Glucose-6-phosphate 1-epimerase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

aldose 1-epimerase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HB57_LEIBR

TriTrypDb:

LbrM.20.2970 , LBRM2903_200043200

Length:

301

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 10

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 8

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	1
GO:0005777	peroxisome	6	1
GO:0020015	glycosome	7	1
GO:0042579	microbody	5	1
GO:0043226	organelle	2	1
GO:0043227	membrane-bounded organelle	3	1
GO:0043229	intracellular organelle	3	1
GO:0043231	intracellular membrane-bounded organelle	4	1
GO:0110165	cellular anatomical entity	1	1

Expansion

Sequence features

A4HB57

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB57

Function

Biological processes
Term	Name	Level	Count
GO:0005975	carbohydrate metabolic process	3	11
GO:0008152	metabolic process	1	11
GO:0044238	primary metabolic process	2	11
GO:0071704	organic substance metabolic process	2	11

Molecular functions
Term	Name	Level	Count
GO:0003824	catalytic activity	1	11
GO:0005488	binding	1	11
GO:0016853	isomerase activity	2	11
GO:0016854	racemase and epimerase activity	3	11
GO:0016857	racemase and epimerase activity, acting on carbohydrates and derivatives	4	11
GO:0030246	carbohydrate binding	2	11
GO:0047938	glucose-6-phosphate 1-epimerase activity	5	11

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_PCSK_KEX2_1	261	263	PF00082	0.330
CLV_PCSK_PC1ET2_1	261	263	PF00082	0.330
CLV_PCSK_SKI1_1	226	230	PF00082	0.206
DEG_Nend_Nbox_1	1	3	PF02207	0.380
DEG_SCF_FBW7_1	275	282	PF00400	0.406
DOC_CKS1_1	276	281	PF01111	0.406
DOC_MAPK_gen_1	39	47	PF00069	0.519
DOC_MAPK_gen_1	9	16	PF00069	0.535
DOC_MAPK_MEF2A_6	60	67	PF00069	0.481
DOC_PP4_MxPP_1	76	79	PF00568	0.406
DOC_USP7_MATH_1	212	216	PF00917	0.406
DOC_USP7_MATH_1	279	283	PF00917	0.558
DOC_USP7_MATH_1	296	300	PF00917	0.710
DOC_USP7_UBL2_3	138	142	PF12436	0.558
DOC_WW_Pin1_4	175	180	PF00397	0.518
DOC_WW_Pin1_4	192	197	PF00397	0.437
DOC_WW_Pin1_4	230	235	PF00397	0.558
DOC_WW_Pin1_4	275	280	PF00397	0.590
DOC_WW_Pin1_4	292	297	PF00397	0.652
DOC_WW_Pin1_4	45	50	PF00397	0.492
LIG_14-3-3_CanoR_1	11	17	PF00244	0.391
LIG_Actin_WH2_2	259	275	PF00022	0.521
LIG_APCC_ABBA_1	14	19	PF00400	0.501
LIG_BRCT_BRCA1_1	150	154	PF00533	0.519
LIG_EVH1_2	78	82	PF00568	0.474
LIG_FHA_1	119	125	PF00498	0.437
LIG_FHA_1	97	103	PF00498	0.427
LIG_FHA_2	144	150	PF00498	0.563
LIG_FHA_2	23	29	PF00498	0.558
LIG_FHA_2	36	42	PF00498	0.558
LIG_HCF-1_HBM_1	43	46	PF13415	0.558
LIG_LIR_Apic_2	43	49	PF02991	0.483
LIG_LIR_Nem_3	160	164	PF02991	0.503
LIG_LIR_Nem_3	258	263	PF02991	0.465
LIG_PDZ_Class_1	296	301	PF00595	0.729
LIG_Pex14_2	154	158	PF04695	0.464
LIG_SH2_SRC	53	56	PF00017	0.406
LIG_SH2_STAP1	128	132	PF00017	0.464
LIG_SH2_STAT3	211	214	PF00017	0.464
LIG_SH2_STAT5	128	131	PF00017	0.464
LIG_SH2_STAT5	161	164	PF00017	0.481
LIG_SH2_STAT5	46	49	PF00017	0.477
LIG_SH2_STAT6	259	263	PF00017	0.478
LIG_SH3_3	191	197	PF00018	0.490
LIG_SH3_3	273	279	PF00018	0.478
LIG_SH3_3	72	78	PF00018	0.521
LIG_TRAF2_1	146	149	PF00917	0.519
LIG_TRAF2_1	295	298	PF00917	0.499
MOD_CK1_1	101	107	PF00069	0.559
MOD_CK1_1	165	171	PF00069	0.570
MOD_CK1_1	22	28	PF00069	0.480
MOD_CK1_1	281	287	PF00069	0.558
MOD_CK1_1	35	41	PF00069	0.528
MOD_CK2_1	102	108	PF00069	0.526
MOD_CK2_1	130	136	PF00069	0.545
MOD_CK2_1	143	149	PF00069	0.458
MOD_CK2_1	192	198	PF00069	0.519
MOD_CK2_1	22	28	PF00069	0.532
MOD_CK2_1	292	298	PF00069	0.619
MOD_CK2_1	35	41	PF00069	0.506
MOD_GlcNHglycan	148	153	PF01048	0.377
MOD_GSK3_1	126	133	PF00069	0.503
MOD_GSK3_1	144	151	PF00069	0.436
MOD_GSK3_1	275	282	PF00069	0.532
MOD_GSK3_1	283	290	PF00069	0.510
MOD_GSK3_1	292	299	PF00069	0.591
MOD_GSK3_1	31	38	PF00069	0.481
MOD_GSK3_1	96	103	PF00069	0.479
MOD_N-GLC_1	144	149	PF02516	0.347
MOD_N-GLC_1	175	180	PF02516	0.264
MOD_N-GLC_2	235	237	PF02516	0.206
MOD_NEK2_1	100	105	PF00069	0.578
MOD_NEK2_1	126	131	PF00069	0.493
MOD_NEK2_1	141	146	PF00069	0.493
MOD_NEK2_1	229	234	PF00069	0.580
MOD_PIKK_1	165	171	PF00454	0.424
MOD_PIKK_1	283	289	PF00454	0.478
MOD_PIKK_1	290	296	PF00454	0.510
MOD_PKA_2	10	16	PF00069	0.359
MOD_Plk_1	287	293	PF00069	0.537
MOD_Plk_4	157	163	PF00069	0.489
MOD_Plk_4	167	173	PF00069	0.485
MOD_Plk_4	267	273	PF00069	0.474
MOD_ProDKin_1	175	181	PF00069	0.518
MOD_ProDKin_1	192	198	PF00069	0.437
MOD_ProDKin_1	230	236	PF00069	0.558
MOD_ProDKin_1	275	281	PF00069	0.590
MOD_ProDKin_1	292	298	PF00069	0.659
MOD_ProDKin_1	45	51	PF00069	0.492
MOD_SUMO_rev_2	133	139	PF00179	0.558
TRG_DiLeu_BaLyEn_6	61	66	PF01217	0.558
TRG_ENDOCYTIC_2	161	164	PF00928	0.464
TRG_ENDOCYTIC_2	260	263	PF00928	0.464
TRG_ENDOCYTIC_2	73	76	PF00928	0.578
TRG_ER_diArg_1	8	11	PF00400	0.458
TRG_ER_diArg_1	84	87	PF00400	0.436

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1I6S8	Leptomonas seymouri	65%	100%
A0A0S4IIG2	Bodo saltans	34%	100%
A0A1X0P9Y8	Trypanosomatidae	48%	100%
A0A3S5H7X6	Leishmania donovani	78%	100%
A0A422NEP9	Trypanosoma rangeli	47%	100%
A4IAA4	Leishmania infantum	78%	100%
C9ZLY9	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	44%	100%
E9B5C7	Leishmania mexicana (strain MHOM/GT/2001/U1103)	80%	100%
P39173	Escherichia coli (strain K12)	34%	100%
P44160	Haemophilus influenzae (strain ATCC 51907 / DSM 11121 / KW20 / Rd)	27%	100%
Q03161	Saccharomyces cerevisiae (strain ATCC 204508 / S288c)	30%	100%
Q40784	Cenchrus ciliaris	30%	91%
Q4Q2K6	Leishmania major	77%	100%
Q8ZPV9	Salmonella typhimurium (strain LT2 / SGSC1412 / ATCC 700720)	35%	100%
V5BV57	Trypanosoma cruzi	48%	100%