Uncharacterized protein

Quick info Localization Expansion Sequence features Structure Putative motif mimicry Homologs Download

Quick info

Protein:

Gene product:

hypothetical protein, conserved

Species:

Leishmania braziliensis

UniProt:

A4HB53_LEIBR

TriTrypDb:

LbrM.20.2930 , LBRM2903_200042800

Length:

716

Localization

Secreted promastigote


Source	Evidence on protein	Close homologs
Cuervo et al.	no	yes: 0
Hassani et al.	no	yes: 0
Forrest at al. (metacyclic)	no	yes: 0
Forrest at al. (procyclic)	no	yes: 0
Silverman et al.	no	yes: 0
Pissara et al.	no	yes: 0

Secreted amastigote


Source	Evidence on protein	Close homologs
Pires et al.	no	yes: 0

Exosome


Source	Evidence on protein	Close homologs
Silverman et al.	no	yes: 0

Glycosome


Source	Evidence on protein	Close homologs
Jamdhade et al.	no	yes: 0

Predictions


Source	Evidence on protein	Close homologs
DeepLoc
SignalP6	no	yes: 0, no: 6
NetGPI	no	yes: 0, no: 6

Could not find GO cellular_component term for this entry.

Expansion

Sequence features

A4HB53

Sequence

MSA

Disorder

Secondary

Topology

Domains

SignalP

GPI

Phosphorylations

ELMs

Structure

Predicted structure by AlphaFold2

Related structures:

AlphaFold database: A4HB53

Putative motif mimicry


Leishmania	From	To	Domain/Motif	Score
CLV_C14_Caspase3-7	223	227	PF00656	0.428
CLV_C14_Caspase3-7	493	497	PF00656	0.579
CLV_C14_Caspase3-7	616	620	PF00656	0.514
CLV_NRD_NRD_1	425	427	PF00675	0.691
CLV_NRD_NRD_1	446	448	PF00675	0.535
CLV_NRD_NRD_1	633	635	PF00675	0.640
CLV_PCSK_KEX2_1	157	159	PF00082	0.625
CLV_PCSK_KEX2_1	30	32	PF00082	0.665
CLV_PCSK_KEX2_1	425	427	PF00082	0.655
CLV_PCSK_KEX2_1	446	448	PF00082	0.606
CLV_PCSK_KEX2_1	531	533	PF00082	0.643
CLV_PCSK_KEX2_1	666	668	PF00082	0.500
CLV_PCSK_PC1ET2_1	157	159	PF00082	0.505
CLV_PCSK_PC1ET2_1	30	32	PF00082	0.649
CLV_PCSK_PC1ET2_1	531	533	PF00082	0.529
CLV_PCSK_PC1ET2_1	666	668	PF00082	0.500
CLV_PCSK_SKI1_1	309	313	PF00082	0.714
CLV_PCSK_SKI1_1	426	430	PF00082	0.686
CLV_PCSK_SKI1_1	447	451	PF00082	0.527
CLV_PCSK_SKI1_1	613	617	PF00082	0.480
CLV_PCSK_SKI1_1	97	101	PF00082	0.545
DEG_SCF_FBW7_1	663	668	PF00400	0.500
DEG_SPOP_SBC_1	219	223	PF00917	0.410
DEG_SPOP_SBC_1	318	322	PF00917	0.536
DEG_SPOP_SBC_1	372	376	PF00917	0.546
DEG_SPOP_SBC_1	534	538	PF00917	0.516
DEG_SPOP_SBC_1	654	658	PF00917	0.504
DOC_CKS1_1	548	553	PF01111	0.564
DOC_CYCLIN_RxL_1	550	560	PF00134	0.561
DOC_CYCLIN_RxL_1	93	104	PF00134	0.480
DOC_MAPK_gen_1	446	452	PF00069	0.611
DOC_MAPK_gen_1	93	102	PF00069	0.523
DOC_MAPK_MEF2A_6	134	143	PF00069	0.433
DOC_MAPK_MEF2A_6	163	172	PF00069	0.422
DOC_MAPK_MEF2A_6	599	607	PF00069	0.605
DOC_MAPK_MEF2A_6	81	89	PF00069	0.439
DOC_PP1_RVXF_1	480	486	PF00149	0.528
DOC_PP1_RVXF_1	569	576	PF00149	0.527
DOC_PP1_RVXF_1	79	85	PF00149	0.438
DOC_PP4_FxxP_1	60	63	PF00568	0.597
DOC_SPAK_OSR1_1	574	578	PF12202	0.449
DOC_USP7_MATH_1	201	205	PF00917	0.595
DOC_USP7_MATH_1	220	224	PF00917	0.418
DOC_USP7_MATH_1	274	278	PF00917	0.477
DOC_USP7_MATH_1	318	322	PF00917	0.557
DOC_USP7_MATH_1	359	363	PF00917	0.586
DOC_USP7_MATH_1	372	376	PF00917	0.609
DOC_USP7_MATH_1	389	393	PF00917	0.558
DOC_USP7_MATH_1	409	413	PF00917	0.654
DOC_USP7_MATH_1	41	45	PF00917	0.614
DOC_USP7_MATH_1	505	509	PF00917	0.477
DOC_USP7_MATH_1	654	658	PF00917	0.494
DOC_USP7_MATH_1	665	669	PF00917	0.470
DOC_USP7_MATH_1	71	75	PF00917	0.501
DOC_WW_Pin1_4	163	168	PF00397	0.590
DOC_WW_Pin1_4	190	195	PF00397	0.509
DOC_WW_Pin1_4	232	237	PF00397	0.401
DOC_WW_Pin1_4	284	289	PF00397	0.520
DOC_WW_Pin1_4	36	41	PF00397	0.643
DOC_WW_Pin1_4	375	380	PF00397	0.575
DOC_WW_Pin1_4	399	404	PF00397	0.596
DOC_WW_Pin1_4	463	468	PF00397	0.601
DOC_WW_Pin1_4	470	475	PF00397	0.594
DOC_WW_Pin1_4	510	515	PF00397	0.633
DOC_WW_Pin1_4	547	552	PF00397	0.559
DOC_WW_Pin1_4	59	64	PF00397	0.553
DOC_WW_Pin1_4	594	599	PF00397	0.585
DOC_WW_Pin1_4	661	666	PF00397	0.591
LIG_14-3-3_CanoR_1	365	371	PF00244	0.663
LIG_14-3-3_CanoR_1	453	461	PF00244	0.475
LIG_14-3-3_CanoR_1	532	539	PF00244	0.617
LIG_14-3-3_CanoR_1	634	639	PF00244	0.583
LIG_14-3-3_CanoR_1	64	70	PF00244	0.514
LIG_BIR_III_2	253	257	PF00653	0.564
LIG_Clathr_ClatBox_1	76	80	PF01394	0.573
LIG_DCNL_PONY_1	1	4	PF03556	0.481
LIG_deltaCOP1_diTrp_1	208	216	PF00928	0.515
LIG_deltaCOP1_diTrp_1	52	61	PF00928	0.541
LIG_EVH1_2	403	407	PF00568	0.518
LIG_FAT_LD_1	706	714	PF03623	0.450
LIG_FHA_1	178	184	PF00498	0.572
LIG_FHA_1	208	214	PF00498	0.637
LIG_FHA_1	242	248	PF00498	0.427
LIG_FHA_1	274	280	PF00498	0.483
LIG_FHA_1	288	294	PF00498	0.473
LIG_FHA_1	318	324	PF00498	0.532
LIG_FHA_1	4	10	PF00498	0.555
LIG_FHA_1	455	461	PF00498	0.459
LIG_FHA_1	578	584	PF00498	0.525
LIG_FHA_1	623	629	PF00498	0.694
LIG_FHA_1	635	641	PF00498	0.579
LIG_FHA_1	64	70	PF00498	0.523
LIG_FHA_2	123	129	PF00498	0.530
LIG_FHA_2	303	309	PF00498	0.535
LIG_FHA_2	379	385	PF00498	0.538
LIG_FHA_2	403	409	PF00498	0.522
LIG_FHA_2	47	53	PF00498	0.533
LIG_FHA_2	614	620	PF00498	0.510
LIG_LIR_Apic_2	58	63	PF02991	0.521
LIG_LIR_Gen_1	142	149	PF02991	0.529
LIG_LIR_Gen_1	405	415	PF02991	0.569
LIG_LIR_Gen_1	445	456	PF02991	0.550
LIG_LIR_Gen_1	636	646	PF02991	0.715
LIG_LIR_Nem_3	142	146	PF02991	0.525
LIG_LIR_Nem_3	269	273	PF02991	0.538
LIG_LIR_Nem_3	405	410	PF02991	0.529
LIG_LIR_Nem_3	445	451	PF02991	0.593
LIG_LIR_Nem_3	636	641	PF02991	0.594
LIG_LIR_Nem_3	679	684	PF02991	0.721
LIG_NRBOX	709	715	PF00104	0.443
LIG_SH2_CRK	448	452	PF00017	0.583
LIG_SH2_STAP1	243	247	PF00017	0.557
LIG_SH2_STAP1	448	452	PF00017	0.583
LIG_SH2_STAT3	629	632	PF00017	0.667
LIG_SH2_STAT5	230	233	PF00017	0.484
LIG_SH2_STAT5	243	246	PF00017	0.523
LIG_SH3_3	580	586	PF00018	0.752
LIG_SH3_3	595	601	PF00018	0.514
LIG_SUMO_SIM_anti_2	164	172	PF11976	0.618
LIG_SUMO_SIM_par_1	486	493	PF11976	0.486
LIG_SUMO_SIM_par_1	74	80	PF11976	0.574
LIG_SUMO_SIM_par_1	98	104	PF11976	0.542
LIG_TRAF2_1	381	384	PF00917	0.545
MOD_CDK_SPK_2	59	64	PF00069	0.514
MOD_CDK_SPK_2	594	599	PF00069	0.626
MOD_CDK_SPK_2	661	666	PF00069	0.504
MOD_CDK_SPxK_1	547	553	PF00069	0.559
MOD_CDK_SPxK_1	661	667	PF00069	0.504
MOD_CDK_SPxxK_3	190	197	PF00069	0.471
MOD_CK1_1	104	110	PF00069	0.627
MOD_CK1_1	112	118	PF00069	0.597
MOD_CK1_1	166	172	PF00069	0.520
MOD_CK1_1	19	25	PF00069	0.549
MOD_CK1_1	302	308	PF00069	0.532
MOD_CK1_1	338	344	PF00069	0.594
MOD_CK1_1	350	356	PF00069	0.683
MOD_CK1_1	375	381	PF00069	0.766
MOD_CK1_1	39	45	PF00069	0.646
MOD_CK1_1	392	398	PF00069	0.509
MOD_CK1_1	470	476	PF00069	0.538
MOD_CK1_1	484	490	PF00069	0.639
MOD_CK1_1	518	524	PF00069	0.663
MOD_CK1_1	535	541	PF00069	0.611
MOD_CK1_1	618	624	PF00069	0.608
MOD_CK2_1	110	116	PF00069	0.542
MOD_CK2_1	122	128	PF00069	0.510
MOD_CK2_1	246	252	PF00069	0.524
MOD_CK2_1	378	384	PF00069	0.537
MOD_CK2_1	402	408	PF00069	0.772
MOD_CK2_1	46	52	PF00069	0.527
MOD_CK2_1	72	78	PF00069	0.625
MOD_GlcNHglycan	103	106	PF01048	0.584
MOD_GlcNHglycan	186	189	PF01048	0.560
MOD_GlcNHglycan	21	24	PF01048	0.534
MOD_GlcNHglycan	236	239	PF01048	0.501
MOD_GlcNHglycan	248	251	PF01048	0.469
MOD_GlcNHglycan	276	279	PF01048	0.492
MOD_GlcNHglycan	301	304	PF01048	0.606
MOD_GlcNHglycan	343	346	PF01048	0.651
MOD_GlcNHglycan	361	364	PF01048	0.616
MOD_GlcNHglycan	375	378	PF01048	0.581
MOD_GlcNHglycan	392	395	PF01048	0.655
MOD_GlcNHglycan	43	46	PF01048	0.613
MOD_GlcNHglycan	434	437	PF01048	0.809
MOD_GlcNHglycan	454	457	PF01048	0.483
MOD_GlcNHglycan	469	472	PF01048	0.608
MOD_GlcNHglycan	486	489	PF01048	0.734
MOD_GlcNHglycan	49	52	PF01048	0.578
MOD_GlcNHglycan	496	499	PF01048	0.474
MOD_GSK3_1	104	111	PF00069	0.581
MOD_GSK3_1	118	125	PF00069	0.576
MOD_GSK3_1	149	156	PF00069	0.574
MOD_GSK3_1	162	169	PF00069	0.432
MOD_GSK3_1	218	225	PF00069	0.424
MOD_GSK3_1	287	294	PF00069	0.504
MOD_GSK3_1	32	39	PF00069	0.595
MOD_GSK3_1	337	344	PF00069	0.607
MOD_GSK3_1	346	353	PF00069	0.700
MOD_GSK3_1	359	366	PF00069	0.544
MOD_GSK3_1	371	378	PF00069	0.728
MOD_GSK3_1	459	466	PF00069	0.599
MOD_GSK3_1	484	491	PF00069	0.717
MOD_GSK3_1	506	513	PF00069	0.614
MOD_GSK3_1	55	62	PF00069	0.574
MOD_GSK3_1	562	569	PF00069	0.630
MOD_GSK3_1	609	616	PF00069	0.590
MOD_GSK3_1	618	625	PF00069	0.609
MOD_GSK3_1	630	637	PF00069	0.530
MOD_GSK3_1	65	72	PF00069	0.530
MOD_GSK3_1	661	668	PF00069	0.765
MOD_LATS_1	561	567	PF00433	0.525
MOD_N-GLC_1	346	351	PF02516	0.567
MOD_NEK2_1	101	106	PF00069	0.544
MOD_NEK2_1	110	115	PF00069	0.604
MOD_NEK2_1	126	131	PF00069	0.483
MOD_NEK2_1	14	19	PF00069	0.608
MOD_NEK2_1	149	154	PF00069	0.458
MOD_NEK2_1	224	229	PF00069	0.415
MOD_NEK2_1	266	271	PF00069	0.448
MOD_NEK2_1	3	8	PF00069	0.549
MOD_NEK2_1	32	37	PF00069	0.502
MOD_NEK2_1	555	560	PF00069	0.486
MOD_NEK2_1	65	70	PF00069	0.511
MOD_NEK2_2	409	414	PF00069	0.641
MOD_NEK2_2	655	660	PF00069	0.497
MOD_PIKK_1	118	124	PF00454	0.526
MOD_PIKK_1	224	230	PF00454	0.435
MOD_PIKK_1	287	293	PF00454	0.625
MOD_PIKK_1	32	38	PF00454	0.590
MOD_PIKK_1	335	341	PF00454	0.663
MOD_PIKK_1	420	426	PF00454	0.531
MOD_PKA_1	634	640	PF00069	0.618
MOD_PKA_2	108	114	PF00069	0.521
MOD_PKA_2	14	20	PF00069	0.664
MOD_PKA_2	177	183	PF00069	0.425
MOD_PKA_2	452	458	PF00069	0.521
MOD_PKA_2	562	568	PF00069	0.517
MOD_PKA_2	63	69	PF00069	0.512
MOD_PKA_2	633	639	PF00069	0.628
MOD_Plk_1	118	124	PF00069	0.555
MOD_Plk_1	207	213	PF00069	0.588
MOD_Plk_1	291	297	PF00069	0.645
MOD_Plk_1	307	313	PF00069	0.545
MOD_Plk_1	318	324	PF00069	0.497
MOD_Plk_1	566	572	PF00069	0.474
MOD_Plk_4	166	172	PF00069	0.645
MOD_Plk_4	266	272	PF00069	0.446
MOD_Plk_4	291	297	PF00069	0.645
MOD_Plk_4	366	372	PF00069	0.651
MOD_Plk_4	402	408	PF00069	0.525
MOD_Plk_4	644	650	PF00069	0.594
MOD_Plk_4	72	78	PF00069	0.562
MOD_ProDKin_1	163	169	PF00069	0.580
MOD_ProDKin_1	190	196	PF00069	0.511
MOD_ProDKin_1	232	238	PF00069	0.408
MOD_ProDKin_1	284	290	PF00069	0.520
MOD_ProDKin_1	36	42	PF00069	0.642
MOD_ProDKin_1	375	381	PF00069	0.576
MOD_ProDKin_1	399	405	PF00069	0.595
MOD_ProDKin_1	463	469	PF00069	0.603
MOD_ProDKin_1	470	476	PF00069	0.595
MOD_ProDKin_1	510	516	PF00069	0.637
MOD_ProDKin_1	547	553	PF00069	0.559
MOD_ProDKin_1	59	65	PF00069	0.552
MOD_ProDKin_1	594	600	PF00069	0.579
MOD_ProDKin_1	661	667	PF00069	0.590
MOD_SUMO_for_1	659	662	PF00179	0.570
MOD_SUMO_rev_2	479	484	PF00179	0.530
TRG_DiLeu_BaLyEn_6	600	605	PF01217	0.520
TRG_DiLeu_BaLyEn_6	709	714	PF01217	0.436
TRG_ENDOCYTIC_2	448	451	PF00928	0.577
TRG_ER_diArg_1	446	448	PF00400	0.518
TRG_Pf-PMV_PEXEL_1	332	337	PF00026	0.542
TRG_Pf-PMV_PEXEL_1	697	701	PF00026	0.588
TRG_Pf-PMV_PEXEL_1	712	716	PF00026	0.452

Homologs


Protein	Taxonomy	Sequence identity	Coverage
A0A0N0P5Q0	Leptomonas seymouri	34%	88%
A0A3S7X8B8	Leishmania donovani	62%	98%
E9AHT9	Leishmania infantum	62%	98%
E9B5C3	Leishmania mexicana (strain MHOM/GT/2001/U1103)	64%	87%
Q4Q2L0	Leishmania major	63%	100%