Adenosine kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Adenosine kinase

Gene product:

adenosine kinase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HB78_LEIBR

TriTrypDb:

LbrM.20.3180 , LBRM2903_200045800

Length:

388

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Cellular components
Term	Name	Level	Count
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	2
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HB78

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB78

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	10
GO:0006163	purine nucleotide metabolic process	5	10
GO:0006164	purine nucleotide biosynthetic process	6	10
GO:0006166	purine ribonucleoside salvage	5	10
GO:0006167	AMP biosynthetic process	8	10
GO:0006725	cellular aromatic compound metabolic process	3	10
GO:0006753	nucleoside phosphate metabolic process	4	10
GO:0006793	phosphorus metabolic process	3	10
GO:0006796	phosphate-containing compound metabolic process	4	10
GO:0006807	nitrogen compound metabolic process	2	10
GO:0008152	metabolic process	1	10
GO:0009058	biosynthetic process	2	10
GO:0009116	nucleoside metabolic process	4	10
GO:0009117	nucleotide metabolic process	5	10
GO:0009119	ribonucleoside metabolic process	5	10
GO:0009123	nucleoside monophosphate metabolic process	5	10
GO:0009124	nucleoside monophosphate biosynthetic process	6	10
GO:0009126	purine nucleoside monophosphate metabolic process	6	10
GO:0009127	purine nucleoside monophosphate biosynthetic process	7	10
GO:0009150	purine ribonucleotide metabolic process	6	10
GO:0009152	purine ribonucleotide biosynthetic process	7	10
GO:0009156	ribonucleoside monophosphate biosynthetic process	7	10
GO:0009161	ribonucleoside monophosphate metabolic process	6	10
GO:0009163	nucleoside biosynthetic process	5	10
GO:0009165	nucleotide biosynthetic process	6	10
GO:0009167	purine ribonucleoside monophosphate metabolic process	7	10
GO:0009168	purine ribonucleoside monophosphate biosynthetic process	8	10
GO:0009259	ribonucleotide metabolic process	5	10
GO:0009260	ribonucleotide biosynthetic process	6	10
GO:0009987	cellular process	1	10
GO:0016310	phosphorylation	5	10
GO:0018130	heterocycle biosynthetic process	4	10
GO:0019438	aromatic compound biosynthetic process	4	10
GO:0019637	organophosphate metabolic process	3	10
GO:0019693	ribose phosphate metabolic process	4	10
GO:0032261	purine nucleotide salvage	5	10
GO:0034404	nucleobase-containing small molecule biosynthetic process	4	10
GO:0034641	cellular nitrogen compound metabolic process	3	10
GO:0034654	nucleobase-containing compound biosynthetic process	4	10
GO:0042278	purine nucleoside metabolic process	5	10
GO:0042451	purine nucleoside biosynthetic process	6	10
GO:0042455	ribonucleoside biosynthetic process	6	10
GO:0043094	cellular metabolic compound salvage	3	10
GO:0043101	purine-containing compound salvage	4	10
GO:0043173	nucleotide salvage	4	10
GO:0043174	nucleoside salvage	4	10
GO:0044209	AMP salvage	7	10
GO:0044237	cellular metabolic process	2	10
GO:0044238	primary metabolic process	2	10
GO:0044249	cellular biosynthetic process	3	10
GO:0044271	cellular nitrogen compound biosynthetic process	4	10
GO:0044281	small molecule metabolic process	2	10
GO:0044283	small molecule biosynthetic process	3	10
GO:0046033	AMP metabolic process	7	10
GO:0046128	purine ribonucleoside metabolic process	6	10
GO:0046129	purine ribonucleoside biosynthetic process	7	10
GO:0046390	ribose phosphate biosynthetic process	5	10
GO:0046483	heterocycle metabolic process	3	10
GO:0055086	nucleobase-containing small molecule metabolic process	3	10
GO:0071704	organic substance metabolic process	2	10
GO:0072521	purine-containing compound metabolic process	4	10
GO:0072522	purine-containing compound biosynthetic process	5	10
GO:0090407	organophosphate biosynthetic process	4	10
GO:0106380	purine ribonucleotide salvage	6	10
GO:1901135	carbohydrate derivative metabolic process	3	10
GO:1901137	carbohydrate derivative biosynthetic process	4	10
GO:1901293	nucleoside phosphate biosynthetic process	5	10
GO:1901360	organic cyclic compound metabolic process	3	10
GO:1901362	organic cyclic compound biosynthetic process	4	10
GO:1901564	organonitrogen compound metabolic process	3	10
GO:1901566	organonitrogen compound biosynthetic process	4	10
GO:1901576	organic substance biosynthetic process	3	10
GO:1901657	glycosyl compound metabolic process	4	10
GO:1901659	glycosyl compound biosynthetic process	5	10
GO:0006144	purine nucleobase metabolic process	5	1
GO:0009112	nucleobase metabolic process	4	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	9
GO:0003824	catalytic activity	1	10
GO:0004001	adenosine kinase activity	5	10
GO:0005488	binding	1	9
GO:0005524	ATP binding	5	9
GO:0016301	kinase activity	4	10
GO:0016740	transferase activity	2	10
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	10
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	10
GO:0017076	purine nucleotide binding	4	9
GO:0019205	nucleobase-containing compound kinase activity	5	10
GO:0019206	nucleoside kinase activity	6	10
GO:0030554	adenyl nucleotide binding	5	9
GO:0032553	ribonucleotide binding	3	9
GO:0032555	purine ribonucleotide binding	4	9
GO:0032559	adenyl ribonucleotide binding	5	9
GO:0035639	purine ribonucleoside triphosphate binding	4	9
GO:0036094	small molecule binding	2	9
GO:0043167	ion binding	2	9
GO:0043168	anion binding	3	9
GO:0097159	organic cyclic compound binding	2	9
GO:0097367	carbohydrate derivative binding	2	9
GO:1901265	nucleoside phosphate binding	3	9
GO:1901363	heterocyclic compound binding	2	9

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	183	187	PF00656	0.451
CLV_NRD_NRD_1	262	264	PF00675	0.287
CLV_NRD_NRD_1	7	9	PF00675	0.695
CLV_PCSK_KEX2_1	262	264	PF00082	0.321
CLV_PCSK_KEX2_1	7	9	PF00082	0.574
CLV_PCSK_PC7_1	258	264	PF00082	0.161
CLV_PCSK_SKI1_1	108	112	PF00082	0.268
CLV_PCSK_SKI1_1	140	144	PF00082	0.217
DEG_APCC_DBOX_1	139	147	PF00400	0.417
DOC_CKS1_1	48	53	PF01111	0.336
DOC_PP2B_LxvP_1	206	209	PF13499	0.417
DOC_PP4_FxxP_1	20	23	PF00568	0.296
DOC_USP7_MATH_1	161	165	PF00917	0.498
DOC_USP7_MATH_1	214	218	PF00917	0.511
DOC_USP7_MATH_1	252	256	PF00917	0.548
DOC_USP7_MATH_1	362	366	PF00917	0.559
DOC_WW_Pin1_4	181	186	PF00397	0.417
DOC_WW_Pin1_4	47	52	PF00397	0.350
LIG_14-3-3_CanoR_1	273	277	PF00244	0.500
LIG_14-3-3_CanoR_1	7	17	PF00244	0.518
LIG_APCC_ABBA_1	222	227	PF00400	0.417
LIG_BRCT_BRCA1_1	211	215	PF00533	0.438
LIG_EVH1_1	308	312	PF00568	0.500
LIG_FHA_1	10	16	PF00498	0.407
LIG_FHA_1	157	163	PF00498	0.515
LIG_FHA_1	342	348	PF00498	0.447
LIG_FHA_1	377	383	PF00498	0.498
LIG_FHA_1	77	83	PF00498	0.488
LIG_FHA_2	28	34	PF00498	0.338
LIG_GBD_Chelix_1	329	337	PF00786	0.200
LIG_LIR_Apic_2	307	311	PF02991	0.500
LIG_LIR_Gen_1	101	111	PF02991	0.459
LIG_LIR_Gen_1	238	245	PF02991	0.518
LIG_LIR_Nem_3	101	106	PF02991	0.470
LIG_LIR_Nem_3	238	242	PF02991	0.481
LIG_PDZ_Class_2	383	388	PF00595	0.410
LIG_Pex14_1	244	248	PF04695	0.500
LIG_Pex14_2	328	332	PF04695	0.417
LIG_SH2_CRK	239	243	PF00017	0.500
LIG_SH2_SRC	173	176	PF00017	0.527
LIG_SH2_SRC	70	73	PF00017	0.463
LIG_SH2_STAT5	210	213	PF00017	0.417
LIG_SH2_STAT5	298	301	PF00017	0.500
LIG_SH2_STAT5	336	339	PF00017	0.437
LIG_SH2_STAT5	70	73	PF00017	0.463
LIG_SH2_STAT5	94	97	PF00017	0.514
LIG_SH3_1	306	312	PF00018	0.500
LIG_SH3_3	239	245	PF00018	0.500
LIG_SH3_3	253	259	PF00018	0.491
LIG_SH3_3	306	312	PF00018	0.500
LIG_SUMO_SIM_anti_2	14	19	PF11976	0.229
LIG_TRAF2_1	30	33	PF00917	0.312
LIG_TRAF2_1	314	317	PF00917	0.493
LIG_TYR_ITIM	237	242	PF00017	0.481
LIG_UBA3_1	56	65	PF00899	0.444
MOD_CK1_1	109	115	PF00069	0.447
MOD_CK1_1	11	17	PF00069	0.426
MOD_CK1_1	279	285	PF00069	0.503
MOD_CK1_1	294	300	PF00069	0.369
MOD_CK2_1	161	167	PF00069	0.463
MOD_CK2_1	27	33	PF00069	0.301
MOD_GlcNHglycan	108	111	PF01048	0.374
MOD_GlcNHglycan	163	166	PF01048	0.339
MOD_GlcNHglycan	249	253	PF01048	0.258
MOD_GlcNHglycan	351	354	PF01048	0.273
MOD_GlcNHglycan	364	367	PF01048	0.467
MOD_GSK3_1	248	255	PF00069	0.513
MOD_GSK3_1	272	279	PF00069	0.416
MOD_GSK3_1	9	16	PF00069	0.565
MOD_N-GLC_1	179	184	PF02516	0.161
MOD_N-GLC_1	375	380	PF02516	0.405
MOD_NEK2_1	178	183	PF00069	0.434
MOD_NEK2_1	248	253	PF00069	0.505
MOD_NEK2_1	267	272	PF00069	0.424
MOD_NEK2_2	2	7	PF00069	0.448
MOD_PKA_2	272	278	PF00069	0.518
MOD_Plk_1	112	118	PF00069	0.430
MOD_Plk_1	138	144	PF00069	0.434
MOD_Plk_1	248	254	PF00069	0.505
MOD_Plk_1	341	347	PF00069	0.447
MOD_Plk_4	13	19	PF00069	0.406
MOD_Plk_4	167	173	PF00069	0.452
MOD_Plk_4	252	258	PF00069	0.558
MOD_Plk_4	294	300	PF00069	0.432
MOD_Plk_4	342	348	PF00069	0.525
MOD_ProDKin_1	181	187	PF00069	0.417
MOD_ProDKin_1	47	53	PF00069	0.340
MOD_SUMO_rev_2	121	128	PF00179	0.459
TRG_DiLeu_BaLyEn_6	20	25	PF01217	0.274
TRG_ENDOCYTIC_2	194	197	PF00928	0.543
TRG_ENDOCYTIC_2	210	213	PF00928	0.477
TRG_ENDOCYTIC_2	239	242	PF00928	0.481
TRG_ER_diArg_1	262	265	PF00400	0.449
TRG_ER_diArg_1	284	287	PF00400	0.475
TRG_ER_diArg_1	6	8	PF00400	0.684

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5A6	Leptomonas seymouri	78%	100%
A0A0N0P8X0	Leptomonas seymouri	32%	100%
A0A0N1PDV7	Leptomonas seymouri	26%	100%
A0A0S4IRE7	Bodo saltans	33%	100%
A0A0S4JPW2	Bodo saltans	44%	100%
A0A1X0P296	Trypanosomatidae	33%	100%
A0A1X0PBE6	Trypanosomatidae	50%	100%
A0A3S5H7M6	Leishmania donovani	35%	100%
A0A3S7X8F0	Leishmania donovani	81%	100%
A0A422P4V2	Trypanosoma rangeli	37%	100%
A4HI44	Leishmania braziliensis	36%	100%
A4I5C0	Leishmania infantum	35%	100%
A4IAC6	Leishmania infantum	81%	100%
C9ZQQ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	34%	100%
C9ZQQ4	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	33%	100%
E9B0L7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	35%	100%
E9B5E9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
O49923	Physcomitrium patens	32%	100%
O93919	Schizophyllum commune	32%	100%
P47143	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
P55262	Cricetulus griseus	36%	100%
P55263	Homo sapiens	34%	100%
P55264	Mus musculus	36%	100%
P78825	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	32%	100%
Q4Q2I4	Leishmania major	81%	100%
Q4Q7L5	Leishmania major	34%	98%
Q54MB5	Dictyostelium discoideum	32%	100%
Q55480	Synechocystis sp. (strain PCC 6803 / Kazusa)	25%	100%
Q64640	Rattus norvegicus	38%	100%
Q9LZG0	Arabidopsis thaliana	33%	100%
Q9SF85	Arabidopsis thaliana	33%	100%
Q9TVW2	Toxoplasma gondii	32%	100%
V5B941	Trypanosoma cruzi	34%	100%
V5BLW1	Trypanosoma cruzi	47%	96%