Nuclear RNA export factor 1

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB66_LEIBR

TriTrypDb:

LbrM.20.3060 , LBRM2903_200044200

Length:

203

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 8
NetGPI	no	yes: 0, no: 8

Cellular components
Term	Name	Level	Count
GO:0005929	cilium	4	9
GO:0042995	cell projection	2	9
GO:0043226	organelle	2	9
GO:0043227	membrane-bounded organelle	3	9
GO:0110165	cellular anatomical entity	1	9
GO:0120025	plasma membrane bounded cell projection	3	9

Expansion

Sequence features

A4HB66

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB66

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	18	22	PF00656	0.560
CLV_NRD_NRD_1	182	184	PF00675	0.544
CLV_NRD_NRD_1	83	85	PF00675	0.457
CLV_PCSK_KEX2_1	182	184	PF00082	0.546
CLV_PCSK_KEX2_1	83	85	PF00082	0.457
CLV_PCSK_SKI1_1	62	66	PF00082	0.659
DEG_Nend_UBRbox_2	1	3	PF02207	0.456
DOC_CYCLIN_RxL_1	80	90	PF00134	0.594
DOC_MAPK_MEF2A_6	94	102	PF00069	0.512
DOC_PP1_RVXF_1	81	88	PF00149	0.596
DOC_USP7_MATH_1	199	203	PF00917	0.699
DOC_USP7_MATH_1	31	35	PF00917	0.654
DOC_USP7_MATH_1	71	75	PF00917	0.583
DOC_WW_Pin1_4	130	135	PF00397	0.434
DOC_WW_Pin1_4	160	165	PF00397	0.564
DOC_WW_Pin1_4	193	198	PF00397	0.598
LIG_14-3-3_CanoR_1	158	164	PF00244	0.614
LIG_14-3-3_CanoR_1	43	49	PF00244	0.505
LIG_CSL_BTD_1	96	99	PF09270	0.568
LIG_FHA_1	127	133	PF00498	0.446
LIG_FHA_1	179	185	PF00498	0.567
LIG_FHA_1	55	61	PF00498	0.489
LIG_FHA_2	101	107	PF00498	0.613
LIG_GBD_Chelix_1	124	132	PF00786	0.589
LIG_LIR_Apic_2	47	51	PF02991	0.441
LIG_LIR_Gen_1	39	48	PF02991	0.510
LIG_LIR_Gen_1	61	71	PF02991	0.554
LIG_LIR_Gen_1	8	17	PF02991	0.542
LIG_LIR_Nem_3	39	44	PF02991	0.571
LIG_LIR_Nem_3	61	66	PF02991	0.530
LIG_LIR_Nem_3	8	12	PF02991	0.584
LIG_NRBOX	123	129	PF00104	0.509
LIG_Pex14_1	97	101	PF04695	0.569
LIG_SH2_CRK	48	52	PF00017	0.634
LIG_SH2_CRK	63	67	PF00017	0.534
LIG_SH2_NCK_1	63	67	PF00017	0.534
LIG_SH2_PTP2	16	19	PF00017	0.559
LIG_SH2_STAP1	56	60	PF00017	0.447
LIG_SH2_STAP1	9	13	PF00017	0.552
LIG_SH2_STAT5	16	19	PF00017	0.616
LIG_SH2_STAT5	41	44	PF00017	0.537
LIG_SH2_STAT5	56	59	PF00017	0.591
LIG_SH2_STAT5	91	94	PF00017	0.513
LIG_SUMO_SIM_anti_2	121	129	PF11976	0.602
LIG_SUMO_SIM_par_1	121	129	PF11976	0.488
LIG_TYR_ITIM	14	19	PF00017	0.496
LIG_TYR_ITIM	7	12	PF00017	0.549
LIG_TYR_ITSM	59	66	PF00017	0.521
MOD_CK1_1	162	168	PF00069	0.580
MOD_GlcNHglycan	142	146	PF01048	0.578
MOD_GlcNHglycan	197	200	PF01048	0.478
MOD_GlcNHglycan	27	30	PF01048	0.693
MOD_GSK3_1	109	116	PF00069	0.599
MOD_GSK3_1	126	133	PF00069	0.536
MOD_GSK3_1	137	144	PF00069	0.504
MOD_GSK3_1	160	167	PF00069	0.568
MOD_GSK3_1	195	202	PF00069	0.654
MOD_GSK3_1	54	61	PF00069	0.583
MOD_N-GLC_1	5	10	PF02516	0.418
MOD_NEK2_1	109	114	PF00069	0.601
MOD_NEK2_1	126	131	PF00069	0.443
MOD_NEK2_1	141	146	PF00069	0.677
MOD_NEK2_1	159	164	PF00069	0.393
MOD_NEK2_1	44	49	PF00069	0.526
MOD_NEK2_1	78	83	PF00069	0.503
MOD_NEK2_1	87	92	PF00069	0.435
MOD_PIKK_1	126	132	PF00454	0.462
MOD_PIKK_1	164	170	PF00454	0.586
MOD_PIKK_1	71	77	PF00454	0.661
MOD_PKB_1	190	198	PF00069	0.457
MOD_Plk_1	5	11	PF00069	0.414
MOD_Plk_4	173	179	PF00069	0.602
MOD_Plk_4	37	43	PF00069	0.666
MOD_Plk_4	87	93	PF00069	0.553
MOD_ProDKin_1	130	136	PF00069	0.435
MOD_ProDKin_1	160	166	PF00069	0.564
MOD_ProDKin_1	193	199	PF00069	0.603
TRG_ENDOCYTIC_2	16	19	PF00928	0.609
TRG_ENDOCYTIC_2	41	44	PF00928	0.566
TRG_ENDOCYTIC_2	63	66	PF00928	0.587
TRG_ENDOCYTIC_2	9	12	PF00928	0.595
TRG_ER_diArg_1	182	184	PF00400	0.518
TRG_ER_diArg_1	82	84	PF00400	0.457

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A1X0P9Z0	Trypanosomatidae	30%	100%
A0A3S7X8B4	Leishmania donovani	75%	86%
A4IAB4	Leishmania infantum	75%	86%
C9ZLY2	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	29%	100%
E9B5D7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	86%
Q4Q2J6	Leishmania major	77%	100%
V5BQJ6	Trypanosoma cruzi	31%	99%