Amidinotransferase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Amidinotransferase

Gene product:

amidinotransferase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB65_LEIBR

TriTrypDb:

LbrM.20.3050 , LBRM2903_200044100

Length:

357

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 5

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 12
NetGPI	no	yes: 0, no: 12

Cellular components
Term	Name	Level	Count
GO:0005856	cytoskeleton	5	1
GO:0030863	cortical cytoskeleton	6	1
GO:0043226	organelle	2	1
GO:0043228	non-membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043232	intracellular non-membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB65

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB65

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	3
GO:0016740	transferase activity	2	2
GO:0016787	hydrolase activity	2	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	103	105	PF00675	0.334
CLV_NRD_NRD_1	120	122	PF00675	0.489
CLV_NRD_NRD_1	319	321	PF00675	0.414
CLV_PCSK_KEX2_1	103	105	PF00082	0.311
CLV_PCSK_KEX2_1	319	321	PF00082	0.418
CLV_PCSK_SKI1_1	297	301	PF00082	0.428
CLV_Separin_Metazoa	349	353	PF03568	0.641
DEG_APCC_KENBOX_2	305	309	PF00400	0.439
DOC_CYCLIN_yCln2_LP_2	264	270	PF00134	0.522
DOC_CYCLIN_yCln2_LP_2	6	12	PF00134	0.533
DOC_MAPK_JIP1_4	186	192	PF00069	0.522
DOC_MAPK_RevD_3	89	104	PF00069	0.324
DOC_PP1_RVXF_1	102	109	PF00149	0.395
DOC_PP2B_LxvP_1	264	267	PF13499	0.522
DOC_USP7_MATH_1	132	136	PF00917	0.415
DOC_USP7_MATH_1	223	227	PF00917	0.536
DOC_USP7_MATH_1	291	295	PF00917	0.370
DOC_USP7_MATH_1	340	344	PF00917	0.663
DOC_WW_Pin1_4	159	164	PF00397	0.461
DOC_WW_Pin1_4	170	175	PF00397	0.396
LIG_14-3-3_CanoR_1	201	206	PF00244	0.299
LIG_14-3-3_CanoR_1	271	280	PF00244	0.372
LIG_14-3-3_CanoR_1	320	326	PF00244	0.447
LIG_APCC_ABBA_1	143	148	PF00400	0.522
LIG_BRCT_BRCA1_1	157	161	PF00533	0.500
LIG_BRCT_BRCA1_1	225	229	PF00533	0.500
LIG_FHA_1	100	106	PF00498	0.325
LIG_FHA_1	135	141	PF00498	0.393
LIG_FHA_1	207	213	PF00498	0.373
LIG_FHA_1	345	351	PF00498	0.571
LIG_FHA_1	58	64	PF00498	0.515
LIG_FHA_2	44	50	PF00498	0.558
LIG_IBAR_NPY_1	112	114	PF08397	0.366
LIG_LIR_Gen_1	242	251	PF02991	0.439
LIG_LIR_Nem_3	242	248	PF02991	0.427
LIG_LIR_Nem_3	311	316	PF02991	0.485
LIG_LIR_Nem_3	49	54	PF02991	0.569
LIG_PCNA_yPIPBox_3	53	62	PF02747	0.376
LIG_REV1ctd_RIR_1	49	57	PF16727	0.586
LIG_SH2_CRK	169	173	PF00017	0.402
LIG_SH2_CRK	245	249	PF00017	0.402
LIG_SH2_CRK	72	76	PF00017	0.529
LIG_SH2_PTP2	280	283	PF00017	0.522
LIG_SH2_SRC	152	155	PF00017	0.465
LIG_SH2_STAP1	245	249	PF00017	0.412
LIG_SH2_STAT5	152	155	PF00017	0.444
LIG_SH2_STAT5	167	170	PF00017	0.357
LIG_SH2_STAT5	280	283	PF00017	0.522
LIG_SH2_STAT5	333	336	PF00017	0.574
LIG_SH3_2	110	115	PF14604	0.441
LIG_SH3_3	104	110	PF00018	0.445
LIG_SH3_3	168	174	PF00018	0.375
LIG_SH3_3	264	270	PF00018	0.505
LIG_SH3_3	336	342	PF00018	0.588
LIG_SUMO_SIM_anti_2	137	142	PF11976	0.307
LIG_SUMO_SIM_anti_2	2	8	PF11976	0.508
LIG_SUMO_SIM_anti_2	346	352	PF11976	0.628
LIG_SUMO_SIM_par_1	133	142	PF11976	0.327
LIG_SUMO_SIM_par_1	2	8	PF11976	0.398
LIG_SUMO_SIM_par_1	246	253	PF11976	0.500
LIG_SUMO_SIM_par_1	280	287	PF11976	0.522
LIG_SxIP_EBH_1	201	212	PF03271	0.269
LIG_TRAF2_1	131	134	PF00917	0.534
LIG_TRAF2_1	145	148	PF00917	0.377
LIG_TRAF2_1	75	78	PF00917	0.656
LIG_TYR_ITSM	309	316	PF00017	0.549
LIG_WRC_WIRS_1	309	314	PF05994	0.511
LIG_WRC_WIRS_1	48	53	PF05994	0.552
MOD_CDK_SPK_2	170	175	PF00069	0.269
MOD_CDK_SPxxK_3	159	166	PF00069	0.468
MOD_CK1_1	173	179	PF00069	0.379
MOD_CK1_1	324	330	PF00069	0.476
MOD_CK1_1	343	349	PF00069	0.418
MOD_CK1_1	43	49	PF00069	0.323
MOD_CK2_1	173	179	PF00069	0.312
MOD_CK2_1	249	255	PF00069	0.465
MOD_CK2_1	259	265	PF00069	0.420
MOD_CK2_1	343	349	PF00069	0.582
MOD_CK2_1	43	49	PF00069	0.576
MOD_GlcNHglycan	133	137	PF01048	0.349
MOD_GlcNHglycan	154	158	PF01048	0.468
MOD_GlcNHglycan	241	244	PF01048	0.501
MOD_GlcNHglycan	261	264	PF01048	0.478
MOD_GlcNHglycan	271	274	PF01048	0.508
MOD_GSK3_1	155	162	PF00069	0.459
MOD_GSK3_1	23	30	PF00069	0.470
MOD_GSK3_1	239	246	PF00069	0.483
MOD_GSK3_1	320	327	PF00069	0.500
MOD_GSK3_1	340	347	PF00069	0.308
MOD_GSK3_1	36	43	PF00069	0.553
MOD_NEK2_1	153	158	PF00069	0.398
MOD_NEK2_1	23	28	PF00069	0.583
MOD_NEK2_1	241	246	PF00069	0.356
MOD_NEK2_1	259	264	PF00069	0.522
MOD_NEK2_1	36	41	PF00069	0.549
MOD_OFUCOSY	321	328	PF10250	0.549
MOD_PIKK_1	340	346	PF00454	0.624
MOD_PIKK_1	36	42	PF00454	0.504
MOD_PK_1	79	85	PF00069	0.560
MOD_Plk_1	36	42	PF00069	0.546
MOD_Plk_2-3	134	140	PF00069	0.453
MOD_Plk_4	155	161	PF00069	0.500
MOD_Plk_4	201	207	PF00069	0.498
MOD_Plk_4	223	229	PF00069	0.532
MOD_Plk_4	308	314	PF00069	0.529
MOD_Plk_4	40	46	PF00069	0.510
MOD_Plk_4	47	53	PF00069	0.524
MOD_Plk_4	57	63	PF00069	0.504
MOD_ProDKin_1	159	165	PF00069	0.461
MOD_ProDKin_1	170	176	PF00069	0.396
MOD_SUMO_rev_2	147	153	PF00179	0.468
TRG_DiLeu_BaEn_4	148	154	PF01217	0.483
TRG_DiLeu_BaLyEn_6	101	106	PF01217	0.399
TRG_ENDOCYTIC_2	167	170	PF00928	0.374
TRG_ENDOCYTIC_2	238	241	PF00928	0.425
TRG_ENDOCYTIC_2	245	248	PF00928	0.308
TRG_ENDOCYTIC_2	280	283	PF00928	0.500
TRG_ENDOCYTIC_2	313	316	PF00928	0.498
TRG_ER_diArg_1	103	105	PF00400	0.313

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q5	Leptomonas seymouri	64%	100%
A0A0N1IKG5	Leptomonas seymouri	36%	99%
A0A0S4JAZ5	Bodo saltans	27%	92%
A0A1X0PAA5	Trypanosomatidae	38%	94%
A0A3R7KYJ2	Trypanosoma rangeli	38%	95%
A0A3S7X8B2	Leishmania donovani	84%	100%
A4IAB3	Leishmania infantum	85%	100%
C9ZLY3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	95%
E9B5D6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	84%	100%
Q4Q2J7	Leishmania major	85%	100%
V5B5E2	Trypanosoma cruzi	38%	95%