HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB76_LEIBR

TriTrypDb:

LbrM.20.3160 , LBRM2903_200045600

Length:

878

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 7
NetGPI	no	yes: 0, no: 7

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005929	cilium	4	1
GO:0042995	cell projection	2	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0110165	cellular anatomical entity	1	2
GO:0120025	plasma membrane bounded cell projection	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HB76

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB76

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	244	246	PF00675	0.600
CLV_NRD_NRD_1	740	742	PF00675	0.645
CLV_NRD_NRD_1	791	793	PF00675	0.627
CLV_PCSK_KEX2_1	740	742	PF00082	0.648
CLV_PCSK_KEX2_1	795	797	PF00082	0.636
CLV_PCSK_PC1ET2_1	795	797	PF00082	0.640
CLV_PCSK_SKI1_1	10	14	PF00082	0.380
CLV_PCSK_SKI1_1	226	230	PF00082	0.215
CLV_PCSK_SKI1_1	259	263	PF00082	0.552
CLV_PCSK_SKI1_1	343	347	PF00082	0.530
CLV_PCSK_SKI1_1	376	380	PF00082	0.641
CLV_PCSK_SKI1_1	51	55	PF00082	0.332
CLV_PCSK_SKI1_1	557	561	PF00082	0.655
CLV_Separin_Metazoa	21	25	PF03568	0.617
CLV_Separin_Metazoa	512	516	PF03568	0.354
DEG_APCC_DBOX_1	262	270	PF00400	0.298
DEG_APCC_DBOX_1	50	58	PF00400	0.479
DEG_MDM2_SWIB_1	469	476	PF02201	0.478
DEG_SCF_FBW7_1	551	558	PF00400	0.411
DEG_SCF_FBW7_1	98	103	PF00400	0.609
DOC_CKS1_1	552	557	PF01111	0.409
DOC_CYCLIN_RxL_1	48	55	PF00134	0.481
DOC_CYCLIN_RxL_1	737	748	PF00134	0.417
DOC_CYCLIN_yCln2_LP_2	522	528	PF00134	0.359
DOC_MAPK_gen_1	105	115	PF00069	0.614
DOC_MAPK_gen_1	740	746	PF00069	0.390
DOC_PP1_RVXF_1	642	649	PF00149	0.378
DOC_PP1_RVXF_1	8	14	PF00149	0.582
DOC_PP2B_LxvP_1	514	517	PF13499	0.460
DOC_PP2B_LxvP_1	768	771	PF13499	0.389
DOC_PP2B_LxvP_1	871	874	PF13499	0.485
DOC_PP4_FxxP_1	195	198	PF00568	0.579
DOC_USP7_MATH_1	100	104	PF00917	0.573
DOC_USP7_MATH_1	537	541	PF00917	0.418
DOC_USP7_MATH_1	555	559	PF00917	0.426
DOC_USP7_MATH_1	580	584	PF00917	0.493
DOC_USP7_MATH_1	626	630	PF00917	0.443
DOC_USP7_MATH_1	666	670	PF00917	0.292
DOC_USP7_MATH_1	700	704	PF00917	0.495
DOC_USP7_MATH_1	745	749	PF00917	0.368
DOC_USP7_MATH_1	80	84	PF00917	0.739
DOC_WW_Pin1_4	114	119	PF00397	0.574
DOC_WW_Pin1_4	301	306	PF00397	0.487
DOC_WW_Pin1_4	447	452	PF00397	0.590
DOC_WW_Pin1_4	503	508	PF00397	0.357
DOC_WW_Pin1_4	551	556	PF00397	0.481
DOC_WW_Pin1_4	843	848	PF00397	0.375
DOC_WW_Pin1_4	96	101	PF00397	0.608
LIG_14-3-3_CanoR_1	108	115	PF00244	0.639
LIG_14-3-3_CanoR_1	145	155	PF00244	0.579
LIG_14-3-3_CanoR_1	175	183	PF00244	0.590
LIG_14-3-3_CanoR_1	197	205	PF00244	0.621
LIG_14-3-3_CanoR_1	226	235	PF00244	0.272
LIG_14-3-3_CanoR_1	252	258	PF00244	0.378
LIG_14-3-3_CanoR_1	27	31	PF00244	0.525
LIG_14-3-3_CanoR_1	343	352	PF00244	0.307
LIG_14-3-3_CanoR_1	376	381	PF00244	0.443
LIG_14-3-3_CanoR_1	557	562	PF00244	0.468
LIG_14-3-3_CanoR_1	731	739	PF00244	0.395
LIG_14-3-3_CanoR_1	803	811	PF00244	0.504
LIG_14-3-3_CanoR_1	837	845	PF00244	0.425
LIG_14-3-3_CanoR_1	85	90	PF00244	0.705
LIG_Actin_WH2_2	8	26	PF00022	0.580
LIG_APCC_ABBA_1	330	335	PF00400	0.470
LIG_BRCT_BRCA1_1	128	132	PF00533	0.595
LIG_BRCT_BRCA1_1	430	434	PF00533	0.521
LIG_BRCT_BRCA1_1	465	469	PF00533	0.375
LIG_BRCT_BRCA1_1	549	553	PF00533	0.298
LIG_BRCT_BRCA1_1	749	753	PF00533	0.343
LIG_BRCT_BRCA1_1	83	87	PF00533	0.710
LIG_CaM_NSCaTE_8	33	40	PF13499	0.562
LIG_CORNRBOX	227	235	PF00104	0.221
LIG_deltaCOP1_diTrp_1	31	36	PF00928	0.560
LIG_deltaCOP1_diTrp_1	4	13	PF00928	0.559
LIG_EH1_1	229	237	PF00400	0.383
LIG_EVH1_1	825	829	PF00568	0.474
LIG_FHA_1	183	189	PF00498	0.587
LIG_FHA_1	227	233	PF00498	0.270
LIG_FHA_1	236	242	PF00498	0.345
LIG_FHA_1	248	254	PF00498	0.387
LIG_FHA_1	273	279	PF00498	0.390
LIG_FHA_1	317	323	PF00498	0.402
LIG_FHA_1	344	350	PF00498	0.256
LIG_FHA_1	414	420	PF00498	0.536
LIG_FHA_1	546	552	PF00498	0.385
LIG_FHA_1	750	756	PF00498	0.372
LIG_FHA_1	803	809	PF00498	0.461
LIG_FHA_2	541	547	PF00498	0.387
LIG_FHA_2	570	576	PF00498	0.522
LIG_GBD_Chelix_1	227	235	PF00786	0.342
LIG_LIR_Apic_2	193	198	PF02991	0.581
LIG_LIR_Gen_1	129	139	PF02991	0.565
LIG_LIR_Gen_1	149	157	PF02991	0.495
LIG_LIR_Gen_1	31	40	PF02991	0.552
LIG_LIR_Gen_1	315	326	PF02991	0.378
LIG_LIR_Gen_1	374	385	PF02991	0.394
LIG_LIR_Gen_1	471	477	PF02991	0.482
LIG_LIR_Gen_1	669	677	PF02991	0.395
LIG_LIR_Gen_1	712	721	PF02991	0.355
LIG_LIR_Gen_1	775	786	PF02991	0.436
LIG_LIR_Gen_1	813	820	PF02991	0.354
LIG_LIR_Gen_1	848	859	PF02991	0.467
LIG_LIR_Nem_3	129	135	PF02991	0.535
LIG_LIR_Nem_3	149	155	PF02991	0.448
LIG_LIR_Nem_3	255	261	PF02991	0.352
LIG_LIR_Nem_3	31	36	PF02991	0.520
LIG_LIR_Nem_3	315	321	PF02991	0.388
LIG_LIR_Nem_3	374	380	PF02991	0.425
LIG_LIR_Nem_3	386	391	PF02991	0.436
LIG_LIR_Nem_3	471	476	PF02991	0.492
LIG_LIR_Nem_3	550	556	PF02991	0.394
LIG_LIR_Nem_3	6	12	PF02991	0.552
LIG_LIR_Nem_3	669	673	PF02991	0.380
LIG_LIR_Nem_3	712	716	PF02991	0.361
LIG_LIR_Nem_3	775	781	PF02991	0.444
LIG_LIR_Nem_3	813	817	PF02991	0.347
LIG_LIR_Nem_3	840	845	PF02991	0.473
LIG_LIR_Nem_3	848	854	PF02991	0.478
LIG_LYPXL_S_1	387	391	PF13949	0.690
LIG_LYPXL_yS_3	388	391	PF13949	0.486
LIG_MLH1_MIPbox_1	465	469	PF16413	0.375
LIG_MYND_2	381	385	PF01753	0.350
LIG_PAM2_1	658	670	PF00658	0.400
LIG_Pex14_1	9	13	PF04695	0.537
LIG_Pex14_2	195	199	PF04695	0.575
LIG_Pex14_2	469	473	PF04695	0.474
LIG_SH2_CRK	152	156	PF00017	0.505
LIG_SH2_CRK	814	818	PF00017	0.348
LIG_SH2_CRK	842	846	PF00017	0.425
LIG_SH2_PTP2	377	380	PF00017	0.320
LIG_SH2_STAP1	190	194	PF00017	0.475
LIG_SH2_STAP1	333	337	PF00017	0.404
LIG_SH2_STAP1	363	367	PF00017	0.306
LIG_SH2_STAT3	339	342	PF00017	0.366
LIG_SH2_STAT5	152	155	PF00017	0.498
LIG_SH2_STAT5	190	193	PF00017	0.540
LIG_SH2_STAT5	372	375	PF00017	0.409
LIG_SH2_STAT5	377	380	PF00017	0.422
LIG_SH2_STAT5	670	673	PF00017	0.334
LIG_SH3_2	736	741	PF14604	0.419
LIG_SH3_3	308	314	PF00018	0.492
LIG_SH3_3	334	340	PF00018	0.419
LIG_SH3_3	375	381	PF00018	0.404
LIG_SH3_3	513	519	PF00018	0.444
LIG_SH3_3	733	739	PF00018	0.400
LIG_SH3_3	820	826	PF00018	0.436
LIG_SUMO_SIM_anti_2	458	464	PF11976	0.361
LIG_SUMO_SIM_anti_2	548	554	PF11976	0.302
LIG_TRAF2_1	799	802	PF00917	0.355
LIG_UBA3_1	240	246	PF00899	0.473
LIG_WRC_WIRS_1	132	137	PF05994	0.463
LIG_WRC_WIRS_1	349	354	PF05994	0.352
LIG_WRC_WIRS_1	701	706	PF05994	0.492
LIG_WRC_WIRS_1	710	715	PF05994	0.318
LIG_WW_2	826	829	PF00397	0.479
MOD_CDK_SPxK_1	551	557	PF00069	0.411
MOD_CK1_1	103	109	PF00069	0.784
MOD_CK1_1	114	120	PF00069	0.639
MOD_CK1_1	312	318	PF00069	0.392
MOD_CK1_1	426	432	PF00069	0.454
MOD_CK1_1	540	546	PF00069	0.482
MOD_CK1_1	566	572	PF00069	0.546
MOD_CK1_1	702	708	PF00069	0.490
MOD_CK1_1	747	753	PF00069	0.448
MOD_CK1_1	81	87	PF00069	0.712
MOD_CK1_1	821	827	PF00069	0.435
MOD_CK1_1	93	99	PF00069	0.626
MOD_CK2_1	15	21	PF00069	0.590
MOD_CK2_1	348	354	PF00069	0.434
MOD_CK2_1	408	414	PF00069	0.389
MOD_CK2_1	447	453	PF00069	0.505
MOD_CK2_1	471	477	PF00069	0.501
MOD_CK2_1	506	512	PF00069	0.434
MOD_CK2_1	569	575	PF00069	0.483
MOD_CK2_1	807	813	PF00069	0.486
MOD_CK2_1	843	849	PF00069	0.464
MOD_GlcNHglycan	105	108	PF01048	0.527
MOD_GlcNHglycan	109	112	PF01048	0.494
MOD_GlcNHglycan	121	124	PF01048	0.372
MOD_GlcNHglycan	168	171	PF01048	0.477
MOD_GlcNHglycan	176	179	PF01048	0.390
MOD_GlcNHglycan	38	41	PF01048	0.370
MOD_GlcNHglycan	430	433	PF01048	0.645
MOD_GlcNHglycan	540	543	PF01048	0.696
MOD_GlcNHglycan	578	581	PF01048	0.692
MOD_GlcNHglycan	628	631	PF01048	0.675
MOD_GlcNHglycan	636	639	PF01048	0.560
MOD_GlcNHglycan	651	654	PF01048	0.578
MOD_GlcNHglycan	687	690	PF01048	0.768
MOD_GlcNHglycan	747	750	PF01048	0.601
MOD_GlcNHglycan	833	836	PF01048	0.592
MOD_GSK3_1	107	114	PF00069	0.715
MOD_GSK3_1	126	133	PF00069	0.586
MOD_GSK3_1	146	153	PF00069	0.434
MOD_GSK3_1	184	191	PF00069	0.578
MOD_GSK3_1	247	254	PF00069	0.436
MOD_GSK3_1	312	319	PF00069	0.404
MOD_GSK3_1	413	420	PF00069	0.589
MOD_GSK3_1	464	471	PF00069	0.501
MOD_GSK3_1	547	554	PF00069	0.512
MOD_GSK3_1	576	583	PF00069	0.551
MOD_GSK3_1	615	622	PF00069	0.538
MOD_GSK3_1	679	686	PF00069	0.460
MOD_GSK3_1	744	751	PF00069	0.465
MOD_GSK3_1	81	88	PF00069	0.722
MOD_GSK3_1	837	844	PF00069	0.449
MOD_GSK3_1	90	97	PF00069	0.751
MOD_GSK3_1	99	106	PF00069	0.619
MOD_NEK2_1	113	118	PF00069	0.647
MOD_NEK2_1	184	189	PF00069	0.677
MOD_NEK2_1	235	240	PF00069	0.363
MOD_NEK2_1	262	267	PF00069	0.381
MOD_NEK2_1	299	304	PF00069	0.448
MOD_NEK2_1	36	41	PF00069	0.528
MOD_NEK2_1	42	47	PF00069	0.550
MOD_NEK2_1	463	468	PF00069	0.396
MOD_NEK2_1	485	490	PF00069	0.593
MOD_NEK2_1	613	618	PF00069	0.345
MOD_NEK2_1	744	749	PF00069	0.430
MOD_NEK2_1	807	812	PF00069	0.452
MOD_NEK2_1	94	99	PF00069	0.702
MOD_NEK2_2	383	388	PF00069	0.424
MOD_NEK2_2	464	469	PF00069	0.427
MOD_PIKK_1	146	152	PF00454	0.573
MOD_PIKK_1	198	204	PF00454	0.648
MOD_PIKK_1	206	212	PF00454	0.644
MOD_PIKK_1	338	344	PF00454	0.321
MOD_PIKK_1	426	432	PF00454	0.405
MOD_PIKK_1	485	491	PF00454	0.404
MOD_PIKK_1	613	619	PF00454	0.398
MOD_PIKK_1	837	843	PF00454	0.445
MOD_PKA_1	794	800	PF00069	0.462
MOD_PKA_2	107	113	PF00069	0.660
MOD_PKA_2	150	156	PF00069	0.596
MOD_PKA_2	166	172	PF00069	0.636
MOD_PKA_2	174	180	PF00069	0.649
MOD_PKA_2	251	257	PF00069	0.351
MOD_PKA_2	26	32	PF00069	0.525
MOD_PKA_2	262	268	PF00069	0.329
MOD_PKA_2	730	736	PF00069	0.402
MOD_PKA_2	802	808	PF00069	0.464
MOD_PKA_2	831	837	PF00069	0.393
MOD_Plk_1	4	10	PF00069	0.624
MOD_Plk_1	413	419	PF00069	0.449
MOD_Plk_1	471	477	PF00069	0.501
MOD_Plk_1	566	572	PF00069	0.409
MOD_Plk_4	131	137	PF00069	0.463
MOD_Plk_4	306	312	PF00069	0.437
MOD_Plk_4	408	414	PF00069	0.441
MOD_Plk_4	464	470	PF00069	0.438
MOD_Plk_4	547	553	PF00069	0.325
MOD_Plk_4	692	698	PF00069	0.531
MOD_Plk_4	719	725	PF00069	0.333
MOD_Plk_4	758	764	PF00069	0.386
MOD_ProDKin_1	114	120	PF00069	0.574
MOD_ProDKin_1	301	307	PF00069	0.483
MOD_ProDKin_1	447	453	PF00069	0.590
MOD_ProDKin_1	503	509	PF00069	0.365
MOD_ProDKin_1	551	557	PF00069	0.487
MOD_ProDKin_1	843	849	PF00069	0.377
MOD_ProDKin_1	96	102	PF00069	0.608
MOD_SUMO_for_1	442	445	PF00179	0.393
TRG_DiLeu_BaEn_1	179	184	PF01217	0.670
TRG_DiLeu_BaLyEn_6	672	677	PF01217	0.307
TRG_DiLeu_BaLyEn_6	7	12	PF01217	0.590
TRG_ENDOCYTIC_2	152	155	PF00928	0.498
TRG_ENDOCYTIC_2	258	261	PF00928	0.353
TRG_ENDOCYTIC_2	377	380	PF00928	0.422
TRG_ENDOCYTIC_2	388	391	PF00928	0.472
TRG_ENDOCYTIC_2	670	673	PF00928	0.386
TRG_ENDOCYTIC_2	778	781	PF00928	0.482
TRG_ENDOCYTIC_2	814	817	PF00928	0.347
TRG_ENDOCYTIC_2	842	845	PF00928	0.456
TRG_ER_diArg_1	739	741	PF00400	0.448
TRG_NES_CRM1_1	137	150	PF08389	0.562
TRG_NES_CRM1_1	320	336	PF08389	0.358
TRG_NES_CRM1_1	41	55	PF08389	0.517
TRG_NLS_MonoCore_2	792	797	PF00514	0.372
TRG_NLS_MonoExtC_3	792	798	PF00514	0.372
TRG_NLS_MonoExtN_4	792	797	PF00514	0.452
TRG_Pf-PMV_PEXEL_1	51	55	PF00026	0.283
TRG_Pf-PMV_PEXEL_1	557	562	PF00026	0.656

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P4W8	Leptomonas seymouri	43%	100%
A0A3S5H7X7	Leishmania donovani	74%	100%
A4IAC4	Leishmania infantum	75%	100%
C9ZLW8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	25%	100%
E9B5E7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	75%	100%
Q4Q2I6	Leishmania major	74%	99%