TPR_REGION domain-containing protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

Tetratricopeptide repeat, putative

Species:

Leishmania braziliensis

UniProt:

A4HB67_LEIBR

TriTrypDb:

LbrM.20.3070 , LBRM2903_200044300

Length:

426

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB67

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB67

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	133	137	PF00656	0.417
CLV_C14_Caspase3-7	294	298	PF00656	0.331
CLV_C14_Caspase3-7	385	389	PF00656	0.319
CLV_NRD_NRD_1	138	140	PF00675	0.334
CLV_PCSK_KEX2_1	183	185	PF00082	0.494
CLV_PCSK_KEX2_1	195	197	PF00082	0.524
CLV_PCSK_KEX2_1	236	238	PF00082	0.295
CLV_PCSK_KEX2_1	279	281	PF00082	0.536
CLV_PCSK_PC1ET2_1	183	185	PF00082	0.494
CLV_PCSK_PC1ET2_1	195	197	PF00082	0.524
CLV_PCSK_PC1ET2_1	236	238	PF00082	0.383
CLV_PCSK_PC1ET2_1	279	281	PF00082	0.455
CLV_PCSK_SKI1_1	139	143	PF00082	0.372
CLV_PCSK_SKI1_1	183	187	PF00082	0.468
CLV_PCSK_SKI1_1	200	204	PF00082	0.277
CLV_PCSK_SKI1_1	206	210	PF00082	0.336
CLV_PCSK_SKI1_1	309	313	PF00082	0.274
CLV_PCSK_SKI1_1	4	8	PF00082	0.522
DEG_Nend_Nbox_1	1	3	PF02207	0.614
DOC_ANK_TNKS_1	367	374	PF00023	0.436
DOC_CKS1_1	112	117	PF01111	0.580
DOC_CYCLIN_RxL_1	183	194	PF00134	0.335
DOC_CYCLIN_RxL_1	200	213	PF00134	0.221
DOC_MAPK_gen_1	200	210	PF00069	0.346
DOC_MAPK_gen_1	9	16	PF00069	0.556
DOC_MAPK_MEF2A_6	173	182	PF00069	0.317
DOC_MAPK_MEF2A_6	203	211	PF00069	0.348
DOC_MAPK_MEF2A_6	9	16	PF00069	0.441
DOC_MAPK_NFAT4_5	173	181	PF00069	0.248
DOC_PP2B_LxvP_1	5	8	PF13499	0.447
DOC_SPAK_OSR1_1	400	404	PF12202	0.279
DOC_USP7_MATH_1	272	276	PF00917	0.318
DOC_USP7_MATH_1	382	386	PF00917	0.570
DOC_USP7_MATH_1	45	49	PF00917	0.615
DOC_USP7_UBL2_3	415	419	PF12436	0.470
DOC_WW_Pin1_4	111	116	PF00397	0.521
DOC_WW_Pin1_4	405	410	PF00397	0.529
LIG_14-3-3_CanoR_1	50	57	PF00244	0.610
LIG_APCC_ABBA_1	176	181	PF00400	0.473
LIG_BIR_III_4	339	343	PF00653	0.334
LIG_eIF4E_1	306	312	PF01652	0.417
LIG_FHA_1	31	37	PF00498	0.511
LIG_FHA_1	419	425	PF00498	0.306
LIG_FHA_1	71	77	PF00498	0.603
LIG_FHA_2	289	295	PF00498	0.289
LIG_LIR_Gen_1	102	108	PF02991	0.432
LIG_LIR_Gen_1	332	340	PF02991	0.275
LIG_LIR_Nem_3	102	107	PF02991	0.451
LIG_LIR_Nem_3	229	235	PF02991	0.417
LIG_LIR_Nem_3	332	337	PF02991	0.275
LIG_SH2_CRK	162	166	PF00017	0.343
LIG_SH2_PTP2	334	337	PF00017	0.417
LIG_SH2_SRC	232	235	PF00017	0.350
LIG_SH2_SRC	354	357	PF00017	0.417
LIG_SH2_STAT3	383	386	PF00017	0.309
LIG_SH2_STAT5	179	182	PF00017	0.384
LIG_SH2_STAT5	334	337	PF00017	0.289
LIG_SH2_STAT5	354	357	PF00017	0.145
LIG_SH3_1	280	286	PF00018	0.537
LIG_SH3_3	112	118	PF00018	0.580
LIG_SH3_3	280	286	PF00018	0.537
LIG_SH3_3	406	412	PF00018	0.526
LIG_Sin3_3	392	399	PF02671	0.488
LIG_SUMO_SIM_par_1	207	213	PF11976	0.244
LIG_SUMO_SIM_par_1	291	297	PF11976	0.311
LIG_SUMO_SIM_par_1	72	78	PF11976	0.353
LIG_TRAF2_1	172	175	PF00917	0.357
LIG_TRAF2_1	275	278	PF00917	0.446
LIG_UBA3_1	1	9	PF00899	0.453
LIG_UBA3_1	81	87	PF00899	0.382
MOD_CK1_1	39	45	PF00069	0.650
MOD_CK1_1	58	64	PF00069	0.660
MOD_CK1_1	67	73	PF00069	0.672
MOD_CK2_1	272	278	PF00069	0.503
MOD_CK2_1	288	294	PF00069	0.188
MOD_CK2_1	74	80	PF00069	0.426
MOD_CK2_1	96	102	PF00069	0.461
MOD_GlcNHglycan	212	215	PF01048	0.308
MOD_GlcNHglycan	42	45	PF01048	0.657
MOD_GlcNHglycan	53	56	PF01048	0.715
MOD_GlcNHglycan	62	65	PF01048	0.537
MOD_GlcNHglycan	66	69	PF01048	0.619
MOD_GlcNHglycan	98	101	PF01048	0.480
MOD_GSK3_1	107	114	PF00069	0.453
MOD_GSK3_1	14	21	PF00069	0.600
MOD_GSK3_1	150	157	PF00069	0.193
MOD_GSK3_1	36	43	PF00069	0.551
MOD_GSK3_1	45	52	PF00069	0.633
MOD_GSK3_1	55	62	PF00069	0.636
MOD_GSK3_1	63	70	PF00069	0.626
MOD_N-GLC_1	405	410	PF02516	0.480
MOD_N-GLC_1	58	63	PF02516	0.698
MOD_NEK2_1	150	155	PF00069	0.303
MOD_NEK2_1	186	191	PF00069	0.410
MOD_NEK2_1	210	215	PF00069	0.461
MOD_NEK2_1	288	293	PF00069	0.343
MOD_NEK2_1	330	335	PF00069	0.289
MOD_NEK2_1	36	41	PF00069	0.458
MOD_PIKK_1	382	388	PF00454	0.456
MOD_PIKK_1	45	51	PF00454	0.658
MOD_PKA_2	45	51	PF00069	0.540
MOD_Plk_4	116	122	PF00069	0.466
MOD_Plk_4	150	156	PF00069	0.389
MOD_Plk_4	20	26	PF00069	0.409
MOD_Plk_4	288	294	PF00069	0.289
MOD_Plk_4	330	336	PF00069	0.374
MOD_ProDKin_1	111	117	PF00069	0.511
MOD_ProDKin_1	405	411	PF00069	0.525
MOD_SUMO_for_1	172	175	PF00179	0.465
MOD_SUMO_rev_2	175	185	PF00179	0.421
TRG_DiLeu_BaEn_2	92	98	PF01217	0.323
TRG_DiLeu_BaLyEn_6	181	186	PF01217	0.239
TRG_ENDOCYTIC_2	131	134	PF00928	0.309
TRG_ENDOCYTIC_2	162	165	PF00928	0.340
TRG_ENDOCYTIC_2	179	182	PF00928	0.291
TRG_ENDOCYTIC_2	232	235	PF00928	0.350
TRG_ENDOCYTIC_2	334	337	PF00928	0.289
TRG_ER_diArg_1	25	28	PF00400	0.540
TRG_ER_diArg_1	362	365	PF00400	0.382
TRG_NES_CRM1_1	133	145	PF08389	0.339
TRG_NES_CRM1_1	181	194	PF08389	0.336
TRG_Pf-PMV_PEXEL_1	148	152	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	309	313	PF00026	0.289
TRG_Pf-PMV_PEXEL_1	400	404	PF00026	0.367
TRG_Pf-PMV_PEXEL_1	422	426	PF00026	0.407
TRG_Pf-PMV_PEXEL_1	79	83	PF00026	0.535

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PCA8	Leptomonas seymouri	75%	96%
A0A0S4IIG6	Bodo saltans	42%	100%
A0A1X0PAU4	Trypanosomatidae	58%	100%
A0A3R7KCS2	Trypanosoma rangeli	55%	100%
A0A3S7X8G8	Leishmania donovani	84%	100%
A4IAB5	Leishmania infantum	84%	100%
C9ZLY1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	57%	100%
E9B5D8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q2J5	Leishmania major	84%	100%
V5DM07	Trypanosoma cruzi	59%	100%