D-aminoacyl-tRNA deacylase

Quick info Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

D-Tyr-tRNA(Tyr) deacylase, putative

Species:

Leishmania braziliensis

UniProt:

A4HB55_LEIBR

TriTrypDb:

LbrM.20.2950 , LBRM2903_200043000

Length:

262

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	yes	yes: 25

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 10
NetGPI	no	yes: 0, no: 10

Cellular components
Term	Name	Level	Count
GO:0005737	cytoplasm	2	11
GO:0110165	cellular anatomical entity	1	11
GO:0031974	membrane-enclosed lumen	2	1
GO:0031981	nuclear lumen	5	1
GO:0032838	plasma membrane bounded cell projection cytoplasm	4	1
GO:0043233	organelle lumen	3	1
GO:0070013	intracellular organelle lumen	4	1
GO:0097014	ciliary plasm	5	1
GO:0099568	cytoplasmic region	3	1
GO:0016020	membrane	2	1

Expansion

Sequence features

A4HB55

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB55

Function

Biological processes
Term	Name	Level	Count
GO:0006139	nucleobase-containing compound metabolic process	3	1
GO:0006399	tRNA metabolic process	7	1
GO:0006725	cellular aromatic compound metabolic process	3	1
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009987	cellular process	1	1
GO:0016070	RNA metabolic process	5	1
GO:0034641	cellular nitrogen compound metabolic process	3	1
GO:0034660	ncRNA metabolic process	6	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044237	cellular metabolic process	2	1
GO:0044238	primary metabolic process	2	1
GO:0046483	heterocycle metabolic process	3	1
GO:0071704	organic substance metabolic process	2	1
GO:0090304	nucleic acid metabolic process	4	1
GO:1901360	organic cyclic compound metabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0002161	aminoacyl-tRNA editing activity	5	11
GO:0003824	catalytic activity	1	11
GO:0016787	hydrolase activity	2	11
GO:0016788	hydrolase activity, acting on ester bonds	3	11
GO:0051499	D-aminoacyl-tRNA deacylase activity	6	11
GO:0052689	carboxylic ester hydrolase activity	4	11
GO:0140098	catalytic activity, acting on RNA	3	11
GO:0140101	catalytic activity, acting on a tRNA	4	11
GO:0140640	catalytic activity, acting on a nucleic acid	2	11
GO:0051500	D-tyrosyl-tRNA(Tyr) deacylase activity	7	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	210	214	PF00656	0.563
CLV_NRD_NRD_1	127	129	PF00675	0.342
CLV_PCSK_KEX2_1	127	129	PF00082	0.342
CLV_PCSK_SKI1_1	137	141	PF00082	0.372
CLV_PCSK_SKI1_1	146	150	PF00082	0.199
CLV_PCSK_SKI1_1	80	84	PF00082	0.344
DEG_APCC_DBOX_1	79	87	PF00400	0.405
DEG_COP1_1	218	227	PF00400	0.455
DOC_CYCLIN_RxL_1	146	156	PF00134	0.455
DOC_MAPK_gen_1	127	134	PF00069	0.455
DOC_MAPK_gen_1	173	181	PF00069	0.546
DOC_MAPK_HePTP_8	71	83	PF00069	0.467
DOC_MAPK_MEF2A_6	104	112	PF00069	0.536
DOC_MAPK_MEF2A_6	127	134	PF00069	0.601
DOC_MAPK_MEF2A_6	74	83	PF00069	0.589
DOC_PP1_RVXF_1	175	182	PF00149	0.559
DOC_PP2B_LxvP_1	163	166	PF13499	0.532
DOC_PP4_FxxP_1	15	18	PF00568	0.494
DOC_USP7_MATH_1	166	170	PF00917	0.563
DOC_WW_Pin1_4	140	145	PF00397	0.612
DOC_WW_Pin1_4	26	31	PF00397	0.490
LIG_14-3-3_CanoR_1	150	155	PF00244	0.501
LIG_BIR_III_4	213	217	PF00653	0.563
LIG_BRCT_BRCA1_1	177	181	PF00533	0.612
LIG_BRCT_BRCA1_1	238	242	PF00533	0.608
LIG_FHA_1	147	153	PF00498	0.552
LIG_FHA_1	35	41	PF00498	0.594
LIG_FHA_2	120	126	PF00498	0.539
LIG_FHA_2	17	23	PF00498	0.489
LIG_FHA_2	208	214	PF00498	0.499
LIG_LIR_Apic_2	12	18	PF02991	0.490
LIG_LIR_Gen_1	136	147	PF02991	0.607
LIG_LIR_Gen_1	178	189	PF02991	0.580
LIG_LIR_Gen_1	195	204	PF02991	0.421
LIG_LIR_Nem_3	136	142	PF02991	0.607
LIG_LIR_Nem_3	178	184	PF02991	0.580
LIG_LIR_Nem_3	195	200	PF02991	0.421
LIG_LIR_Nem_3	229	233	PF02991	0.614
LIG_LIR_Nem_3	27	31	PF02991	0.488
LIG_PCNA_PIPBox_1	135	144	PF02747	0.566
LIG_PDZ_Class_2	257	262	PF00595	0.532
LIG_Pex14_2	256	260	PF04695	0.608
LIG_SH2_STAT5	109	112	PF00017	0.486
LIG_SH2_STAT5	47	50	PF00017	0.741
LIG_SH2_STAT5	99	102	PF00017	0.544
LIG_SUMO_SIM_anti_2	161	166	PF11976	0.532
LIG_SUMO_SIM_par_1	149	156	PF11976	0.549
LIG_SUMO_SIM_par_1	29	35	PF11976	0.474
LIG_TRAF2_1	122	125	PF00917	0.455
LIG_TRAF2_1	153	156	PF00917	0.580
LIG_TRAF2_1	65	68	PF00917	0.483
LIG_WRC_WIRS_1	25	30	PF05994	0.489
LIG_WRC_WIRS_1	54	59	PF05994	0.488
MOD_CDC14_SPxK_1	143	146	PF00782	0.612
MOD_CDK_SPxK_1	140	146	PF00069	0.612
MOD_CK1_1	56	62	PF00069	0.488
MOD_CK2_1	111	117	PF00069	0.455
MOD_CK2_1	119	125	PF00069	0.433
MOD_CK2_1	150	156	PF00069	0.577
MOD_CK2_1	16	22	PF00069	0.492
MOD_CK2_1	215	221	PF00069	0.485
MOD_CK2_1	62	68	PF00069	0.489
MOD_GlcNHglycan	188	192	PF01048	0.326
MOD_GlcNHglycan	238	241	PF01048	0.382
MOD_GlcNHglycan	50	53	PF01048	0.464
MOD_GSK3_1	133	140	PF00069	0.583
MOD_GSK3_1	146	153	PF00069	0.493
MOD_GSK3_1	232	239	PF00069	0.608
MOD_GSK3_1	55	62	PF00069	0.486
MOD_N-GLC_1	117	122	PF02516	0.323
MOD_NEK2_1	133	138	PF00069	0.612
MOD_NEK2_1	34	39	PF00069	0.459
MOD_PIKK_1	4	10	PF00454	0.494
MOD_PIKK_1	84	90	PF00454	0.455
MOD_PK_1	175	181	PF00069	0.612
MOD_Plk_1	116	122	PF00069	0.480
MOD_Plk_1	207	213	PF00069	0.556
MOD_Plk_1	34	40	PF00069	0.461
MOD_Plk_2-3	117	123	PF00069	0.549
MOD_Plk_4	226	232	PF00069	0.455
MOD_ProDKin_1	140	146	PF00069	0.612
MOD_ProDKin_1	26	32	PF00069	0.486
TRG_DiLeu_BaEn_1	159	164	PF01217	0.636
TRG_ENDOCYTIC_2	109	112	PF00928	0.594
TRG_ENDOCYTIC_2	194	197	PF00928	0.546
TRG_ENDOCYTIC_2	47	50	PF00928	0.583
TRG_ER_diArg_1	126	128	PF00400	0.542
TRG_Pf-PMV_PEXEL_1	150	155	PF00026	0.255

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N1IKW6	Leptomonas seymouri	75%	100%
A0A0S4JLF2	Bodo saltans	36%	100%
A0A1X0P9Y0	Trypanosomatidae	48%	100%
A0A3S7X8A0	Leishmania donovani	79%	100%
A0A422NEP7	Trypanosoma rangeli	45%	100%
A4IAA2	Leishmania infantum	79%	100%
C9ZLZ1	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	45%	100%
E9B5C5	Leishmania mexicana (strain MHOM/GT/2001/U1103)	79%	100%
P84066	Leishmania major	81%	100%
Q4Q2K8	Leishmania major	80%	100%