RuvB-like helicase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

RuvB-like helicase

Gene product:

ruvb-like 1 DNA helicase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB68_LEIBR

TriTrypDb:

LbrM.20.3080 , LBRM2903_200044400

Length:

459

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 4
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

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Cellular components
Term	Name	Level	Count
GO:0000118	histone deacetylase complex	3	1
GO:0000123	histone acetyltransferase complex	4	12
GO:0000812	Swr1 complex	4	1
GO:0005654	nucleoplasm	2	1
GO:0005737	cytoplasm	2	1
GO:0031011	Ino80 complex	5	12
GO:0031248	protein acetyltransferase complex	3	12
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1

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Expansion

Sequence features

A4HB68

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB68

Function

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Biological processes
Term	Name	Level	Count
GO:0000491	small nucleolar ribonucleoprotein complex assembly	7	1
GO:0000492	box C/D snoRNP assembly	8	1
GO:0006139	nucleobase-containing compound metabolic process	3	12
GO:0006259	DNA metabolic process	4	12
GO:0006281	DNA repair	5	12
GO:0006325	chromatin organization	4	1
GO:0006338	chromatin remodeling	5	1
GO:0006355	regulation of DNA-templated transcription	6	1
GO:0006357	regulation of transcription by RNA polymerase II	7	1
GO:0006473	protein acetylation	6	1

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Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003678	DNA helicase activity	3	12
GO:0003824	catalytic activity	1	12
GO:0004386	helicase activity	2	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0008094	ATP-dependent activity, acting on DNA	2	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12

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Putative motif mimicry

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Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	144	148	PF00656	0.400
CLV_NRD_NRD_1	120	122	PF00675	0.200
CLV_PCSK_KEX2_1	120	122	PF00082	0.200
CLV_PCSK_KEX2_1	204	206	PF00082	0.202
CLV_PCSK_PC1ET2_1	204	206	PF00082	0.200
CLV_PCSK_SKI1_1	171	175	PF00082	0.217
CLV_PCSK_SKI1_1	67	71	PF00082	0.218
CLV_PCSK_SKI1_1	79	83	PF00082	0.218
DEG_APCC_KENBOX_2	127	131	PF00400	0.467
DEG_SPOP_SBC_1	9	13	PF00917	0.496

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Homologs

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Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I796	Leptomonas seymouri	44%	95%
A0A0N1IKW9	Leptomonas seymouri	92%	100%
A0A0S4JTM7	Bodo saltans	43%	97%
A0A0S4KMK6	Bodo saltans	82%	100%
A0A1X0P9Z8	Trypanosomatidae	87%	100%
A0A1X0PAP4	Trypanosomatidae	43%	97%
A0A3Q8IEM3	Leishmania donovani	98%	100%
A0A3Q8IFN2	Leishmania donovani	43%	95%
A0A422NEN7	Trypanosoma rangeli	86%	100%
A0A422NS36	Trypanosoma rangeli	44%	97%

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