Titin-like

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Titin-like

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB75_LEIBR

TriTrypDb:

LbrM.20.3150 , LBRM2903_200045500

Length:

1049

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	yes	yes: 5, no: 0
NetGPI	no	yes: 0, no: 5

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB75

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB75

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	636	640	PF00656	0.441
CLV_C14_Caspase3-7	660	664	PF00656	0.434
CLV_C14_Caspase3-7	832	836	PF00656	0.559
CLV_MEL_PAP_1	581	587	PF00089	0.507
CLV_NRD_NRD_1	1030	1032	PF00675	0.705
CLV_NRD_NRD_1	139	141	PF00675	0.573
CLV_NRD_NRD_1	305	307	PF00675	0.449
CLV_NRD_NRD_1	402	404	PF00675	0.575
CLV_NRD_NRD_1	407	409	PF00675	0.528
CLV_NRD_NRD_1	455	457	PF00675	0.500
CLV_NRD_NRD_1	469	471	PF00675	0.494
CLV_NRD_NRD_1	475	477	PF00675	0.482
CLV_NRD_NRD_1	480	482	PF00675	0.540
CLV_NRD_NRD_1	498	500	PF00675	0.364
CLV_NRD_NRD_1	512	514	PF00675	0.414
CLV_NRD_NRD_1	575	577	PF00675	0.359
CLV_NRD_NRD_1	609	611	PF00675	0.376
CLV_NRD_NRD_1	936	938	PF00675	0.573
CLV_NRD_NRD_1	985	987	PF00675	0.530
CLV_PCSK_KEX2_1	1030	1032	PF00082	0.720
CLV_PCSK_KEX2_1	139	141	PF00082	0.573
CLV_PCSK_KEX2_1	402	404	PF00082	0.575
CLV_PCSK_KEX2_1	455	457	PF00082	0.500
CLV_PCSK_KEX2_1	469	471	PF00082	0.494
CLV_PCSK_KEX2_1	475	477	PF00082	0.482
CLV_PCSK_KEX2_1	480	482	PF00082	0.540
CLV_PCSK_KEX2_1	562	564	PF00082	0.403
CLV_PCSK_KEX2_1	575	577	PF00082	0.330
CLV_PCSK_KEX2_1	655	657	PF00082	0.371
CLV_PCSK_KEX2_1	936	938	PF00082	0.573
CLV_PCSK_KEX2_1	985	987	PF00082	0.530
CLV_PCSK_PC1ET2_1	562	564	PF00082	0.368
CLV_PCSK_PC1ET2_1	655	657	PF00082	0.371
CLV_PCSK_PC7_1	476	482	PF00082	0.442
CLV_PCSK_PC7_1	932	938	PF00082	0.566
CLV_PCSK_SKI1_1	13	17	PF00082	0.530
CLV_PCSK_SKI1_1	170	174	PF00082	0.459
CLV_PCSK_SKI1_1	208	212	PF00082	0.583
CLV_PCSK_SKI1_1	514	518	PF00082	0.495
CLV_PCSK_SKI1_1	655	659	PF00082	0.479
CLV_PCSK_SKI1_1	840	844	PF00082	0.593
CLV_PCSK_SKI1_1	986	990	PF00082	0.544
CLV_Separin_Metazoa	149	153	PF03568	0.439
DEG_APCC_DBOX_1	12	20	PF00400	0.467
DEG_SPOP_SBC_1	258	262	PF00917	0.621
DEG_SPOP_SBC_1	991	995	PF00917	0.556
DOC_ANK_TNKS_1	382	389	PF00023	0.464
DOC_CKS1_1	945	950	PF01111	0.541
DOC_CYCLIN_yCln2_LP_2	61	67	PF00134	0.644
DOC_MAPK_DCC_7	100	108	PF00069	0.501
DOC_MAPK_gen_1	575	581	PF00069	0.354
DOC_MAPK_gen_1	985	991	PF00069	0.534
DOC_MAPK_MEF2A_6	100	108	PF00069	0.467
DOC_MAPK_MEF2A_6	282	290	PF00069	0.425
DOC_MAPK_MEF2A_6	672	680	PF00069	0.348
DOC_MAPK_MEF2A_6	81	89	PF00069	0.709
DOC_MIT_MIM_1	668	676	PF04212	0.343
DOC_PP2B_LxvP_1	61	64	PF13499	0.649
DOC_PP2B_LxvP_1	743	746	PF13499	0.552
DOC_PP2B_LxvP_1	957	960	PF13499	0.565
DOC_PP4_FxxP_1	981	984	PF00568	0.549
DOC_USP7_MATH_1	1014	1018	PF00917	0.556
DOC_USP7_MATH_1	206	210	PF00917	0.656
DOC_USP7_MATH_1	218	222	PF00917	0.614
DOC_USP7_MATH_1	308	312	PF00917	0.525
DOC_USP7_MATH_1	461	465	PF00917	0.461
DOC_USP7_MATH_1	622	626	PF00917	0.512
DOC_USP7_MATH_1	633	637	PF00917	0.438
DOC_USP7_MATH_1	642	646	PF00917	0.341
DOC_USP7_MATH_1	695	699	PF00917	0.508
DOC_USP7_MATH_1	717	721	PF00917	0.600
DOC_USP7_MATH_1	973	977	PF00917	0.537
DOC_USP7_UBL2_3	186	190	PF12436	0.409
DOC_USP7_UBL2_3	756	760	PF12436	0.562
DOC_USP7_UBL2_3	780	784	PF12436	0.496
DOC_WW_Pin1_4	1010	1015	PF00397	0.569
DOC_WW_Pin1_4	1022	1027	PF00397	0.592
DOC_WW_Pin1_4	238	243	PF00397	0.597
DOC_WW_Pin1_4	25	30	PF00397	0.642
DOC_WW_Pin1_4	251	256	PF00397	0.538
DOC_WW_Pin1_4	704	709	PF00397	0.677
DOC_WW_Pin1_4	722	727	PF00397	0.525
DOC_WW_Pin1_4	835	840	PF00397	0.780
DOC_WW_Pin1_4	864	869	PF00397	0.617
DOC_WW_Pin1_4	871	876	PF00397	0.547
DOC_WW_Pin1_4	909	914	PF00397	0.629
DOC_WW_Pin1_4	944	949	PF00397	0.562
DOC_WW_Pin1_4	961	966	PF00397	0.614
DOC_WW_Pin1_4	976	981	PF00397	0.532
LIG_14-3-3_CanoR_1	127	135	PF00244	0.410
LIG_14-3-3_CanoR_1	13	22	PF00244	0.407
LIG_14-3-3_CanoR_1	152	159	PF00244	0.481
LIG_14-3-3_CanoR_1	208	216	PF00244	0.717
LIG_14-3-3_CanoR_1	362	370	PF00244	0.421
LIG_14-3-3_CanoR_1	508	516	PF00244	0.454
LIG_14-3-3_CanoR_1	575	580	PF00244	0.477
LIG_14-3-3_CanoR_1	672	677	PF00244	0.342
LIG_14-3-3_CanoR_1	921	925	PF00244	0.560
LIG_Actin_WH2_2	560	577	PF00022	0.365
LIG_Actin_WH2_2	67	83	PF00022	0.596
LIG_APCC_ABBA_1	789	794	PF00400	0.552
LIG_BIR_II_1	1	5	PF00653	0.455
LIG_BIR_III_2	941	945	PF00653	0.651
LIG_BRCT_BRCA1_1	740	744	PF00533	0.565
LIG_EH_1	1041	1045	PF12763	0.614
LIG_FHA_1	225	231	PF00498	0.560
LIG_FHA_1	281	287	PF00498	0.427
LIG_FHA_1	529	535	PF00498	0.368
LIG_FHA_1	673	679	PF00498	0.349
LIG_FHA_1	807	813	PF00498	0.555
LIG_FHA_1	841	847	PF00498	0.653
LIG_FHA_2	169	175	PF00498	0.526
LIG_FHA_2	258	264	PF00498	0.571
LIG_FHA_2	347	353	PF00498	0.425
LIG_FHA_2	35	41	PF00498	0.665
LIG_FHA_2	516	522	PF00498	0.363
LIG_FHA_2	658	664	PF00498	0.400
LIG_FHA_2	717	723	PF00498	0.570
LIG_GBD_Chelix_1	552	560	PF00786	0.504
LIG_IBAR_NPY_1	265	267	PF08397	0.546
LIG_Integrin_RGD_1	890	892	PF01839	0.567
LIG_IRF3_LxIS_1	21	28	PF10401	0.404
LIG_LIR_Apic_2	979	984	PF02991	0.523
LIG_LIR_Apic_2	995	1001	PF02991	0.503
LIG_LIR_Gen_1	614	623	PF02991	0.377
LIG_LIR_Nem_3	45	50	PF02991	0.653
LIG_LIR_Nem_3	614	619	PF02991	0.377
LIG_LIR_Nem_3	741	747	PF02991	0.558
LIG_NRBOX	20	26	PF00104	0.640
LIG_PCNA_yPIPBox_3	185	195	PF02747	0.415
LIG_PCNA_yPIPBox_3	575	589	PF02747	0.363
LIG_PDZ_Wminus1_1	1047	1049	PF00595	0.487
LIG_Pex14_2	1044	1048	PF04695	0.602
LIG_SH2_CRK	803	807	PF00017	0.466
LIG_SH2_NCK_1	489	493	PF00017	0.408
LIG_SH2_SRC	20	23	PF00017	0.384
LIG_SH2_SRC	70	73	PF00017	0.602
LIG_SH2_STAT5	20	23	PF00017	0.390
LIG_SH2_STAT5	267	270	PF00017	0.604
LIG_SH2_STAT5	70	73	PF00017	0.666
LIG_SH3_2	76	81	PF14604	0.515
LIG_SH3_3	1008	1014	PF00018	0.643
LIG_SH3_3	241	247	PF00018	0.563
LIG_SH3_3	269	275	PF00018	0.519
LIG_SH3_3	45	51	PF00018	0.528
LIG_SH3_3	62	68	PF00018	0.505
LIG_SH3_3	691	697	PF00018	0.627
LIG_SH3_3	705	711	PF00018	0.556
LIG_SH3_3	73	79	PF00018	0.603
LIG_SH3_3	86	92	PF00018	0.506
LIG_SH3_3	942	948	PF00018	0.637
LIG_SH3_4	593	600	PF00018	0.394
LIG_SH3_4	858	865	PF00018	0.567
LIG_SH3_CIN85_PxpxPR_1	746	751	PF14604	0.602
LIG_SUMO_SIM_anti_2	644	653	PF11976	0.477
LIG_SUMO_SIM_anti_2	809	814	PF11976	0.533
LIG_SUMO_SIM_par_1	808	814	PF11976	0.477
LIG_SUMO_SIM_par_1	82	88	PF11976	0.661
LIG_SxIP_EBH_1	928	939	PF03271	0.562
LIG_TRAF2_1	116	119	PF00917	0.464
LIG_TRAF2_1	356	359	PF00917	0.413
LIG_TRAF2_1	376	379	PF00917	0.380
LIG_TRAF2_1	398	401	PF00917	0.578
LIG_TRAF2_1	410	413	PF00917	0.624
LIG_TRAF2_1	464	467	PF00917	0.482
LIG_TRAF2_1	665	668	PF00917	0.348
LIG_TRAF2_1	719	722	PF00917	0.694
LIG_UBA3_1	769	775	PF00899	0.454
MOD_CDK_SPK_2	25	30	PF00069	0.443
MOD_CDK_SPK_2	704	709	PF00069	0.542
MOD_CDK_SPK_2	727	732	PF00069	0.539
MOD_CDK_SPK_2	835	840	PF00069	0.564
MOD_CK1_1	1013	1019	PF00069	0.557
MOD_CK1_1	2	8	PF00069	0.441
MOD_CK1_1	202	208	PF00069	0.639
MOD_CK1_1	238	244	PF00069	0.618
MOD_CK1_1	28	34	PF00069	0.620
MOD_CK1_1	583	589	PF00069	0.450
MOD_CK1_1	638	644	PF00069	0.392
MOD_CK1_1	698	704	PF00069	0.530
MOD_CK1_1	725	731	PF00069	0.671
MOD_CK1_1	818	824	PF00069	0.449
MOD_CK1_1	838	844	PF00069	0.658
MOD_CK1_1	848	854	PF00069	0.683
MOD_CK1_1	874	880	PF00069	0.685
MOD_CK1_1	905	911	PF00069	0.640
MOD_CK1_1	914	920	PF00069	0.676
MOD_CK1_1	950	956	PF00069	0.555
MOD_CK1_1	976	982	PF00069	0.648
MOD_CK1_1	992	998	PF00069	0.555
MOD_CK2_1	168	174	PF00069	0.566
MOD_CK2_1	206	212	PF00069	0.716
MOD_CK2_1	346	352	PF00069	0.426
MOD_CK2_1	353	359	PF00069	0.403
MOD_CK2_1	373	379	PF00069	0.378
MOD_CK2_1	461	467	PF00069	0.462
MOD_CK2_1	716	722	PF00069	0.568
MOD_CK2_1	782	788	PF00069	0.641
MOD_CK2_1	894	900	PF00069	0.801
MOD_CK2_1	920	926	PF00069	0.557
MOD_Cter_Amidation	406	409	PF01082	0.530
MOD_Cter_Amidation	560	563	PF01082	0.357
MOD_GlcNHglycan	1	4	PF01048	0.468
MOD_GlcNHglycan	176	179	PF01048	0.451
MOD_GlcNHglycan	204	207	PF01048	0.675
MOD_GlcNHglycan	220	223	PF01048	0.592
MOD_GlcNHglycan	318	321	PF01048	0.428
MOD_GlcNHglycan	355	358	PF01048	0.425
MOD_GlcNHglycan	375	378	PF01048	0.381
MOD_GlcNHglycan	493	496	PF01048	0.469
MOD_GlcNHglycan	543	546	PF01048	0.511
MOD_GlcNHglycan	585	588	PF01048	0.462
MOD_GlcNHglycan	639	643	PF01048	0.396
MOD_GlcNHglycan	702	705	PF01048	0.525
MOD_GlcNHglycan	740	743	PF01048	0.683
MOD_GlcNHglycan	826	829	PF01048	0.665
MOD_GlcNHglycan	852	855	PF01048	0.647
MOD_GlcNHglycan	862	865	PF01048	0.685
MOD_GlcNHglycan	902	905	PF01048	0.697
MOD_GlcNHglycan	913	916	PF01048	0.573
MOD_GlcNHglycan	949	952	PF01048	0.553
MOD_GlcNHglycan	975	978	PF01048	0.558
MOD_GSK3_1	1009	1016	PF00069	0.549
MOD_GSK3_1	170	177	PF00069	0.478
MOD_GSK3_1	202	209	PF00069	0.645
MOD_GSK3_1	25	32	PF00069	0.628
MOD_GSK3_1	253	260	PF00069	0.674
MOD_GSK3_1	261	268	PF00069	0.618
MOD_GSK3_1	528	535	PF00069	0.485
MOD_GSK3_1	622	629	PF00069	0.377
MOD_GSK3_1	638	645	PF00069	0.403
MOD_GSK3_1	70	77	PF00069	0.515
MOD_GSK3_1	700	707	PF00069	0.651
MOD_GSK3_1	713	720	PF00069	0.589
MOD_GSK3_1	811	818	PF00069	0.494
MOD_GSK3_1	841	848	PF00069	0.656
MOD_GSK3_1	860	867	PF00069	0.592
MOD_GSK3_1	870	877	PF00069	0.570
MOD_GSK3_1	900	907	PF00069	0.658
MOD_GSK3_1	961	968	PF00069	0.646
MOD_GSK3_1	972	979	PF00069	0.600
MOD_N-GLC_1	782	787	PF02516	0.527
MOD_NEK2_1	14	19	PF00069	0.518
MOD_NEK2_1	314	319	PF00069	0.505
MOD_NEK2_1	556	561	PF00069	0.355
MOD_NEK2_1	588	593	PF00069	0.527
MOD_NEK2_1	626	631	PF00069	0.380
MOD_NEK2_1	769	774	PF00069	0.467
MOD_NEK2_1	860	865	PF00069	0.573
MOD_NEK2_1	989	994	PF00069	0.612
MOD_PIKK_1	181	187	PF00454	0.471
MOD_PIKK_1	346	352	PF00454	0.426
MOD_PIKK_1	633	639	PF00454	0.401
MOD_PIKK_1	686	692	PF00454	0.467
MOD_PIKK_1	717	723	PF00454	0.570
MOD_PIKK_1	858	864	PF00454	0.566
MOD_PIKK_1	905	911	PF00454	0.704
MOD_PK_1	575	581	PF00069	0.354
MOD_PKA_1	499	505	PF00069	0.381
MOD_PKA_1	575	581	PF00069	0.354
MOD_PKA_2	126	132	PF00069	0.439
MOD_PKA_2	151	157	PF00069	0.470
MOD_PKA_2	361	367	PF00069	0.417
MOD_PKA_2	413	419	PF00069	0.535
MOD_PKA_2	507	513	PF00069	0.373
MOD_PKA_2	575	581	PF00069	0.487
MOD_PKA_2	583	589	PF00069	0.447
MOD_PKA_2	881	887	PF00069	0.664
MOD_PKA_2	892	898	PF00069	0.569
MOD_PKA_2	920	926	PF00069	0.557
MOD_Plk_1	123	129	PF00069	0.529
MOD_Plk_1	199	205	PF00069	0.585
MOD_Plk_1	440	446	PF00069	0.498
MOD_Plk_1	782	788	PF00069	0.659
MOD_Plk_1	85	91	PF00069	0.671
MOD_Plk_2-3	413	419	PF00069	0.535
MOD_Plk_4	31	37	PF00069	0.713
MOD_Plk_4	806	812	PF00069	0.539
MOD_ProDKin_1	1010	1016	PF00069	0.573
MOD_ProDKin_1	1022	1028	PF00069	0.594
MOD_ProDKin_1	238	244	PF00069	0.594
MOD_ProDKin_1	25	31	PF00069	0.646
MOD_ProDKin_1	251	257	PF00069	0.537
MOD_ProDKin_1	704	710	PF00069	0.679
MOD_ProDKin_1	722	728	PF00069	0.524
MOD_ProDKin_1	835	841	PF00069	0.781
MOD_ProDKin_1	864	870	PF00069	0.620
MOD_ProDKin_1	871	877	PF00069	0.547
MOD_ProDKin_1	909	915	PF00069	0.628
MOD_ProDKin_1	944	950	PF00069	0.565
MOD_ProDKin_1	961	967	PF00069	0.614
MOD_ProDKin_1	976	982	PF00069	0.532
MOD_SUMO_rev_2	118	123	PF00179	0.416
MOD_SUMO_rev_2	263	272	PF00179	0.607
MOD_SUMO_rev_2	291	298	PF00179	0.476
MOD_SUMO_rev_2	309	314	PF00179	0.528
MOD_SUMO_rev_2	315	320	PF00179	0.466
MOD_SUMO_rev_2	478	486	PF00179	0.426
MOD_SUMO_rev_2	507	516	PF00179	0.390
TRG_DiLeu_BaEn_1	309	314	PF01217	0.422
TRG_DiLeu_BaEn_1	646	651	PF01217	0.435
TRG_DiLeu_BaEn_4	309	315	PF01217	0.511
TRG_ENDOCYTIC_2	803	806	PF00928	0.476
TRG_ER_diArg_1	455	457	PF00400	0.500
TRG_ER_diArg_1	474	476	PF00400	0.407
TRG_ER_diArg_1	524	527	PF00400	0.443
TRG_ER_diArg_1	574	576	PF00400	0.435
TRG_ER_diArg_1	935	937	PF00400	0.581
TRG_ER_diArg_1	984	986	PF00400	0.521
TRG_NES_CRM1_1	667	682	PF08389	0.353
TRG_NES_CRM1_1	78	90	PF08389	0.517
TRG_Pf-PMV_PEXEL_1	208	212	PF00026	0.583
TRG_Pf-PMV_PEXEL_1	312	316	PF00026	0.510
TRG_Pf-PMV_PEXEL_1	455	460	PF00026	0.491

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A3S7X8C0	Leishmania donovani	51%	89%
A4IAC3	Leishmania infantum	46%	100%
E9B5E6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	54%	100%
Q4Q2I7	Leishmania major	49%	89%