LicD family protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

LicD family protein

Gene product:

LicD family, putative

Species:

Leishmania braziliensis

UniProt:

A4HB72_LEIBR

TriTrypDb:

LbrM.20.3120 , LBRM2903_200045200

Length:

224

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	9
GO:0110165	cellular anatomical entity	1	9

Expansion

Sequence features

A4HB72

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB72

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	193	197	PF00656	0.230
CLV_NRD_NRD_1	151	153	PF00675	0.490
CLV_PCSK_KEX2_1	80	82	PF00082	0.622
CLV_PCSK_PC1ET2_1	80	82	PF00082	0.451
CLV_PCSK_SKI1_1	101	105	PF00082	0.517
DOC_MAPK_gen_1	140	150	PF00069	0.312
DOC_MAPK_HePTP_8	138	150	PF00069	0.244
DOC_MAPK_MEF2A_6	141	150	PF00069	0.381
DOC_PP1_RVXF_1	62	69	PF00149	0.299
DOC_PP1_RVXF_1	99	106	PF00149	0.288
DOC_PP2B_LxvP_1	216	219	PF13499	0.346
DOC_USP7_MATH_1	186	190	PF00917	0.389
DOC_USP7_MATH_1	47	51	PF00917	0.292
DOC_WW_Pin1_4	1	6	PF00397	0.697
DOC_WW_Pin1_4	114	119	PF00397	0.391
LIG_BIR_II_1	1	5	PF00653	0.739
LIG_BRCT_BRCA1_1	178	182	PF00533	0.340
LIG_FHA_1	153	159	PF00498	0.287
LIG_FHA_1	163	169	PF00498	0.288
LIG_FHA_1	215	221	PF00498	0.319
LIG_LIR_Gen_1	179	187	PF02991	0.232
LIG_LIR_Gen_1	214	223	PF02991	0.351
LIG_LIR_Gen_1	50	56	PF02991	0.346
LIG_LIR_Nem_3	179	185	PF02991	0.230
LIG_LIR_Nem_3	214	218	PF02991	0.403
LIG_LIR_Nem_3	50	54	PF02991	0.307
LIG_SH2_STAT3	206	209	PF00017	0.387
LIG_SH2_STAT5	206	209	PF00017	0.294
LIG_SH2_STAT5	56	59	PF00017	0.383
LIG_SH2_STAT5	61	64	PF00017	0.318
LIG_SH3_3	110	116	PF00018	0.369
LIG_SUMO_SIM_anti_2	44	50	PF11976	0.197
LIG_SUMO_SIM_par_1	44	50	PF11976	0.383
LIG_TRFH_1	182	186	PF08558	0.231
LIG_UBA3_1	184	188	PF00899	0.363
MOD_CK1_1	50	56	PF00069	0.410
MOD_GlcNHglycan	1	4	PF01048	0.442
MOD_GlcNHglycan	124	127	PF01048	0.559
MOD_GlcNHglycan	192	195	PF01048	0.576
MOD_GlcNHglycan	21	24	PF01048	0.390
MOD_GSK3_1	186	193	PF00069	0.385
MOD_GSK3_1	89	96	PF00069	0.301
MOD_N-GLC_1	18	23	PF02516	0.428
MOD_N-GLC_1	200	205	PF02516	0.426
MOD_N-GLC_1	89	94	PF02516	0.465
MOD_NEK2_1	162	167	PF00069	0.274
MOD_NEK2_1	89	94	PF00069	0.286
MOD_PKA_1	152	158	PF00069	0.344
MOD_Plk_1	163	169	PF00069	0.293
MOD_Plk_1	200	206	PF00069	0.224
MOD_Plk_1	28	34	PF00069	0.636
MOD_Plk_4	163	169	PF00069	0.325
MOD_Plk_4	41	47	PF00069	0.429
MOD_Plk_4	89	95	PF00069	0.289
MOD_ProDKin_1	1	7	PF00069	0.698
MOD_ProDKin_1	114	120	PF00069	0.391
MOD_SUMO_for_1	9	12	PF00179	0.575
MOD_SUMO_rev_2	193	200	PF00179	0.222
TRG_DiLeu_BaLyEn_6	216	221	PF01217	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1P990	Leptomonas seymouri	65%	100%
A0A0S4JMC1	Bodo saltans	38%	100%
A0A1X0PAV6	Trypanosomatidae	53%	100%
A0A3S7X8D8	Leishmania donovani	79%	100%
A0A422MZF8	Trypanosoma rangeli	51%	100%
A4IAC0	Leishmania infantum	79%	100%
C9ZLX2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	51%	100%
E9B5E3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	100%
Q4Q2J0	Leishmania major	77%	100%