Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB56_LEIBR

TriTrypDb:

LbrM.20.2960 , LBRM2903_200043100

Length:

151

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 18

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 9
NetGPI	no	yes: 0, no: 9

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB56

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB56

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_NRD_NRD_1	142	144	PF00675	0.357
CLV_NRD_NRD_1	33	35	PF00675	0.275
CLV_PCSK_KEX2_1	115	117	PF00082	0.464
CLV_PCSK_KEX2_1	142	144	PF00082	0.358
CLV_PCSK_PC1ET2_1	115	117	PF00082	0.457
CLV_PCSK_SKI1_1	35	39	PF00082	0.490
CLV_PCSK_SKI1_1	72	76	PF00082	0.502
DEG_SPOP_SBC_1	2	6	PF00917	0.626
DOC_CYCLIN_yClb3_PxF_3	145	151	PF00134	0.317
DOC_MAPK_gen_1	55	62	PF00069	0.357
DOC_MAPK_MEF2A_6	133	140	PF00069	0.441
DOC_MAPK_MEF2A_6	55	62	PF00069	0.375
DOC_MAPK_MEF2A_6	72	80	PF00069	0.366
DOC_MAPK_NFAT4_5	133	141	PF00069	0.443
DOC_PP1_RVXF_1	48	54	PF00149	0.351
DOC_USP7_MATH_1	2	6	PF00917	0.548
DOC_USP7_MATH_1	21	25	PF00917	0.510
LIG_BIR_II_1	1	5	PF00653	0.616
LIG_BRCT_BRCA1_1	48	52	PF00533	0.366
LIG_eIF4E_1	117	123	PF01652	0.488
LIG_EVH1_2	146	150	PF00568	0.389
LIG_LIR_Gen_1	90	99	PF02991	0.484
LIG_LIR_Nem_3	61	65	PF02991	0.341
LIG_LIR_Nem_3	90	94	PF02991	0.476
LIG_OCRL_FandH_1	51	63	PF00620	0.345
LIG_SH2_NCK_1	65	69	PF00017	0.476
LIG_SH2_STAT5	121	124	PF00017	0.374
LIG_SH2_STAT5	44	47	PF00017	0.368
LIG_SH3_1	143	149	PF00018	0.375
LIG_SH3_3	141	147	PF00018	0.360
LIG_SUMO_SIM_anti_2	73	79	PF11976	0.460
LIG_SUMO_SIM_par_1	73	79	PF11976	0.264
LIG_WW_1	145	148	PF00397	0.377
MOD_CK1_1	24	30	PF00069	0.332
MOD_CK1_1	5	11	PF00069	0.569
MOD_CK2_1	63	69	PF00069	0.391
MOD_GlcNHglycan	26	29	PF01048	0.333
MOD_GlcNHglycan	5	8	PF01048	0.531
MOD_GSK3_1	1	8	PF00069	0.591
MOD_NEK2_1	1	6	PF00069	0.585
MOD_NEK2_1	36	41	PF00069	0.386
MOD_NEK2_1	76	81	PF00069	0.248
MOD_PIKK_1	21	27	PF00454	0.362
MOD_PKA_2	16	22	PF00069	0.506
MOD_SUMO_rev_2	66	74	PF00179	0.439
TRG_DiLeu_BaEn_1	71	76	PF01217	0.433
TRG_DiLeu_BaEn_2	82	88	PF01217	0.317
TRG_DiLeu_BaLyEn_6	134	139	PF01217	0.293
TRG_ENDOCYTIC_2	148	151	PF00928	0.351
TRG_ENDOCYTIC_2	65	68	PF00928	0.470
TRG_ENDOCYTIC_2	91	94	PF00928	0.491
TRG_ER_diArg_1	135	138	PF00400	0.399
TRG_ER_diArg_1	142	144	PF00400	0.351
TRG_ER_diArg_1	55	58	PF00400	0.349
TRG_NES_CRM1_1	83	95	PF08389	0.457
TRG_Pf-PMV_PEXEL_1	137	141	PF00026	0.288
TRG_Pf-PMV_PEXEL_1	57	61	PF00026	0.340

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q2	Leptomonas seymouri	75%	99%
A0A1X0PAT6	Trypanosomatidae	61%	92%
A0A3Q8IFS7	Leishmania donovani	87%	100%
A0A422NEQ0	Trypanosoma rangeli	63%	98%
A4IAA3	Leishmania infantum	87%	100%
C9ZLZ0	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	58%	100%
E9B5C6	Leishmania mexicana (strain MHOM/GT/2001/U1103)	87%	100%
Q4Q2K7	Leishmania major	85%	100%