SET domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB69_LEIBR

TriTrypDb:

LbrM.20.3090 , LBRM2903_200044500

Length:

329

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB69

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB69

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	165	169	PF00656	0.645
CLV_NRD_NRD_1	12	14	PF00675	0.477
CLV_NRD_NRD_1	209	211	PF00675	0.442
CLV_NRD_NRD_1	291	293	PF00675	0.508
CLV_NRD_NRD_1	46	48	PF00675	0.483
CLV_PCSK_KEX2_1	12	14	PF00082	0.475
CLV_PCSK_KEX2_1	209	211	PF00082	0.427
CLV_PCSK_KEX2_1	267	269	PF00082	0.590
CLV_PCSK_KEX2_1	291	293	PF00082	0.501
CLV_PCSK_KEX2_1	46	48	PF00082	0.511
CLV_PCSK_PC1ET2_1	267	269	PF00082	0.421
CLV_PCSK_PC7_1	42	48	PF00082	0.507
CLV_PCSK_SKI1_1	307	311	PF00082	0.422
DEG_APCC_DBOX_1	129	137	PF00400	0.433
DEG_Nend_Nbox_1	1	3	PF02207	0.601
DOC_MAPK_gen_1	291	302	PF00069	0.465
DOC_MAPK_gen_1	307	317	PF00069	0.456
DOC_PP1_RVXF_1	196	202	PF00149	0.437
DOC_PP1_RVXF_1	271	278	PF00149	0.647
DOC_PP2B_PxIxI_1	283	289	PF00149	0.304
DOC_USP7_MATH_1	172	176	PF00917	0.695
DOC_USP7_MATH_1	219	223	PF00917	0.411
DOC_USP7_MATH_2	59	65	PF00917	0.397
DOC_WW_Pin1_4	124	129	PF00397	0.522
DOC_WW_Pin1_4	59	64	PF00397	0.670
DOC_WW_Pin1_4	93	98	PF00397	0.601
LIG_14-3-3_CanoR_1	191	199	PF00244	0.495
LIG_14-3-3_CanoR_1	307	317	PF00244	0.460
LIG_14-3-3_CanoR_1	81	87	PF00244	0.398
LIG_Actin_WH2_2	281	297	PF00022	0.535
LIG_deltaCOP1_diTrp_1	316	322	PF00928	0.379
LIG_eIF4E_1	24	30	PF01652	0.494
LIG_FHA_1	72	78	PF00498	0.432
LIG_FHA_2	309	315	PF00498	0.469
LIG_HCF-1_HBM_1	154	157	PF13415	0.453
LIG_LIR_Apic_2	21	27	PF02991	0.505
LIG_LIR_Gen_1	112	122	PF02991	0.537
LIG_LIR_Gen_1	19	30	PF02991	0.456
LIG_LIR_Gen_1	200	207	PF02991	0.432
LIG_LIR_Gen_1	259	266	PF02991	0.607
LIG_LIR_Nem_3	112	117	PF02991	0.503
LIG_LIR_Nem_3	19	25	PF02991	0.418
LIG_LIR_Nem_3	200	204	PF02991	0.436
LIG_LIR_Nem_3	243	248	PF02991	0.405
LIG_LIR_Nem_3	259	263	PF02991	0.447
LIG_LYPXL_S_1	244	248	PF13949	0.376
LIG_LYPXL_yS_3	245	248	PF13949	0.377
LIG_Pex14_1	26	30	PF04695	0.418
LIG_Pex14_1	318	322	PF04695	0.501
LIG_SH2_PTP2	22	25	PF00017	0.423
LIG_SH2_PTP2	260	263	PF00017	0.584
LIG_SH2_STAT5	132	135	PF00017	0.414
LIG_SH2_STAT5	22	25	PF00017	0.421
LIG_SH2_STAT5	260	263	PF00017	0.584
LIG_SH2_STAT5	28	31	PF00017	0.363
LIG_SH2_STAT5	324	327	PF00017	0.438
LIG_SH2_STAT5	70	73	PF00017	0.506
LIG_SH3_2	125	130	PF14604	0.555
LIG_SH3_3	122	128	PF00018	0.523
LIG_SH3_3	70	76	PF00018	0.503
LIG_SH3_3	91	97	PF00018	0.567
MOD_CDC14_SPxK_1	127	130	PF00782	0.509
MOD_CDK_SPK_2	93	98	PF00069	0.597
MOD_CDK_SPxK_1	124	130	PF00069	0.524
MOD_CK1_1	93	99	PF00069	0.594
MOD_CK2_1	106	112	PF00069	0.553
MOD_GlcNHglycan	108	111	PF01048	0.540
MOD_GlcNHglycan	193	196	PF01048	0.538
MOD_GlcNHglycan	63	66	PF01048	0.510
MOD_GSK3_1	225	232	PF00069	0.380
MOD_GSK3_1	4	11	PF00069	0.635
MOD_GSK3_1	57	64	PF00069	0.514
MOD_GSK3_1	88	95	PF00069	0.468
MOD_NEK2_1	229	234	PF00069	0.451
MOD_NEK2_1	4	9	PF00069	0.629
MOD_NEK2_1	71	76	PF00069	0.436
MOD_NEK2_1	90	95	PF00069	0.447
MOD_PIKK_1	5	11	PF00454	0.584
MOD_PKA_2	190	196	PF00069	0.333
MOD_Plk_1	18	24	PF00069	0.505
MOD_Plk_1	240	246	PF00069	0.408
MOD_Plk_4	18	24	PF00069	0.512
MOD_Plk_4	225	231	PF00069	0.335
MOD_Plk_4	240	246	PF00069	0.445
MOD_Plk_4	256	262	PF00069	0.337
MOD_ProDKin_1	124	130	PF00069	0.524
MOD_ProDKin_1	59	65	PF00069	0.667
MOD_ProDKin_1	93	99	PF00069	0.607
TRG_DiLeu_BaLyEn_6	243	248	PF01217	0.446
TRG_DiLeu_BaLyEn_6	281	286	PF01217	0.559
TRG_ENDOCYTIC_2	108	111	PF00928	0.517
TRG_ENDOCYTIC_2	132	135	PF00928	0.400
TRG_ENDOCYTIC_2	22	25	PF00928	0.414
TRG_ENDOCYTIC_2	245	248	PF00928	0.368
TRG_ENDOCYTIC_2	260	263	PF00928	0.446
TRG_ENDOCYTIC_2	70	73	PF00928	0.506
TRG_ER_diArg_1	12	14	PF00400	0.465
TRG_ER_diArg_1	209	211	PF00400	0.472
TRG_ER_diArg_1	291	293	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	209	213	PF00026	0.496

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6T7	Leptomonas seymouri	69%	97%
A0A0S4KKV6	Bodo saltans	34%	95%
A0A1X0PAA6	Trypanosomatidae	44%	100%
A0A3S5IR23	Trypanosoma rangeli	48%	100%
A0A3S7X8A6	Leishmania donovani	86%	100%
A4IAB7	Leishmania infantum	86%	100%
C9ZLX9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	99%
E9B5E0	Leishmania mexicana (strain MHOM/GT/2001/U1103)	86%	100%
Q4Q2J3	Leishmania major	87%	100%
V5BV68	Trypanosoma cruzi	48%	95%