Lactamase_B domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

metallo-beta-lactamase superfamily, putative

Species:

Leishmania braziliensis

UniProt:

A4HB60_LEIBR

TriTrypDb:

LbrM.20.3000 , LBRM2903_200043500

Length:

518

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0016020	membrane	2	6
GO:0110165	cellular anatomical entity	1	6

Expansion

Sequence features

A4HB60

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB60

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	4
GO:0004416	hydroxyacylglutathione hydrolase activity	5	3
GO:0016787	hydrolase activity	2	4
GO:0016788	hydrolase activity, acting on ester bonds	3	3
GO:0016790	thiolester hydrolase activity	4	3

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	434	438	PF00656	0.610
CLV_NRD_NRD_1	510	512	PF00675	0.359
CLV_PCSK_FUR_1	121	125	PF00082	0.482
CLV_PCSK_KEX2_1	123	125	PF00082	0.492
CLV_PCSK_KEX2_1	510	512	PF00082	0.324
CLV_PCSK_PC1ET2_1	123	125	PF00082	0.492
CLV_PCSK_SKI1_1	391	395	PF00082	0.255
CLV_PCSK_SKI1_1	402	406	PF00082	0.262
CLV_PCSK_SKI1_1	427	431	PF00082	0.349
DEG_APCC_DBOX_1	509	517	PF00400	0.438
DOC_CYCLIN_yClb3_PxF_3	63	71	PF00134	0.571
DOC_CYCLIN_yCln2_LP_2	206	212	PF00134	0.508
DOC_MAPK_DCC_7	158	167	PF00069	0.470
DOC_MAPK_DCC_7	3	13	PF00069	0.341
DOC_MAPK_gen_1	233	241	PF00069	0.466
DOC_MAPK_MEF2A_6	142	151	PF00069	0.161
DOC_MAPK_MEF2A_6	158	167	PF00069	0.453
DOC_MAPK_MEF2A_6	203	212	PF00069	0.508
DOC_MAPK_MEF2A_6	471	479	PF00069	0.430
DOC_PP1_RVXF_1	1	8	PF00149	0.491
DOC_PP2B_LxvP_1	206	209	PF13499	0.508
DOC_PP2B_LxvP_1	239	242	PF13499	0.503
DOC_PP4_FxxP_1	456	459	PF00568	0.593
DOC_USP7_MATH_1	495	499	PF00917	0.614
DOC_USP7_MATH_2	343	349	PF00917	0.572
DOC_USP7_UBL2_3	233	237	PF12436	0.441
DOC_WW_Pin1_4	115	120	PF00397	0.382
DOC_WW_Pin1_4	280	285	PF00397	0.562
DOC_WW_Pin1_4	320	325	PF00397	0.545
LIG_14-3-3_CanoR_1	203	207	PF00244	0.421
LIG_14-3-3_CanoR_1	356	360	PF00244	0.510
LIG_14-3-3_CanoR_1	364	369	PF00244	0.499
LIG_14-3-3_CanoR_1	391	400	PF00244	0.534
LIG_Actin_WH2_2	107	125	PF00022	0.395
LIG_APCC_ABBA_1	165	170	PF00400	0.534
LIG_BIR_II_1	1	5	PF00653	0.595
LIG_BIR_III_2	281	285	PF00653	0.505
LIG_BRCT_BRCA1_1	282	286	PF00533	0.561
LIG_BRCT_BRCA1_1	306	310	PF00533	0.434
LIG_BRCT_BRCA1_1	66	70	PF00533	0.597
LIG_Clathr_ClatBox_1	476	480	PF01394	0.539
LIG_FHA_1	179	185	PF00498	0.474
LIG_FHA_1	203	209	PF00498	0.453
LIG_FHA_1	211	217	PF00498	0.425
LIG_FHA_1	344	350	PF00498	0.522
LIG_FHA_1	387	393	PF00498	0.481
LIG_FHA_1	399	405	PF00498	0.509
LIG_FHA_2	369	375	PF00498	0.598
LIG_FHA_2	432	438	PF00498	0.636
LIG_FHA_2	476	482	PF00498	0.534
LIG_LIR_Apic_2	6	10	PF02991	0.450
LIG_LIR_Gen_1	130	141	PF02991	0.323
LIG_LIR_Gen_1	170	179	PF02991	0.405
LIG_LIR_Gen_1	283	293	PF02991	0.498
LIG_LIR_Nem_3	130	136	PF02991	0.335
LIG_LIR_Nem_3	170	175	PF02991	0.405
LIG_LIR_Nem_3	43	49	PF02991	0.355
LIG_MYND_1	256	260	PF01753	0.500
LIG_Pex14_2	135	139	PF04695	0.358
LIG_SH2_CRK	172	176	PF00017	0.471
LIG_SH2_CRK	37	41	PF00017	0.468
LIG_SH2_CRK	46	50	PF00017	0.389
LIG_SH2_CRK	89	93	PF00017	0.274
LIG_SH2_NCK_1	140	144	PF00017	0.304
LIG_SH2_SRC	174	177	PF00017	0.508
LIG_SH2_SRC	19	22	PF00017	0.304
LIG_SH2_SRC	85	88	PF00017	0.183
LIG_SH2_STAP1	172	176	PF00017	0.404
LIG_SH2_STAP1	251	255	PF00017	0.477
LIG_SH2_STAP1	388	392	PF00017	0.458
LIG_SH2_STAT5	174	177	PF00017	0.404
LIG_SH2_STAT5	19	22	PF00017	0.221
LIG_SH2_STAT5	383	386	PF00017	0.435
LIG_SH2_STAT5	388	391	PF00017	0.460
LIG_SH2_STAT5	418	421	PF00017	0.501
LIG_SH2_STAT5	46	49	PF00017	0.315
LIG_SH2_STAT5	506	509	PF00017	0.480
LIG_SH2_STAT5	54	57	PF00017	0.238
LIG_SH2_STAT5	82	85	PF00017	0.293
LIG_SH2_STAT5	89	92	PF00017	0.242
LIG_SH3_3	160	166	PF00018	0.465
LIG_SH3_3	186	192	PF00018	0.409
LIG_SH3_3	407	413	PF00018	0.556
LIG_SH3_3	57	63	PF00018	0.556
LIG_SH3_3	88	94	PF00018	0.420
LIG_SH3_3	97	103	PF00018	0.337
LIG_SUMO_SIM_par_1	145	150	PF11976	0.210
LIG_SUMO_SIM_par_1	475	482	PF11976	0.489
LIG_TRAF2_1	314	317	PF00917	0.510
LIG_TRAF2_1	371	374	PF00917	0.553
LIG_TYR_ITIM	44	49	PF00017	0.304
LIG_TYR_ITIM	87	92	PF00017	0.273
LIG_UBA3_1	175	183	PF00899	0.508
LIG_UBA3_1	74	80	PF00899	0.384
LIG_WRC_WIRS_1	65	70	PF05994	0.560
LIG_WW_3	241	245	PF00397	0.542
MOD_CDC14_SPxK_1	118	121	PF00782	0.423
MOD_CDK_SPxK_1	115	121	PF00069	0.415
MOD_CDK_SPxK_1	320	326	PF00069	0.536
MOD_CK1_1	134	140	PF00069	0.221
MOD_CK1_1	178	184	PF00069	0.404
MOD_CK1_1	201	207	PF00069	0.431
MOD_CK2_1	232	238	PF00069	0.552
MOD_CK2_1	311	317	PF00069	0.496
MOD_CK2_1	368	374	PF00069	0.615
MOD_CK2_1	422	428	PF00069	0.496
MOD_GlcNHglycan	26	29	PF01048	0.597
MOD_GlcNHglycan	313	316	PF01048	0.320
MOD_GlcNHglycan	32	35	PF01048	0.653
MOD_GlcNHglycan	55	58	PF01048	0.298
MOD_GSK3_1	127	134	PF00069	0.408
MOD_GSK3_1	198	205	PF00069	0.433
MOD_GSK3_1	210	217	PF00069	0.406
MOD_GSK3_1	364	371	PF00069	0.524
MOD_GSK3_1	391	398	PF00069	0.558
MOD_GSK3_1	433	440	PF00069	0.633
MOD_GSK3_1	459	466	PF00069	0.469
MOD_N-GLC_1	152	157	PF02516	0.323
MOD_NEK2_1	175	180	PF00069	0.415
MOD_NEK2_1	202	207	PF00069	0.463
MOD_NEK2_1	81	86	PF00069	0.239
MOD_NEK2_2	40	45	PF00069	0.304
MOD_PIKK_1	364	370	PF00454	0.633
MOD_PIKK_1	448	454	PF00454	0.524
MOD_PK_1	237	243	PF00069	0.503
MOD_PKA_2	202	208	PF00069	0.428
MOD_PKA_2	355	361	PF00069	0.559
MOD_PKB_1	455	463	PF00069	0.437
MOD_Plk_1	237	243	PF00069	0.511
MOD_Plk_1	469	475	PF00069	0.470
MOD_Plk_4	152	158	PF00069	0.507
MOD_Plk_4	3	9	PF00069	0.567
MOD_Plk_4	304	310	PF00069	0.447
MOD_Plk_4	331	337	PF00069	0.524
MOD_Plk_4	355	361	PF00069	0.559
MOD_Plk_4	395	401	PF00069	0.514
MOD_Plk_4	64	70	PF00069	0.619
MOD_ProDKin_1	115	121	PF00069	0.388
MOD_ProDKin_1	280	286	PF00069	0.559
MOD_ProDKin_1	320	326	PF00069	0.536
MOD_SUMO_for_1	488	491	PF00179	0.440
MOD_SUMO_rev_2	424	432	PF00179	0.416
TRG_DiLeu_BaEn_1	395	400	PF01217	0.615
TRG_DiLeu_BaEn_4	268	274	PF01217	0.465
TRG_DiLeu_BaLyEn_6	253	258	PF01217	0.528
TRG_DiLeu_BaLyEn_6	388	393	PF01217	0.511
TRG_DiLeu_BaLyEn_6	472	477	PF01217	0.454
TRG_DiLeu_BaLyEn_6	73	78	PF01217	0.508
TRG_ENDOCYTIC_2	172	175	PF00928	0.471
TRG_ENDOCYTIC_2	46	49	PF00928	0.403
TRG_ENDOCYTIC_2	89	92	PF00928	0.295
TRG_ER_diArg_1	363	366	PF00400	0.528
TRG_Pf-PMV_PEXEL_1	391	395	PF00026	0.323

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1PD83	Leptomonas seymouri	66%	99%
A0A0S4IM37	Bodo saltans	34%	100%
A0A1X0PA00	Trypanosomatidae	37%	100%
A0A3R7K9K9	Trypanosoma rangeli	40%	100%
A0A3S7X8A7	Leishmania donovani	82%	100%
A4IAA8	Leishmania infantum	83%	100%
A7YY46	Bos taurus	28%	100%
C9ZLY8	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	36%	100%
E9B5D1	Leishmania mexicana (strain MHOM/GT/2001/U1103)	82%	100%
Q4Q2K2	Leishmania major	82%	100%
Q8N490	Homo sapiens	27%	100%
V5B5D7	Trypanosoma cruzi	38%	100%