Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB58_LEIBR

TriTrypDb:

LbrM.20.2980 , LBRM2903_200043300

Length:

613

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB58

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB58

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	261	265	PF00656	0.587
CLV_C14_Caspase3-7	456	460	PF00656	0.757
CLV_C14_Caspase3-7	507	511	PF00656	0.503
CLV_NRD_NRD_1	10	12	PF00675	0.508
CLV_NRD_NRD_1	126	128	PF00675	0.767
CLV_NRD_NRD_1	176	178	PF00675	0.519
CLV_NRD_NRD_1	409	411	PF00675	0.510
CLV_NRD_NRD_1	537	539	PF00675	0.631
CLV_PCSK_KEX2_1	126	128	PF00082	0.767
CLV_PCSK_KEX2_1	176	178	PF00082	0.486
CLV_PCSK_KEX2_1	408	410	PF00082	0.557
CLV_PCSK_KEX2_1	536	538	PF00082	0.682
CLV_PCSK_PC7_1	533	539	PF00082	0.682
CLV_PCSK_SKI1_1	146	150	PF00082	0.551
CLV_PCSK_SKI1_1	177	181	PF00082	0.500
CLV_PCSK_SKI1_1	192	196	PF00082	0.570
CLV_PCSK_SKI1_1	23	27	PF00082	0.585
CLV_PCSK_SKI1_1	32	36	PF00082	0.616
CLV_PCSK_SKI1_1	346	350	PF00082	0.463
CLV_PCSK_SKI1_1	468	472	PF00082	0.586
CLV_PCSK_SKI1_1	526	530	PF00082	0.641
CLV_PCSK_SKI1_1	87	91	PF00082	0.657
CLV_Separin_Metazoa	492	496	PF03568	0.703
DEG_APCC_DBOX_1	535	543	PF00400	0.680
DEG_APCC_KENBOX_2	220	224	PF00400	0.704
DEG_Nend_Nbox_1	1	3	PF02207	0.457
DEG_SPOP_SBC_1	284	288	PF00917	0.602
DOC_CKS1_1	289	294	PF01111	0.700
DOC_CYCLIN_RxL_1	20	29	PF00134	0.625
DOC_CYCLIN_yCln2_LP_2	584	587	PF00134	0.531
DOC_MAPK_gen_1	526	534	PF00069	0.661
DOC_MAPK_gen_1	536	544	PF00069	0.524
DOC_MAPK_HePTP_8	534	546	PF00069	0.680
DOC_MAPK_MEF2A_6	329	337	PF00069	0.482
DOC_MAPK_MEF2A_6	537	546	PF00069	0.582
DOC_PP1_RVXF_1	366	373	PF00149	0.565
DOC_PP2B_LxvP_1	137	140	PF13499	0.593
DOC_PP2B_LxvP_1	569	572	PF13499	0.594
DOC_PP2B_LxvP_1	584	587	PF13499	0.531
DOC_PP2B_LxvP_1	604	607	PF13499	0.676
DOC_PP4_FxxP_1	372	375	PF00568	0.537
DOC_USP7_MATH_1	144	148	PF00917	0.650
DOC_USP7_MATH_1	158	162	PF00917	0.697
DOC_USP7_MATH_1	260	264	PF00917	0.740
DOC_USP7_MATH_1	277	281	PF00917	0.703
DOC_USP7_MATH_1	565	569	PF00917	0.584
DOC_USP7_MATH_1	58	62	PF00917	0.636
DOC_USP7_MATH_2	556	562	PF00917	0.540
DOC_USP7_UBL2_3	302	306	PF12436	0.594
DOC_WW_Pin1_4	131	136	PF00397	0.793
DOC_WW_Pin1_4	181	186	PF00397	0.666
DOC_WW_Pin1_4	197	202	PF00397	0.384
DOC_WW_Pin1_4	256	261	PF00397	0.782
DOC_WW_Pin1_4	285	290	PF00397	0.679
DOC_WW_Pin1_4	37	42	PF00397	0.553
DOC_WW_Pin1_4	486	491	PF00397	0.729
DOC_WW_Pin1_4	508	513	PF00397	0.499
DOC_WW_Pin1_4	593	598	PF00397	0.670
LIG_14-3-3_CanoR_1	108	113	PF00244	0.639
LIG_14-3-3_CanoR_1	11	19	PF00244	0.478
LIG_14-3-3_CanoR_1	127	137	PF00244	0.487
LIG_14-3-3_CanoR_1	283	289	PF00244	0.673
LIG_14-3-3_CanoR_1	495	501	PF00244	0.711
LIG_14-3-3_CanoR_1	87	95	PF00244	0.391
LIG_APCC_ABBAyCdc20_2	176	182	PF00400	0.692
LIG_Clathr_ClatBox_1	80	84	PF01394	0.613
LIG_Clathr_ClatBox_1	92	96	PF01394	0.437
LIG_deltaCOP1_diTrp_1	558	564	PF00928	0.798
LIG_eIF4E_1	599	605	PF01652	0.533
LIG_EVH1_1	569	573	PF00568	0.518
LIG_FHA_1	147	153	PF00498	0.739
LIG_FHA_1	170	176	PF00498	0.406
LIG_FHA_1	307	313	PF00498	0.638
LIG_FHA_1	315	321	PF00498	0.657
LIG_FHA_1	38	44	PF00498	0.637
LIG_FHA_1	392	398	PF00498	0.638
LIG_FHA_1	433	439	PF00498	0.760
LIG_FHA_1	478	484	PF00498	0.608
LIG_FHA_1	501	507	PF00498	0.697
LIG_FHA_1	599	605	PF00498	0.684
LIG_FHA_1	69	75	PF00498	0.497
LIG_FHA_1	88	94	PF00498	0.546
LIG_FHA_2	158	164	PF00498	0.734
LIG_FHA_2	259	265	PF00498	0.579
LIG_FHA_2	334	340	PF00498	0.630
LIG_FHA_2	359	365	PF00498	0.579
LIG_Integrin_isoDGR_2	223	225	PF01839	0.713
LIG_Integrin_isoDGR_2	386	388	PF01839	0.571
LIG_IRF3_LxIS_1	22	29	PF10401	0.584
LIG_LIR_Apic_2	71	75	PF02991	0.594
LIG_LIR_Gen_1	16	27	PF02991	0.482
LIG_LIR_Gen_1	168	175	PF02991	0.661
LIG_LIR_Gen_1	378	385	PF02991	0.556
LIG_LIR_Gen_1	530	539	PF02991	0.683
LIG_LIR_Gen_1	561	572	PF02991	0.759
LIG_LIR_Gen_1	62	73	PF02991	0.521
LIG_LIR_Nem_3	16	22	PF02991	0.583
LIG_LIR_Nem_3	168	173	PF02991	0.675
LIG_LIR_Nem_3	187	193	PF02991	0.322
LIG_LIR_Nem_3	37	42	PF02991	0.655
LIG_LIR_Nem_3	378	384	PF02991	0.548
LIG_LIR_Nem_3	530	534	PF02991	0.683
LIG_LIR_Nem_3	561	567	PF02991	0.769
LIG_LIR_Nem_3	62	68	PF02991	0.537
LIG_NRBOX	111	117	PF00104	0.563
LIG_PCNA_yPIPBox_3	244	252	PF02747	0.547
LIG_PDZ_Class_2	608	613	PF00595	0.737
LIG_Pex14_1	501	505	PF04695	0.622
LIG_Pex14_2	209	213	PF04695	0.548
LIG_PTB_Apo_2	33	40	PF02174	0.579
LIG_PTB_Phospho_1	33	39	PF10480	0.686
LIG_RPA_C_Fungi	533	545	PF08784	0.681
LIG_SH2_CRK	19	23	PF00017	0.448
LIG_SH2_CRK	381	385	PF00017	0.542
LIG_SH2_CRK	39	43	PF00017	0.302
LIG_SH2_CRK	5	9	PF00017	0.692
LIG_SH2_CRK	72	76	PF00017	0.597
LIG_SH2_NCK_1	381	385	PF00017	0.542
LIG_SH2_NCK_1	513	517	PF00017	0.746
LIG_SH2_NCK_1	72	76	PF00017	0.597
LIG_SH2_STAT5	101	104	PF00017	0.501
LIG_SH2_STAT5	193	196	PF00017	0.523
LIG_SH2_STAT5	251	254	PF00017	0.577
LIG_SH2_STAT5	39	42	PF00017	0.642
LIG_SH2_STAT5	403	406	PF00017	0.636
LIG_SH2_STAT5	513	516	PF00017	0.731
LIG_SH2_STAT5	531	534	PF00017	0.560
LIG_SH3_3	286	292	PF00018	0.666
LIG_SH3_3	298	304	PF00018	0.813
LIG_SH3_3	317	323	PF00018	0.564
LIG_SH3_3	519	525	PF00018	0.705
LIG_SH3_3	550	556	PF00018	0.770
LIG_SH3_3	564	570	PF00018	0.712
LIG_SH3_3	82	88	PF00018	0.635
LIG_SUMO_SIM_par_1	149	157	PF11976	0.650
LIG_SUMO_SIM_par_1	469	475	PF11976	0.655
LIG_TRAF2_1	489	492	PF00917	0.560
LIG_TRAF2_2	201	206	PF00917	0.585
LIG_TRFH_1	381	385	PF08558	0.542
MOD_CK1_1	114	120	PF00069	0.697
MOD_CK1_1	147	153	PF00069	0.584
MOD_CK1_1	157	163	PF00069	0.658
MOD_CK1_1	263	269	PF00069	0.771
MOD_CK1_1	273	279	PF00069	0.793
MOD_CK1_1	37	43	PF00069	0.646
MOD_CK1_1	486	492	PF00069	0.725
MOD_CK1_1	508	514	PF00069	0.499
MOD_CK2_1	157	163	PF00069	0.743
MOD_CK2_1	181	187	PF00069	0.553
MOD_CK2_1	344	350	PF00069	0.656
MOD_CK2_1	358	364	PF00069	0.493
MOD_CK2_1	486	492	PF00069	0.660
MOD_GlcNHglycan	146	149	PF01048	0.697
MOD_GlcNHglycan	156	159	PF01048	0.595
MOD_GlcNHglycan	160	163	PF01048	0.490
MOD_GlcNHglycan	256	259	PF01048	0.620
MOD_GlcNHglycan	274	278	PF01048	0.765
MOD_GlcNHglycan	279	282	PF01048	0.801
MOD_GlcNHglycan	28	31	PF01048	0.680
MOD_GlcNHglycan	515	519	PF01048	0.503
MOD_GlcNHglycan	560	563	PF01048	0.544
MOD_GSK3_1	111	118	PF00069	0.660
MOD_GSK3_1	140	147	PF00069	0.683
MOD_GSK3_1	150	157	PF00069	0.664
MOD_GSK3_1	250	257	PF00069	0.594
MOD_GSK3_1	273	280	PF00069	0.842
MOD_GSK3_1	283	290	PF00069	0.570
MOD_GSK3_1	340	347	PF00069	0.664
MOD_GSK3_1	428	435	PF00069	0.684
MOD_GSK3_1	472	479	PF00069	0.578
MOD_GSK3_1	500	507	PF00069	0.697
MOD_GSK3_1	554	561	PF00069	0.635
MOD_N-GLC_1	35	40	PF02516	0.674
MOD_NEK2_1	115	120	PF00069	0.600
MOD_NEK2_1	154	159	PF00069	0.523
MOD_NEK2_1	34	39	PF00069	0.667
MOD_NEK2_1	483	488	PF00069	0.623
MOD_NEK2_1	68	73	PF00069	0.601
MOD_PIKK_1	11	17	PF00454	0.715
MOD_PIKK_1	199	205	PF00454	0.676
MOD_PIKK_1	294	300	PF00454	0.600
MOD_PIKK_1	350	356	PF00454	0.671
MOD_PIKK_1	494	500	PF00454	0.716
MOD_PIKK_1	52	58	PF00454	0.664
MOD_PK_1	538	544	PF00069	0.678
MOD_PKA_1	11	17	PF00069	0.462
MOD_PKA_2	270	276	PF00069	0.676
MOD_PKA_2	358	364	PF00069	0.595
MOD_PKA_2	494	500	PF00069	0.681
MOD_PKB_1	536	544	PF00069	0.685
MOD_Plk_1	140	146	PF00069	0.556
MOD_Plk_1	205	211	PF00069	0.682
MOD_Plk_1	314	320	PF00069	0.626
MOD_Plk_1	340	346	PF00069	0.639
MOD_Plk_1	35	41	PF00069	0.676
MOD_Plk_1	514	520	PF00069	0.503
MOD_Plk_1	565	571	PF00069	0.526
MOD_Plk_2-3	472	478	PF00069	0.685
MOD_Plk_4	111	117	PF00069	0.665
MOD_Plk_4	247	253	PF00069	0.403
MOD_Plk_4	315	321	PF00069	0.628
MOD_Plk_4	340	346	PF00069	0.693
MOD_Plk_4	527	533	PF00069	0.624
MOD_Plk_4	59	65	PF00069	0.624
MOD_ProDKin_1	131	137	PF00069	0.798
MOD_ProDKin_1	181	187	PF00069	0.655
MOD_ProDKin_1	197	203	PF00069	0.390
MOD_ProDKin_1	256	262	PF00069	0.789
MOD_ProDKin_1	285	291	PF00069	0.679
MOD_ProDKin_1	37	43	PF00069	0.544
MOD_ProDKin_1	486	492	PF00069	0.725
MOD_ProDKin_1	508	514	PF00069	0.499
MOD_ProDKin_1	593	599	PF00069	0.671
TRG_DiLeu_BaEn_2	221	227	PF01217	0.717
TRG_DiLeu_BaLyEn_6	530	535	PF01217	0.681
TRG_ENDOCYTIC_2	101	104	PF00928	0.501
TRG_ENDOCYTIC_2	19	22	PF00928	0.469
TRG_ENDOCYTIC_2	381	384	PF00928	0.525
TRG_ENDOCYTIC_2	39	42	PF00928	0.312
TRG_ENDOCYTIC_2	5	8	PF00928	0.598
TRG_ENDOCYTIC_2	531	534	PF00928	0.581
TRG_ER_diArg_1	125	127	PF00400	0.744
TRG_ER_diArg_1	175	177	PF00400	0.452
TRG_ER_diArg_1	408	410	PF00400	0.520
TRG_ER_diArg_1	535	538	PF00400	0.679
TRG_Pf-PMV_PEXEL_1	11	15	PF00026	0.466
TRG_Pf-PMV_PEXEL_1	346	350	PF00026	0.611

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I561	Leptomonas seymouri	40%	83%
A0A3S7X8F7	Leishmania donovani	80%	84%
A4IAA5	Leishmania infantum	80%	84%
E9B5C8	Leishmania mexicana (strain MHOM/GT/2001/U1103)	78%	84%
Q4Q2K5	Leishmania major	79%	100%