ATPase-like protein

Quick info Annotations Localization Expansion Sequence features Structure Function Putative motif mimicry Homologs Download

Quick info

Protein:

ATPase-like protein

Gene product:

ATPase-like protein

Species:

Leishmania braziliensis

UniProt:

A4HB54_LEIBR

TriTrypDb:

LbrM.20.2940 , LBRM2903_200042900

Length:

532

Annotations

LeishMANIAdb annotations

A large and likely artifical grouping of protease domain carrying proteins related to proteasomal proteases. Only a tiny subgroup (the AFG3-related mitochondrail proteins) seem to have a TM segment.. Localization: Cytoplasmic (by homology) / Mitochondrial (by homology)

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 11
NetGPI	no	yes: 0, no: 11

Cellular components
Term	Name	Level	Count
GO:0010008	endosome membrane	5	11
GO:0012506	vesicle membrane	4	11
GO:0016020	membrane	2	11
GO:0030659	cytoplasmic vesicle membrane	5	11
GO:0031090	organelle membrane	3	11
GO:0031902	late endosome membrane	6	11
GO:0098588	bounding membrane of organelle	4	11
GO:0110165	cellular anatomical entity	1	12
GO:0005737	cytoplasm	2	2
GO:0000502	proteasome complex	3	1
GO:0032991	protein-containing complex	1	1
GO:0140535	intracellular protein-containing complex	2	1
GO:1902494	catalytic complex	2	1
GO:1905368	peptidase complex	3	1
GO:1905369	endopeptidase complex	4	1

Expansion

Sequence features

A4HB54

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB54

Function

Biological processes
Term	Name	Level	Count
GO:0006807	nitrogen compound metabolic process	2	1
GO:0008152	metabolic process	1	1
GO:0009056	catabolic process	2	1
GO:0009057	macromolecule catabolic process	4	1
GO:0019538	protein metabolic process	3	1
GO:0030163	protein catabolic process	4	1
GO:0043170	macromolecule metabolic process	3	1
GO:0044238	primary metabolic process	2	1
GO:0071704	organic substance metabolic process	2	1
GO:1901564	organonitrogen compound metabolic process	3	1
GO:1901565	organonitrogen compound catabolic process	4	1
GO:1901575	organic substance catabolic process	3	1

Molecular functions
Term	Name	Level	Count
GO:0000166	nucleotide binding	3	12
GO:0003824	catalytic activity	1	12
GO:0005488	binding	1	12
GO:0005524	ATP binding	5	12
GO:0016462	pyrophosphatase activity	5	12
GO:0016787	hydrolase activity	2	12
GO:0016817	hydrolase activity, acting on acid anhydrides	3	12
GO:0016818	hydrolase activity, acting on acid anhydrides, in phosphorus-containing anhydrides	4	12
GO:0016887	ATP hydrolysis activity	7	12
GO:0017076	purine nucleotide binding	4	12
GO:0017111	ribonucleoside triphosphate phosphatase activity	6	12
GO:0030554	adenyl nucleotide binding	5	12
GO:0032553	ribonucleotide binding	3	12
GO:0032555	purine ribonucleotide binding	4	12
GO:0032559	adenyl ribonucleotide binding	5	12
GO:0035639	purine ribonucleoside triphosphate binding	4	12
GO:0036094	small molecule binding	2	12
GO:0043167	ion binding	2	12
GO:0043168	anion binding	3	12
GO:0097159	organic cyclic compound binding	2	12
GO:0097367	carbohydrate derivative binding	2	12
GO:1901265	nucleoside phosphate binding	3	12
GO:1901363	heterocyclic compound binding	2	12
GO:0036402	proteasome-activating activity	2	1
GO:0140657	ATP-dependent activity	1	1

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	250	254	PF00656	0.274
CLV_C14_Caspase3-7	391	395	PF00656	0.531
CLV_C14_Caspase3-7	82	86	PF00656	0.451
CLV_NRD_NRD_1	184	186	PF00675	0.415
CLV_NRD_NRD_1	269	271	PF00675	0.289
CLV_NRD_NRD_1	304	306	PF00675	0.312
CLV_NRD_NRD_1	321	323	PF00675	0.448
CLV_NRD_NRD_1	356	358	PF00675	0.475
CLV_NRD_NRD_1	37	39	PF00675	0.388
CLV_PCSK_KEX2_1	184	186	PF00082	0.398
CLV_PCSK_KEX2_1	269	271	PF00082	0.289
CLV_PCSK_KEX2_1	304	306	PF00082	0.319
CLV_PCSK_KEX2_1	320	322	PF00082	0.433
CLV_PCSK_KEX2_1	356	358	PF00082	0.496
CLV_PCSK_KEX2_1	36	38	PF00082	0.526
CLV_PCSK_PC1ET2_1	320	322	PF00082	0.454
CLV_PCSK_PC1ET2_1	36	38	PF00082	0.620
CLV_PCSK_PC7_1	180	186	PF00082	0.425
CLV_PCSK_SKI1_1	163	167	PF00082	0.360
CLV_PCSK_SKI1_1	17	21	PF00082	0.420
CLV_PCSK_SKI1_1	184	188	PF00082	0.274
CLV_PCSK_SKI1_1	232	236	PF00082	0.303
CLV_PCSK_SKI1_1	244	248	PF00082	0.353
CLV_PCSK_SKI1_1	269	273	PF00082	0.274
CLV_PCSK_SKI1_1	321	325	PF00082	0.422
CLV_PCSK_SKI1_1	329	333	PF00082	0.437
CLV_PCSK_SKI1_1	356	360	PF00082	0.535
CLV_PCSK_SKI1_1	75	79	PF00082	0.469
DEG_APCC_DBOX_1	40	48	PF00400	0.513
DEG_APCC_DBOX_1	74	82	PF00400	0.360
DEG_Kelch_Keap1_1	382	387	PF01344	0.511
DEG_Nend_UBRbox_2	1	3	PF02207	0.547
DEG_SCF_TRCP1_1	384	389	PF00400	0.500
DOC_CDC14_PxL_1	425	433	PF14671	0.488
DOC_CYCLIN_RxL_1	318	327	PF00134	0.455
DOC_CYCLIN_yClb5_NLxxxL_5	289	298	PF00134	0.368
DOC_CYCLIN_yCln2_LP_2	170	176	PF00134	0.417
DOC_MAPK_gen_1	269	279	PF00069	0.289
DOC_MAPK_gen_1	304	314	PF00069	0.288
DOC_MAPK_HePTP_8	267	279	PF00069	0.350
DOC_MAPK_MEF2A_6	270	279	PF00069	0.308
DOC_MAPK_MEF2A_6	305	314	PF00069	0.289
DOC_MAPK_MEF2A_6	75	83	PF00069	0.439
DOC_MAPK_NFAT4_5	272	280	PF00069	0.308
DOC_PP1_RVXF_1	242	249	PF00149	0.304
DOC_PP4_FxxP_1	176	179	PF00568	0.474
DOC_SPAK_OSR1_1	349	353	PF12202	0.424
DOC_USP7_MATH_1	238	242	PF00917	0.366
DOC_USP7_MATH_1	254	258	PF00917	0.376
DOC_USP7_MATH_1	28	32	PF00917	0.588
DOC_USP7_MATH_1	458	462	PF00917	0.743
DOC_USP7_MATH_1	512	516	PF00917	0.518
DOC_WW_Pin1_4	412	417	PF00397	0.761
DOC_WW_Pin1_4	454	459	PF00397	0.767
DOC_WW_Pin1_4	473	478	PF00397	0.489
LIG_14-3-3_CanoR_1	10	20	PF00244	0.467
LIG_14-3-3_CanoR_1	139	145	PF00244	0.448
LIG_14-3-3_CanoR_1	150	154	PF00244	0.490
LIG_14-3-3_CanoR_1	163	169	PF00244	0.415
LIG_14-3-3_CanoR_1	269	279	PF00244	0.328
LIG_14-3-3_CanoR_1	349	353	PF00244	0.424
LIG_14-3-3_CanoR_1	356	362	PF00244	0.477
LIG_14-3-3_CanoR_1	41	45	PF00244	0.387
LIG_14-3-3_CanoR_1	469	477	PF00244	0.515
LIG_14-3-3_CanoR_1	521	526	PF00244	0.573
LIG_Actin_WH2_2	316	331	PF00022	0.448
LIG_APCC_ABBAyCdc20_2	244	250	PF00400	0.289
LIG_BRCT_BRCA1_1	460	464	PF00533	0.704
LIG_Clathr_ClatBox_1	78	82	PF01394	0.294
LIG_FHA_1	119	125	PF00498	0.600
LIG_FHA_1	165	171	PF00498	0.380
LIG_FHA_1	271	277	PF00498	0.289
LIG_FHA_1	283	289	PF00498	0.256
LIG_FHA_1	330	336	PF00498	0.374
LIG_FHA_1	366	372	PF00498	0.526
LIG_FHA_1	432	438	PF00498	0.711
LIG_FHA_1	449	455	PF00498	0.516
LIG_FHA_1	490	496	PF00498	0.540
LIG_FHA_1	64	70	PF00498	0.497
LIG_FHA_1	7	13	PF00498	0.523
LIG_FHA_2	124	130	PF00498	0.638
LIG_FHA_2	201	207	PF00498	0.334
LIG_FHA_2	375	381	PF00498	0.608
LIG_FHA_2	512	518	PF00498	0.558
LIG_GBD_Chelix_1	267	275	PF00786	0.350
LIG_LIR_Gen_1	307	315	PF02991	0.438
LIG_LIR_Gen_1	347	358	PF02991	0.439
LIG_LIR_Gen_1	360	367	PF02991	0.363
LIG_LIR_Nem_3	205	210	PF02991	0.266
LIG_LIR_Nem_3	307	312	PF02991	0.438
LIG_LIR_Nem_3	347	353	PF02991	0.448
LIG_LIR_Nem_3	422	428	PF02991	0.531
LIG_MYND_1	409	413	PF01753	0.523
LIG_PDZ_Class_2	527	532	PF00595	0.388
LIG_Pex14_1	149	153	PF04695	0.511
LIG_Pex14_2	302	306	PF04695	0.334
LIG_PTAP_UEV_1	119	124	PF05743	0.556
LIG_PTB_Apo_2	94	101	PF02174	0.423
LIG_PTB_Phospho_1	94	100	PF10480	0.417
LIG_RPA_C_Fungi	317	329	PF08784	0.285
LIG_SH2_CRK	189	193	PF00017	0.289
LIG_SH2_CRK	207	211	PF00017	0.289
LIG_SH2_CRK	425	429	PF00017	0.492
LIG_SH2_STAP1	361	365	PF00017	0.266
LIG_SH2_STAP1	67	71	PF00017	0.512
LIG_SH2_STAT3	57	60	PF00017	0.351
LIG_SH2_STAT5	522	525	PF00017	0.332
LIG_SH2_STAT5	63	66	PF00017	0.469
LIG_SH3_2	120	125	PF14604	0.474
LIG_SH3_2	179	184	PF14604	0.474
LIG_SH3_2	413	418	PF14604	0.483
LIG_SH3_3	117	123	PF00018	0.630
LIG_SH3_3	176	182	PF00018	0.432
LIG_SH3_3	309	315	PF00018	0.308
LIG_SH3_3	360	366	PF00018	0.381
LIG_SH3_3	410	416	PF00018	0.758
LIG_SUMO_SIM_anti_2	285	290	PF11976	0.208
LIG_SUMO_SIM_anti_2	393	400	PF11976	0.640
LIG_SUMO_SIM_par_1	77	82	PF11976	0.409
LIG_TYR_ITSM	203	210	PF00017	0.193
MOD_CDC14_SPxK_1	415	418	PF00782	0.616
MOD_CDK_SPxK_1	412	418	PF00069	0.616
MOD_CK1_1	382	388	PF00069	0.748
MOD_CK1_1	414	420	PF00069	0.692
MOD_CK1_1	443	449	PF00069	0.738
MOD_CK1_1	450	456	PF00069	0.764
MOD_CK1_1	471	477	PF00069	0.743
MOD_CK2_1	123	129	PF00069	0.590
MOD_CK2_1	200	206	PF00069	0.323
MOD_CK2_1	385	391	PF00069	0.670
MOD_CK2_1	443	449	PF00069	0.659
MOD_CK2_1	475	481	PF00069	0.506
MOD_CK2_1	512	518	PF00069	0.494
MOD_CK2_1	62	68	PF00069	0.533
MOD_GlcNHglycan	214	217	PF01048	0.285
MOD_GlcNHglycan	256	259	PF01048	0.417
MOD_GlcNHglycan	384	387	PF01048	0.760
MOD_GlcNHglycan	442	445	PF01048	0.785
MOD_GlcNHglycan	514	517	PF01048	0.584
MOD_GSK3_1	145	152	PF00069	0.545
MOD_GSK3_1	329	336	PF00069	0.435
MOD_GSK3_1	344	351	PF00069	0.413
MOD_GSK3_1	382	389	PF00069	0.770
MOD_GSK3_1	443	450	PF00069	0.734
MOD_GSK3_1	454	461	PF00069	0.761
MOD_GSK3_1	468	475	PF00069	0.669
MOD_GSK3_1	49	56	PF00069	0.501
MOD_GSK3_1	508	515	PF00069	0.619
MOD_GSK3_1	520	527	PF00069	0.510
MOD_GSK3_1	59	66	PF00069	0.541
MOD_NEK2_1	174	179	PF00069	0.499
MOD_NEK2_1	212	217	PF00069	0.283
MOD_NEK2_1	289	294	PF00069	0.374
MOD_NEK2_1	371	376	PF00069	0.570
MOD_NEK2_1	40	45	PF00069	0.342
MOD_PIKK_1	371	377	PF00454	0.509
MOD_PK_1	424	430	PF00069	0.649
MOD_PKA_2	149	155	PF00069	0.501
MOD_PKA_2	348	354	PF00069	0.431
MOD_PKA_2	380	386	PF00069	0.725
MOD_PKA_2	40	46	PF00069	0.468
MOD_PKA_2	468	474	PF00069	0.581
MOD_PKA_2	520	526	PF00069	0.462
MOD_PKB_1	485	493	PF00069	0.469
MOD_Plk_1	448	454	PF00069	0.679
MOD_Plk_1	6	12	PF00069	0.488
MOD_Plk_1	67	73	PF00069	0.392
MOD_Plk_2-3	348	354	PF00069	0.498
MOD_Plk_4	284	290	PF00069	0.378
MOD_Plk_4	49	55	PF00069	0.439
MOD_Plk_4	59	65	PF00069	0.531
MOD_ProDKin_1	412	418	PF00069	0.761
MOD_ProDKin_1	454	460	PF00069	0.766
MOD_ProDKin_1	473	479	PF00069	0.514
MOD_SUMO_for_1	271	274	PF00179	0.289
TRG_DiLeu_BaEn_1	8	13	PF01217	0.399
TRG_DiLeu_BaLyEn_6	182	187	PF01217	0.427
TRG_DiLeu_BaLyEn_6	319	324	PF01217	0.489
TRG_DiLeu_BaLyEn_6	354	359	PF01217	0.474
TRG_DiLeu_BaLyEn_6	406	411	PF01217	0.719
TRG_DiLeu_BaLyEn_6	484	489	PF01217	0.607
TRG_ENDOCYTIC_2	207	210	PF00928	0.350
TRG_ENDOCYTIC_2	361	364	PF00928	0.268
TRG_ENDOCYTIC_2	425	428	PF00928	0.494
TRG_ER_diArg_1	183	185	PF00400	0.424
TRG_ER_diArg_1	269	271	PF00400	0.289
TRG_ER_diArg_1	303	305	PF00400	0.296
TRG_ER_diArg_1	321	323	PF00400	0.444
TRG_ER_diArg_1	355	357	PF00400	0.544
TRG_ER_diArg_1	485	488	PF00400	0.494
TRG_NES_CRM1_1	266	280	PF08389	0.417
TRG_NLS_Bipartite_1	304	324	PF00514	0.421
TRG_Pf-PMV_PEXEL_1	269	274	PF00026	0.417
TRG_Pf-PMV_PEXEL_1	322	327	PF00026	0.511

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P643	Leptomonas seymouri	49%	99%
A0A1X0P9Z1	Trypanosomatidae	41%	100%
A0A3Q8IIF1	Leishmania donovani	74%	99%
A0A422NNS9	Trypanosoma rangeli	44%	100%
A4IAA1	Leishmania infantum	74%	99%
C9ZLZ3	Trypanosoma brucei gambiense (strain MHOM/CI/86/DAL972)	42%	100%
E9B5C4	Leishmania mexicana (strain MHOM/GT/2001/U1103)	76%	99%
Q4Q2K9	Leishmania major	75%	100%
V5B5D2	Trypanosoma cruzi	44%	100%
V5BKL6	Trypanosoma cruzi	28%	100%