HECT domain-containing protein

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

HECT-domain (ubiquitin-transferase), putative

Species:

Leishmania braziliensis

UniProt:

A4HB59_LEIBR

TriTrypDb:

LbrM.20.2990 , LBRM2903_200043400

Length:

322

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB59

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB59

Function

Could not find GO biological_process term for this entry.

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	7
GO:0004842	ubiquitin-protein transferase activity	4	7
GO:0016740	transferase activity	2	7
GO:0019787	ubiquitin-like protein transferase activity	3	7
GO:0140096	catalytic activity, acting on a protein	2	7

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	262	264	PF00675	0.542
CLV_NRD_NRD_1	286	288	PF00675	0.586
CLV_NRD_NRD_1	290	292	PF00675	0.571
CLV_PCSK_KEX2_1	262	264	PF00082	0.542
CLV_PCSK_KEX2_1	286	288	PF00082	0.586
CLV_PCSK_KEX2_1	290	292	PF00082	0.571
CLV_PCSK_PC7_1	286	292	PF00082	0.558
CLV_PCSK_SKI1_1	301	305	PF00082	0.532
CLV_Separin_Metazoa	167	171	PF03568	0.740
DEG_Nend_UBRbox_3	1	3	PF02207	0.635
DOC_ANK_TNKS_1	182	189	PF00023	0.634
DOC_CDC14_PxL_1	112	120	PF14671	0.496
DOC_CYCLIN_RxL_1	298	307	PF00134	0.473
DOC_MAPK_gen_1	176	184	PF00069	0.638
DOC_PP2B_LxvP_1	313	316	PF13499	0.775
DOC_PP4_FxxP_1	124	127	PF00568	0.516
DOC_PP4_FxxP_1	192	195	PF00568	0.618
DOC_USP7_MATH_1	23	27	PF00917	0.495
DOC_USP7_MATH_1	261	265	PF00917	0.699
DOC_USP7_UBL2_3	53	57	PF12436	0.231
DOC_WW_Pin1_4	123	128	PF00397	0.587
DOC_WW_Pin1_4	257	262	PF00397	0.613
DOC_WW_Pin1_4	302	307	PF00397	0.678
LIG_14-3-3_CanoR_1	151	158	PF00244	0.569
LIG_14-3-3_CanoR_1	20	29	PF00244	0.494
LIG_14-3-3_CanoR_1	214	219	PF00244	0.579
LIG_14-3-3_CanoR_1	247	255	PF00244	0.559
LIG_14-3-3_CanoR_1	262	267	PF00244	0.716
LIG_14-3-3_CanoR_1	268	274	PF00244	0.608
LIG_14-3-3_CanoR_1	290	297	PF00244	0.566
LIG_14-3-3_CanoR_1	92	99	PF00244	0.391
LIG_Actin_WH2_2	98	115	PF00022	0.366
LIG_APCC_ABBA_1	198	203	PF00400	0.563
LIG_APCC_ABBA_1	314	319	PF00400	0.583
LIG_BRCT_BRCA1_1	176	180	PF00533	0.553
LIG_deltaCOP1_diTrp_1	145	152	PF00928	0.524
LIG_DLG_GKlike_1	262	270	PF00625	0.534
LIG_EVH1_1	251	255	PF00568	0.527
LIG_FHA_1	142	148	PF00498	0.664
LIG_FHA_1	202	208	PF00498	0.514
LIG_FHA_1	268	274	PF00498	0.629
LIG_FHA_1	308	314	PF00498	0.619
LIG_FHA_1	65	71	PF00498	0.319
LIG_FHA_2	208	214	PF00498	0.397
LIG_Integrin_isoDGR_2	87	89	PF01839	0.509
LIG_LIR_Apic_2	122	127	PF02991	0.517
LIG_LIR_Apic_2	189	195	PF02991	0.630
LIG_LIR_Gen_1	100	109	PF02991	0.183
LIG_LIR_Gen_1	43	51	PF02991	0.316
LIG_LIR_Gen_1	62	72	PF02991	0.211
LIG_LIR_Gen_1	80	86	PF02991	0.464
LIG_LIR_Nem_3	100	105	PF02991	0.183
LIG_LIR_Nem_3	217	222	PF02991	0.539
LIG_LIR_Nem_3	43	48	PF02991	0.228
LIG_LIR_Nem_3	62	68	PF02991	0.353
LIG_LIR_Nem_3	71	75	PF02991	0.357
LIG_LIR_Nem_3	80	85	PF02991	0.464
LIG_NRBOX	204	210	PF00104	0.486
LIG_PDZ_Class_2	317	322	PF00595	0.562
LIG_REV1ctd_RIR_1	99	107	PF16727	0.388
LIG_SH2_CRK	109	113	PF00017	0.458
LIG_SH2_CRK	82	86	PF00017	0.352
LIG_SH2_GRB2like	109	112	PF00017	0.546
LIG_SH2_NCK_1	82	86	PF00017	0.352
LIG_SH3_2	165	170	PF14604	0.627
LIG_SH3_2	252	257	PF14604	0.534
LIG_SH3_3	102	108	PF00018	0.307
LIG_SH3_3	162	168	PF00018	0.624
LIG_SH3_3	249	255	PF00018	0.555
LIG_SUMO_SIM_anti_2	203	211	PF11976	0.553
LIG_TRAF2_1	316	319	PF00917	0.585
LIG_TRFH_1	82	86	PF08558	0.352
LIG_WW_3	126	130	PF00397	0.488
LIG_WW_3	244	248	PF00397	0.533
MOD_CDC14_SPxK_1	126	129	PF00782	0.491
MOD_CDC14_SPxK_1	260	263	PF00782	0.534
MOD_CDK_SPK_2	257	262	PF00069	0.534
MOD_CDK_SPxK_1	123	129	PF00069	0.526
MOD_CDK_SPxK_1	257	263	PF00069	0.535
MOD_CK1_1	239	245	PF00069	0.695
MOD_CK1_1	269	275	PF00069	0.518
MOD_CK2_1	207	213	PF00069	0.480
MOD_CK2_1	290	296	PF00069	0.521
MOD_CMANNOS	149	152	PF00535	0.518
MOD_DYRK1A_RPxSP_1	257	261	PF00069	0.532
MOD_GlcNHglycan	273	276	PF01048	0.563
MOD_GlcNHglycan	293	296	PF01048	0.625
MOD_GSK3_1	119	126	PF00069	0.673
MOD_GSK3_1	137	144	PF00069	0.678
MOD_GSK3_1	236	243	PF00069	0.636
MOD_GSK3_1	257	264	PF00069	0.810
MOD_GSK3_1	267	274	PF00069	0.602
MOD_GSK3_1	64	71	PF00069	0.306
MOD_GSK3_1	73	80	PF00069	0.355
MOD_N-GLC_1	77	82	PF02516	0.363
MOD_NEK2_1	130	135	PF00069	0.578
MOD_NEK2_1	137	142	PF00069	0.556
MOD_NEK2_1	201	206	PF00069	0.397
MOD_NEK2_1	266	271	PF00069	0.611
MOD_NEK2_1	68	73	PF00069	0.312
MOD_PIKK_1	21	27	PF00454	0.517
MOD_PIKK_1	240	246	PF00454	0.584
MOD_PIKK_1	91	97	PF00454	0.388
MOD_PK_1	214	220	PF00069	0.670
MOD_PKA_1	262	268	PF00069	0.537
MOD_PKA_1	290	296	PF00069	0.524
MOD_PKA_2	130	136	PF00069	0.581
MOD_PKA_2	137	143	PF00069	0.552
MOD_PKA_2	150	156	PF00069	0.563
MOD_PKA_2	246	252	PF00069	0.606
MOD_PKA_2	261	267	PF00069	0.606
MOD_PKA_2	290	296	PF00069	0.563
MOD_PKA_2	91	97	PF00069	0.312
MOD_Plk_1	188	194	PF00069	0.633
MOD_Plk_1	77	83	PF00069	0.262
MOD_Plk_4	188	194	PF00069	0.699
MOD_ProDKin_1	123	129	PF00069	0.584
MOD_ProDKin_1	257	263	PF00069	0.614
MOD_ProDKin_1	302	308	PF00069	0.679
TRG_ENDOCYTIC_2	109	112	PF00928	0.470
TRG_ENDOCYTIC_2	82	85	PF00928	0.352
TRG_ER_diArg_1	128	131	PF00400	0.565
TRG_ER_diArg_1	136	139	PF00400	0.562
TRG_ER_diArg_1	175	178	PF00400	0.608
TRG_ER_diArg_1	261	263	PF00400	0.535
TRG_ER_diArg_1	286	288	PF00400	0.551
TRG_ER_diArg_1	289	291	PF00400	0.561
TRG_NES_CRM1_1	196	211	PF08389	0.492
TRG_NES_CRM1_1	66	79	PF08389	0.388

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1HYK9	Leptomonas seymouri	49%	98%
A0A3Q8INP3	Leishmania donovani	82%	100%
A4IAA6	Leishmania infantum	82%	100%
E9B5C9	Leishmania mexicana (strain MHOM/GT/2001/U1103)	81%	100%
Q4Q2K4	Leishmania major	80%	100%