Peroxin-1

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Peroxin-1

Gene product:

peroxisome biosynthesis protein-like protein

Species:

Leishmania braziliensis

UniProt:

A4HB70_LEIBR

TriTrypDb:

LbrM.20.3100 , LBRM2903_200044600

Length:

949

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005778	peroxisomal membrane	6	12
GO:0016020	membrane	2	12
GO:0031090	organelle membrane	3	12
GO:0031903	microbody membrane	5	12
GO:0042579	microbody	5	12
GO:0043226	organelle	2	13
GO:0043227	membrane-bounded organelle	3	13
GO:0043229	intracellular organelle	3	13
GO:0043231	intracellular membrane-bounded organelle	4	13
GO:0098588	bounding membrane of organelle	4	12
GO:0110165	cellular anatomical entity	1	13
GO:0005634	nucleus	5	1
GO:0005829	cytosol	2	1

Expansion

Sequence features

A4HB70

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB70

Function

Biological processes
Term	Name	Level	Count
GO:0006605	protein targeting	5	12
GO:0006625	protein targeting to peroxisome	5	12
GO:0006810	transport	3	12
GO:0006886	intracellular protein transport	4	12
GO:0006996	organelle organization	4	12
GO:0007031	peroxisome organization	5	12
GO:0008104	protein localization	4	12
GO:0009987	cellular process	1	13
GO:0015031	protein transport	4	12
GO:0016043	cellular component organization	3	12
GO:0033036	macromolecule localization	2	12
GO:0033365	protein localization to organelle	5	12
GO:0043574	peroxisomal transport	4	12
GO:0045184	establishment of protein localization	3	12
GO:0046907	intracellular transport	3	12
GO:0051179	localization	1	12
GO:0051234	establishment of localization	2	12
GO:0051641	cellular localization	2	12
GO:0051649	establishment of localization in cell	3	12
GO:0070727	cellular macromolecule localization	3	12
GO:0071702	organic substance transport	4	12
GO:0071705	nitrogen compound transport	4	12
GO:0071840	cellular component organization or biogenesis	2	13
GO:0072594	establishment of protein localization to organelle	4	12
GO:0072662	protein localization to peroxisome	6	12
GO:0072663	establishment of protein localization to peroxisome	5	12
GO:0009889	regulation of biosynthetic process	4	1
GO:0009891	positive regulation of biosynthetic process	5	1
GO:0009893	positive regulation of metabolic process	4	1
GO:0010556	regulation of macromolecule biosynthetic process	5	1
GO:0010557	positive regulation of macromolecule biosynthetic process	6	1
GO:0010604	positive regulation of macromolecule metabolic process	5	1
GO:0019219	regulation of nucleobase-containing compound metabolic process	5	1
GO:0019222	regulation of metabolic process	3	1
GO:0022613	ribonucleoprotein complex biogenesis	4	1
GO:0031323	regulation of cellular metabolic process	4	1
GO:0031325	positive regulation of cellular metabolic process	5	1
GO:0031326	regulation of cellular biosynthetic process	5	1
GO:0031328	positive regulation of cellular biosynthetic process	6	1
GO:0042254	ribosome biogenesis	5	1
GO:0043085	positive regulation of catalytic activity	4	1
GO:0044085	cellular component biogenesis	3	1
GO:0044093	positive regulation of molecular function	3	1
GO:0045935	positive regulation of nucleobase-containing compound metabolic process	6	1
GO:0048518	positive regulation of biological process	3	1
GO:0048522	positive regulation of cellular process	4	1
GO:0050789	regulation of biological process	2	1
GO:0050790	regulation of catalytic activity	3	1
GO:0050794	regulation of cellular process	3	1
GO:0051052	regulation of DNA metabolic process	5	1
GO:0051054	positive regulation of DNA metabolic process	6	1
GO:0051171	regulation of nitrogen compound metabolic process	4	1
GO:0051173	positive regulation of nitrogen compound metabolic process	5	1
GO:0051338	regulation of transferase activity	4	1
GO:0051347	positive regulation of transferase activity	5	1
GO:0051972	regulation of telomerase activity	5	1
GO:0051973	positive regulation of telomerase activity	6	1
GO:0060255	regulation of macromolecule metabolic process	4	1
GO:0065007	biological regulation	1	1
GO:0065009	regulation of molecular function	2	1
GO:0080090	regulation of primary metabolic process	4	1
GO:2000278	regulation of DNA biosynthetic process	6	1
GO:2000573	positive regulation of DNA biosynthetic process	7	1
GO:0015919	peroxisomal membrane transport	5	1
GO:0016558	protein import into peroxisome matrix	5	1
GO:0044743	protein transmembrane import into intracellular organelle	4	1
GO:0055085	transmembrane transport	2	1
GO:0065002	intracellular protein transmembrane transport	4	1
GO:0071806	protein transmembrane transport	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	13
GO:0003824	catalytic activity	1	13
GO:0005488	binding	1	13
GO:0005524	ATP binding	5	13
GO:0016462	pyrophosphatase activity	5	13
GO:0016787	hydrolase activity	2	13
GO:0016817	hydrolase activity, acting on acid anhydrides	3	13
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	13
GO:0016887	ATP hydrolysis activity	7	13
GO:0017076	purine nucleotide binding	4	13
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	13
GO:0030554	adenyl nucleotide binding	5	13
GO:0032553	ribonucleotide binding	3	13
GO:0032555	purine ribonucleotide binding	4	13
GO:0032559	adenyl ribonucleotide binding	5	13
GO:0035639	purine ribonucleoside triphosphate binding	4	13
GO:0036094	small molecule binding	2	13
GO:0043167	ion binding	2	13
GO:0043168	anion binding	3	13
GO:0097159	organic cyclic compound binding	2	13
GO:0097367	carbohydrate derivative binding	2	13
GO:1901265	nucleoside phosphate binding	3	13
GO:1901363	heterocyclic compound binding	2	13
GO:0043021	ribonucleoprotein complex binding	3	1
GO:0044877	protein-containing complex binding	2	1
GO:1990275	preribosome binding	4	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	188	192	PF00656	0.481
CLV_C14_Caspase3-7	495	499	PF00656	0.391
CLV_C14_Caspase3-7	751	755	PF00656	0.279
CLV_NRD_NRD_1	186	188	PF00675	0.626
CLV_NRD_NRD_1	737	739	PF00675	0.287
CLV_NRD_NRD_1	802	804	PF00675	0.590
CLV_PCSK_FUR_1	184	188	PF00082	0.605
CLV_PCSK_KEX2_1	186	188	PF00082	0.626
CLV_PCSK_KEX2_1	802	804	PF00082	0.508
CLV_PCSK_PC7_1	798	804	PF00082	0.497
CLV_PCSK_SKI1_1	230	234	PF00082	0.454
CLV_PCSK_SKI1_1	271	275	PF00082	0.485
CLV_PCSK_SKI1_1	400	404	PF00082	0.354
CLV_PCSK_SKI1_1	420	424	PF00082	0.405
CLV_PCSK_SKI1_1	511	515	PF00082	0.270
CLV_PCSK_SKI1_1	524	528	PF00082	0.314
CLV_PCSK_SKI1_1	68	72	PF00082	0.557
CLV_PCSK_SKI1_1	687	691	PF00082	0.287
CLV_PCSK_SKI1_1	739	743	PF00082	0.391
CLV_PCSK_SKI1_1	782	786	PF00082	0.440
DEG_APCC_DBOX_1	266	274	PF00400	0.556
DEG_APCC_DBOX_1	399	407	PF00400	0.391
DEG_Nend_UBRbox_3	1	3	PF02207	0.550
DOC_ANK_TNKS_1	186	193	PF00023	0.468
DOC_CKS1_1	307	312	PF01111	0.552
DOC_CYCLIN_RxL_1	777	789	PF00134	0.490
DOC_CYCLIN_yCln2_LP_2	334	340	PF00134	0.484
DOC_CYCLIN_yCln2_LP_2	435	441	PF00134	0.391
DOC_CYCLIN_yCln2_LP_2	620	626	PF00134	0.360
DOC_CYCLIN_yCln2_LP_2	71	77	PF00134	0.407
DOC_MAPK_DCC_7	102	110	PF00069	0.522
DOC_MAPK_DCC_7	68	77	PF00069	0.534
DOC_MAPK_gen_1	418	426	PF00069	0.386
DOC_MAPK_gen_1	636	643	PF00069	0.334
DOC_MAPK_gen_1	66	73	PF00069	0.565
DOC_MAPK_JIP1_4	437	443	PF00069	0.391
DOC_MAPK_MEF2A_6	565	574	PF00069	0.391
DOC_PP1_RVXF_1	598	604	PF00149	0.545
DOC_PP1_RVXF_1	801	808	PF00149	0.380
DOC_PP2B_LxvP_1	620	623	PF13499	0.313
DOC_USP7_MATH_1	459	463	PF00917	0.376
DOC_USP7_MATH_1	492	496	PF00917	0.370
DOC_USP7_MATH_1	715	719	PF00917	0.421
DOC_USP7_MATH_1	745	749	PF00917	0.244
DOC_USP7_MATH_1	770	774	PF00917	0.343
DOC_USP7_MATH_1	814	818	PF00917	0.417
DOC_USP7_MATH_1	836	840	PF00917	0.540
DOC_USP7_UBL2_3	391	395	PF12436	0.274
DOC_USP7_UBL2_3	918	922	PF12436	0.489
DOC_WW_Pin1_4	259	264	PF00397	0.509
DOC_WW_Pin1_4	306	311	PF00397	0.514
DOC_WW_Pin1_4	548	553	PF00397	0.389
DOC_WW_Pin1_4	583	588	PF00397	0.356
DOC_WW_Pin1_4	805	810	PF00397	0.347
DOC_WW_Pin1_4	933	938	PF00397	0.633
LIG_14-3-3_CanoR_1	12	19	PF00244	0.545
LIG_14-3-3_CanoR_1	228	237	PF00244	0.495
LIG_14-3-3_CanoR_1	339	347	PF00244	0.410
LIG_14-3-3_CanoR_1	511	517	PF00244	0.301
LIG_14-3-3_CanoR_1	521	531	PF00244	0.446
LIG_14-3-3_CanoR_1	802	806	PF00244	0.510
LIG_14-3-3_CanoR_1	912	920	PF00244	0.420
LIG_Actin_WH2_2	70	86	PF00022	0.495
LIG_AP2alpha_1	702	706	PF02296	0.244
LIG_BRCT_BRCA1_1	788	792	PF00533	0.528
LIG_FHA_1	175	181	PF00498	0.426
LIG_FHA_1	222	228	PF00498	0.565
LIG_FHA_1	256	262	PF00498	0.409
LIG_FHA_1	272	278	PF00498	0.530
LIG_FHA_1	302	308	PF00498	0.428
LIG_FHA_1	409	415	PF00498	0.370
LIG_FHA_1	526	532	PF00498	0.563
LIG_FHA_1	617	623	PF00498	0.351
LIG_FHA_1	650	656	PF00498	0.244
LIG_FHA_1	719	725	PF00498	0.244
LIG_FHA_1	830	836	PF00498	0.390
LIG_FHA_2	107	113	PF00498	0.483
LIG_FHA_2	403	409	PF00498	0.279
LIG_FHA_2	549	555	PF00498	0.334
LIG_FHA_2	806	812	PF00498	0.369
LIG_FHA_2	846	852	PF00498	0.537
LIG_FHA_2	914	920	PF00498	0.385
LIG_GBD_Chelix_1	357	365	PF00786	0.429
LIG_GBD_Chelix_1	724	732	PF00786	0.287
LIG_LIR_Gen_1	444	452	PF02991	0.257
LIG_LIR_Gen_1	602	609	PF02991	0.448
LIG_LIR_Gen_1	615	624	PF02991	0.368
LIG_LIR_Gen_1	67	77	PF02991	0.428
LIG_LIR_Gen_1	704	711	PF02991	0.244
LIG_LIR_Gen_1	902	913	PF02991	0.463
LIG_LIR_Nem_3	143	148	PF02991	0.442
LIG_LIR_Nem_3	444	449	PF02991	0.244
LIG_LIR_Nem_3	548	553	PF02991	0.379
LIG_LIR_Nem_3	584	588	PF02991	0.417
LIG_LIR_Nem_3	602	606	PF02991	0.460
LIG_LIR_Nem_3	615	620	PF02991	0.368
LIG_LIR_Nem_3	67	72	PF02991	0.557
LIG_LIR_Nem_3	673	678	PF02991	0.244
LIG_LIR_Nem_3	704	709	PF02991	0.244
LIG_LIR_Nem_3	902	908	PF02991	0.438
LIG_NRBOX	780	786	PF00104	0.482
LIG_Pex14_2	476	480	PF04695	0.333
LIG_Pex14_2	69	73	PF04695	0.528
LIG_Pex14_2	702	706	PF04695	0.244
LIG_PTB_Apo_2	821	828	PF02174	0.470
LIG_SH2_CRK	617	621	PF00017	0.321
LIG_SH2_SRC	25	28	PF00017	0.427
LIG_SH2_SRC	731	734	PF00017	0.244
LIG_SH2_SRC	79	82	PF00017	0.377
LIG_SH2_STAT3	678	681	PF00017	0.244
LIG_SH2_STAT5	25	28	PF00017	0.457
LIG_SH2_STAT5	508	511	PF00017	0.333
LIG_SH2_STAT5	55	58	PF00017	0.422
LIG_SH2_STAT5	550	553	PF00017	0.374
LIG_SH2_STAT5	678	681	PF00017	0.244
LIG_SH2_STAT5	731	734	PF00017	0.244
LIG_SH3_2	146	151	PF14604	0.442
LIG_SH3_2	40	45	PF14604	0.388
LIG_SH3_3	130	136	PF00018	0.456
LIG_SH3_3	143	149	PF00018	0.456
LIG_SH3_3	26	32	PF00018	0.493
LIG_SH3_3	37	43	PF00018	0.435
LIG_SH3_3	530	536	PF00018	0.512
LIG_SH3_3	764	770	PF00018	0.313
LIG_SH3_3	935	941	PF00018	0.735
LIG_SUMO_SIM_anti_2	274	280	PF11976	0.459
LIG_SUMO_SIM_anti_2	773	783	PF11976	0.367
LIG_SUMO_SIM_par_1	106	114	PF11976	0.522
LIG_SUMO_SIM_par_1	137	143	PF11976	0.442
LIG_SUMO_SIM_par_1	273	280	PF11976	0.518
LIG_SUMO_SIM_par_1	410	415	PF11976	0.391
LIG_SUMO_SIM_par_1	439	444	PF11976	0.244
LIG_SUMO_SIM_par_1	487	493	PF11976	0.278
LIG_SUMO_SIM_par_1	512	517	PF11976	0.474
LIG_TRAF2_1	288	291	PF00917	0.682
LIG_TRAF2_1	452	455	PF00917	0.348
LIG_TRAF2_1	793	796	PF00917	0.468
LIG_UBA3_1	629	636	PF00899	0.404
LIG_UBA3_1	780	787	PF00899	0.400
LIG_WRC_WIRS_1	582	587	PF05994	0.316
MOD_CDK_SPxxK_3	933	940	PF00069	0.479
MOD_CK1_1	14	20	PF00069	0.572
MOD_CK1_1	221	227	PF00069	0.389
MOD_CK1_1	316	322	PF00069	0.651
MOD_CK1_1	462	468	PF00069	0.212
MOD_CK1_1	602	608	PF00069	0.359
MOD_CK1_1	718	724	PF00069	0.257
MOD_CK1_1	783	789	PF00069	0.451
MOD_CK1_1	907	913	PF00069	0.552
MOD_CK2_1	1	7	PF00069	0.503
MOD_CK2_1	570	576	PF00069	0.518
MOD_CK2_1	790	796	PF00069	0.379
MOD_CK2_1	911	917	PF00069	0.474
MOD_GlcNHglycan	167	170	PF01048	0.255
MOD_GlcNHglycan	220	223	PF01048	0.630
MOD_GlcNHglycan	230	233	PF01048	0.439
MOD_GlcNHglycan	314	318	PF01048	0.768
MOD_GlcNHglycan	323	326	PF01048	0.731
MOD_GlcNHglycan	34	37	PF01048	0.516
MOD_GlcNHglycan	342	345	PF01048	0.549
MOD_GlcNHglycan	461	464	PF01048	0.225
MOD_GlcNHglycan	49	52	PF01048	0.594
MOD_GlcNHglycan	638	641	PF01048	0.319
MOD_GlcNHglycan	646	649	PF01048	0.264
MOD_GlcNHglycan	716	720	PF01048	0.257
MOD_GlcNHglycan	788	791	PF01048	0.406
MOD_GlcNHglycan	811	815	PF01048	0.383
MOD_GlcNHglycan	817	820	PF01048	0.352
MOD_GlcNHglycan	845	848	PF01048	0.619
MOD_GSK3_1	10	17	PF00069	0.521
MOD_GSK3_1	106	113	PF00069	0.427
MOD_GSK3_1	134	141	PF00069	0.522
MOD_GSK3_1	255	262	PF00069	0.404
MOD_GSK3_1	312	319	PF00069	0.653
MOD_GSK3_1	612	619	PF00069	0.460
MOD_GSK3_1	786	793	PF00069	0.443
MOD_GSK3_1	801	808	PF00069	0.302
MOD_GSK3_1	810	817	PF00069	0.333
MOD_GSK3_1	904	911	PF00069	0.487
MOD_GSK3_1	941	948	PF00069	0.710
MOD_LATS_1	238	244	PF00433	0.418
MOD_LATS_1	269	275	PF00433	0.423
MOD_N-GLC_1	240	245	PF02516	0.376
MOD_N-GLC_1	548	553	PF02516	0.398
MOD_N-GLC_1	805	810	PF02516	0.442
MOD_NEK2_1	1	6	PF00069	0.539
MOD_NEK2_1	138	143	PF00069	0.439
MOD_NEK2_1	313	318	PF00069	0.654
MOD_NEK2_1	369	374	PF00069	0.543
MOD_NEK2_1	380	385	PF00069	0.478
MOD_NEK2_1	393	398	PF00069	0.379
MOD_NEK2_1	44	49	PF00069	0.379
MOD_NEK2_1	469	474	PF00069	0.270
MOD_NEK2_1	588	593	PF00069	0.369
MOD_NEK2_1	616	621	PF00069	0.347
MOD_NEK2_1	785	790	PF00069	0.354
MOD_NEK2_1	815	820	PF00069	0.330
MOD_NEK2_1	827	832	PF00069	0.385
MOD_NEK2_1	908	913	PF00069	0.477
MOD_NEK2_2	478	483	PF00069	0.391
MOD_NEK2_2	570	575	PF00069	0.388
MOD_NEK2_2	612	617	PF00069	0.346
MOD_PIKK_1	11	17	PF00454	0.585
MOD_PIKK_1	19	25	PF00454	0.557
MOD_PIKK_1	462	468	PF00454	0.269
MOD_PIKK_1	941	947	PF00454	0.500
MOD_PKA_2	11	17	PF00069	0.560
MOD_PKA_2	208	214	PF00069	0.512
MOD_PKA_2	44	50	PF00069	0.442
MOD_PKA_2	520	526	PF00069	0.438
MOD_PKA_2	801	807	PF00069	0.473
MOD_PKA_2	911	917	PF00069	0.450
MOD_PKA_2	98	104	PF00069	0.309
MOD_PKB_1	228	236	PF00069	0.458
MOD_Plk_1	469	475	PF00069	0.312
MOD_Plk_1	810	816	PF00069	0.460
MOD_Plk_4	122	128	PF00069	0.537
MOD_Plk_4	134	140	PF00069	0.513
MOD_Plk_4	14	20	PF00069	0.515
MOD_Plk_4	240	246	PF00069	0.378
MOD_Plk_4	25	31	PF00069	0.456
MOD_Plk_4	271	277	PF00069	0.482
MOD_Plk_4	394	400	PF00069	0.380
MOD_Plk_4	418	424	PF00069	0.250
MOD_Plk_4	612	618	PF00069	0.370
MOD_Plk_4	649	655	PF00069	0.303
MOD_ProDKin_1	259	265	PF00069	0.498
MOD_ProDKin_1	306	312	PF00069	0.518
MOD_ProDKin_1	548	554	PF00069	0.381
MOD_ProDKin_1	583	589	PF00069	0.358
MOD_ProDKin_1	805	811	PF00069	0.342
MOD_ProDKin_1	933	939	PF00069	0.634
MOD_SUMO_rev_2	161	166	PF00179	0.517
MOD_SUMO_rev_2	548	558	PF00179	0.337
MOD_SUMO_rev_2	605	615	PF00179	0.386
MOD_SUMO_rev_2	682	686	PF00179	0.244
MOD_SUMO_rev_2	733	741	PF00179	0.269
TRG_DiLeu_BaEn_2	174	180	PF01217	0.439
TRG_ENDOCYTIC_2	550	553	PF00928	0.314
TRG_ENDOCYTIC_2	617	620	PF00928	0.327
TRG_ER_diArg_1	184	187	PF00400	0.600
TRG_ER_diArg_1	206	209	PF00400	0.567
TRG_ER_diArg_1	227	230	PF00400	0.451
TRG_ER_diArg_1	560	563	PF00400	0.454
TRG_NES_CRM1_1	404	415	PF08389	0.279
TRG_Pf-PMV_PEXEL_1	428	432	PF00026	0.346

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I568	Leptomonas seymouri	75%	99%
A0A0S4IKL1	Bodo saltans	42%	100%
A0A1X0PA10	Trypanosomatidae	47%	100%
A0A3Q8IIU8	Leishmania donovani	84%	99%
A0A3R7MK02	Trypanosoma rangeli	48%	100%
A4IAB8	Leishmania infantum	84%	99%
C9ZLX8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	47%	100%
E9AD83	Leishmania major	32%	100%
E9B5E1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	99%
Q4Q2J2	Leishmania major	84%	100%
V5BKY8	Trypanosoma cruzi	47%	100%