Plk_4	237	243	PF00069	0.404
MOD_Plk_4	247	253	PF00069	0.409
MOD_Plk_4	315	321	PF00069	0.300
MOD_Plk_4	352	358	PF00069	0.395
MOD_Plk_4	383	389	PF00069	0.516
MOD_Plk_4	512	518	PF00069	0.464
MOD_Plk_4	86	92	PF00069	0.423
MOD_ProDKin_1	334	340	PF00069	0.401
MOD_ProDKin_1	349	355	PF00069	0.335
MOD_ProDKin_1	489	495	PF00069	0.598
MOD_ProDKin_1	522	528	PF00069	0.474
TRG_DiLeu_BaEn_4	101	107	PF01217	0.421
TRG_DiLeu_BaLyEn_6	269	274	PF01217	0.380
TRG_DiLeu_BaLyEn_6	475	480	PF01217	0.541
TRG_ENDOCYTIC_2	149	152	PF00928	0.332
TRG_ENDOCYTIC_2	16	19	PF00928	0.461
TRG_ENDOCYTIC_2	27	30	PF00928	0.356
TRG_ENDOCYTIC_2	409	412	PF00928	0.668
TRG_ENDOCYTIC_2	485	488	PF00928	0.579
TRG_ENDOCYTIC_2	50	53	PF00928	0.492
TRG_ENDOCYTIC_2	519	522	PF00928	0.526
TRG_ENDOCYTIC_2	90	93	PF00928	0.367
TRG_ER_diArg_1	133	135	PF00400	0.440
TRG_ER_diArg_1	168	170	PF00400	0.554
TRG_ER_diArg_1	172	175	PF00400	0.492
TRG_ER_diArg_1	321	323	PF00400	0.435
TRG_ER_diArg_1	380	383	PF00400	0.508
TRG_NES_CRM1_1	416	431	PF08389	0.395
TRG_Pf-PMV_PEXEL_1	291	295	PF00026	0.444
TRG_Pf-PMV_PEXEL_1	98	102	PF00026	0.377

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P8P1	Leptomonas seymouri	27%	69%
A0A0N1P9M9	Leptomonas seymouri	57%	99%
A0A0S4JME6	Bodo saltans	28%	100%
A0A0S4JR20	Bodo saltans	28%	100%
A0A1X0P1R5	Trypanosomatidae	25%	77%
A0A1X0PA17	Trypanosomatidae	33%	100%
A0A3Q8INR2	Leishmania donovani	85%	100%
A0A3R7LQ57	Trypanosoma rangeli	26%	82%
A0A422N5R5	Trypanosoma rangeli	32%	100%
A1CRG6	Aspergillus clavatus (strain ATCC 1007 / CBS 513.65 / DSM 816 / NCTC 3887 / NRRL 1 / QM 1276 / 107)	24%	80%
A1D4C8	Neosartorya fischeri (strain ATCC 1020 / DSM 3700 / CBS 544.65 / FGSC A1164 / JCM 1740 / NRRL 181 / WB 181)	24%	80%
A2Q8F7	Aspergillus niger (strain CBS 513.88 / FGSC A1513)	24%	76%
A4HIE6	Leishmania braziliensis	29%	75%
A4IAC8	Leishmania infantum	85%	100%
A4R8V2	Magnaporthe oryzae (strain 70-15 / ATCC MYA-4617 / FGSC 8958)	24%	72%
A5DIR3	Meyerozyma guilliermondii (strain ATCC 6260 / CBS 566 / DSM 6381 / JCM 1539 / NBRC 10279 / NRRL Y-324)	26%	79%
A5DUA8	Lodderomyces elongisporus (strain ATCC 11503 / CBS 2605 / JCM 1781 / NBRC 1676 / NRRL YB-4239)	26%	70%
E9B0Y7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	27%	75%
E9B5F1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	85%	92%
O14115	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	90%
P0CT18	Magnaporthe oryzae (strain Y34)	24%	72%
Q0CUP0	Aspergillus terreus (strain NIH 2624 / FGSC A1156)	24%	80%
Q12043	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	24%	76%
Q1DXR6	Coccidioides immitis (strain RS)	25%	78%
Q2HA54	Chaetomium globosum (strain ATCC 6205 / CBS 148.51 / DSM 1962 / NBRC 6347 / NRRL 1970)	26%	67%
Q2UKE6	Aspergillus oryzae (strain ATCC 42149 / RIB 40)	28%	79%
Q4Q2I2	Leishmania major	83%	100%
Q4Q779	Leishmania major	27%	70%
Q4WJS4	Neosartorya fumigata (strain ATCC MYA-4609 / Af293 / CBS 101355 / FGSC A1100)	24%	80%
Q5AM72	Candida albicans (strain SC5314 / ATCC MYA-2876)	24%	67%
Q5BGC2	Emericella nidulans (strain FGSC A4 / ATCC 38163 / CBS 112.46 / NRRL 194 / M139)	26%	76%
Q6BXC8	Debaryomyces hansenii (strain ATCC 36239 / CBS 767 / BCRC 21394 / JCM 1990 / NBRC 0083 / IGC 2968)	25%	72%
Q6C8W4	Yarrowia lipolytica (strain CLIB 122 / E 150)	25%	70%
Q9LZA6	Arabidopsis thaliana	24%	69%
Q9M1I6	Arabidopsis thaliana	25%	71%
Q9Y7P3	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
V5BLA0	Trypanosoma cruzi	25%	98%
V5BW64	Trypanosoma cruzi	33%	100%