PDCD2_C domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Programmed cell death protein 2, C-terminal putative domain containing protein, putative

Species:

Leishmania braziliensis

UniProt:

A4HB73_LEIBR

TriTrypDb:

LbrM.20.3130 , LBRM2903_200045300

Length:

402

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	12
GO:0110165	cellular anatomical entity	1	12

Expansion

Sequence features

A4HB73

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB73

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_MEL_PAP_1	36	42	PF00089	0.244
CLV_NRD_NRD_1	95	97	PF00675	0.527
CLV_PCSK_KEX2_1	95	97	PF00082	0.527
CLV_PCSK_SKI1_1	226	230	PF00082	0.516
CLV_PCSK_SKI1_1	233	237	PF00082	0.436
CLV_PCSK_SKI1_1	364	368	PF00082	0.171
DEG_SCF_FBW7_1	312	319	PF00400	0.328
DEG_SCF_FBW7_2	11	17	PF00400	0.290
DOC_CKS1_1	11	16	PF01111	0.389
DOC_CKS1_1	212	217	PF01111	0.479
DOC_CYCLIN_yCln2_LP_2	348	354	PF00134	0.267
DOC_MAPK_MEF2A_6	318	326	PF00069	0.429
DOC_PP2B_LxvP_1	331	334	PF13499	0.458
DOC_PP2B_LxvP_1	348	351	PF13499	0.271
DOC_PP4_FxxP_1	330	333	PF00568	0.171
DOC_PP4_FxxP_1	57	60	PF00568	0.334
DOC_USP7_MATH_1	127	131	PF00917	0.537
DOC_USP7_MATH_1	137	141	PF00917	0.270
DOC_USP7_MATH_1	222	226	PF00917	0.598
DOC_USP7_MATH_1	26	30	PF00917	0.431
DOC_USP7_MATH_1	265	269	PF00917	0.557
DOC_USP7_MATH_1	66	70	PF00917	0.447
DOC_WW_Pin1_4	10	15	PF00397	0.397
DOC_WW_Pin1_4	110	115	PF00397	0.473
DOC_WW_Pin1_4	193	198	PF00397	0.738
DOC_WW_Pin1_4	211	216	PF00397	0.689
DOC_WW_Pin1_4	284	289	PF00397	0.534
DOC_WW_Pin1_4	300	305	PF00397	0.415
DOC_WW_Pin1_4	312	317	PF00397	0.292
LIG_14-3-3_CanoR_1	154	162	PF00244	0.560
LIG_14-3-3_CanoR_1	226	231	PF00244	0.552
LIG_14-3-3_CanoR_1	318	323	PF00244	0.308
LIG_14-3-3_CanoR_1	63	71	PF00244	0.275
LIG_14-3-3_CanoR_1	96	102	PF00244	0.568
LIG_APCC_ABBA_1	243	248	PF00400	0.369
LIG_BIR_II_1	1	5	PF00653	0.552
LIG_BRCT_BRCA1_1	132	136	PF00533	0.306
LIG_BRCT_BRCA1_1	139	143	PF00533	0.334
LIG_BRCT_BRCA1_1	53	57	PF00533	0.448
LIG_FHA_1	218	224	PF00498	0.564
LIG_FHA_1	227	233	PF00498	0.501
LIG_FHA_1	236	242	PF00498	0.375
LIG_FHA_1	26	32	PF00498	0.331
LIG_FHA_1	319	325	PF00498	0.342
LIG_FHA_1	347	353	PF00498	0.269
LIG_FHA_1	355	361	PF00498	0.268
LIG_FHA_1	63	69	PF00498	0.419
LIG_FHA_2	161	167	PF00498	0.607
LIG_FHA_2	212	218	PF00498	0.692
LIG_LIR_Apic_2	244	249	PF02991	0.402
LIG_LIR_Apic_2	54	60	PF02991	0.350
LIG_LIR_Gen_1	146	155	PF02991	0.540
LIG_LIR_Gen_1	367	376	PF02991	0.273
LIG_LIR_Gen_1	394	402	PF02991	0.287
LIG_LIR_Gen_1	79	89	PF02991	0.356
LIG_LIR_Nem_3	146	151	PF02991	0.507
LIG_LIR_Nem_3	367	373	PF02991	0.260
LIG_LIR_Nem_3	394	398	PF02991	0.287
LIG_LIR_Nem_3	79	84	PF02991	0.393
LIG_MLH1_MIPbox_1	53	57	PF16413	0.475
LIG_MYND_1	110	114	PF01753	0.473
LIG_PDZ_Class_3	397	402	PF00595	0.398
LIG_SH2_CRK	81	85	PF00017	0.311
LIG_SH2_NCK_1	246	250	PF00017	0.476
LIG_SH2_PTP2	395	398	PF00017	0.395
LIG_SH2_PTP2	86	89	PF00017	0.241
LIG_SH2_SRC	246	249	PF00017	0.531
LIG_SH2_STAP1	27	31	PF00017	0.350
LIG_SH2_STAP1	81	85	PF00017	0.311
LIG_SH2_STAT3	296	299	PF00017	0.319
LIG_SH2_STAT5	147	150	PF00017	0.526
LIG_SH2_STAT5	237	240	PF00017	0.497
LIG_SH2_STAT5	27	30	PF00017	0.358
LIG_SH2_STAT5	355	358	PF00017	0.348
LIG_SH2_STAT5	37	40	PF00017	0.345
LIG_SH2_STAT5	376	379	PF00017	0.307
LIG_SH2_STAT5	391	394	PF00017	0.199
LIG_SH2_STAT5	395	398	PF00017	0.141
LIG_SH2_STAT5	56	59	PF00017	0.235
LIG_SH2_STAT5	86	89	PF00017	0.297
LIG_SH3_1	194	200	PF00018	0.627
LIG_SH3_3	1	7	PF00018	0.397
LIG_SH3_3	194	200	PF00018	0.734
LIG_SH3_3	20	26	PF00018	0.483
LIG_SH3_3	209	215	PF00018	0.625
LIG_SH3_3	216	222	PF00018	0.557
LIG_SH3_3	330	336	PF00018	0.314
LIG_SH3_3	387	393	PF00018	0.395
LIG_SH3_3	71	77	PF00018	0.379
LIG_SUMO_SIM_par_1	76	82	PF11976	0.376
LIG_TRAF2_1	18	21	PF00917	0.506
LIG_TRAF2_1	214	217	PF00917	0.530
LIG_TYR_ITIM	84	89	PF00017	0.241
MOD_CDK_SPxK_1	10	16	PF00069	0.450
MOD_CDK_SPxK_1	312	318	PF00069	0.328
MOD_CK1_1	130	136	PF00069	0.422
MOD_CK1_1	272	278	PF00069	0.494
MOD_CK2_1	160	166	PF00069	0.640
MOD_CK2_1	211	217	PF00069	0.660
MOD_CK2_1	255	261	PF00069	0.558
MOD_CK2_1	276	282	PF00069	0.523
MOD_CK2_1	284	290	PF00069	0.439
MOD_CK2_1	40	46	PF00069	0.516
MOD_GlcNHglycan	1	4	PF01048	0.633
MOD_GlcNHglycan	119	122	PF01048	0.735
MOD_GlcNHglycan	155	158	PF01048	0.353
MOD_GlcNHglycan	238	241	PF01048	0.431
MOD_GlcNHglycan	277	281	PF01048	0.647
MOD_GlcNHglycan	42	45	PF01048	0.535
MOD_GlcNHglycan	49	52	PF01048	0.568
MOD_GSK3_1	113	120	PF00069	0.509
MOD_GSK3_1	137	144	PF00069	0.398
MOD_GSK3_1	222	229	PF00069	0.505
MOD_GSK3_1	265	272	PF00069	0.609
MOD_GSK3_1	312	319	PF00069	0.376
MOD_GSK3_1	364	371	PF00069	0.171
MOD_GSK3_1	377	384	PF00069	0.139
MOD_GSK3_1	42	49	PF00069	0.476
MOD_GSK3_1	62	69	PF00069	0.394
MOD_GSK3_1	91	98	PF00069	0.417
MOD_N-GLC_1	141	146	PF02516	0.507
MOD_N-GLC_1	270	275	PF02516	0.518
MOD_N-GLC_1	364	369	PF02516	0.171
MOD_NEK2_1	236	241	PF00069	0.418
MOD_NEK2_1	269	274	PF00069	0.632
MOD_NEK2_1	276	281	PF00069	0.662
MOD_NEK2_1	317	322	PF00069	0.318
MOD_NEK2_1	346	351	PF00069	0.247
MOD_NEK2_1	374	379	PF00069	0.268
MOD_NEK2_2	265	270	PF00069	0.506
MOD_PIKK_1	137	143	PF00454	0.331
MOD_PIKK_1	302	308	PF00454	0.252
MOD_PK_1	255	261	PF00069	0.623
MOD_PKA_1	95	101	PF00069	0.408
MOD_PKA_2	153	159	PF00069	0.605
MOD_PKA_2	317	323	PF00069	0.308
MOD_PKA_2	62	68	PF00069	0.333
MOD_PKA_2	95	101	PF00069	0.610
MOD_Plk_1	270	276	PF00069	0.456
MOD_Plk_1	364	370	PF00069	0.281
MOD_Plk_4	265	271	PF00069	0.560
MOD_Plk_4	66	72	PF00069	0.310
MOD_ProDKin_1	10	16	PF00069	0.415
MOD_ProDKin_1	110	116	PF00069	0.469
MOD_ProDKin_1	193	199	PF00069	0.738
MOD_ProDKin_1	211	217	PF00069	0.686
MOD_ProDKin_1	284	290	PF00069	0.532
MOD_ProDKin_1	300	306	PF00069	0.415
MOD_ProDKin_1	312	318	PF00069	0.292
MOD_SUMO_rev_2	116	120	PF00179	0.457
MOD_SUMO_rev_2	359	366	PF00179	0.314
TRG_ENDOCYTIC_2	37	40	PF00928	0.504
TRG_ENDOCYTIC_2	395	398	PF00928	0.286
TRG_ENDOCYTIC_2	75	78	PF00928	0.312
TRG_ENDOCYTIC_2	81	84	PF00928	0.303
TRG_ENDOCYTIC_2	86	89	PF00928	0.268
TRG_ER_diArg_1	95	97	PF00400	0.527

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYV7	Leptomonas seymouri	60%	99%
A0A0S4JQH8	Bodo saltans	30%	100%
A0A1X0PA07	Trypanosomatidae	35%	100%
A0A3R7N1R1	Trypanosoma rangeli	35%	100%
A0A3S7X8B9	Leishmania donovani	75%	99%
A4IAC1	Leishmania infantum	75%	99%
C9ZLX1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	35%	100%
E9B5E4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	98%
P87156	Schizosaccharomyces pombe (strain 972 / ATCC 24843)	26%	100%
Q4Q2I9	Leishmania major	76%	100%
Q5ZID2	Gallus gallus	22%	100%
V5DMW4	Trypanosoma cruzi	33%	100%