LeishMANIAdb
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ANK_REP_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:
ANK_REP_REGION domain-containing protein
Gene product:
Ankyrin repeats (3 copies)/Ankyrin repeats (many copies), putative
Species:
Leishmania braziliensis
UniProt:
A4HB74_LEIBR
TriTrypDb:
LbrM.20.3140 , LBRM2903_200045400
Length:
341

Localization

Secreted promastigote
Source Evidence on protein Close homologs
Cuervo et al. no yes: 0
Hassani et al. no yes: 0
Forrest at al. (metacyclic) no yes: 0
Forrest at al. (procyclic) no yes: 0
Silverman et al. no yes: 0
Pissara et al. no yes: 0
Secreted amastigote
Source Evidence on protein Close homologs
Pires et al. no yes: 0
Exosome
Source Evidence on protein Close homologs
Silverman et al. no yes: 0
Glycosome
Source Evidence on protein Close homologs
Jamdhade et al. no yes: 0
Predictions
Source Evidence on protein Close homologs
DeepLoc
SignalP6 no yes: 1, no: 11
NetGPI no yes: 0, no: 12
Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB74
Sequence
MSA
Disorder
Secondary
Topology
Domains
SignalP
GPI
Phosphorylations
ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB74

Putative motif mimicry

Leishmania From To Domain/Motif Score
CLV_C14_Caspase3-7 200 204 PF00656 0.328
CLV_NRD_NRD_1 235 237 PF00675 0.708
CLV_NRD_NRD_1 262 264 PF00675 0.525
CLV_PCSK_KEX2_1 234 236 PF00082 0.699
CLV_PCSK_KEX2_1 262 264 PF00082 0.525
CLV_Separin_Metazoa 54 58 PF03568 0.157
DEG_COP1_1 250 259 PF00400 0.633
DOC_CKS1_1 136 141 PF01111 0.371
DOC_MAPK_gen_1 179 188 PF00069 0.237
DOC_MAPK_MEF2A_6 148 156 PF00069 0.371
DOC_MAPK_MEF2A_6 179 188 PF00069 0.237
DOC_MAPK_MEF2A_6 247 256 PF00069 0.495
DOC_MAPK_MEF2A_6 32 40 PF00069 0.215
DOC_MAPK_MEF2A_6 320 327 PF00069 0.422
DOC_MAPK_MEF2A_6 44 51 PF00069 0.154
DOC_USP7_MATH_1 160 164 PF00917 0.274
DOC_USP7_MATH_1 212 216 PF00917 0.469
DOC_WW_Pin1_4 135 140 PF00397 0.237
DOC_WW_Pin1_4 168 173 PF00397 0.304
DOC_WW_Pin1_4 282 287 PF00397 0.677
DOC_WW_Pin1_4 68 73 PF00397 0.284
LIG_14-3-3_CanoR_1 234 244 PF00244 0.644
LIG_BIR_II_1 1 5 PF00653 0.471
LIG_FHA_1 149 155 PF00498 0.371
LIG_FHA_1 305 311 PF00498 0.650
LIG_FHA_2 275 281 PF00498 0.396
LIG_FHA_2 311 317 PF00498 0.556
LIG_LIR_Apic_2 280 286 PF02991 0.482
LIG_LIR_Gen_1 150 160 PF02991 0.306
LIG_LIR_Gen_1 71 82 PF02991 0.371
LIG_LIR_Nem_3 150 156 PF02991 0.268
LIG_LIR_Nem_3 178 184 PF02991 0.394
LIG_LIR_Nem_3 33 38 PF02991 0.290
LIG_LIR_Nem_3 331 336 PF02991 0.359
LIG_LIR_Nem_3 71 77 PF02991 0.371
LIG_NRBOX 118 124 PF00104 0.319
LIG_SH2_CRK 283 287 PF00017 0.569
LIG_SH2_NCK_1 141 145 PF00017 0.166
LIG_SH2_NCK_1 283 287 PF00017 0.509
LIG_SH2_PTP2 35 38 PF00017 0.293
LIG_SH2_PTP2 74 77 PF00017 0.371
LIG_SH2_SRC 336 339 PF00017 0.472
LIG_SH2_SRC 87 90 PF00017 0.263
LIG_SH2_STAT5 153 156 PF00017 0.371
LIG_SH2_STAT5 174 177 PF00017 0.274
LIG_SH2_STAT5 35 38 PF00017 0.271
LIG_SH2_STAT5 39 42 PF00017 0.234
LIG_SH2_STAT5 74 77 PF00017 0.275
LIG_SH2_STAT5 87 90 PF00017 0.275
LIG_SH3_3 253 259 PF00018 0.512
LIG_SH3_3 284 290 PF00018 0.531
LIG_SH3_3 44 50 PF00018 0.250
LIG_SH3_3 95 101 PF00018 0.263
LIG_TRAF2_1 134 137 PF00917 0.357
LIG_TRAF2_1 277 280 PF00917 0.483
MOD_CK2_1 174 180 PF00069 0.441
MOD_CK2_1 274 280 PF00069 0.489
MOD_CK2_1 310 316 PF00069 0.672
MOD_GlcNHglycan 124 127 PF01048 0.340
MOD_GlcNHglycan 237 240 PF01048 0.562
MOD_GSK3_1 117 124 PF00069 0.419
MOD_GSK3_1 155 162 PF00069 0.157
MOD_GSK3_1 193 200 PF00069 0.544
MOD_N-GLC_1 160 165 PF02516 0.284
MOD_NEK2_1 122 127 PF00069 0.316
MOD_NEK2_1 197 202 PF00069 0.347
MOD_NEK2_1 43 48 PF00069 0.319
MOD_NEK2_1 73 78 PF00069 0.375
MOD_PKA_1 234 240 PF00069 0.517
MOD_PKA_2 102 108 PF00069 0.263
MOD_PKA_2 234 240 PF00069 0.644
MOD_PKA_2 299 305 PF00069 0.586
MOD_Plk_1 160 166 PF00069 0.157
MOD_Plk_1 193 199 PF00069 0.463
MOD_Plk_4 148 154 PF00069 0.371
MOD_Plk_4 305 311 PF00069 0.629
MOD_ProDKin_1 135 141 PF00069 0.237
MOD_ProDKin_1 168 174 PF00069 0.304
MOD_ProDKin_1 282 288 PF00069 0.679
MOD_ProDKin_1 68 74 PF00069 0.284
MOD_SUMO_rev_2 163 172 PF00179 0.235
MOD_SUMO_rev_2 177 184 PF00179 0.241
MOD_SUMO_rev_2 250 257 PF00179 0.609
TRG_DiLeu_BaEn_4 53 59 PF01217 0.336
TRG_ENDOCYTIC_2 153 156 PF00928 0.237
TRG_ENDOCYTIC_2 181 184 PF00928 0.344
TRG_ENDOCYTIC_2 35 38 PF00928 0.285
TRG_ENDOCYTIC_2 74 77 PF00928 0.382
TRG_ER_diArg_1 206 209 PF00400 0.486
TRG_ER_diArg_1 233 236 PF00400 0.488
TRG_ER_diArg_1 261 263 PF00400 0.530
TRG_Pf-PMV_PEXEL_1 276 280 PF00026 0.495

Homologs

Protein Taxonomy Sequence identity Coverage
A0A0N1PB55 Leptomonas seymouri 66% 100%
A0A0S4IZ37 Bodo saltans 24% 93%
A0A1X0PAB8 Trypanosomatidae 49% 100%
A0A3Q8IFT3 Leishmania donovani 86% 100%
A0A3R7N419 Trypanosoma rangeli 27% 87%
A0A3R7RA24 Trypanosoma rangeli 46% 100%
A0A3S7WRN0 Leishmania donovani 25% 100%
A4IAC2 Leishmania infantum 86% 100%
C9ZLX0 Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972) 45% 100%
E9B5E5 Leishmania mexicana (strain MHOM/GT/2001/U1103) 85% 100%
Q4Q2I8 Leishmania major 86% 100%
Q9GKW8 Macaca fascicularis 25% 72%
V5B6C0 Trypanosoma cruzi 50% 93%

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LeishMANIAdb - Server version: v0.0.2. - Database version: v0.0.1. - ChangeLog - © 2022-2025 Protein Bioinformatics Research Group, Institute of Enzymology, RCNS