Putative phosphatidylinositol 4-kinase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

phosphatidylinositol 4-kinase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB77_LEIBR

TriTrypDb:

LbrM.20.3170 , LBRM2903_200045700

Length:

611

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0016020	membrane	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB77

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB77

Function

Biological processes
Term	Name	Level	Count
GO:0006793	phosphorus metabolic process	3	11
GO:0006796	phosphate-containing compound metabolic process	4	11
GO:0007165	signal transduction	2	11
GO:0008152	metabolic process	1	11
GO:0009987	cellular process	1	11
GO:0016310	phosphorylation	5	11
GO:0035556	intracellular signal transduction	3	11
GO:0044237	cellular metabolic process	2	11
GO:0048015	phosphatidylinositol-mediated signaling	5	11
GO:0048017	inositol lipid-mediated signaling	4	11
GO:0050789	regulation of biological process	2	11
GO:0050794	regulation of cellular process	3	11
GO:0065007	biological regulation	1	11
GO:0006629	lipid metabolic process	3	4
GO:0006644	phospholipid metabolic process	4	4
GO:0006650	glycerophospholipid metabolic process	5	4
GO:0006661	phosphatidylinositol biosynthetic process	6	4
GO:0008610	lipid biosynthetic process	4	4
GO:0008654	phospholipid biosynthetic process	5	4
GO:0009058	biosynthetic process	2	4
GO:0019637	organophosphate metabolic process	3	4
GO:0044238	primary metabolic process	2	4
GO:0044249	cellular biosynthetic process	3	4
GO:0044255	cellular lipid metabolic process	3	4
GO:0045017	glycerolipid biosynthetic process	4	4
GO:0046474	glycerophospholipid biosynthetic process	5	4
GO:0046486	glycerolipid metabolic process	4	4
GO:0046488	phosphatidylinositol metabolic process	6	4
GO:0046854	phosphatidylinositol phosphate biosynthetic process	7	4
GO:0071704	organic substance metabolic process	2	4
GO:0090407	organophosphate biosynthetic process	4	4
GO:1901576	organic substance biosynthetic process	3	4

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0004430	1-phosphatidylinositol 4-kinase activity	6	8
GO:0016301	kinase activity	4	11
GO:0016740	transferase activity	2	11
GO:0016772	transferase activity, transferring phosphorus-containing groups	3	11
GO:0016773	phosphotransferase activity, alcohol group as acceptor	4	8
GO:0052742	phosphatidylinositol kinase activity	5	8

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	134	138	PF00656	0.764
CLV_C14_Caspase3-7	150	154	PF00656	0.399
CLV_C14_Caspase3-7	408	412	PF00656	0.306
CLV_C14_Caspase3-7	590	594	PF00656	0.381
CLV_NRD_NRD_1	13	15	PF00675	0.445
CLV_NRD_NRD_1	158	160	PF00675	0.436
CLV_NRD_NRD_1	192	194	PF00675	0.391
CLV_NRD_NRD_1	198	200	PF00675	0.405
CLV_NRD_NRD_1	335	337	PF00675	0.431
CLV_NRD_NRD_1	438	440	PF00675	0.452
CLV_NRD_NRD_1	598	600	PF00675	0.422
CLV_NRD_NRD_1	7	9	PF00675	0.529
CLV_PCSK_FUR_1	596	600	PF00082	0.428
CLV_PCSK_KEX2_1	13	15	PF00082	0.443
CLV_PCSK_KEX2_1	158	160	PF00082	0.376
CLV_PCSK_KEX2_1	198	200	PF00082	0.431
CLV_PCSK_KEX2_1	598	600	PF00082	0.435
CLV_PCSK_KEX2_1	7	9	PF00082	0.528
CLV_PCSK_SKI1_1	14	18	PF00082	0.486
CLV_PCSK_SKI1_1	22	26	PF00082	0.485
CLV_PCSK_SKI1_1	321	325	PF00082	0.380
CLV_PCSK_SKI1_1	414	418	PF00082	0.492
CLV_PCSK_SKI1_1	522	526	PF00082	0.229
DEG_APCC_DBOX_1	13	21	PF00400	0.474
DEG_APCC_DBOX_1	197	205	PF00400	0.461
DOC_CKS1_1	545	550	PF01111	0.361
DOC_CYCLIN_RxL_1	519	527	PF00134	0.200
DOC_CYCLIN_RxL_1	582	593	PF00134	0.254
DOC_CYCLIN_RxL_1	8	18	PF00134	0.492
DOC_CYCLIN_yClb1_LxF_4	181	187	PF00134	0.508
DOC_CYCLIN_yCln2_LP_2	284	290	PF00134	0.353
DOC_MAPK_gen_1	158	166	PF00069	0.412
DOC_MAPK_gen_1	462	471	PF00069	0.308
DOC_MAPK_gen_1	533	542	PF00069	0.297
DOC_MAPK_MEF2A_6	158	166	PF00069	0.434
DOC_MAPK_MEF2A_6	361	369	PF00069	0.311
DOC_MAPK_MEF2A_6	473	482	PF00069	0.380
DOC_MAPK_MEF2A_6	81	89	PF00069	0.362
DOC_PP1_RVXF_1	20	26	PF00149	0.281
DOC_PP1_RVXF_1	86	92	PF00149	0.347
DOC_PP2B_LxvP_1	268	271	PF13499	0.310
DOC_PP2B_LxvP_1	284	287	PF13499	0.312
DOC_SPAK_OSR1_1	274	278	PF12202	0.541
DOC_USP7_MATH_1	296	300	PF00917	0.678
DOC_USP7_MATH_1	541	545	PF00917	0.355
DOC_USP7_MATH_1	79	83	PF00917	0.406
DOC_USP7_MATH_2	145	151	PF00917	0.461
DOC_WW_Pin1_4	292	297	PF00397	0.716
DOC_WW_Pin1_4	310	315	PF00397	0.481
DOC_WW_Pin1_4	336	341	PF00397	0.521
DOC_WW_Pin1_4	486	491	PF00397	0.308
DOC_WW_Pin1_4	544	549	PF00397	0.354
LIG_14-3-3_CanoR_1	13	17	PF00244	0.448
LIG_14-3-3_CanoR_1	171	180	PF00244	0.439
LIG_14-3-3_CanoR_1	207	212	PF00244	0.367
LIG_14-3-3_CanoR_1	334	340	PF00244	0.434
LIG_Actin_WH2_2	313	330	PF00022	0.282
LIG_AP_GAE_1	146	152	PF02883	0.452
LIG_APCC_ABBA_1	164	169	PF00400	0.391
LIG_APCC_ABBAyCdc20_2	163	169	PF00400	0.388
LIG_BIR_III_2	311	315	PF00653	0.585
LIG_BRCT_BRCA1_1	496	500	PF00533	0.312
LIG_BRCT_BRCA1_1	514	518	PF00533	0.308
LIG_Clathr_ClatBox_1	477	481	PF01394	0.308
LIG_FHA_1	126	132	PF00498	0.582
LIG_FHA_1	381	387	PF00498	0.306
LIG_FHA_2	139	145	PF00498	0.718
LIG_FHA_2	217	223	PF00498	0.425
LIG_FHA_2	257	263	PF00498	0.383
LIG_FHA_2	392	398	PF00498	0.380
LIG_FHA_2	45	51	PF00498	0.415
LIG_FHA_2	59	65	PF00498	0.345
LIG_LIR_Gen_1	146	157	PF02991	0.403
LIG_LIR_Gen_1	481	490	PF02991	0.327
LIG_LIR_Gen_1	597	606	PF02991	0.409
LIG_LIR_Gen_1	82	92	PF02991	0.220
LIG_LIR_Nem_3	146	152	PF02991	0.711
LIG_LIR_Nem_3	420	426	PF02991	0.394
LIG_LIR_Nem_3	481	487	PF02991	0.327
LIG_LIR_Nem_3	515	521	PF02991	0.308
LIG_LIR_Nem_3	577	583	PF02991	0.375
LIG_LIR_Nem_3	597	603	PF02991	0.223
LIG_LIR_Nem_3	82	87	PF02991	0.446
LIG_PCNA_yPIPBox_3	198	212	PF02747	0.287
LIG_PCNA_yPIPBox_3	346	355	PF02747	0.471
LIG_PCNA_yPIPBox_3	68	81	PF02747	0.454
LIG_Pex14_2	373	377	PF04695	0.308
LIG_Pex14_2	482	486	PF04695	0.380
LIG_Rb_pABgroove_1	35	43	PF01858	0.510
LIG_SH2_CRK	389	393	PF00017	0.341
LIG_SH2_CRK	452	456	PF00017	0.327
LIG_SH2_CRK	521	525	PF00017	0.322
LIG_SH2_NCK_1	452	456	PF00017	0.313
LIG_SH2_PTP2	84	87	PF00017	0.219
LIG_SH2_STAP1	250	254	PF00017	0.458
LIG_SH2_STAP1	41	45	PF00017	0.506
LIG_SH2_STAP1	423	427	PF00017	0.200
LIG_SH2_STAP1	526	530	PF00017	0.446
LIG_SH2_STAP1	580	584	PF00017	0.460
LIG_SH2_STAT3	371	374	PF00017	0.322
LIG_SH2_STAT3	457	460	PF00017	0.327
LIG_SH2_STAT5	426	429	PF00017	0.398
LIG_SH2_STAT5	457	460	PF00017	0.379
LIG_SH2_STAT5	84	87	PF00017	0.436
LIG_SH3_2	287	292	PF14604	0.396
LIG_SH3_3	283	289	PF00018	0.510
LIG_SH3_3	484	490	PF00018	0.314
LIG_SH3_CIN85_PxpxPR_1	287	292	PF14604	0.396
LIG_SUMO_SIM_anti_2	505	511	PF11976	0.327
LIG_SUMO_SIM_anti_2	537	544	PF11976	0.323
LIG_SUMO_SIM_par_1	399	409	PF11976	0.413
LIG_SUMO_SIM_par_1	537	544	PF11976	0.282
LIG_TRAF2_1	231	234	PF00917	0.411
LIG_TRAF2_1	47	50	PF00917	0.414
LIG_TYR_ITIM	248	253	PF00017	0.452
LIG_TYR_ITIM	524	529	PF00017	0.419
LIG_UBA3_1	454	462	PF00899	0.362
LIG_WRC_WIRS_1	96	101	PF05994	0.587
LIG_WW_3	289	293	PF00397	0.431
MOD_CDK_SPK_2	544	549	PF00069	0.246
MOD_CK1_1	130	136	PF00069	0.679
MOD_CK1_1	139	145	PF00069	0.649
MOD_CK1_1	220	226	PF00069	0.488
MOD_CK1_1	421	427	PF00069	0.370
MOD_CK1_1	453	459	PF00069	0.277
MOD_CK1_1	544	550	PF00069	0.377
MOD_CK1_1	95	101	PF00069	0.502
MOD_CK2_1	12	18	PF00069	0.431
MOD_CK2_1	140	146	PF00069	0.715
MOD_CK2_1	216	222	PF00069	0.460
MOD_CK2_1	228	234	PF00069	0.373
MOD_CK2_1	236	242	PF00069	0.313
MOD_CK2_1	296	302	PF00069	0.677
MOD_CK2_1	44	50	PF00069	0.424
MOD_Cter_Amidation	191	194	PF01082	0.295
MOD_DYRK1A_RPxSP_1	292	296	PF00069	0.475
MOD_GlcNHglycan	133	136	PF01048	0.741
MOD_GlcNHglycan	28	31	PF01048	0.565
MOD_GlcNHglycan	496	499	PF01048	0.304
MOD_GlcNHglycan	590	593	PF01048	0.479
MOD_GSK3_1	125	132	PF00069	0.666
MOD_GSK3_1	136	143	PF00069	0.676
MOD_GSK3_1	169	176	PF00069	0.420
MOD_GSK3_1	216	223	PF00069	0.495
MOD_GSK3_1	233	240	PF00069	0.289
MOD_GSK3_1	292	299	PF00069	0.524
MOD_GSK3_1	40	47	PF00069	0.474
MOD_GSK3_1	414	421	PF00069	0.513
MOD_GSK3_1	95	102	PF00069	0.488
MOD_LATS_1	113	119	PF00433	0.459
MOD_N-GLC_1	178	183	PF02516	0.389
MOD_N-GLC_1	228	233	PF02516	0.492
MOD_N-GLC_1	26	31	PF02516	0.537
MOD_N-GLC_2	346	348	PF02516	0.258
MOD_NEK2_1	173	178	PF00069	0.403
MOD_NEK2_1	40	45	PF00069	0.458
MOD_NEK2_1	445	450	PF00069	0.312
MOD_NEK2_1	485	490	PF00069	0.327
MOD_NEK2_1	53	58	PF00069	0.334
MOD_NEK2_1	587	592	PF00069	0.413
MOD_NEK2_1	99	104	PF00069	0.612
MOD_NEK2_2	380	385	PF00069	0.452
MOD_NEK2_2	79	84	PF00069	0.353
MOD_PIKK_1	414	420	PF00454	0.526
MOD_PIKK_1	500	506	PF00454	0.308
MOD_PKA_1	414	420	PF00069	0.492
MOD_PKA_2	12	18	PF00069	0.462
MOD_PKA_2	335	341	PF00069	0.442
MOD_PKB_1	276	284	PF00069	0.429
MOD_Plk_1	152	158	PF00069	0.564
MOD_Plk_1	169	175	PF00069	0.475
MOD_Plk_1	228	234	PF00069	0.420
MOD_Plk_1	405	411	PF00069	0.261
MOD_Plk_1	432	438	PF00069	0.419
MOD_Plk_2-3	147	153	PF00069	0.552
MOD_Plk_2-3	256	262	PF00069	0.421
MOD_Plk_2-3	406	412	PF00069	0.380
MOD_Plk_2-3	573	579	PF00069	0.417
MOD_Plk_4	152	158	PF00069	0.595
MOD_Plk_4	207	213	PF00069	0.355
MOD_Plk_4	233	239	PF00069	0.419
MOD_Plk_4	296	302	PF00069	0.632
MOD_Plk_4	418	424	PF00069	0.382
MOD_Plk_4	432	438	PF00069	0.355
MOD_Plk_4	450	456	PF00069	0.167
MOD_Plk_4	473	479	PF00069	0.463
MOD_Plk_4	541	547	PF00069	0.345
MOD_ProDKin_1	292	298	PF00069	0.720
MOD_ProDKin_1	310	316	PF00069	0.467
MOD_ProDKin_1	336	342	PF00069	0.514
MOD_ProDKin_1	486	492	PF00069	0.308
MOD_ProDKin_1	544	550	PF00069	0.358
TRG_ENDOCYTIC_2	250	253	PF00928	0.421
TRG_ENDOCYTIC_2	389	392	PF00928	0.327
TRG_ENDOCYTIC_2	452	455	PF00928	0.308
TRG_ENDOCYTIC_2	520	523	PF00928	0.308
TRG_ENDOCYTIC_2	526	529	PF00928	0.308
TRG_ENDOCYTIC_2	600	603	PF00928	0.405
TRG_ENDOCYTIC_2	84	87	PF00928	0.219
TRG_ER_diArg_1	157	159	PF00400	0.386
TRG_ER_diArg_1	197	199	PF00400	0.451
TRG_ER_diArg_1	267	270	PF00400	0.466
TRG_ER_diArg_1	275	278	PF00400	0.490
TRG_ER_diArg_1	566	569	PF00400	0.377
TRG_ER_diArg_1	595	598	PF00400	0.433
TRG_ER_diArg_1	7	9	PF00400	0.484
TRG_NES_CRM1_1	50	64	PF08389	0.316
TRG_Pf-PMV_PEXEL_1	14	18	PF00026	0.361
TRG_Pf-PMV_PEXEL_1	202	206	PF00026	0.394
TRG_Pf-PMV_PEXEL_1	38	42	PF00026	0.519
TRG_Pf-PMV_PEXEL_1	522	527	PF00026	0.434

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I2J4	Leptomonas seymouri	71%	97%
A0A0S4JIN0	Bodo saltans	47%	100%
A0A1X0PA54	Trypanosomatidae	54%	100%
A0A3S7X8H7	Leishmania donovani	87%	100%
A0A422N5M8	Trypanosoma rangeli	51%	100%
A4IAC5	Leishmania infantum	87%	100%
A4IID4	Xenopus tropicalis	28%	76%
C9ZLW7	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	50%	100%
E9B5E8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q2I5	Leishmania major	85%	100%
Q6GN16	Xenopus laevis	28%	76%